RAP2A_HUMAN
Evidence for PS localization
Functions
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RAP2A_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 52.0000 | 4 | yes |
| GO:0000166 | nucleotide binding | 52.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 48.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 44.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 40.0000 | 4 | yes |
| GO:0043169 | cation binding | 32.0000 | 4 | yes |
| GO:0046872 | metal ion binding | 32.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 32.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 28.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 28.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 28.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 28.0000 | 6 | yes |
| GO:0005524 | ATP binding | 24.0000 | 5 | no |
| GO:0003924 | GTPase activity | 20.0000 | 7 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 16.0000 | 5 | yes |
| GO:0005525 | GTP binding | 16.0000 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 16.0000 | 6 | yes |
| GO:0019003 | GDP binding | 12.0000 | 5 | yes |
| GO:0000287 | magnesium ion binding | 8.0000 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RAP2A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 68.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 60.0000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 60.0000 | 4 | yes |
| GO:0008104 | protein localization | 52.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 52.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 52.0000 | 5 | yes |
| GO:0010646 | regulation of cell communication | 52.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 52.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 52.0000 | 5 | yes |
| GO:0022607 | cellular component assembly | 48.0000 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 44.0000 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 44.0000 | 5 | yes |
| GO:0006996 | organelle organization | 40.0000 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 40.0000 | 5 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 36.0000 | 6 | yes |
| GO:0023056 | positive regulation of signaling | 36.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 36.0000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.0000 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.0000 | 5 | no |
| GO:0007010 | cytoskeleton organization | 32.0000 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 32.0000 | 6 | yes |
| GO:0042325 | regulation of phosphorylation | 32.0000 | 7 | yes |
| GO:0051128 | regulation of cellular component organization | 32.0000 | 4 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 32.0000 | 5 | yes |
| GO:0141124 | intracellular signaling cassette | 32.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 32.0000 | 5 | no |
| GO:0010468 | regulation of gene expression | 32.0000 | 6 | no |
| GO:0043933 | protein-containing complex organization | 32.0000 | 4 | no |
| GO:0071702 | organic substance transport | 32.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 32.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 28.0000 | 7 | yes |
| GO:0030030 | cell projection organization | 28.0000 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 28.0000 | 6 | yes |
| GO:0043408 | regulation of MAPK cascade | 28.0000 | 6 | yes |
| GO:2000145 | regulation of cell motility | 28.0000 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 28.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.0000 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.0000 | 6 | no |
| GO:0060341 | regulation of cellular localization | 28.0000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 28.0000 | 5 | no |
| GO:0051049 | regulation of transport | 28.0000 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 24.0000 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 24.0000 | 6 | yes |
| GO:0030334 | regulation of cell migration | 24.0000 | 5 | yes |
| GO:0031401 | positive regulation of protein modification process | 24.0000 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 24.0000 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 24.0000 | 7 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.0000 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 24.0000 | 5 | no |
| GO:0036211 | protein modification process | 24.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 24.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 24.0000 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0000 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 24.0000 | 5 | no |
| GO:0015031 | protein transport | 24.0000 | 4 | no |
| GO:0023057 | negative regulation of signaling | 24.0000 | 4 | no |
| GO:0009894 | regulation of catabolic process | 24.0000 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.0000 | 5 | yes |
| GO:0072657 | protein localization to membrane | 20.0000 | 4 | yes |
| GO:0072659 | protein localization to plasma membrane | 20.0000 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.0000 | 6 | yes |
| GO:1990778 | protein localization to cell periphery | 20.0000 | 5 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 16.0000 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 16.0000 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 16.0000 | 4 | yes |
| GO:0030336 | negative regulation of cell migration | 16.0000 | 6 | yes |
| GO:0040013 | negative regulation of locomotion | 16.0000 | 4 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 16.0000 | 4 | yes |
| GO:0046328 | regulation of JNK cascade | 16.0000 | 7 | yes |
| GO:0048814 | regulation of dendrite morphogenesis | 16.0000 | 5 | yes |
| GO:0050773 | regulation of dendrite development | 16.0000 | 4 | yes |
| GO:2000146 | negative regulation of cell motility | 16.0000 | 5 | yes |
| GO:0030031 | cell projection assembly | 12.0000 | 5 | yes |
| GO:0030033 | microvillus assembly | 12.0000 | 7 | yes |
| GO:0031952 | regulation of protein autophosphorylation | 12.0000 | 8 | yes |
| GO:0031954 | positive regulation of protein autophosphorylation | 12.0000 | 9 | yes |
| GO:0032486 | Rap protein signal transduction | 12.0000 | 6 | yes |
| GO:0032528 | microvillus organization | 12.0000 | 6 | yes |
| GO:0050807 | regulation of synapse organization | 12.0000 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 12.0000 | 6 | yes |
| GO:0051963 | regulation of synapse assembly | 8.0000 | 6 | yes |
| GO:0071466 | cellular response to xenobiotic stimulus | 8.0000 | 4 | yes |
| GO:1901888 | regulation of cell junction assembly | 8.0000 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RASF5_HUMAN | [view interactions] | Low throughput | no | yes |
| MINK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EMP3_HUMAN | [view interactions] | Low throughput | no | no |
| GNDS_HUMAN | [view interactions] | Low throughput | no | yes |
| RUN3A_HUMAN | [view interactions] | Low throughput | no | yes |
| NEDD4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATX3_HUMAN | [view interactions] | Low throughput | no | yes |
| RPGF6_HUMAN | [view interactions] | Low throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RB40B_HUMAN | [view interactions] | Low throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPGF3_HUMAN | [view interactions] | Low throughput | no | yes |
| RPGF4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RPGF5_HUMAN | [view interactions] | Low throughput | no | yes |
| RAP2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLMN_HUMAN | [view interactions] | High throughput | no | no |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| U3IP2_HUMAN | [view interactions] | High throughput | no | yes |
| ERG24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A1AT_HUMAN | [view interactions] | High throughput | no | no |
| FRIL_HUMAN | [view interactions] | High throughput | no | yes |
| ENSA_HUMAN | [view interactions] | High throughput | no | yes |
| PGTB2_HUMAN | [view interactions] | High throughput | no | yes |
| S1PR1_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| MALD2_HUMAN | [view interactions] | High throughput | no | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| FNTA_HUMAN | [view interactions] | High throughput | no | yes |
| RGL1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| ACVR1_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1B_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| PHF19_HUMAN | [view interactions] | High throughput | no | no |
| P2Y14_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| SGK1_HUMAN | [view interactions] | High throughput | no | yes |
| CMAP3_HUMAN | [view interactions] | High throughput | no | no |
| CP2S1_HUMAN | [view interactions] | High throughput | no | no |
| NICA_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| M4K4_HUMAN | [view interactions] | High throughput | no | yes |
| AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARIP4_HUMAN | [view interactions] | High throughput | no | yes |
| PECR_HUMAN | [view interactions] | High throughput | no | yes |
| KPTN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM8_HUMAN | [view interactions] | High throughput | no | no |
| NCOA1_HUMAN | [view interactions] | High throughput | no | yes |
| C19L1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTU1_HUMAN | [view interactions] | High throughput | no | no |
| JOS1_HUMAN | [view interactions] | High throughput | no | no |
| ITFG2_HUMAN | [view interactions] | High throughput | no | yes |
| RAP2B_HUMAN | [view interactions] | High throughput | no | no |
| TYDP2_HUMAN | [view interactions] | High throughput | no | no |
| CTU2_HUMAN | [view interactions] | High throughput | no | yes |
| MTU1_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| MEMO1_HUMAN | [view interactions] | High throughput | no | yes |
| RAP2C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MOCOS_HUMAN | [view interactions] | High throughput | no | no |
| CHK1_HUMAN | [view interactions] | High throughput | no | no |
| LONF2_HUMAN | [view interactions] | High throughput | no | yes |
| TSR3_HUMAN | [view interactions] | High throughput | no | yes |
| TRM6_HUMAN | [view interactions] | High throughput | no | yes |
| BLMH_HUMAN | [view interactions] | High throughput | no | yes |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ACVL1_HUMAN | [view interactions] | High throughput | no | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DX39A_HUMAN | [view interactions] | High throughput | no | yes |
| NSF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |