KIF3A_HUMAN
Evidence for PS localization
Functions
Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KIF3A_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 24.2424 | 4 | no |
| GO:0019901 | protein kinase binding | 24.2424 | 5 | no |
| GO:0019902 | phosphatase binding | 21.2121 | 4 | yes |
| GO:0019903 | protein phosphatase binding | 18.1818 | 5 | yes |
| GO:0015631 | tubulin binding | 15.1515 | 4 | yes |
| GO:0008017 | microtubule binding | 12.1212 | 5 | yes |
| GO:0017076 | purine nucleotide binding | 12.1212 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 12.1212 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 9.0909 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 9.0909 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 9.0909 | 4 | yes |
| GO:0005524 | ATP binding | 6.0606 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 6.0606 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 6.0606 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 6.0606 | 6 | yes |
| GO:0031267 | small GTPase binding | 6.0606 | 5 | yes |
| GO:0051020 | GTPase binding | 6.0606 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KIF3A_HUMAN |
|---|---|---|---|---|
| GO:0008104 | protein localization | 57.5758 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.4545 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.4242 | 4 | no |
| GO:0006996 | organelle organization | 42.4242 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.4242 | 5 | no |
| GO:0010646 | regulation of cell communication | 42.4242 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.3939 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 39.3939 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 39.3939 | 5 | no |
| GO:0080090 | regulation of primary metabolic process | 39.3939 | 4 | no |
| GO:0022607 | cellular component assembly | 39.3939 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 39.3939 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 39.3939 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 36.3636 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 36.3636 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 33.3333 | 5 | no |
| GO:0071702 | organic substance transport | 33.3333 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 33.3333 | 4 | yes |
| GO:0051049 | regulation of transport | 30.3030 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 30.3030 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 30.3030 | 6 | no |
| GO:0015031 | protein transport | 30.3030 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 30.3030 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.3030 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 27.2727 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0033365 | protein localization to organelle | 27.2727 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 27.2727 | 5 | no |
| GO:0023056 | positive regulation of signaling | 27.2727 | 4 | no |
| GO:0007010 | cytoskeleton organization | 27.2727 | 5 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0023057 | negative regulation of signaling | 24.2424 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.2424 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 24.2424 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 24.2424 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.2424 | 5 | no |
| GO:0072657 | protein localization to membrane | 24.2424 | 4 | no |
| GO:0031399 | regulation of protein modification process | 24.2424 | 6 | no |
| GO:0010941 | regulation of cell death | 24.2424 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.2424 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 24.2424 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.2424 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 24.2424 | 6 | no |
| GO:0010648 | negative regulation of cell communication | 24.2424 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.2424 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 21.2121 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.2121 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 21.2121 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 21.2121 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 21.2121 | 6 | no |
| GO:0043269 | regulation of ion transport | 21.2121 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.2121 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 21.2121 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.2121 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 21.2121 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.2121 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 21.2121 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.2121 | 7 | no |
| GO:0019220 | regulation of phosphate metabolic process | 21.2121 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 21.2121 | 7 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.2121 | 5 | no |
| GO:0051248 | negative regulation of protein metabolic process | 21.2121 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.2121 | 7 | no |
| GO:0030030 | cell projection organization | 21.2121 | 4 | yes |
| GO:0051650 | establishment of vesicle localization | 21.2121 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 21.2121 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 21.2121 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 21.2121 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 21.2121 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 21.2121 | 5 | no |
| GO:0043933 | protein-containing complex organization | 21.2121 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 21.2121 | 6 | no |
| GO:0010970 | transport along microtubule | 18.1818 | 4 | yes |
| GO:0030705 | cytoskeleton-dependent intracellular transport | 18.1818 | 4 | yes |
| GO:0099111 | microtubule-based transport | 18.1818 | 4 | yes |
| GO:0008088 | axo-dendritic transport | 15.1515 | 5 | yes |
| GO:0044782 | cilium organization | 15.1515 | 5 | yes |
| GO:0047496 | vesicle transport along microtubule | 15.1515 | 5 | yes |
| GO:0072384 | organelle transport along microtubule | 15.1515 | 4 | yes |
| GO:0099518 | vesicle cytoskeletal trafficking | 15.1515 | 5 | yes |
| GO:0008089 | anterograde axonal transport | 12.1212 | 7 | yes |
| GO:0030031 | cell projection assembly | 12.1212 | 5 | yes |
| GO:0060271 | cilium assembly | 12.1212 | 6 | yes |
| GO:0070925 | organelle assembly | 12.1212 | 5 | yes |
| GO:0098930 | axonal transport | 12.1212 | 6 | yes |
| GO:0120031 | plasma membrane bounded cell projection assembly | 12.1212 | 6 | yes |
| GO:1902414 | protein localization to cell junction | 9.0909 | 5 | yes |
| GO:0034453 | microtubule anchoring | 6.0606 | 4 | yes |
| GO:0034454 | microtubule anchoring at centrosome | 6.0606 | 6 | yes |
| GO:0072383 | plus-end-directed vesicle transport along microtubule | 6.0606 | 6 | yes |
| GO:0072386 | plus-end-directed organelle transport along microtubule | 6.0606 | 5 | yes |
| GO:0072393 | microtubule anchoring at microtubule organizing center | 6.0606 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KIF3A_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 6.0606 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TRI60_HUMAN | [view interactions] | Low throughput | no | no |
| AP3B1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| KIF3B_HUMAN | [view interactions] | Low throughput | no | no |
| KIFA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DCTN1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RFIP5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CE290_HUMAN | [view interactions] | Low throughput | no | no |
| AP3D1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NIN_HUMAN | [view interactions] | Low throughput | no | no |
| CE170_HUMAN | [view interactions] | Low throughput | no | yes |
| ARRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| M3K10_HUMAN | [view interactions] | Low throughput | no | yes |
| PR15A_HUMAN | [view interactions] | Low throughput | no | yes |
| UHMK1_HUMAN | [view interactions] | Low throughput | no | no |
| TNKS1_HUMAN | [view interactions] | Low throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | Low throughput | no | yes |
| RBP2_HUMAN | [view interactions] | Low throughput | no | yes |
| NEK1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP7_HUMAN | [view interactions] | High throughput | no | yes |
| KIF3C_HUMAN | [view interactions] | High throughput | no | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| PIP30_HUMAN | [view interactions] | High throughput | no | yes |
| CTBL1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX34_HUMAN | [view interactions] | High throughput | no | no |
| SSH2_HUMAN | [view interactions] | High throughput | no | no |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STN1_HUMAN | [view interactions] | High throughput | no | no |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| PKP3_HUMAN | [view interactions] | High throughput | no | yes |
| PADI3_HUMAN | [view interactions] | High throughput | no | no |
| P4K2A_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| LYG2_HUMAN | [view interactions] | High throughput | no | no |
| HPHL1_HUMAN | [view interactions] | High throughput | no | no |
| ATG9B_HUMAN | [view interactions] | High throughput | no | no |
| VSIG8_HUMAN | [view interactions] | High throughput | no | no |
| CAHM4_HUMAN | [view interactions] | High throughput | no | no |
| H33_HUMAN | [view interactions] | High throughput | no | yes |
| PLCD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPCE_HUMAN | [view interactions] | High throughput | no | yes |
| SPB5_HUMAN | [view interactions] | High throughput | no | no |
| ANXA8_HUMAN | [view interactions] | High throughput | no | no |
| LYPA2_HUMAN | [view interactions] | High throughput | no | no |
| DUS14_HUMAN | [view interactions] | High throughput | no | yes |
| MP3B2_HUMAN | [view interactions] | High throughput | no | yes |
| KBP_HUMAN | [view interactions] | High throughput | no | yes |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| EXOC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TNR8_HUMAN | [view interactions] | High throughput | no | no |
| HENMT_HUMAN | [view interactions] | High throughput | no | yes |
| SSX2_HUMAN | [view interactions] | High throughput | no | no |
| H32_HUMAN | [view interactions] | High throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
| ANK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASF1A_HUMAN | [view interactions] | High throughput | no | no |
| NMDE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCLT1_HUMAN | [view interactions] | High throughput | no | yes |
| MED4_HUMAN | [view interactions] | High throughput | no | yes |
| NHRF2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DNJC9_HUMAN | [view interactions] | High throughput | no | yes |
| HSDL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XRCC4_HUMAN | [view interactions] | High throughput | no | yes |
| SSNA1_HUMAN | [view interactions] | High throughput | no | no |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| DNPEP_HUMAN | [view interactions] | High throughput | no | yes |
| M3K11_HUMAN | [view interactions] | High throughput | no | yes |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI14_HUMAN | [view interactions] | High throughput | no | yes |
| ATPB_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| CASP1_HUMAN | [view interactions] | High throughput | no | yes |
| DTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNH28_HUMAN | [view interactions] | High throughput | no | no |
| SBP1_HUMAN | [view interactions] | High throughput | no | no |
| TRI29_HUMAN | [view interactions] | High throughput | no | no |
| ZN785_HUMAN | [view interactions] | High throughput | no | no |
| LX15B_HUMAN | [view interactions] | High throughput | no | no |
| APTX_HUMAN | [view interactions] | High throughput | no | yes |
| RGS20_HUMAN | [view interactions] | High throughput | no | no |
| PPAP_HUMAN | [view interactions] | High throughput | no | no |
| LRC15_HUMAN | [view interactions] | High throughput | no | no |
| DSG4_HUMAN | [view interactions] | High throughput | no | no |
| PKP1_HUMAN | [view interactions] | High throughput | no | no |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MKRN2_HUMAN | [view interactions] | High throughput | no | yes |
| CART_HUMAN | [view interactions] | High throughput | no | yes |
| PAFA2_HUMAN | [view interactions] | High throughput | no | yes |
| LURA1_HUMAN | [view interactions] | High throughput | no | yes |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHO2_HUMAN | [view interactions] | High throughput | no | yes |
| AT7L1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHJ1_HUMAN | [view interactions] | High throughput | no | yes |
| CAN12_HUMAN | [view interactions] | High throughput | no | no |
| BEX4_HUMAN | [view interactions] | High throughput | no | no |
| CJ082_HUMAN | [view interactions] | High throughput | no | no |
| MAGA9_HUMAN | [view interactions] | High throughput | no | no |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| INSY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| F153A_HUMAN | [view interactions] | High throughput | no | no |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| BD1L1_HUMAN | [view interactions] | High throughput | no | yes |
| CAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA6_HUMAN | [view interactions] | High throughput | no | no |
| MAP1S_HUMAN | [view interactions] | High throughput | no | no |
| IKIP_HUMAN | [view interactions] | High throughput | no | no |
| NFYC_HUMAN | [view interactions] | High throughput | no | no |
| PGRC2_HUMAN | [view interactions] | High throughput | no | yes |
| IDHP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTPB1_HUMAN | [view interactions] | High throughput | no | yes |
| TRUA_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | High throughput | no | yes |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP33A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |