KIFA3_HUMAN
Evidence for PS localization
Functions
Involved in tethering the chromosomes to the spindle pole and in chromosome movement. Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIFA3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.1111 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 36.1111 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 33.3333 | 4 | no |
| GO:0019900 | kinase binding | 27.7778 | 4 | no |
| GO:0019901 | protein kinase binding | 27.7778 | 5 | no |
| GO:0045296 | cadherin binding | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0046872 | metal ion binding | 22.2222 | 4 | no |
| GO:0005524 | ATP binding | 22.2222 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 22.2222 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.2222 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.2222 | 6 | no |
| GO:0019902 | phosphatase binding | 13.8889 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 11.1111 | 5 | yes |
| GO:0019894 | kinesin binding | 8.3333 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIFA3_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.7778 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.7778 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.7778 | 4 | no |
| GO:0022607 | cellular component assembly | 50.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 47.2222 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 44.4444 | 5 | no |
| GO:0008104 | protein localization | 44.4444 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 38.8889 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.8889 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 38.8889 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 38.8889 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.1111 | 5 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.5556 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.5556 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.5556 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.5556 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.5556 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 30.5556 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.5556 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 30.5556 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.5556 | 6 | no |
| GO:0007010 | cytoskeleton organization | 27.7778 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.7778 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0051338 | regulation of transferase activity | 27.7778 | 4 | no |
| GO:0033043 | regulation of organelle organization | 25.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 25.0000 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 25.0000 | 7 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | no |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | no |
| GO:0045859 | regulation of protein kinase activity | 25.0000 | 6 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | yes |
| GO:0043067 | regulation of programmed cell death | 25.0000 | 5 | yes |
| GO:0010468 | regulation of gene expression | 22.2222 | 5 | no |
| GO:0034329 | cell junction assembly | 22.2222 | 5 | no |
| GO:0034330 | cell junction organization | 22.2222 | 4 | no |
| GO:0051049 | regulation of transport | 22.2222 | 4 | no |
| GO:0072657 | protein localization to membrane | 22.2222 | 4 | no |
| GO:1990778 | protein localization to cell periphery | 22.2222 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 22.2222 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 22.2222 | 6 | no |
| GO:0030111 | regulation of Wnt signaling pathway | 22.2222 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 22.2222 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 22.2222 | 7 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0023056 | positive regulation of signaling | 22.2222 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 22.2222 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 22.2222 | 6 | no |
| GO:0030030 | cell projection organization | 22.2222 | 4 | yes |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | yes |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | yes |
| GO:0043933 | protein-containing complex organization | 22.2222 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 22.2222 | 5 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.2222 | 5 | yes |
| GO:0043069 | negative regulation of programmed cell death | 19.4444 | 6 | yes |
| GO:0060548 | negative regulation of cell death | 19.4444 | 5 | yes |
| GO:0008285 | negative regulation of cell population proliferation | 16.6667 | 5 | yes |
| GO:0043066 | negative regulation of apoptotic process | 16.6667 | 7 | yes |
| GO:0051650 | establishment of vesicle localization | 16.6667 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 13.8889 | 4 | yes |
| GO:0010970 | transport along microtubule | 11.1111 | 4 | yes |
| GO:0022407 | regulation of cell-cell adhesion | 11.1111 | 5 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 11.1111 | 4 | yes |
| GO:0045785 | positive regulation of cell adhesion | 11.1111 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 11.1111 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 11.1111 | 4 | yes |
| GO:0099111 | microtubule-based transport | 11.1111 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 11.1111 | 5 | yes |
| GO:0022409 | positive regulation of cell-cell adhesion | 8.3333 | 6 | yes |
| GO:0044782 | cilium organization | 8.3333 | 5 | yes |
| GO:0072383 | plus-end-directed vesicle transport along microtubule | 5.5556 | 6 | yes |
| GO:0072386 | plus-end-directed organelle transport along microtubule | 5.5556 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KIFA3_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 5.5556 | 3 | no |
| DOID:2476 | hereditary spastic paraplegia | 5.5556 | 5 | no |
| DOID:331 | central nervous system disease | 5.5556 | 3 | no |
| DOID:607 | paraplegia | 5.5556 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KIF3A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF3B_HUMAN | [view interactions] | Low throughput | no | no |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| GDS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| M3K10_HUMAN | [view interactions] | Low throughput | no | yes |
| SMC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| ZN821_HUMAN | [view interactions] | Low throughput | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| H2AX_HUMAN | [view interactions] | Low throughput | no | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| TP53B_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NCF2_HUMAN | [view interactions] | High throughput | no | no |
| MEST_HUMAN | [view interactions] | High throughput | no | no |
| NPS3A_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| MED24_HUMAN | [view interactions] | High throughput | no | no |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| EFR3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF5_HUMAN | [view interactions] | High throughput | no | yes |
| BUD13_HUMAN | [view interactions] | High throughput | no | yes |
| GILT_HUMAN | [view interactions] | High throughput | no | no |
| MUC13_HUMAN | [view interactions] | High throughput | no | no |
| TAF7_HUMAN | [view interactions] | High throughput | no | yes |
| TAF4_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL1_HUMAN | [view interactions] | High throughput | no | yes |
| SYF1_HUMAN | [view interactions] | High throughput | no | no |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| RUSC2_HUMAN | [view interactions] | High throughput | no | yes |
| DDX23_HUMAN | [view interactions] | High throughput | no | yes |
| HMGX4_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCC2_HUMAN | [view interactions] | High throughput | no | yes |
| CE350_HUMAN | [view interactions] | High throughput | no | yes |
| RBM22_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD5_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| GLGB_HUMAN | [view interactions] | High throughput | no | yes |
| CRBG1_HUMAN | [view interactions] | High throughput | no | no |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VPS25_HUMAN | [view interactions] | High throughput | no | yes |
| S10AD_HUMAN | [view interactions] | High throughput | no | yes |
| ERIC5_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAK2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEUM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YES_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3C_HUMAN | [view interactions] | High throughput | no | no |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
| PEX19_HUMAN | [view interactions] | High throughput | no | yes |
| NAA10_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| MYPOP_HUMAN | [view interactions] | High throughput | no | no |
| NAA11_HUMAN | [view interactions] | High throughput | no | no |
| KANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOS_HUMAN | [view interactions] | High throughput | no | no |
| RTP5_HUMAN | [view interactions] | High throughput | no | yes |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| CE170_HUMAN | [view interactions] | High throughput | no | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| CEP19_HUMAN | [view interactions] | High throughput | no | no |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| ANDR_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| CCSE2_HUMAN | [view interactions] | High throughput | no | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| DHX37_HUMAN | [view interactions] | High throughput | no | yes |
| NAV1_HUMAN | [view interactions] | High throughput | no | yes |
| MARK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAR6G_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CS044_HUMAN | [view interactions] | High throughput | no | no |
| RS18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CO4A1_HUMAN | [view interactions] | High throughput | no | yes |
| SON_HUMAN | [view interactions] | High throughput | no | yes |
| TAF1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| ORC3_HUMAN | [view interactions] | High throughput | no | yes |
| RBM26_HUMAN | [view interactions] | High throughput | no | yes |
| CCNY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| NCKP5_HUMAN | [view interactions] | High throughput | no | no |
| NAA50_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| SPTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| KAP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| IFT52_HUMAN | [view interactions] | Computational | no | no |
| KIF5A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KIF27_HUMAN | [view interactions] | Computational | no | no |
| WDR19_HUMAN | [view interactions] | Computational | no | yes |
| IF122_HUMAN | [view interactions] | Computational | no | yes |
| KIF17_HUMAN | [view interactions] | Computational | no | no |
| IFT20_HUMAN | [view interactions] | Computational | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IFT81_HUMAN | [view interactions] | Computational | no | yes |
| KIF1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| TT30B_HUMAN | [view interactions] | Computational | no | no |
| IFT57_HUMAN | [view interactions] | Computational | no | yes |
| DC2L1_HUMAN | [view interactions] | Computational | no | no |
| IFT80_HUMAN | [view interactions] | Computational | no | yes |
| IFT27_HUMAN | [view interactions] | Computational | no | yes |
| IF140_HUMAN | [view interactions] | Computational | no | yes |
| IFT88_HUMAN | [view interactions] | Computational | no | no |