Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KIF3B_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Microtubule-based molecular motor that transport intracellular cargos, such as vesicles, organelles and protein complexes. Uses ATP hydrolysis to generate force to bind and move along the microtubule . Plays a role in cilia formation (PubMed). Involved in photoreceptor integrity and opsin trafficking in rod photoreceptors (PubMed). Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit GRIN2A into neuronal dendrites . [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
250 Glu Gln Retinitispigmentosa89(RP89) -
523 Leu Pro Retinitispigmentosa89(RP89) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KIF3B_HUMAN
GO:0015631 tubulin binding 33.3333 4 yes
GO:0043168 anion binding 33.3333 4 yes
GO:0000166 nucleotide binding 29.1667 4 yes
GO:0008017 microtubule binding 29.1667 5 yes
GO:0017076 purine nucleotide binding 29.1667 5 yes
GO:0032555 purine ribonucleotide binding 29.1667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 29.1667 4 yes
GO:0043169 cation binding 29.1667 4 no
GO:0046872 metal ion binding 29.1667 5 no
GO:0016462 pyrophosphatase activity 25.0000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 25.0000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 25.0000 6 yes
GO:0005524 ATP binding 20.8333 5 yes
GO:0030554 adenyl nucleotide binding 20.8333 6 yes
GO:0032559 adenyl ribonucleotide binding 20.8333 5 yes
GO:0019900 kinase binding 20.8333 4 no
GO:0019901 protein kinase binding 20.8333 5 no
GO:0046914 transition metal ion binding 20.8333 6 no
GO:0016887 ATP hydrolysis activity 16.6667 7 yes
GO:0031267 small GTPase binding 12.5000 5 yes
GO:0051020 GTPase binding 12.5000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KIF3B_HUMAN
GO:0048522 positive regulation of cellular process 83.3333 4 yes
GO:0022607 cellular component assembly 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0008104 protein localization 62.5000 4 yes
GO:0051128 regulation of cellular component organization 62.5000 4 no
GO:0009966 regulation of signal transduction 58.3333 4 no
GO:0048523 negative regulation of cellular process 58.3333 4 no
GO:0051049 regulation of transport 58.3333 4 no
GO:0010647 positive regulation of cell communication 45.8333 5 no
GO:0023056 positive regulation of signaling 45.8333 4 no
GO:0050804 modulation of chemical synaptic transmission 45.8333 5 no
GO:0099177 regulation of trans-synaptic signaling 45.8333 4 no
GO:0009893 positive regulation of metabolic process 45.8333 4 no
GO:0060255 regulation of macromolecule metabolic process 45.8333 4 no
GO:0006996 organelle organization 41.6667 4 yes
GO:0009967 positive regulation of signal transduction 41.6667 5 no
GO:0031344 regulation of cell projection organization 41.6667 5 no
GO:0048584 positive regulation of response to stimulus 41.6667 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 41.6667 6 no
GO:0010604 positive regulation of macromolecule metabolic process 41.6667 5 no
GO:0051130 positive regulation of cellular component organization 41.6667 5 no
GO:0080090 regulation of primary metabolic process 41.6667 4 no
GO:0031323 regulation of cellular metabolic process 41.6667 4 no
GO:0071702 organic substance transport 37.5000 4 yes
GO:0071705 nitrogen compound transport 37.5000 4 yes
GO:0051050 positive regulation of transport 37.5000 4 no
GO:0042981 regulation of apoptotic process 37.5000 5 no
GO:0043067 regulation of programmed cell death 37.5000 4 no
GO:0010605 negative regulation of macromolecule metabolic process 33.3333 5 no
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 no
GO:0051240 positive regulation of multicellular organismal process 33.3333 4 no
GO:0030030 cell projection organization 33.3333 4 yes
GO:0051726 regulation of cell cycle 33.3333 4 yes
GO:0009968 negative regulation of signal transduction 33.3333 5 no
GO:0010648 negative regulation of cell communication 33.3333 5 no
GO:0023057 negative regulation of signaling 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0042127 regulation of cell population proliferation 33.3333 4 no
GO:0048585 negative regulation of response to stimulus 33.3333 4 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0009894 regulation of catabolic process 33.3333 4 no
GO:0034762 regulation of transmembrane transport 33.3333 4 no
GO:0051094 positive regulation of developmental process 33.3333 4 no
GO:0051246 regulation of protein metabolic process 33.3333 5 no
GO:0051247 positive regulation of protein metabolic process 33.3333 6 no
GO:0044087 regulation of cellular component biogenesis 33.3333 4 no
GO:0045595 regulation of cell differentiation 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 no
GO:0009892 negative regulation of metabolic process 33.3333 4 no
GO:0010468 regulation of gene expression 33.3333 6 no
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 29.1667 5 no
GO:0031324 negative regulation of cellular metabolic process 29.1667 5 no
GO:0031325 positive regulation of cellular metabolic process 29.1667 5 no
GO:0051252 regulation of RNA metabolic process 29.1667 5 no
GO:0010970 transport along microtubule 29.1667 4 yes
GO:0015031 protein transport 29.1667 4 yes
GO:0030705 cytoskeleton-dependent intracellular transport 29.1667 4 yes
GO:0070925 organelle assembly 29.1667 5 yes
GO:0099111 microtubule-based transport 29.1667 4 yes
GO:0120036 plasma membrane bounded cell projection organization 29.1667 5 yes
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0034330 cell junction organization 29.1667 4 no
GO:0050807 regulation of synapse organization 29.1667 5 no
GO:0043269 regulation of monoatomic ion transport 29.1667 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0010629 negative regulation of gene expression 25.0000 7 no
GO:0031327 negative regulation of cellular biosynthetic process 25.0000 6 no
GO:0031328 positive regulation of cellular biosynthetic process 25.0000 6 no
GO:0097435 supramolecular fiber organization 25.0000 4 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0010243 response to organonitrogen compound 25.0000 4 no
GO:0031399 regulation of protein modification process 25.0000 6 no
GO:0043065 positive regulation of apoptotic process 25.0000 6 no
GO:0043068 positive regulation of programmed cell death 25.0000 5 no
GO:0050890 cognition 25.0000 4 no
GO:0051248 negative regulation of protein metabolic process 25.0000 6 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 yes
GO:0008088 axo-dendritic transport 25.0000 5 yes
GO:0010564 regulation of cell cycle process 25.0000 5 yes
GO:0051650 establishment of vesicle localization 25.0000 4 yes
GO:0022603 regulation of anatomical structure morphogenesis 25.0000 4 no
GO:0030111 regulation of Wnt signaling pathway 25.0000 5 no
GO:0034329 cell junction assembly 25.0000 5 no
GO:0043408 regulation of MAPK cascade 25.0000 6 no
GO:0006508 proteolysis 25.0000 4 no
GO:0009057 macromolecule catabolic process 25.0000 4 no
GO:0030163 protein catabolic process 25.0000 4 no
GO:0034765 regulation of monoatomic ion transmembrane transport 25.0000 5 no
GO:0036211 protein modification process 25.0000 4 no
GO:0043412 macromolecule modification 25.0000 4 no
GO:1901565 organonitrogen compound catabolic process 25.0000 4 no
GO:0008285 negative regulation of cell population proliferation 25.0000 5 no
GO:0043066 negative regulation of apoptotic process 25.0000 6 no
GO:0043069 negative regulation of programmed cell death 25.0000 5 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0009890 negative regulation of biosynthetic process 25.0000 5 no
GO:0009891 positive regulation of biosynthetic process 25.0000 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 25.0000 6 no
GO:0045597 positive regulation of cell differentiation 20.8333 5 no
GO:1902532 negative regulation of intracellular signal transduction 20.8333 6 no
GO:0051493 regulation of cytoskeleton organization 20.8333 6 no
GO:0001932 regulation of protein phosphorylation 20.8333 7 no
GO:0019220 regulation of phosphate metabolic process 20.8333 6 no
GO:0042325 regulation of phosphorylation 20.8333 7 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0051174 regulation of phosphorus metabolic process 20.8333 5 no
GO:0071417 cellular response to organonitrogen compound 20.8333 4 no
GO:1901699 cellular response to nitrogen compound 20.8333 4 no
GO:1901701 cellular response to oxygen-containing compound 20.8333 4 no
GO:0007268 chemical synaptic transmission 20.8333 7 no
GO:0010628 positive regulation of gene expression 20.8333 7 no
GO:0098916 anterograde trans-synaptic signaling 20.8333 6 no
GO:0099536 synaptic signaling 20.8333 4 no
GO:0099537 trans-synaptic signaling 20.8333 5 no
GO:0045787 positive regulation of cell cycle 20.8333 5 yes
GO:0047496 vesicle transport along microtubule 20.8333 5 yes
GO:0072384 organelle transport along microtubule 20.8333 4 yes
GO:0098930 axonal transport 20.8333 6 yes
GO:0099518 vesicle cytoskeletal trafficking 20.8333 5 yes
GO:0010975 regulation of neuron projection development 20.8333 7 no
GO:0030178 negative regulation of Wnt signaling pathway 20.8333 6 no
GO:0045216 cell-cell junction organization 20.8333 5 no
GO:0060828 regulation of canonical Wnt signaling pathway 20.8333 6 no
GO:0090090 negative regulation of canonical Wnt signaling pathway 20.8333 7 no
GO:0099175 regulation of postsynapse organization 20.8333 6 no
GO:1902533 positive regulation of intracellular signal transduction 20.8333 6 no
GO:0006511 ubiquitin-dependent protein catabolic process 20.8333 7 no
GO:0009896 positive regulation of catabolic process 20.8333 5 no
GO:0010498 proteasomal protein catabolic process 20.8333 5 no
GO:0010959 regulation of metal ion transport 20.8333 6 no
GO:0019941 modification-dependent protein catabolic process 20.8333 6 no
GO:0022898 regulation of transmembrane transporter activity 20.8333 4 no
GO:0032412 regulation of monoatomic ion transmembrane transporter activity 20.8333 5 no
GO:0042176 regulation of protein catabolic process 20.8333 5 no
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 20.8333 6 no
GO:0043632 modification-dependent macromolecule catabolic process 20.8333 5 no
GO:0051603 proteolysis involved in protein catabolic process 20.8333 5 no
GO:0060627 regulation of vesicle-mediated transport 20.8333 4 no
GO:1904062 regulation of monoatomic cation transmembrane transport 20.8333 6 no
GO:0043933 protein-containing complex organization 20.8333 4 no
GO:0050767 regulation of neurogenesis 20.8333 6 no
GO:0051960 regulation of nervous system development 20.8333 5 no
GO:0060284 regulation of cell development 20.8333 5 no
GO:0065003 protein-containing complex assembly 20.8333 5 no
GO:2000026 regulation of multicellular organismal development 20.8333 4 no
GO:0044782 cilium organization 16.6667 5 yes
GO:0072383 plus-end-directed vesicle transport along microtubule 16.6667 6 yes
GO:0072386 plus-end-directed organelle transport along microtubule 16.6667 5 yes
GO:0090068 positive regulation of cell cycle process 16.6667 6 yes
GO:0140694 non-membrane-bounded organelle assembly 16.6667 6 yes
GO:1902850 microtubule cytoskeleton organization involved in mitosis 16.6667 4 yes
GO:0007052 mitotic spindle organization 12.5000 4 yes
GO:0008089 anterograde axonal transport 12.5000 7 yes
GO:0030031 cell projection assembly 12.5000 5 yes
GO:0060271 cilium assembly 12.5000 6 yes
GO:0120031 plasma membrane bounded cell projection assembly 12.5000 6 yes
GO:0007100 mitotic centrosome separation 8.3333 4 yes
GO:0007368 determination of left/right symmetry 8.3333 5 yes
GO:0009855 determination of bilateral symmetry 8.3333 4 yes
GO:0032465 regulation of cytokinesis 8.3333 5 yes
GO:0032467 positive regulation of cytokinesis 8.3333 6 yes
GO:0036372 opsin transport 8.3333 5 yes
GO:0051225 spindle assembly 8.3333 4 yes
GO:0051302 regulation of cell division 8.3333 4 yes
GO:0051781 positive regulation of cell division 8.3333 5 yes
GO:0090307 mitotic spindle assembly 8.3333 5 yes
GO:0098935 dendritic transport 8.3333 6 yes
GO:0098937 anterograde dendritic transport 8.3333 7 yes
GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex 8.3333 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
ARHGA_HUMAN [view interactions] Low throughput no yes
CLCN5_HUMAN [view interactions] Low throughput no yes
TRI60_HUMAN [view interactions] Low throughput no no
KIF3A_HUMAN [view entry] [view interactions] Low throughput yes yes
KIFA3_HUMAN [view entry] [view interactions] Low throughput yes yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
APC_HUMAN [view entry] [view interactions] Low throughput yes no
NED4L_HUMAN [view entry] [view interactions] Low throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] Low throughput yes no
RAB5A_HUMAN [view entry] [view interactions] Low throughput yes yes
RBP2_HUMAN [view interactions] Low throughput no yes
KIF3B_HUMAN [view entry] [view interactions] Low throughput yes no
LMO4_HUMAN [view interactions] High throughput no yes
RBTN2_HUMAN [view interactions] High throughput no yes
HAX1_HUMAN [view interactions] High throughput no no
MGN2_HUMAN [view interactions] High throughput no yes
MGN_HUMAN [view interactions] High throughput no yes
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
SPTC2_HUMAN [view interactions] High throughput no no
KBP_HUMAN [view interactions] High throughput no yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
NMDE1_HUMAN [view entry] [view interactions] High throughput yes yes
PRS8_HUMAN [view interactions] High throughput no yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
EXOC1_HUMAN [view entry] [view interactions] High throughput yes yes
KIF3C_HUMAN [view interactions] High throughput no no
AKA12_HUMAN [view entry] [view interactions] High throughput yes no
STK4_HUMAN [view interactions] High throughput no yes
STK3_HUMAN [view interactions] High throughput no yes
DYRK2_HUMAN [view interactions] High throughput no yes
SAV1_HUMAN [view interactions] High throughput no yes
NHRF2_HUMAN [view interactions] High throughput no no
M3K11_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
SASH1_HUMAN [view interactions] High throughput no yes
FEZ2_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
CADH2_HUMAN [view entry] [view interactions] High throughput yes no
CTND1_HUMAN [view entry] [view interactions] High throughput yes no
RAD21_HUMAN [view interactions] High throughput no yes
MOV10_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
MPP9_HUMAN [view interactions] High throughput no yes
RGS20_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
SMAD4_HUMAN [view interactions] High throughput no yes
NCKP5_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
RICTR_HUMAN [view interactions] High throughput no yes
KIF11_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
OTUD4_HUMAN [view interactions] High throughput no yes
DYHC1_HUMAN [view entry] [view interactions] High throughput yes yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
M3K10_HUMAN [view interactions] High throughput no yes
PARD3_HUMAN [view interactions] High throughput no yes
PAR6A_HUMAN [view interactions] High throughput no yes
WIZ_HUMAN [view interactions] High throughput no yes
KPCI_HUMAN [view entry] [view interactions] High throughput yes yes
GOGA3_HUMAN [view interactions] High throughput no yes
RPAP2_HUMAN [view interactions] High throughput no yes
IF172_HUMAN [view interactions] High throughput no no
RPC8_HUMAN [view interactions] High throughput no yes
PLOD1_HUMAN [view interactions] High throughput no yes
MEX3B_HUMAN [view interactions] High throughput no no