Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RPGF4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in RPGF4_HUMAN
GO:0043169 cation binding 43.7500 4 no
GO:0046872 metal ion binding 43.7500 5 no
GO:0000166 nucleotide binding 34.3750 4 yes
GO:0017076 purine nucleotide binding 34.3750 5 yes
GO:0030695 GTPase regulator activity 34.3750 4 yes
GO:0032555 purine ribonucleotide binding 34.3750 4 yes
GO:0043168 anion binding 34.3750 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0005085 guanyl-nucleotide exchange factor activity 21.8750 5 yes
GO:0030554 adenyl nucleotide binding 21.8750 6 yes
GO:0032559 adenyl ribonucleotide binding 21.8750 5 yes
GO:0019900 kinase binding 21.8750 4 no
GO:0031267 small GTPase binding 18.7500 5 yes
GO:0051020 GTPase binding 18.7500 4 yes
GO:0030551 cyclic nucleotide binding 9.3750 5 yes
GO:0030552 cAMP binding 9.3750 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RPGF4_HUMAN
GO:0010646 regulation of cell communication 68.7500 4 yes
GO:0048522 positive regulation of cellular process 68.7500 4 yes
GO:0009966 regulation of signal transduction 65.6250 4 no
GO:0051128 regulation of cellular component organization 59.3750 4 no
GO:0048584 positive regulation of response to stimulus 50.0000 4 no
GO:0022607 cellular component assembly 46.8750 4 no
GO:0060255 regulation of macromolecule metabolic process 46.8750 4 no
GO:0008104 protein localization 46.8750 4 yes
GO:0010647 positive regulation of cell communication 46.8750 5 yes
GO:0023056 positive regulation of signaling 46.8750 4 yes
GO:0048523 negative regulation of cellular process 46.8750 4 no
GO:0031323 regulation of cellular metabolic process 43.7500 4 no
GO:0009967 positive regulation of signal transduction 43.7500 5 no
GO:1902531 regulation of intracellular signal transduction 43.7500 5 no
GO:0006996 organelle organization 40.6250 4 no
GO:0080090 regulation of primary metabolic process 40.6250 4 no
GO:0044087 regulation of cellular component biogenesis 40.6250 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0051049 regulation of transport 37.5000 4 yes
GO:0007010 cytoskeleton organization 34.3750 5 no
GO:0019220 regulation of phosphate metabolic process 34.3750 6 no
GO:0031399 regulation of protein modification process 34.3750 6 no
GO:0051174 regulation of phosphorus metabolic process 34.3750 5 no
GO:0141124 intracellular signaling cassette 34.3750 4 yes
GO:0050804 modulation of chemical synaptic transmission 34.3750 5 no
GO:0051130 positive regulation of cellular component organization 34.3750 5 no
GO:0099177 regulation of trans-synaptic signaling 34.3750 4 no
GO:0009893 positive regulation of metabolic process 31.2500 4 no
GO:0022603 regulation of anatomical structure morphogenesis 31.2500 4 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0031344 regulation of cell projection organization 31.2500 5 no
GO:0042325 regulation of phosphorylation 31.2500 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.2500 6 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 no
GO:0010604 positive regulation of macromolecule metabolic process 28.1250 5 no
GO:0030030 cell projection organization 28.1250 4 no
GO:0120036 plasma membrane bounded cell projection organization 28.1250 5 no
GO:0051094 positive regulation of developmental process 28.1250 4 no
GO:0051046 regulation of secretion 28.1250 5 yes
GO:1903530 regulation of secretion by cell 28.1250 4 yes
GO:0010975 regulation of neuron projection development 25.0000 7 no
GO:0031401 positive regulation of protein modification process 25.0000 7 no
GO:0051247 positive regulation of protein metabolic process 25.0000 6 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0050807 regulation of synapse organization 25.0000 5 no
GO:0007264 small GTPase-mediated signal transduction 25.0000 5 yes
GO:0017157 regulation of exocytosis 25.0000 5 yes
GO:0032880 regulation of protein localization 25.0000 5 yes
GO:0060341 regulation of cellular localization 25.0000 4 yes
GO:0060627 regulation of vesicle-mediated transport 25.0000 4 yes
GO:1901888 regulation of cell junction assembly 25.0000 5 no
GO:1902533 positive regulation of intracellular signal transduction 25.0000 6 no
GO:0010562 positive regulation of phosphorus metabolic process 21.8750 6 no
GO:0042327 positive regulation of phosphorylation 21.8750 8 no
GO:0045937 positive regulation of phosphate metabolic process 21.8750 7 no
GO:0072657 protein localization to membrane 21.8750 4 no
GO:0009892 negative regulation of metabolic process 21.8750 4 no
GO:0043549 regulation of kinase activity 21.8750 5 no
GO:0051338 regulation of transferase activity 21.8750 4 no
GO:2000026 regulation of multicellular organismal development 21.8750 4 no
GO:0051240 positive regulation of multicellular organismal process 21.8750 4 no
GO:0046903 secretion 21.8750 4 yes
GO:0051050 positive regulation of transport 21.8750 4 yes
GO:0010243 response to organonitrogen compound 21.8750 4 no
GO:0034330 cell junction organization 21.8750 4 no
GO:0043408 regulation of MAPK cascade 21.8750 6 no
GO:0044089 positive regulation of cellular component biogenesis 21.8750 5 no
GO:0001934 positive regulation of protein phosphorylation 21.8750 8 no
GO:0045055 regulated exocytosis 18.7500 4 yes
GO:0071702 organic substance transport 18.7500 4 yes
GO:0071705 nitrogen compound transport 18.7500 4 yes
GO:0015031 protein transport 15.6250 4 yes
GO:0023061 signal release 15.6250 4 yes
GO:1903829 positive regulation of protein localization 15.6250 5 yes
GO:0007265 Ras protein signal transduction 12.5000 6 yes
GO:0017156 calcium-ion regulated exocytosis 12.5000 5 yes
GO:0070201 regulation of establishment of protein localization 12.5000 6 yes
GO:0002790 peptide secretion 9.3750 5 yes
GO:0002791 regulation of peptide secretion 9.3750 6 yes
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 9.3750 4 yes
GO:0009306 protein secretion 9.3750 4 yes
GO:0009914 hormone transport 9.3750 4 yes
GO:0015833 peptide transport 9.3750 5 yes
GO:0030072 peptide hormone secretion 9.3750 6 yes
GO:0030073 insulin secretion 9.3750 5 yes
GO:0035592 establishment of protein localization to extracellular region 9.3750 4 yes
GO:0042886 amide transport 9.3750 5 yes
GO:0046879 hormone secretion 9.3750 5 yes
GO:0046883 regulation of hormone secretion 9.3750 4 yes
GO:0050708 regulation of protein secretion 9.3750 5 yes
GO:0050796 regulation of insulin secretion 9.3750 6 yes
GO:0051047 positive regulation of secretion 9.3750 5 yes
GO:0051223 regulation of protein transport 9.3750 5 yes
GO:0071692 protein localization to extracellular region 9.3750 5 yes
GO:0090087 regulation of peptide transport 9.3750 5 yes
GO:0090276 regulation of peptide hormone secretion 9.3750 5 yes
GO:1903532 positive regulation of secretion by cell 9.3750 5 yes
GO:1904951 positive regulation of establishment of protein localization 9.3750 6 yes
GO:0002793 positive regulation of peptide secretion 6.2500 6 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 6.2500 5 yes
GO:0032024 positive regulation of insulin secretion 6.2500 7 yes
GO:0046887 positive regulation of hormone secretion 6.2500 5 yes
GO:0050714 positive regulation of protein secretion 6.2500 6 yes
GO:0051222 positive regulation of protein transport 6.2500 5 yes
GO:0090277 positive regulation of peptide hormone secretion 6.2500 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RASH_HUMAN [view entry] [view interactions] Low throughput yes no
RIMS1_HUMAN [view entry] [view interactions] Low throughput yes yes
ABCC8_HUMAN [view interactions] Low throughput no yes
RIMS2_HUMAN [view entry] [view interactions] Low throughput yes no
PCLO_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP2A_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1A_HUMAN [view entry] [view interactions] Low throughput yes no
NLGN3_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN2_HUMAN [view entry] [view interactions] Low throughput yes yes
NLGN1_HUMAN [view entry] [view interactions] Low throughput yes yes
RAP1B_HUMAN [view entry] [view interactions] Low throughput yes no
ATX1_HUMAN [view interactions] High throughput no yes
MTA70_HUMAN [view interactions] High throughput no no
MAGT1_HUMAN [view interactions] High throughput no yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
MERB1_HUMAN [view interactions] High throughput no yes
SWP70_HUMAN [view entry] [view interactions] High throughput yes no
TRAF2_HUMAN [view interactions] High throughput no yes
ZC11A_HUMAN [view interactions] High throughput no yes
DEFI6_HUMAN [view interactions] High throughput no no
LA_HUMAN [view interactions] High throughput no yes
UBE2A_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
DSCAM_HUMAN [view interactions] High throughput no yes
S22A7_HUMAN [view interactions] High throughput no no
RIMB1_HUMAN [view interactions] High throughput no yes
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
FXL13_HUMAN [view interactions] High throughput no yes
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
RIGI_HUMAN [view interactions] High throughput no yes
RADX_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
RHG26_HUMAN [view entry] [view interactions] High throughput yes yes
CHIO_HUMAN [view interactions] High throughput no yes
DOCK1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH17_HUMAN [view entry] [view interactions] High throughput yes no
KLHL7_HUMAN [view interactions] High throughput no yes
LPXN_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
PRIC2_HUMAN [view entry] [view interactions] High throughput yes no
RPGF2_HUMAN [view entry] [view interactions] High throughput yes no
RGF1B_HUMAN [view interactions] High throughput no no
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
SRGP1_HUMAN [view interactions] High throughput no no
SRGP2_HUMAN [view entry] [view interactions] High throughput yes no
STRP2_HUMAN [view interactions] High throughput no yes