Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CCNY_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI002330 MOD_NMyristoyl MOD 1 7 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CCNY_HUMAN
GO:0019900 kinase binding 31.2500 4 yes
GO:0019901 protein kinase binding 31.2500 5 yes
GO:0003723 RNA binding 31.2500 4 no
GO:0003924 GTPase activity 25.0000 7 no
GO:0005525 GTP binding 25.0000 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 no
GO:0017076 purine nucleotide binding 25.0000 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 no
GO:0019001 guanyl nucleotide binding 25.0000 5 no
GO:0019003 GDP binding 25.0000 4 no
GO:0032555 purine ribonucleotide binding 25.0000 4 no
GO:0032561 guanyl ribonucleotide binding 25.0000 5 no
GO:0035639 purine ribonucleoside triphosphate binding 25.0000 4 no
GO:0045296 cadherin binding 25.0000 4 no
GO:0019887 protein kinase regulator activity 18.7500 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in CCNY_HUMAN
GO:0048522 positive regulation of cellular process 75.0000 4 yes
GO:0048523 negative regulation of cellular process 68.7500 4 no
GO:0031323 regulation of cellular metabolic process 62.5000 4 yes
GO:0051171 regulation of nitrogen compound metabolic process 62.5000 4 yes
GO:0060255 regulation of macromolecule metabolic process 62.5000 4 yes
GO:0080090 regulation of primary metabolic process 62.5000 4 yes
GO:0008104 protein localization 56.2500 4 no
GO:0010646 regulation of cell communication 50.0000 4 yes
GO:0051246 regulation of protein metabolic process 50.0000 5 yes
GO:0009966 regulation of signal transduction 43.7500 4 yes
GO:0019220 regulation of phosphate metabolic process 43.7500 6 yes
GO:0031399 regulation of protein modification process 43.7500 6 yes
GO:0051174 regulation of phosphorus metabolic process 43.7500 5 yes
GO:0006886 intracellular protein transport 43.7500 4 no
GO:0015031 protein transport 43.7500 4 no
GO:0071702 organic substance transport 43.7500 4 no
GO:0071705 nitrogen compound transport 43.7500 4 no
GO:0009892 negative regulation of metabolic process 43.7500 4 no
GO:0010605 negative regulation of macromolecule metabolic process 43.7500 5 no
GO:0051128 regulation of cellular component organization 37.5000 4 no
GO:0006996 organelle organization 37.5000 4 no
GO:0031324 negative regulation of cellular metabolic process 37.5000 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 37.5000 5 no
GO:0001932 regulation of protein phosphorylation 31.2500 7 yes
GO:0009893 positive regulation of metabolic process 31.2500 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 31.2500 5 yes
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 yes
GO:0042325 regulation of phosphorylation 31.2500 7 yes
GO:0051173 positive regulation of nitrogen compound metabolic process 31.2500 5 yes
GO:0010468 regulation of gene expression 31.2500 5 no
GO:0010941 regulation of cell death 31.2500 4 no
GO:0042981 regulation of apoptotic process 31.2500 6 no
GO:0043067 regulation of programmed cell death 31.2500 5 no
GO:0000165 MAPK cascade 31.2500 4 no
GO:0043085 positive regulation of catalytic activity 25.0000 4 yes
GO:0043549 regulation of kinase activity 25.0000 5 yes
GO:0045859 regulation of protein kinase activity 25.0000 6 yes
GO:0051247 positive regulation of protein metabolic process 25.0000 6 yes
GO:0051338 regulation of transferase activity 25.0000 4 yes
GO:0051726 regulation of cell cycle 25.0000 4 yes
GO:0009889 regulation of biosynthetic process 25.0000 4 no
GO:0010556 regulation of macromolecule biosynthetic process 25.0000 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0031326 regulation of cellular biosynthetic process 25.0000 5 no
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0050804 modulation of chemical synaptic transmission 25.0000 5 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:0099177 regulation of trans-synaptic signaling 25.0000 4 no
GO:0007264 small GTPase mediated signal transduction 25.0000 4 no
GO:0007265 Ras protein signal transduction 25.0000 5 no
GO:0042127 regulation of cell population proliferation 25.0000 4 no
GO:0006605 protein targeting 25.0000 5 no
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0022607 cellular component assembly 25.0000 4 no
GO:0043066 negative regulation of apoptotic process 25.0000 7 no
GO:0043069 negative regulation of programmed cell death 25.0000 6 no
GO:0060548 negative regulation of cell death 25.0000 5 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0001934 positive regulation of protein phosphorylation 18.7500 8 yes
GO:0010562 positive regulation of phosphorus metabolic process 18.7500 6 yes
GO:0031401 positive regulation of protein modification process 18.7500 7 yes
GO:0042327 positive regulation of phosphorylation 18.7500 8 yes
GO:0045937 positive regulation of phosphate metabolic process 18.7500 7 yes
GO:0033674 positive regulation of kinase activity 12.5000 6 yes
GO:0045860 positive regulation of protein kinase activity 12.5000 7 yes
GO:0051347 positive regulation of transferase activity 12.5000 5 yes
GO:0071900 regulation of protein serine/threonine kinase activity 12.5000 7 yes
GO:0071902 positive regulation of protein serine/threonine kinase activity 12.5000 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDK14_HUMAN [view interactions] Low throughput no yes
CDK16_HUMAN [view interactions] Low throughput no yes
CUL1_HUMAN [view interactions] Low throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA7_HUMAN [view interactions] High throughput no yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
ABCE1_HUMAN [view interactions] High throughput no yes
HXB5_HUMAN [view interactions] High throughput no no
UIF_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
CP51A_HUMAN [view interactions] High throughput no no
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
CCYL1_HUMAN [view interactions] High throughput no yes
CXB7_HUMAN [view interactions] High throughput no no
KIFA3_HUMAN [view entry] [view interactions] High throughput yes yes
GP141_HUMAN [view interactions] High throughput no no
SDC1_HUMAN [view interactions] High throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
RNF4_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
DHRS3_HUMAN [view interactions] High throughput no yes
HIDE1_HUMAN [view interactions] High throughput no no
EFNB1_HUMAN [view interactions] High throughput no yes
HORM2_HUMAN [view interactions] High throughput no no
HBG2_HUMAN [view interactions] High throughput no no
TCAL2_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
MED21_HUMAN [view interactions] High throughput no yes
ATG3_HUMAN [view interactions] High throughput no yes
CERS2_HUMAN [view interactions] High throughput no no
RNF13_HUMAN [view interactions] High throughput no yes
CMTD1_HUMAN [view entry] [view interactions] High throughput yes yes
ZDH23_HUMAN [view interactions] High throughput no no
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
WDR5_HUMAN [view interactions] High throughput no no
WDR82_HUMAN [view interactions] High throughput no no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
CCNA1_HUMAN [view interactions] Computational no no
CDK7_HUMAN [view interactions] Computational no yes
CDK9_HUMAN [view interactions] Computational no yes
CDK15_HUMAN [view interactions] Computational no no
CCNE2_HUMAN [view interactions] Computational no no
CDK1_HUMAN [view interactions] Computational no no
CCNE1_HUMAN [view interactions] Computational no no
CCNK_HUMAN [view interactions] Computational no yes
CCNT2_HUMAN [view interactions] Computational no yes
CCND3_HUMAN [view interactions] Computational no no
CDK13_HUMAN [view interactions] Computational no no
CCND2_HUMAN [view interactions] Computational no yes
CCNB3_HUMAN [view interactions] Computational no no
CDK6_HUMAN [view interactions] Computational no yes
CCNA2_HUMAN [view interactions] Computational no no
MAT1_HUMAN [view interactions] Computational no yes
CCNB1_HUMAN [view interactions] Computational no no
BCCIP_HUMAN [view interactions] Computational no no
CDK2_HUMAN [view interactions] Computational no yes
CDK4_HUMAN [view interactions] Computational no no
CCNH_HUMAN [view interactions] Computational no yes
CCNT1_HUMAN [view interactions] Computational no yes