KIF3A_HUMAN
Evidence for PS localization
Functions
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF3A_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 25.6410 | 4 | no |
| GO:0046872 | metal ion binding | 25.6410 | 5 | no |
| GO:0019900 | kinase binding | 25.6410 | 4 | no |
| GO:0015631 | tubulin binding | 20.5128 | 4 | yes |
| GO:0043168 | anion binding | 20.5128 | 4 | yes |
| GO:0019901 | protein kinase binding | 20.5128 | 5 | no |
| GO:0000166 | nucleotide binding | 17.9487 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 17.9487 | 5 | yes |
| GO:0019902 | phosphatase binding | 17.9487 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 17.9487 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 15.3846 | 6 | yes |
| GO:0032555 | purine ribonucleotide binding | 15.3846 | 4 | yes |
| GO:0008017 | microtubule binding | 12.8205 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 12.8205 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 12.8205 | 4 | yes |
| GO:0005524 | ATP binding | 10.2564 | 5 | yes |
| GO:0051020 | GTPase binding | 10.2564 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 7.6923 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 7.6923 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 7.6923 | 6 | yes |
| GO:0031267 | small GTPase binding | 7.6923 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 5.1282 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF3A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 64.1026 | 4 | no |
| GO:0008104 | protein localization | 58.9744 | 4 | yes |
| GO:0006996 | organelle organization | 56.4103 | 4 | yes |
| GO:0022607 | cellular component assembly | 51.2821 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 48.7179 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.7179 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7179 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.7179 | 4 | no |
| GO:0010646 | regulation of cell communication | 48.7179 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.7179 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 43.5897 | 5 | no |
| GO:0071702 | organic substance transport | 41.0256 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 41.0256 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 41.0256 | 5 | no |
| GO:0009966 | regulation of signal transduction | 41.0256 | 4 | no |
| GO:0051049 | regulation of transport | 38.4615 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 35.8974 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.8974 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 35.8974 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.8974 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 35.8974 | 5 | no |
| GO:0015031 | protein transport | 33.3333 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 33.3333 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 33.3333 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
| GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 33.3333 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 30.7692 | 6 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.7692 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.7692 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.7692 | 6 | no |
| GO:0007010 | cytoskeleton organization | 28.2051 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 28.2051 | 7 | no |
| GO:0033365 | protein localization to organelle | 28.2051 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 28.2051 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 28.2051 | 4 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.2051 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 28.2051 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.2051 | 4 | no |
| GO:0031399 | regulation of protein modification process | 28.2051 | 6 | no |
| GO:0030030 | cell projection organization | 25.6410 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 25.6410 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.6410 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 25.6410 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.6410 | 5 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.6410 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.6410 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 25.6410 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.6410 | 5 | no |
| GO:0070925 | organelle assembly | 23.0769 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 23.0769 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 23.0769 | 5 | no |
| GO:0023057 | negative regulation of signaling | 23.0769 | 4 | no |
| GO:0009057 | macromolecule catabolic process | 23.0769 | 4 | no |
| GO:0009894 | regulation of catabolic process | 23.0769 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.0769 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 23.0769 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 23.0769 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.0769 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 23.0769 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.0769 | 6 | no |
| GO:0036211 | protein modification process | 23.0769 | 4 | no |
| GO:0043412 | macromolecule modification | 23.0769 | 4 | no |
| GO:0051050 | positive regulation of transport | 23.0769 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 23.0769 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.5128 | 8 | no |
| GO:0045597 | positive regulation of cell differentiation | 20.5128 | 5 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.5128 | 8 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.5128 | 5 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 20.5128 | 6 | no |
| GO:0061024 | membrane organization | 20.5128 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.5128 | 7 | no |
| GO:0032880 | regulation of protein localization | 20.5128 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.5128 | 4 | no |
| GO:0006508 | proteolysis | 20.5128 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.5128 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 20.5128 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 20.5128 | 7 | no |
| GO:0030163 | protein catabolic process | 20.5128 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.5128 | 4 | no |
| GO:1901565 | organonitrogen compound catabolic process | 20.5128 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 20.5128 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.5128 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 20.5128 | 7 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5128 | 7 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.5128 | 4 | no |
| GO:0051248 | negative regulation of protein metabolic process | 20.5128 | 6 | no |
| GO:0098657 | import into cell | 20.5128 | 4 | no |
| GO:0016070 | RNA metabolic process | 20.5128 | 5 | no |
| GO:0010970 | transport along microtubule | 17.9487 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 17.9487 | 4 | yes |
| GO:0099111 | microtubule-based transport | 17.9487 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 15.3846 | 5 | yes |
| GO:0030031 | cell projection assembly | 15.3846 | 5 | yes |
| GO:0044782 | cilium organization | 15.3846 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 15.3846 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 15.3846 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 15.3846 | 5 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 15.3846 | 6 | yes |
| GO:0008089 | anterograde axonal transport | 12.8205 | 7 | yes |
| GO:0060271 | cilium assembly | 12.8205 | 6 | yes |
| GO:0098930 | axonal transport | 12.8205 | 6 | yes |
| GO:0072383 | plus-end-directed vesicle transport along microtubule | 7.6923 | 6 | yes |
| GO:0072386 | plus-end-directed organelle transport along microtubule | 7.6923 | 5 | yes |
| GO:1902414 | protein localization to cell junction | 7.6923 | 5 | yes |
| GO:0034453 | microtubule anchoring | 5.1282 | 4 | yes |
| GO:0034454 | microtubule anchoring at centrosome | 5.1282 | 6 | yes |
| GO:0072393 | microtubule anchoring at microtubule organizing center | 5.1282 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRI60_HUMAN | [view interactions] | Low throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF3B_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| KIFA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CE290_HUMAN | [view interactions] | Low throughput | no | no |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NIN_HUMAN | [view interactions] | Low throughput | no | no |
| CE170_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K10_HUMAN | [view interactions] | Low throughput | no | yes |
| PR15A_HUMAN | [view interactions] | Low throughput | no | yes |
| UHMK1_HUMAN | [view interactions] | Low throughput | no | no |
| TNKS1_HUMAN | [view interactions] | Low throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| KIF3C_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SSH2_HUMAN | [view interactions] | High throughput | no | no |
| DHX34_HUMAN | [view interactions] | High throughput | no | no |
| CTBL1_HUMAN | [view interactions] | High throughput | no | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STN1_HUMAN | [view interactions] | High throughput | no | no |
| MP3B2_HUMAN | [view interactions] | High throughput | no | yes |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| LYPA2_HUMAN | [view interactions] | High throughput | no | no |
| ANXA8_HUMAN | [view interactions] | High throughput | no | no |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| PPCE_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| CAHM4_HUMAN | [view interactions] | High throughput | no | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| ATG9B_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| LYG2_HUMAN | [view interactions] | High throughput | no | no |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| PADI3_HUMAN | [view interactions] | High throughput | no | no |
| PKP3_HUMAN | [view interactions] | High throughput | no | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR8_HUMAN | [view interactions] | High throughput | no | no |
| HENMT_HUMAN | [view interactions] | High throughput | no | yes |
| SSX2_HUMAN | [view interactions] | High throughput | no | no |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MORC3_HUMAN | [view interactions] | High throughput | no | yes |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| DSCAM_HUMAN | [view interactions] | High throughput | no | yes |
| DSCR9_HUMAN | [view interactions] | High throughput | no | no |
| BTG3_HUMAN | [view interactions] | High throughput | no | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view interactions] | High throughput | no | no |
| SSNA1_HUMAN | [view interactions] | High throughput | no | no |
| XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
| DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CASP1_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| LX15B_HUMAN | [view interactions] | High throughput | no | no |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| PAFA2_HUMAN | [view interactions] | High throughput | no | yes |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHO2_HUMAN | [view interactions] | High throughput | no | yes |
| AT7L1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHJ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| BEX4_HUMAN | [view interactions] | High throughput | no | no |
| SMIP5_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| F153A_HUMAN | [view interactions] | High throughput | no | no |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| NFYC_HUMAN | [view interactions] | High throughput | no | no |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| PUS1_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| KIF11_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| IF2P_HUMAN | [view interactions] | High throughput | no | yes |
| KPCI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAX_HUMAN | [view interactions] | High throughput | no | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |