Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RPGF4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RPGF4_HUMAN
GO:0046872 metal ion binding 45.9459 4 no
GO:0017076 purine nucleotide binding 40.5405 4 yes
GO:0032555 purine ribonucleotide binding 40.5405 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 32.4324 4 no
GO:0030695 GTPase regulator activity 27.0270 4 yes
GO:0003924 GTPase activity 24.3243 7 no
GO:0005525 GTP binding 24.3243 5 no
GO:0016462 pyrophosphatase activity 24.3243 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 24.3243 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 24.3243 6 no
GO:0019001 guanyl nucleotide binding 24.3243 5 no
GO:0032561 guanyl ribonucleotide binding 24.3243 5 no
GO:0030554 adenyl nucleotide binding 18.9189 5 yes
GO:0032559 adenyl ribonucleotide binding 18.9189 5 yes
GO:0005085 guanyl-nucleotide exchange factor activity 16.2162 5 yes
GO:0031267 small GTPase binding 13.5135 5 yes
GO:0051020 GTPase binding 13.5135 4 yes
GO:0030551 cyclic nucleotide binding 8.1081 4 yes
GO:0030552 cAMP binding 8.1081 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RPGF4_HUMAN
GO:0010646 regulation of cell communication 72.9730 4 no
GO:0048522 positive regulation of cellular process 67.5676 4 no
GO:0009966 regulation of signal transduction 62.1622 4 no
GO:0051049 regulation of transport 48.6486 4 yes
GO:0051128 regulation of cellular component organization 48.6486 4 no
GO:0050804 modulation of chemical synaptic transmission 45.9459 5 no
GO:0099177 regulation of trans-synaptic signaling 45.9459 4 no
GO:0010647 positive regulation of cell communication 45.9459 5 no
GO:0023056 positive regulation of signaling 45.9459 4 no
GO:0048523 negative regulation of cellular process 43.2432 4 no
GO:0060255 regulation of macromolecule metabolic process 40.5405 4 no
GO:1902531 regulation of intracellular signal transduction 40.5405 5 no
GO:0008104 protein localization 37.8378 4 yes
GO:0031323 regulation of cellular metabolic process 37.8378 4 no
GO:0051171 regulation of nitrogen compound metabolic process 37.8378 4 no
GO:0051246 regulation of protein metabolic process 37.8378 5 no
GO:0080090 regulation of primary metabolic process 37.8378 4 no
GO:0009967 positive regulation of signal transduction 37.8378 5 no
GO:0048584 positive regulation of response to stimulus 37.8378 4 no
GO:0016192 vesicle-mediated transport 35.1351 4 yes
GO:0019220 regulation of phosphate metabolic process 35.1351 6 no
GO:0031399 regulation of protein modification process 35.1351 6 no
GO:0051174 regulation of phosphorus metabolic process 35.1351 5 no
GO:0006996 organelle organization 35.1351 4 no
GO:0022607 cellular component assembly 35.1351 4 no
GO:0009893 positive regulation of metabolic process 35.1351 4 no
GO:0051046 regulation of secretion 32.4324 5 yes
GO:1903530 regulation of secretion by cell 32.4324 4 yes
GO:0001932 regulation of protein phosphorylation 32.4324 7 no
GO:0042325 regulation of phosphorylation 32.4324 7 no
GO:0031344 regulation of cell projection organization 29.7297 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 29.7297 6 no
GO:0022603 regulation of anatomical structure morphogenesis 29.7297 4 no
GO:0031325 positive regulation of cellular metabolic process 29.7297 5 no
GO:0051240 positive regulation of multicellular organismal process 27.0270 4 no
GO:0051050 positive regulation of transport 27.0270 4 no
GO:0043085 positive regulation of catalytic activity 27.0270 4 no
GO:0044087 regulation of cellular component biogenesis 27.0270 4 no
GO:0007010 cytoskeleton organization 27.0270 5 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 24.3243 4 yes
GO:0043549 regulation of kinase activity 24.3243 5 no
GO:0045859 regulation of protein kinase activity 24.3243 6 no
GO:0051338 regulation of transferase activity 24.3243 4 no
GO:0010975 regulation of neuron projection development 24.3243 7 no
GO:0032880 regulation of protein localization 24.3243 5 no
GO:0050806 positive regulation of synaptic transmission 24.3243 5 no
GO:0060341 regulation of cellular localization 24.3243 4 no
GO:0044057 regulation of system process 24.3243 4 no
GO:0010604 positive regulation of macromolecule metabolic process 24.3243 5 no
GO:0030030 cell projection organization 24.3243 4 no
GO:0051094 positive regulation of developmental process 24.3243 4 no
GO:0051130 positive regulation of cellular component organization 24.3243 5 no
GO:0120036 plasma membrane bounded cell projection organization 24.3243 5 no
GO:0007264 small GTPase mediated signal transduction 21.6216 4 yes
GO:0060627 regulation of vesicle-mediated transport 21.6216 4 yes
GO:0010243 response to organonitrogen compound 21.6216 4 no
GO:0014070 response to organic cyclic compound 21.6216 4 no
GO:0001934 positive regulation of protein phosphorylation 21.6216 8 no
GO:0010562 positive regulation of phosphorus metabolic process 21.6216 6 no
GO:0031401 positive regulation of protein modification process 21.6216 7 no
GO:0042327 positive regulation of phosphorylation 21.6216 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.6216 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 21.6216 5 no
GO:0051247 positive regulation of protein metabolic process 21.6216 6 no
GO:1902533 positive regulation of intracellular signal transduction 21.6216 6 no
GO:0017157 regulation of exocytosis 18.9189 5 yes
GO:0006887 exocytosis 16.2162 4 yes
GO:0015031 protein transport 16.2162 4 yes
GO:0046903 secretion 16.2162 4 yes
GO:0071702 organic substance transport 16.2162 4 yes
GO:0071705 nitrogen compound transport 16.2162 4 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 13.5135 5 yes
GO:0023061 signal release 13.5135 4 yes
GO:0045055 regulated exocytosis 13.5135 5 yes
GO:0002790 peptide secretion 8.1081 5 yes
GO:0009306 protein secretion 8.1081 4 yes
GO:0009914 hormone transport 8.1081 4 yes
GO:0015833 peptide transport 8.1081 5 yes
GO:0017156 calcium-ion regulated exocytosis 8.1081 6 yes
GO:0030072 peptide hormone secretion 8.1081 6 yes
GO:0030073 insulin secretion 8.1081 5 yes
GO:0035592 establishment of protein localization to extracellular region 8.1081 4 yes
GO:0042886 amide transport 8.1081 5 yes
GO:0046879 hormone secretion 8.1081 5 yes
GO:0071692 protein localization to extracellular region 8.1081 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
ABCC8_HUMAN [view interactions] Low throughput no yes
RIMS2_HUMAN [view entry] [view interactions] Low throughput yes no
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP2A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
NLGN3_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] Low throughput yes no
ATX1_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
MAGT1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
MERB1_HUMAN [view interactions] High throughput no yes
ZC11A_HUMAN [view interactions] High throughput no yes
TRAF2_HUMAN [view interactions] High throughput no yes
SWP70_HUMAN [view interactions] High throughput no no
DEFI6_HUMAN [view interactions] High throughput no no
UBE2A_HUMAN [view interactions] High throughput no no
LA_HUMAN [view interactions] High throughput no yes
HD_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
S22A7_HUMAN [view interactions] High throughput no no
RIMB1_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
DRC6_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
DDX58_HUMAN [view interactions] High throughput no yes
RADX_HUMAN [view interactions] High throughput no yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH17_HUMAN [view entry] [view interactions] High throughput yes no
KLHL7_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STRP2_HUMAN [view interactions] High throughput no yes
GNAI3_HUMAN [view entry] [view interactions] Computational yes yes
MK11_HUMAN [view interactions] Computational no yes
GNAI1_HUMAN [view entry] [view interactions] Computational yes yes
MK14_HUMAN [view interactions] Computational no yes
ADCY8_HUMAN [view entry] [view interactions] Computational yes yes
AKAP6_HUMAN [view interactions] Computational no no
SNP25_HUMAN [view entry] [view interactions] Computational yes yes
GNAI2_HUMAN [view entry] [view interactions] Computational yes yes
ADCY6_HUMAN [view interactions] Computational no yes
RRAS2_HUMAN [view interactions] Computational no yes
AKAP5_HUMAN [view entry] [view interactions] Computational yes yes
RASF5_HUMAN [view interactions] Computational no yes
ADCY4_HUMAN [view interactions] Computational no yes
MK12_HUMAN [view interactions] Computational no no
PDE4A_HUMAN [view interactions] Computational no no
ADCY5_HUMAN [view interactions] Computational no no
MK09_HUMAN [view interactions] Computational no yes
GNAS1_HUMAN [view entry] [view interactions] Computational yes yes
MK08_HUMAN [view interactions] Computational no yes
RRAS_HUMAN [view interactions] Computational no yes
MK13_HUMAN [view interactions] Computational no yes
KAP3_HUMAN [view entry] [view interactions] Computational yes yes
RPGF3_HUMAN [view interactions] Computational no yes
KCJ11_HUMAN [view interactions] Computational no no
ADCY9_HUMAN [view interactions] Computational no yes
RYR2_HUMAN [view entry] [view interactions] Computational yes yes