CCNY_HUMAN
Evidence for PS localization
Functions
Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
| ELM instance | Name | Type | Start | End | Partner |
|---|---|---|---|---|---|
| ELMI002330 | MOD_NMyristoyl | MOD | 1 | 7 | - |
| ELMI002330 | MOD_NMyristoyl | MOD | 1 | 7 | - |
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CCNY_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 31.2500 | 4 | no |
| GO:0019900 | kinase binding | 25.0000 | 4 | yes |
| GO:0019901 | protein kinase binding | 25.0000 | 5 | yes |
| GO:0045296 | cadherin binding | 25.0000 | 4 | no |
| GO:0045309 | protein phosphorylated amino acid binding | 25.0000 | 4 | no |
| GO:0050815 | phosphoserine residue binding | 25.0000 | 5 | no |
| GO:0000166 | nucleotide binding | 25.0000 | 4 | no |
| GO:0003924 | GTPase activity | 25.0000 | 7 | no |
| GO:0005525 | GTP binding | 25.0000 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 5 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | no |
| GO:0019001 | guanyl nucleotide binding | 25.0000 | 6 | no |
| GO:0019003 | GDP binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0043168 | anion binding | 25.0000 | 4 | no |
| GO:0019887 | protein kinase regulator activity | 18.7500 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CCNY_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 68.7500 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 68.7500 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 62.5000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 62.5000 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 62.5000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 50.0000 | 5 | yes |
| GO:0008104 | protein localization | 50.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.7500 | 4 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 43.7500 | 6 | yes |
| GO:0031399 | regulation of protein modification process | 43.7500 | 6 | yes |
| GO:0051174 | regulation of phosphorus metabolic process | 43.7500 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 43.7500 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 43.7500 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 43.7500 | 5 | no |
| GO:0009966 | regulation of signal transduction | 37.5000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 37.5000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 31.2500 | 7 | yes |
| GO:0009893 | positive regulation of metabolic process | 31.2500 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.2500 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 31.2500 | 5 | yes |
| GO:0042325 | regulation of phosphorylation | 31.2500 | 7 | yes |
| GO:0006996 | organelle organization | 31.2500 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 31.2500 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 31.2500 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.2500 | 4 | no |
| GO:0010468 | regulation of gene expression | 31.2500 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.2500 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.2500 | 5 | no |
| GO:0141124 | intracellular signaling cassette | 31.2500 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 25.0000 | 4 | yes |
| GO:0043549 | regulation of kinase activity | 25.0000 | 5 | yes |
| GO:0045859 | regulation of protein kinase activity | 25.0000 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | yes |
| GO:0051338 | regulation of transferase activity | 25.0000 | 4 | yes |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | yes |
| GO:0006915 | apoptotic process | 25.0000 | 4 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 25.0000 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 25.0000 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 25.0000 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 25.0000 | 4 | no |
| GO:0010563 | negative regulation of phosphorus metabolic process | 25.0000 | 6 | no |
| GO:0031400 | negative regulation of protein modification process | 25.0000 | 7 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 25.0000 | 7 | no |
| GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0000165 | MAPK cascade | 25.0000 | 5 | no |
| GO:0007264 | small GTPase-mediated signal transduction | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 18.7500 | 8 | yes |
| GO:0010562 | positive regulation of phosphorus metabolic process | 18.7500 | 6 | yes |
| GO:0031401 | positive regulation of protein modification process | 18.7500 | 7 | yes |
| GO:0042327 | positive regulation of phosphorylation | 18.7500 | 8 | yes |
| GO:0045937 | positive regulation of phosphate metabolic process | 18.7500 | 7 | yes |
| GO:0009894 | regulation of catabolic process | 12.5000 | 4 | yes |
| GO:0033674 | positive regulation of kinase activity | 12.5000 | 6 | yes |
| GO:0045860 | positive regulation of protein kinase activity | 12.5000 | 7 | yes |
| GO:0051347 | positive regulation of transferase activity | 12.5000 | 5 | yes |
| GO:0071900 | regulation of protein serine/threonine kinase activity | 12.5000 | 7 | yes |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | 12.5000 | 8 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDK14_HUMAN | [view interactions] | Low throughput | no | yes |
| CDK16_HUMAN | [view interactions] | Low throughput | no | yes |
| CUL1_HUMAN | [view interactions] | Low throughput | no | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| CP51A_HUMAN | [view interactions] | High throughput | no | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCYL1_HUMAN | [view interactions] | High throughput | no | yes |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| KIFA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GP141_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| DHRS3_HUMAN | [view interactions] | High throughput | no | yes |
| HIDE1_HUMAN | [view interactions] | High throughput | no | no |
| EFNB1_HUMAN | [view interactions] | High throughput | no | yes |
| HORM2_HUMAN | [view interactions] | High throughput | no | no |
| HBG2_HUMAN | [view interactions] | High throughput | no | no |
| TCAL2_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| MED21_HUMAN | [view interactions] | High throughput | no | yes |
| ATG3_HUMAN | [view interactions] | High throughput | no | yes |
| CERS2_HUMAN | [view interactions] | High throughput | no | no |
| RNF13_HUMAN | [view interactions] | High throughput | no | yes |
| CMTD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSR3_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |