SYT6_HUMAN
Evidence for PS localization
Functions
May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SYT6_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 29.2683 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 26.8293 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.8293 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.8293 | 4 | no |
| GO:0019905 | syntaxin binding | 14.6341 | 4 | yes |
| GO:0042803 | protein homodimerization activity | 14.6341 | 4 | yes |
| GO:0005509 | calcium ion binding | 12.1951 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SYT6_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 56.0976 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7805 | 4 | no |
| GO:0071702 | organic substance transport | 46.3415 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.3415 | 4 | no |
| GO:0071705 | nitrogen compound transport | 43.9024 | 4 | no |
| GO:0051049 | regulation of transport | 41.4634 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 41.4634 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.4634 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.4634 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.4634 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.0244 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.0244 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 36.5854 | 4 | yes |
| GO:0010468 | regulation of gene expression | 36.5854 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.5854 | 4 | no |
| GO:0008104 | protein localization | 36.5854 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.1463 | 5 | no |
| GO:0006996 | organelle organization | 34.1463 | 4 | no |
| GO:0015031 | protein transport | 34.1463 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 31.7073 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.7073 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 29.2683 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 29.2683 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.2683 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.2683 | 6 | no |
| GO:0009966 | regulation of signal transduction | 29.2683 | 4 | no |
| GO:0071310 | cellular response to organic substance | 29.2683 | 4 | no |
| GO:0051046 | regulation of secretion | 26.8293 | 5 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 26.8293 | 4 | yes |
| GO:1903530 | regulation of secretion by cell | 26.8293 | 4 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.8293 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.8293 | 5 | no |
| GO:0022607 | cellular component assembly | 26.8293 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 24.3902 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.3902 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.3902 | 5 | no |
| GO:0080134 | regulation of response to stress | 24.3902 | 4 | no |
| GO:0023056 | positive regulation of signaling | 24.3902 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.3902 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 21.9512 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.9512 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 21.9512 | 5 | no |
| GO:0031399 | regulation of protein modification process | 21.9512 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.9512 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 21.9512 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.9512 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.9512 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.9512 | 4 | no |
| GO:0043269 | regulation of ion transport | 19.5122 | 5 | yes |
| GO:0017157 | regulation of exocytosis | 17.0732 | 5 | yes |
| GO:0010038 | response to metal ion | 14.6341 | 4 | yes |
| GO:0046903 | secretion | 14.6341 | 4 | yes |
| GO:0071241 | cellular response to inorganic substance | 14.6341 | 4 | yes |
| GO:1903305 | regulation of regulated secretory pathway | 14.6341 | 6 | yes |
| GO:0006887 | exocytosis | 12.1951 | 4 | yes |
| GO:0017156 | calcium-ion regulated exocytosis | 12.1951 | 6 | yes |
| GO:0045055 | regulated exocytosis | 12.1951 | 5 | yes |
| GO:0071248 | cellular response to metal ion | 12.1951 | 5 | yes |
| GO:0014059 | regulation of dopamine secretion | 9.7561 | 6 | yes |
| GO:0017158 | regulation of calcium ion-dependent exocytosis | 9.7561 | 7 | yes |
| GO:0050433 | regulation of catecholamine secretion | 9.7561 | 5 | yes |
| GO:0051592 | response to calcium ion | 9.7561 | 5 | yes |
| GO:0051952 | regulation of amine transport | 9.7561 | 5 | yes |
| GO:0071277 | cellular response to calcium ion | 7.3171 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in SYT6_HUMAN |
|---|---|---|---|---|
| DOID:10595 | Charcot-Marie-Tooth disease | 4.8780 | 6 | no |
| DOID:440 | neuromuscular disease | 4.8780 | 5 | no |
| DOID:574 | peripheral nervous system disease | 4.8780 | 3 | no |
| DOID:870 | neuropathy | 4.8780 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYT6_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KPCB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| SYT9_HUMAN | [view interactions] | High throughput | no | no |
| SYT3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYT10_HUMAN | [view interactions] | High throughput | no | no |
| DVL3_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT43_HUMAN | [view interactions] | High throughput | no | yes |
| MTUS2_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD9_HUMAN | [view interactions] | High throughput | no | no |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| K1C40_HUMAN | [view interactions] | High throughput | no | no |
| ZBT8A_HUMAN | [view interactions] | High throughput | no | yes |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| LZTS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GMCL1_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| FXR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CC136_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| HMBX1_HUMAN | [view interactions] | High throughput | no | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| KIF24_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI27_HUMAN | [view interactions] | High throughput | no | yes |
| CETN3_HUMAN | [view interactions] | High throughput | no | yes |
| SAHH3_HUMAN | [view interactions] | High throughput | no | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM11E_HUMAN | [view interactions] | High throughput | no | no |
| CD166_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| TYPH_HUMAN | [view interactions] | High throughput | no | no |
| CKAP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| RMD1_HUMAN | [view interactions] | High throughput | no | no |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA15_HUMAN | [view interactions] | High throughput | no | yes |
| NAA50_HUMAN | [view interactions] | High throughput | no | yes |
| PRPS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VTA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI1_HUMAN | [view interactions] | High throughput | no | yes |
| TOPK_HUMAN | [view interactions] | High throughput | no | no |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB2_HUMAN | [view interactions] | High throughput | no | no |
| FACE1_HUMAN | [view interactions] | High throughput | no | yes |
| VRK1_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTH2_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| VPP2_HUMAN | [view interactions] | High throughput | no | yes |
| SND1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RDH11_HUMAN | [view interactions] | High throughput | no | no |
| GALE_HUMAN | [view interactions] | High throughput | no | no |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| MIPEP_HUMAN | [view interactions] | High throughput | no | yes |
| EDC4_HUMAN | [view interactions] | High throughput | no | yes |
| TMM70_HUMAN | [view interactions] | High throughput | no | yes |
| PUS7_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MCTS1_HUMAN | [view interactions] | High throughput | no | no |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| F162A_HUMAN | [view interactions] | High throughput | no | yes |
| SFXN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRE1B_HUMAN | [view interactions] | High throughput | no | yes |
| HDGR2_HUMAN | [view interactions] | High throughput | no | yes |
| QCR8_HUMAN | [view interactions] | High throughput | no | yes |
| PGES2_HUMAN | [view interactions] | High throughput | no | yes |
| CND1_HUMAN | [view interactions] | High throughput | no | yes |
| CYRIB_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDS5A_HUMAN | [view interactions] | High throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TKFC_HUMAN | [view interactions] | High throughput | no | no |
| JAM1_HUMAN | [view interactions] | High throughput | no | yes |
| RAVR1_HUMAN | [view interactions] | High throughput | no | yes |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| SAHH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK25_HUMAN | [view interactions] | High throughput | no | no |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| NSDHL_HUMAN | [view interactions] | High throughput | no | yes |
| RAB14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| S29A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRPRA_HUMAN | [view interactions] | High throughput | no | no |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RRP44_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |