Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GAK_HUMAN

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GAK_HUMAN
GO:0017076 purine nucleotide binding 31.1688 4 yes
GO:0032555 purine ribonucleotide binding 28.5714 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 yes
GO:0030554 adenyl nucleotide binding 23.3766 5 yes
GO:0005524 ATP binding 20.7792 5 yes
GO:0032559 adenyl ribonucleotide binding 20.7792 5 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 7.7922 4 yes
GO:0016301 kinase activity 7.7922 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 7.7922 4 yes
GO:0004674 protein serine/threonine kinase activity 6.4935 4 yes
GO:0106310 protein serine kinase activity 6.4935 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GAK_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0051128 regulation of cellular component organization 53.2468 4 yes
GO:0016192 vesicle-mediated transport 49.3506 4 yes
GO:0008104 protein localization 46.7532 4 yes
GO:0048523 negative regulation of cellular process 45.4545 4 yes
GO:0060255 regulation of macromolecule metabolic process 44.1558 4 no
GO:0006996 organelle organization 42.8571 4 yes
GO:0080090 regulation of primary metabolic process 41.5584 4 no
GO:0010646 regulation of cell communication 41.5584 4 no
GO:0051171 regulation of nitrogen compound metabolic process 40.2597 4 no
GO:0071702 organic substance transport 40.2597 4 no
GO:0071705 nitrogen compound transport 38.9610 4 no
GO:0015031 protein transport 36.3636 4 no
GO:0051049 regulation of transport 36.3636 4 no
GO:0031323 regulation of cellular metabolic process 35.0649 4 no
GO:0009966 regulation of signal transduction 35.0649 4 no
GO:0006897 endocytosis 35.0649 5 yes
GO:0022607 cellular component assembly 35.0649 4 yes
GO:0009893 positive regulation of metabolic process 31.1688 4 no
GO:0010468 regulation of gene expression 29.8701 5 no
GO:0010604 positive regulation of macromolecule metabolic process 29.8701 5 no
GO:0006886 intracellular protein transport 28.5714 4 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0009889 regulation of biosynthetic process 27.2727 4 no
GO:0010647 positive regulation of cell communication 27.2727 5 no
GO:0023056 positive regulation of signaling 27.2727 4 no
GO:0048584 positive regulation of response to stimulus 27.2727 4 no
GO:0051129 negative regulation of cellular component organization 25.9740 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 25.9740 5 no
GO:0031325 positive regulation of cellular metabolic process 25.9740 5 no
GO:0009892 negative regulation of metabolic process 25.9740 4 no
GO:0009967 positive regulation of signal transduction 25.9740 5 no
GO:0033043 regulation of organelle organization 24.6753 5 no
GO:0031326 regulation of cellular biosynthetic process 24.6753 5 no
GO:0010605 negative regulation of macromolecule metabolic process 24.6753 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 24.6753 5 no
GO:0051050 positive regulation of transport 24.6753 4 no
GO:0051130 positive regulation of cellular component organization 24.6753 5 no
GO:0043933 protein-containing complex organization 24.6753 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.3766 5 no
GO:1902531 regulation of intracellular signal transduction 23.3766 5 no
GO:0006898 receptor-mediated endocytosis 23.3766 6 yes
GO:0061024 membrane organization 22.0779 4 yes
GO:0006355 regulation of DNA-templated transcription 22.0779 6 no
GO:0051252 regulation of RNA metabolic process 22.0779 5 no
GO:1903506 regulation of nucleic acid-templated transcription 22.0779 7 no
GO:2001141 regulation of RNA biosynthetic process 22.0779 6 no
GO:0010941 regulation of cell death 22.0779 4 no
GO:0051246 regulation of protein metabolic process 22.0779 5 no
GO:0030030 cell projection organization 22.0779 4 no
GO:0044087 regulation of cellular component biogenesis 20.7792 4 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 19.4805 6 yes
GO:0031344 regulation of cell projection organization 19.4805 5 yes
GO:0072583 clathrin-dependent endocytosis 15.5844 7 yes
GO:0031345 negative regulation of cell projection organization 14.2857 6 yes
GO:0033365 protein localization to organelle 14.2857 5 yes
GO:0010975 regulation of neuron projection development 12.9870 7 yes
GO:0048193 Golgi vesicle transport 12.9870 5 yes
GO:0072657 protein localization to membrane 11.6883 4 yes
GO:0007034 vacuolar transport 11.6883 4 yes
GO:0016482 cytosolic transport 11.6883 4 yes
GO:0007041 lysosomal transport 10.3896 5 yes
GO:0010977 negative regulation of neuron projection development 10.3896 7 yes
GO:0006892 post-Golgi vesicle-mediated transport 9.0909 6 yes
GO:0022411 cellular component disassembly 7.7922 4 yes
GO:0051085 chaperone cofactor-dependent protein refolding 6.4935 4 yes
GO:0007030 Golgi organization 6.4935 5 yes
GO:0051084 de novo post-translational protein folding 6.4935 4 yes
GO:1990778 protein localization to cell periphery 5.1948 5 yes
GO:0006896 Golgi to vacuole transport 5.1948 5 yes
GO:0032984 protein-containing complex disassembly 5.1948 5 yes
GO:0051261 protein depolymerization 3.8961 6 yes
GO:0071709 membrane assembly 3.8961 5 yes
GO:0072318 clathrin coat disassembly 3.8961 8 yes
GO:0072319 vesicle uncoating 3.8961 7 yes
GO:0072659 protein localization to plasma membrane 3.8961 5 yes
GO:0090160 Golgi to lysosome transport 3.8961 5 yes
GO:1905224 clathrin-coated pit assembly 3.8961 6 yes
GO:0016191 synaptic vesicle uncoating 3.8961 9 yes
GO:0007029 endoplasmic reticulum organization 2.5974 5 yes
GO:0034067 protein localization to Golgi apparatus 2.5974 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in GAK_HUMAN
DOID:574 peripheral nervous system disease 2.5974 3 no
DOID:870 neuropathy 2.5974 4 no
DOID:0050700 cardiomyopathy 2.5974 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5974 5 no
DOID:114 heart disease 2.5974 3 no
DOID:2843 long QT syndrome 2.5974 6 no
DOID:331 central nervous system disease 2.5974 3 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
LRRK2_HUMAN [view interactions] Low throughput no yes
BAG5_HUMAN [view entry] [view interactions] Low throughput yes no
DYN2_HUMAN [view entry] [view interactions] Low throughput yes yes
ANDR_HUMAN [view interactions] Low throughput no no
CDK5_HUMAN [view entry] [view interactions] Low throughput yes yes
CCNG1_HUMAN [view interactions] Low throughput no yes
GAK_HUMAN [view entry] [view interactions] Low throughput yes yes
I12R2_HUMAN [view interactions] Low throughput no no
AT132_HUMAN [view interactions] Low throughput no yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7L_HUMAN [view interactions] High throughput no yes
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
CE152_HUMAN [view interactions] High throughput no yes
LIS1_HUMAN [view entry] [view interactions] High throughput yes yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
SC24C_HUMAN [view entry] [view interactions] High throughput yes yes
CLCB_HUMAN [view entry] [view interactions] High throughput yes yes
GTSE1_HUMAN [view interactions] High throughput no no
PICAL_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
SC16A_HUMAN [view interactions] High throughput no yes
USO1_HUMAN [view entry] [view interactions] High throughput yes yes
PHKG2_HUMAN [view interactions] High throughput no no
PLXA3_HUMAN [view entry] [view interactions] High throughput yes no
ACK1_HUMAN [view interactions] High throughput no yes
ZN106_HUMAN [view interactions] High throughput no no
CE162_HUMAN [view interactions] High throughput no yes
DEN1A_HUMAN [view interactions] High throughput no no
KIF3A_HUMAN [view entry] [view interactions] High throughput yes yes
GOGB1_HUMAN [view entry] [view interactions] High throughput yes yes
AFAP1_HUMAN [view interactions] High throughput no yes
SERA_HUMAN [view entry] [view interactions] High throughput yes yes
HIP1R_HUMAN [view entry] [view interactions] High throughput yes yes
CALL3_HUMAN [view interactions] High throughput no yes
EPN4_HUMAN [view interactions] High throughput no yes
LIMA1_HUMAN [view entry] [view interactions] High throughput yes no
EPS15_HUMAN [view entry] [view interactions] High throughput yes yes
SEC13_HUMAN [view entry] [view interactions] High throughput yes yes
SPTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM14_HUMAN [view interactions] High throughput no yes
STALP_HUMAN [view interactions] High throughput no yes
MISP_HUMAN [view interactions] High throughput no no
CLH2_HUMAN [view interactions] High throughput no no
SP1_HUMAN [view interactions] High throughput no yes
PUS7L_HUMAN [view interactions] High throughput no yes
STON2_HUMAN [view interactions] High throughput no yes
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
CBPM_HUMAN [view interactions] High throughput no no
PSA5_HUMAN [view interactions] High throughput no yes
EDRF1_HUMAN [view interactions] High throughput no no
FA83H_HUMAN [view interactions] High throughput no yes
XPR1_HUMAN [view interactions] High throughput no yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
FA83B_HUMAN [view interactions] High throughput no no
P3C2A_HUMAN [view interactions] High throughput no yes
BMP2K_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
FEM1B_HUMAN [view interactions] High throughput no yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
ACTT1_HUMAN [view interactions] High throughput no no
HIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4A_HUMAN [view interactions] High throughput no no
DAB2_HUMAN [view interactions] High throughput no yes
F174A_HUMAN [view interactions] High throughput no yes
C5AR2_HUMAN [view interactions] High throughput no yes
STABP_HUMAN [view interactions] High throughput no yes
HPBP1_HUMAN [view interactions] High throughput no yes
DMWD_HUMAN [view entry] [view interactions] High throughput yes no
CBLC_HUMAN [view interactions] High throughput no yes
GPX7_HUMAN [view interactions] High throughput no no
SYIM_HUMAN [view entry] [view interactions] High throughput yes yes
OCRL_HUMAN [view interactions] High throughput no yes
PAXI_HUMAN [view interactions] High throughput no yes
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
P53_HUMAN [view interactions] High throughput no no
MB212_HUMAN [view interactions] High throughput no no
IRAK1_HUMAN [view interactions] High throughput no yes
WNK3_HUMAN [view interactions] High throughput no no
BCAR1_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
PKHA7_HUMAN [view interactions] High throughput no yes
ICOS_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
AXIN1_HUMAN [view interactions] High throughput no yes
LRRK1_HUMAN [view interactions] High throughput no yes
MFHA1_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
LGR4_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
AP2A1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2A2_HUMAN [view entry] [view interactions] High throughput yes yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
AP2M1_HUMAN [view entry] [view interactions] High throughput yes yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
MYO6_HUMAN [view entry] [view interactions] High throughput yes no
NUMB_HUMAN [view entry] [view interactions] High throughput yes yes
TNK1_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
AAK1_HUMAN [view entry] [view interactions] High throughput yes yes
KDIS_HUMAN [view interactions] High throughput no yes
WNK1_HUMAN [view entry] [view interactions] High throughput yes no
CPSF7_HUMAN [view interactions] High throughput no yes
PAR10_HUMAN [view interactions] High throughput no yes
RABX5_HUMAN [view interactions] High throughput no no
CLASR_HUMAN [view interactions] High throughput no yes
PALS1_HUMAN [view interactions] High throughput no no
TRI25_HUMAN [view interactions] High throughput no yes
ESR2_HUMAN [view interactions] High throughput no no
RN181_HUMAN [view interactions] High throughput no no
GLP1R_HUMAN [view interactions] High throughput no no
PTPRO_HUMAN [view entry] [view interactions] High throughput yes no
PKHA4_HUMAN [view interactions] High throughput no yes
SC6A4_HUMAN [view entry] [view interactions] High throughput yes no
CFAD_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
DDX58_HUMAN [view interactions] High throughput no yes
LGI1_HUMAN [view entry] [view interactions] High throughput yes no
DAPP1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
BAG2_HUMAN [view entry] [view interactions] High throughput yes no
NIPA3_HUMAN [view interactions] High throughput no no
COPT1_HUMAN [view interactions] High throughput no no
BAG1_HUMAN [view interactions] High throughput no yes
TGFA_HUMAN [view interactions] High throughput no yes
DNJA2_HUMAN [view entry] [view interactions] High throughput yes yes
S10A4_HUMAN [view entry] [view interactions] High throughput yes no
EFMT2_HUMAN [view interactions] High throughput no yes
EFMT3_HUMAN [view interactions] High throughput no no
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
CIB2_HUMAN [view interactions] High throughput no yes
PPM1M_HUMAN [view interactions] High throughput no yes
ATG7_HUMAN [view interactions] High throughput no yes
CIA2A_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
NPAS1_HUMAN [view interactions] High throughput no no
PAAT_HUMAN [view interactions] High throughput no yes
AUXI_HUMAN [view entry] [view interactions] High throughput yes yes
PSG11_HUMAN [view interactions] High throughput no no
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
RHG18_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
MRE11_HUMAN [view interactions] High throughput no yes
ROA2_HUMAN [view entry] [view interactions] High throughput yes yes
RACK1_HUMAN [view interactions] High throughput no yes
RBM42_HUMAN [view interactions] High throughput no yes
RL5_HUMAN [view entry] [view interactions] High throughput yes yes
SRP68_HUMAN [view interactions] High throughput no yes
FBXW7_HUMAN [view interactions] High throughput no yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
PPM1B_HUMAN [view interactions] High throughput no yes
ALMS1_HUMAN [view interactions] High throughput no no
APC1_HUMAN [view interactions] High throughput no no
ARHGC_HUMAN [view interactions] High throughput no yes
EMAL3_HUMAN [view interactions] High throughput no no
HERC2_HUMAN [view interactions] High throughput no yes
OSBL6_HUMAN [view interactions] High throughput no yes
GOGA1_HUMAN [view interactions] High throughput no yes
GBF1_HUMAN [view interactions] High throughput no yes
SMAP2_HUMAN [view interactions] High throughput no yes
RN183_HUMAN [view interactions] High throughput no no
HYOU1_HUMAN [view interactions] High throughput no yes
CBPD_HUMAN [view interactions] High throughput no yes
WDR11_HUMAN [view interactions] High throughput no yes
SCAM1_HUMAN [view interactions] High throughput no no
ARP3_HUMAN [view entry] [view interactions] High throughput yes yes
ANC2_HUMAN [view interactions] High throughput no no
RCAS1_HUMAN [view interactions] High throughput no yes
IMDH2_HUMAN [view interactions] High throughput no yes
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
PEX14_HUMAN [view interactions] High throughput no yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
SYNE3_HUMAN [view interactions] High throughput no no
NAA40_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
1433S_HUMAN [view entry] [view interactions] High throughput yes yes
EPN3_HUMAN [view interactions] Computational no no
SNX5_HUMAN [view entry] [view interactions] Computational yes yes
AP4E1_HUMAN [view interactions] Computational no no
SORT_HUMAN [view interactions] Computational no yes
AP3B1_HUMAN [view entry] [view interactions] Computational yes yes
YIPF6_HUMAN [view interactions] Computational no yes
CLHC1_HUMAN [view interactions] Computational no no
AP3S1_HUMAN [view entry] [view interactions] Computational yes no
MIX23_HUMAN [view interactions] Computational no yes
DNM1L_HUMAN [view entry] [view interactions] Computational yes yes
AP4B1_HUMAN [view interactions] Computational no yes
SNAPN_HUMAN [view interactions] Computational no yes
SNX2_HUMAN [view entry] [view interactions] Computational yes no
DYN1_HUMAN [view entry] [view interactions] Computational yes yes
ENTD1_HUMAN [view interactions] Computational no no
AP1G1_HUMAN [view entry] [view interactions] Computational yes yes
DYN3_HUMAN [view entry] [view interactions] Computational yes no
AP1M1_HUMAN [view entry] [view interactions] Computational yes yes
VPS35_HUMAN [view entry] [view interactions] Computational yes yes
HSP74_HUMAN [view entry] [view interactions] Computational yes yes
EPN1_HUMAN [view entry] [view interactions] Computational yes yes
EPN2_HUMAN [view entry] [view interactions] Computational yes yes