LZTS1_HUMAN
Evidence for PS localization
Functions
Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in LZTS1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 28.5714 | 4 | no |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
| GO:0017076 | purine nucleotide binding | 21.4286 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 21.4286 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.4286 | 4 | no |
| GO:0046872 | metal ion binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in LZTS1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0016192 | vesicle-mediated transport | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 42.8571 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 35.7143 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 35.7143 | 5 | yes |
| GO:0006996 | organelle organization | 35.7143 | 4 | no |
| GO:0008104 | protein localization | 35.7143 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 35.7143 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 35.7143 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.7143 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 35.7143 | 4 | no |
| GO:0010646 | regulation of cell communication | 28.5714 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.5714 | 4 | yes |
| GO:0015031 | protein transport | 28.5714 | 4 | no |
| GO:0071702 | organic substance transport | 28.5714 | 4 | no |
| GO:0071705 | nitrogen compound transport | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0051049 | regulation of transport | 28.5714 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
| GO:0010975 | regulation of neuron projection development | 21.4286 | 7 | yes |
| GO:0031344 | regulation of cell projection organization | 21.4286 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 21.4286 | 6 | yes |
| GO:0006886 | intracellular protein transport | 21.4286 | 4 | no |
| GO:0006915 | apoptotic process | 21.4286 | 4 | no |
| GO:0006887 | exocytosis | 21.4286 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 21.4286 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 21.4286 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0046903 | secretion | 21.4286 | 4 | no |
| GO:0051046 | regulation of secretion | 21.4286 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 21.4286 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 21.4286 | 5 | no |
| GO:1903530 | regulation of secretion by cell | 21.4286 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0010468 | regulation of gene expression | 21.4286 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 21.4286 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 21.4286 | 4 | no |
| GO:0009894 | regulation of catabolic process | 14.2857 | 4 | yes |
| GO:0010506 | regulation of autophagy | 14.2857 | 6 | yes |
| GO:0016241 | regulation of macroautophagy | 14.2857 | 7 | yes |
| GO:0031329 | regulation of cellular catabolic process | 14.2857 | 5 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 14.2857 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 14.2857 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 14.2857 | 5 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 14.2857 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| EF1G_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | Low throughput | no | no |
| MPIP3_HUMAN | [view interactions] | Low throughput | no | yes |
| DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MT21A_HUMAN | [view interactions] | High throughput | no | yes |
| MCRS1_HUMAN | [view interactions] | High throughput | no | yes |
| TSG10_HUMAN | [view interactions] | High throughput | no | no |
| DRC4_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| ENKD1_HUMAN | [view interactions] | High throughput | no | yes |
| PPR18_HUMAN | [view interactions] | High throughput | no | no |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| CKS1_HUMAN | [view interactions] | High throughput | no | yes |
| SGF29_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| PICK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GPKOW_HUMAN | [view interactions] | High throughput | no | yes |
| KIF9_HUMAN | [view interactions] | High throughput | no | yes |
| TCEA2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC23_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD7_HUMAN | [view interactions] | High throughput | no | no |
| RBTN1_HUMAN | [view interactions] | High throughput | no | no |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| MK09_HUMAN | [view interactions] | High throughput | no | yes |
| RSP14_HUMAN | [view interactions] | High throughput | no | no |
| COG2_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| T10IP_HUMAN | [view interactions] | High throughput | no | no |
| COPB_HUMAN | [view interactions] | High throughput | no | yes |
| FA50B_HUMAN | [view interactions] | High throughput | no | yes |
| F161A_HUMAN | [view interactions] | High throughput | no | no |
| FA81B_HUMAN | [view interactions] | High throughput | no | no |
| F161B_HUMAN | [view interactions] | High throughput | no | yes |
| AP1M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| SCNM1_HUMAN | [view interactions] | High throughput | no | no |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| SUFU_HUMAN | [view interactions] | High throughput | no | yes |
| LSM2_HUMAN | [view interactions] | High throughput | no | yes |
| MFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TTC9C_HUMAN | [view interactions] | High throughput | no | yes |
| TXND9_HUMAN | [view interactions] | High throughput | no | yes |
| SYT17_HUMAN | [view interactions] | High throughput | no | no |
| ZN587_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF35_HUMAN | [view interactions] | High throughput | no | no |
| SPDYC_HUMAN | [view interactions] | High throughput | no | yes |
| TBCD1_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| C19L2_HUMAN | [view interactions] | High throughput | no | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| ZN572_HUMAN | [view interactions] | High throughput | no | yes |
| LENG1_HUMAN | [view interactions] | High throughput | no | no |
| SYTL4_HUMAN | [view interactions] | High throughput | no | yes |
| CCD13_HUMAN | [view interactions] | High throughput | no | no |
| CDC7_HUMAN | [view interactions] | High throughput | no | yes |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| KDM1A_HUMAN | [view interactions] | High throughput | no | yes |
| LMO4_HUMAN | [view interactions] | High throughput | no | yes |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| AAKB2_HUMAN | [view interactions] | High throughput | no | yes |
| RHPN1_HUMAN | [view interactions] | High throughput | no | yes |
| KAT5_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| ZMY19_HUMAN | [view interactions] | High throughput | no | yes |
| RPC3_HUMAN | [view interactions] | High throughput | no | yes |
| ZNF3_HUMAN | [view interactions] | High throughput | no | yes |
| ELOA1_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNB_HUMAN | [view interactions] | High throughput | no | no |
| ZN417_HUMAN | [view interactions] | High throughput | no | yes |
| AGTR1_HUMAN | [view interactions] | High throughput | no | no |
| LMO3_HUMAN | [view interactions] | High throughput | no | no |
| MTG8_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM1_HUMAN | [view interactions] | High throughput | no | no |
| PIBF1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK6_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| AMOT_HUMAN | [view interactions] | High throughput | no | no |
| SYT6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| F71F1_HUMAN | [view interactions] | High throughput | no | no |
| RBTN2_HUMAN | [view interactions] | High throughput | no | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| SOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| CEP83_HUMAN | [view interactions] | High throughput | no | yes |
| CCD57_HUMAN | [view interactions] | High throughput | no | yes |
| CARD9_HUMAN | [view interactions] | High throughput | no | no |
| I23O2_HUMAN | [view interactions] | High throughput | no | no |
| KAZRN_HUMAN | [view interactions] | High throughput | no | yes |
| ZN250_HUMAN | [view interactions] | High throughput | no | yes |
| ZGPAT_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| U119A_HUMAN | [view interactions] | High throughput | no | no |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| SI1L2_HUMAN | [view interactions] | High throughput | no | yes |
| YLAT2_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAD_HUMAN | [view interactions] | High throughput | no | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZMY11_HUMAN | [view interactions] | High throughput | no | no |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| ALMS1_HUMAN | [view interactions] | Computational | no | no |
| SASH1_HUMAN | [view interactions] | Computational | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 4ET_HUMAN | [view interactions] | Computational | no | yes |
| F214B_HUMAN | [view interactions] | Computational | no | yes |