PKHA5_HUMAN
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in PKHA5_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 39.7436 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 38.4615 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 38.4615 | 4 | no |
GO:0019900 | kinase binding | 30.7692 | 4 | no |
GO:0019901 | protein kinase binding | 30.7692 | 5 | no |
GO:0016462 | pyrophosphatase activity | 23.0769 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.0769 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.0769 | 6 | no |
GO:0003723 | RNA binding | 21.7949 | 4 | no |
GO:0003924 | GTPase activity | 20.5128 | 7 | no |
GO:0005525 | GTP binding | 20.5128 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 20.5128 | 5 | no |
GO:0032561 | guanyl ribonucleotide binding | 20.5128 | 5 | no |
GO:0035091 | phosphatidylinositol binding | 7.6923 | 4 | yes |
GO:1901981 | phosphatidylinositol phosphate binding | 7.6923 | 5 | yes |
GO:1902936 | phosphatidylinositol bisphosphate binding | 7.6923 | 6 | yes |
GO:0010314 | phosphatidylinositol-5-phosphate binding | 3.8462 | 6 | yes |
GO:0032266 | phosphatidylinositol-3-phosphate binding | 3.8462 | 6 | yes |
GO:0070273 | phosphatidylinositol-4-phosphate binding | 3.8462 | 6 | yes |
GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding | 2.5641 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in PKHA5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 64.1026 | 4 | no |
GO:0048523 | negative regulation of cellular process | 56.4103 | 4 | no |
GO:0051128 | regulation of cellular component organization | 56.4103 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 53.8462 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
GO:0006996 | organelle organization | 50.0000 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 48.7179 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 48.7179 | 4 | no |
GO:0022607 | cellular component assembly | 46.1538 | 4 | no |
GO:0010646 | regulation of cell communication | 46.1538 | 4 | no |
GO:0008104 | protein localization | 44.8718 | 4 | no |
GO:0009966 | regulation of signal transduction | 43.5897 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 38.4615 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.4615 | 5 | no |
GO:0007010 | cytoskeleton organization | 38.4615 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 37.1795 | 5 | no |
GO:0051049 | regulation of transport | 34.6154 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 34.6154 | 5 | no |
GO:0010468 | regulation of gene expression | 34.6154 | 5 | no |
GO:0071702 | organic substance transport | 33.3333 | 4 | no |
GO:0030030 | cell projection organization | 33.3333 | 4 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 32.0513 | 5 | no |
GO:0033043 | regulation of organelle organization | 30.7692 | 5 | no |
GO:0071705 | nitrogen compound transport | 30.7692 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.7692 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 29.4872 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 28.2051 | 6 | no |
GO:0051174 | regulation of phosphorus metabolic process | 28.2051 | 5 | no |
GO:0044087 | regulation of cellular component biogenesis | 28.2051 | 4 | no |
GO:2000145 | regulation of cell motility | 28.2051 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 26.9231 | 4 | no |
GO:0031399 | regulation of protein modification process | 26.9231 | 6 | no |
GO:0071310 | cellular response to organic substance | 26.9231 | 4 | no |
GO:0030334 | regulation of cell migration | 26.9231 | 5 | no |
GO:0097435 | supramolecular fiber organization | 26.9231 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 25.6410 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 25.6410 | 5 | no |
GO:0015031 | protein transport | 25.6410 | 4 | no |
GO:0051493 | regulation of cytoskeleton organization | 25.6410 | 6 | no |
GO:0042325 | regulation of phosphorylation | 25.6410 | 7 | no |
GO:0045595 | regulation of cell differentiation | 25.6410 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.6410 | 5 | no |
GO:0031344 | regulation of cell projection organization | 25.6410 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 25.6410 | 6 | no |
GO:0032880 | regulation of protein localization | 24.3590 | 5 | no |
GO:0060341 | regulation of cellular localization | 24.3590 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 24.3590 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 24.3590 | 6 | no |
GO:0031326 | regulation of cellular biosynthetic process | 24.3590 | 5 | no |
GO:0010941 | regulation of cell death | 24.3590 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 24.3590 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 23.0769 | 5 | no |
GO:0016192 | vesicle-mediated transport | 23.0769 | 4 | no |
GO:0051726 | regulation of cell cycle | 23.0769 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 23.0769 | 7 | no |
GO:1901701 | cellular response to oxygen-containing compound | 23.0769 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 23.0769 | 5 | no |
GO:0010647 | positive regulation of cell communication | 23.0769 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.0769 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
GO:0042981 | regulation of apoptotic process | 23.0769 | 6 | no |
GO:0043067 | regulation of programmed cell death | 23.0769 | 5 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.7949 | 5 | no |
GO:0010562 | positive regulation of phosphorus metabolic process | 21.7949 | 6 | no |
GO:0031324 | negative regulation of cellular metabolic process | 21.7949 | 5 | no |
GO:0042327 | positive regulation of phosphorylation | 21.7949 | 8 | no |
GO:0045937 | positive regulation of phosphate metabolic process | 21.7949 | 7 | no |
GO:0051050 | positive regulation of transport | 21.7949 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 21.7949 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.7949 | 4 | no |
GO:0006796 | phosphate-containing compound metabolic process | 20.5128 | 4 | no |
GO:0036211 | protein modification process | 20.5128 | 4 | no |
GO:0043412 | macromolecule modification | 20.5128 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 20.5128 | 5 | no |
GO:0061458 | reproductive system development | 3.8462 | 4 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in PKHA5_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 3.8462 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 3.8462 | 5 | no |
DOID:114 | heart disease | 3.8462 | 3 | no |
DOID:2843 | long QT syndrome | 3.8462 | 6 | no |
DOID:10273 | heart conduction disease | 2.5641 | 4 | no |
DOID:331 | central nervous system disease | 2.5641 | 3 | no |
DOID:0111962 | combined immunodeficiency | 2.5641 | 4 | no |
DOID:612 | primary immunodeficiency disease | 2.5641 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI36_HUMAN | [view interactions] | High throughput | no | no |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
VIME_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
VP33B_HUMAN | [view interactions] | High throughput | no | yes |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
KEAP1_HUMAN | [view interactions] | High throughput | no | yes |
UBP7_HUMAN | [view interactions] | High throughput | no | yes |
1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
H31T_HUMAN | [view interactions] | High throughput | no | yes |
RFOX1_HUMAN | [view interactions] | High throughput | no | yes |
ATN1_HUMAN | [view interactions] | High throughput | no | yes |
ATX1_HUMAN | [view interactions] | High throughput | no | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
PDZ11_HUMAN | [view interactions] | High throughput | no | yes |
MAX_HUMAN | [view interactions] | High throughput | no | yes |
CE350_HUMAN | [view interactions] | High throughput | no | yes |
ARHG9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP250_HUMAN | [view interactions] | High throughput | no | no |
EVPL_HUMAN | [view interactions] | High throughput | no | yes |
EXTL3_HUMAN | [view interactions] | High throughput | no | yes |
CC88B_HUMAN | [view interactions] | High throughput | no | no |
K1C19_HUMAN | [view interactions] | High throughput | no | no |
KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K1C20_HUMAN | [view interactions] | High throughput | no | no |
KTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMB2_HUMAN | [view interactions] | High throughput | no | yes |
PKHA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BL1S6_HUMAN | [view interactions] | High throughput | no | yes |
PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASPP1_HUMAN | [view interactions] | High throughput | no | yes |
PROM1_HUMAN | [view interactions] | High throughput | no | no |
SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KANL1_HUMAN | [view interactions] | High throughput | no | yes |
SOGA1_HUMAN | [view interactions] | High throughput | no | yes |
CC186_HUMAN | [view interactions] | High throughput | no | yes |
CCD92_HUMAN | [view interactions] | High throughput | no | yes |
3BP5L_HUMAN | [view interactions] | High throughput | no | yes |
LATS2_HUMAN | [view interactions] | High throughput | no | yes |
DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOONR_HUMAN | [view interactions] | High throughput | no | yes |
DRC5_HUMAN | [view interactions] | High throughput | no | no |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
SPICE_HUMAN | [view interactions] | High throughput | no | yes |
POC1A_HUMAN | [view interactions] | High throughput | no | yes |
KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
EPHA5_HUMAN | [view interactions] | High throughput | no | no |
EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EPHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPHB6_HUMAN | [view interactions] | High throughput | no | no |
FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STYK1_HUMAN | [view interactions] | High throughput | no | yes |
HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
DCLK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SI1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GGYF1_HUMAN | [view interactions] | High throughput | no | yes |
SYDE1_HUMAN | [view interactions] | High throughput | no | yes |
SRS12_HUMAN | [view interactions] | High throughput | no | no |
MAGI1_HUMAN | [view interactions] | High throughput | no | no |
TESK2_HUMAN | [view interactions] | High throughput | no | yes |
KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
RTKN_HUMAN | [view interactions] | High throughput | no | yes |
RAB3I_HUMAN | [view interactions] | High throughput | no | no |
DEN1A_HUMAN | [view interactions] | High throughput | no | no |
KSR1_HUMAN | [view interactions] | High throughput | no | yes |
SPD2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZN638_HUMAN | [view interactions] | High throughput | no | yes |
CDK16_HUMAN | [view interactions] | High throughput | no | yes |
MPIP2_HUMAN | [view interactions] | High throughput | no | no |
SRGP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IF4E2_HUMAN | [view interactions] | High throughput | no | no |
MAST3_HUMAN | [view interactions] | High throughput | no | yes |
KI13B_HUMAN | [view interactions] | High throughput | no | yes |
LRFN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZBT21_HUMAN | [view interactions] | High throughput | no | yes |
AGAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CBY1_HUMAN | [view interactions] | High throughput | no | no |
LSM4_HUMAN | [view interactions] | High throughput | no | yes |
RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DESM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CIAO1_HUMAN | [view interactions] | High throughput | no | yes |
AURKB_HUMAN | [view interactions] | High throughput | no | yes |
FHL3_HUMAN | [view interactions] | High throughput | no | no |
GINM1_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HIF1A_HUMAN | [view interactions] | High throughput | no | no |
KIF11_HUMAN | [view interactions] | High throughput | no | yes |
PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SC16A_HUMAN | [view interactions] | High throughput | no | yes |
TMEDA_HUMAN | [view interactions] | High throughput | no | yes |
ZNRD2_HUMAN | [view interactions] | High throughput | no | yes |
I17RA_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
RNF31_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
M4K2_HUMAN | [view interactions] | High throughput | no | yes |
ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
TRI52_HUMAN | [view interactions] | High throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PNMA2_HUMAN | [view interactions] | High throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
FHL2_HUMAN | [view interactions] | High throughput | no | yes |
MR1L1_HUMAN | [view interactions] | High throughput | no | no |
2A5A_HUMAN | [view interactions] | High throughput | no | yes |
FRIL_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
RHBT1_HUMAN | [view interactions] | High throughput | no | yes |
RND2_HUMAN | [view interactions] | High throughput | no | no |
MAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRPK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYLT1_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARHG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KS6A2_HUMAN | [view interactions] | High throughput | no | yes |
RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
MIB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LZTS2_HUMAN | [view interactions] | High throughput | no | no |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAMP2_HUMAN | [view interactions] | High throughput | no | yes |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXAR_HUMAN | [view interactions] | High throughput | no | yes |
DEN6A_HUMAN | [view interactions] | High throughput | no | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
KIF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
K2C8_HUMAN | [view interactions] | High throughput | no | no |
LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LATS1_HUMAN | [view interactions] | High throughput | no | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AFAD_HUMAN | [view interactions] | High throughput | no | yes |