KIFA3_HUMAN
Evidence for PS localization
Functions
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIFA3_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 38.2353 | 4 | no |
| GO:0000166 | nucleotide binding | 35.2941 | 4 | no |
| GO:0017076 | purine nucleotide binding | 35.2941 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 35.2941 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 32.3529 | 4 | no |
| GO:0019900 | kinase binding | 29.4118 | 4 | no |
| GO:0019901 | protein kinase binding | 29.4118 | 5 | no |
| GO:0043169 | cation binding | 26.4706 | 4 | no |
| GO:0046872 | metal ion binding | 26.4706 | 5 | no |
| GO:0045296 | cadherin binding | 23.5294 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 23.5294 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.5294 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 20.5882 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.5882 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.5882 | 6 | no |
| GO:0005524 | ATP binding | 20.5882 | 5 | no |
| GO:0019902 | phosphatase binding | 11.7647 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 11.7647 | 5 | yes |
| GO:0019894 | kinesin binding | 5.8824 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIFA3_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 64.7059 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 58.8235 | 4 | no |
| GO:0022607 | cellular component assembly | 55.8824 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 55.8824 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 55.8824 | 4 | yes |
| GO:0010646 | regulation of cell communication | 55.8824 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 50.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 50.0000 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.0588 | 4 | no |
| GO:0008104 | protein localization | 47.0588 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 44.1176 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.2353 | 5 | no |
| GO:0031399 | regulation of protein modification process | 38.2353 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 38.2353 | 6 | no |
| GO:0006996 | organelle organization | 38.2353 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 35.2941 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 35.2941 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 35.2941 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 35.2941 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 35.2941 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 35.2941 | 5 | no |
| GO:0033043 | regulation of organelle organization | 35.2941 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 32.3529 | 4 | no |
| GO:0051049 | regulation of transport | 32.3529 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 32.3529 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 32.3529 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.4118 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 29.4118 | 6 | no |
| GO:0043549 | regulation of kinase activity | 29.4118 | 5 | no |
| GO:0051338 | regulation of transferase activity | 29.4118 | 4 | no |
| GO:0007010 | cytoskeleton organization | 29.4118 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.4118 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.4118 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 29.4118 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 29.4118 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 26.4706 | 7 | no |
| GO:0045859 | regulation of protein kinase activity | 26.4706 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 26.4706 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.4706 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.4706 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.4706 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 26.4706 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 26.4706 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 26.4706 | 5 | yes |
| GO:0009968 | negative regulation of signal transduction | 26.4706 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 26.4706 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.4706 | 4 | no |
| GO:0023057 | negative regulation of signaling | 26.4706 | 4 | no |
| GO:0030111 | regulation of Wnt signaling pathway | 26.4706 | 5 | no |
| GO:0034330 | cell junction organization | 23.5294 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 23.5294 | 6 | no |
| GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
| GO:0060828 | regulation of canonical Wnt signaling pathway | 23.5294 | 6 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 23.5294 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 23.5294 | 6 | no |
| GO:0042327 | positive regulation of phosphorylation | 23.5294 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 23.5294 | 7 | no |
| GO:0071310 | cellular response to organic substance | 23.5294 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 23.5294 | 5 | no |
| GO:0030030 | cell projection organization | 23.5294 | 4 | yes |
| GO:0043069 | negative regulation of programmed cell death | 23.5294 | 5 | yes |
| GO:0043933 | protein-containing complex organization | 23.5294 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 23.5294 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 23.5294 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 23.5294 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.5294 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.5294 | 5 | no |
| GO:0034329 | cell junction assembly | 23.5294 | 5 | no |
| GO:0045216 | cell-cell junction organization | 20.5882 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 20.5882 | 5 | no |
| GO:0072657 | protein localization to membrane | 20.5882 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 20.5882 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 20.5882 | 5 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.5882 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 20.5882 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.5882 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 20.5882 | 6 | no |
| GO:0010639 | negative regulation of organelle organization | 20.5882 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 20.5882 | 6 | no |
| GO:0036211 | protein modification process | 20.5882 | 4 | no |
| GO:0043412 | macromolecule modification | 20.5882 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.5882 | 7 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5882 | 5 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5882 | 6 | no |
| GO:0051726 | regulation of cell cycle | 20.5882 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.5882 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 20.5882 | 7 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.5882 | 6 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 17.6471 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 17.6471 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 14.7059 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 11.7647 | 5 | yes |
| GO:0044782 | cilium organization | 11.7647 | 5 | yes |
| GO:0045785 | positive regulation of cell adhesion | 11.7647 | 5 | yes |
| GO:0051650 | establishment of vesicle localization | 11.7647 | 4 | yes |
| GO:2000177 | regulation of neural precursor cell proliferation | 11.7647 | 5 | yes |
| GO:0006915 | apoptotic process | 8.8235 | 4 | yes |
| GO:0010970 | transport along microtubule | 8.8235 | 4 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 8.8235 | 6 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 8.8235 | 4 | yes |
| GO:0047496 | vesicle transport along microtubule | 8.8235 | 5 | yes |
| GO:0050767 | regulation of neurogenesis | 8.8235 | 6 | yes |
| GO:0051093 | negative regulation of developmental process | 8.8235 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 8.8235 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 8.8235 | 5 | yes |
| GO:0060284 | regulation of cell development | 8.8235 | 5 | yes |
| GO:0072383 | plus-end-directed vesicle transport along microtubule | 8.8235 | 6 | yes |
| GO:0072384 | organelle transport along microtubule | 8.8235 | 4 | yes |
| GO:0072386 | plus-end-directed organelle transport along microtubule | 8.8235 | 5 | yes |
| GO:0099111 | microtubule-based transport | 8.8235 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 8.8235 | 5 | yes |
| GO:1902692 | regulation of neuroblast proliferation | 8.8235 | 6 | yes |
| GO:2000026 | regulation of multicellular organismal development | 8.8235 | 4 | yes |
| GO:0007405 | neuroblast proliferation | 5.8824 | 4 | yes |
| GO:0010721 | negative regulation of cell development | 5.8824 | 6 | yes |
| GO:0045596 | negative regulation of cell differentiation | 5.8824 | 5 | yes |
| GO:0050768 | negative regulation of neurogenesis | 5.8824 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 5.8824 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZN821_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIF3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GDS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K10_HUMAN | [view interactions] | Low throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CS044_HUMAN | [view interactions] | High throughput | no | no |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CO4A1_HUMAN | [view interactions] | High throughput | no | yes |
| SON_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| ORC3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| CCNY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP5_HUMAN | [view interactions] | High throughput | no | no |
| NAA50_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCF2_HUMAN | [view interactions] | High throughput | no | no |
| MEST_HUMAN | [view interactions] | High throughput | no | no |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| HMGX4_HUMAN | [view interactions] | High throughput | no | yes |
| CE350_HUMAN | [view interactions] | High throughput | no | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUSC2_HUMAN | [view interactions] | High throughput | no | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| SYF1_HUMAN | [view interactions] | High throughput | no | no |
| OSBL1_HUMAN | [view interactions] | High throughput | no | yes |
| TAF4_HUMAN | [view interactions] | High throughput | no | yes |
| TAF7_HUMAN | [view interactions] | High throughput | no | yes |
| MUC13_HUMAN | [view interactions] | High throughput | no | no |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| BUD13_HUMAN | [view interactions] | High throughput | no | yes |
| TAF5_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| MED24_HUMAN | [view interactions] | High throughput | no | no |
| KIF3C_HUMAN | [view interactions] | High throughput | no | no |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERIC5_HUMAN | [view interactions] | High throughput | no | no |
| S10AD_HUMAN | [view interactions] | High throughput | no | yes |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| MYPOP_HUMAN | [view interactions] | High throughput | no | no |
| NAA11_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| RTP5_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| DHX37_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR6G_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |