GAK_HUMAN
Evidence for PS localization
Functions
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GAK_HUMAN |
|---|---|---|---|---|
| GO:0043168 | anion binding | 32.8571 | 4 | yes |
| GO:0000166 | nucleotide binding | 31.4286 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 31.4286 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.5714 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 25.7143 | 6 | yes |
| GO:0005524 | ATP binding | 22.8571 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 22.8571 | 5 | yes |
| GO:0016301 | kinase activity | 10.0000 | 4 | yes |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 10.0000 | 4 | yes |
| GO:0004674 | protein serine/threonine kinase activity | 8.5714 | 4 | yes |
| GO:0106310 | protein serine kinase activity | 8.5714 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GAK_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 57.1429 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 54.2857 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.1429 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.7143 | 4 | yes |
| GO:0008104 | protein localization | 41.4286 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 41.4286 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0010646 | regulation of cell communication | 38.5714 | 4 | no |
| GO:0006996 | organelle organization | 35.7143 | 4 | yes |
| GO:0022607 | cellular component assembly | 34.2857 | 4 | yes |
| GO:0071702 | organic substance transport | 32.8571 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 32.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 32.8571 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 32.8571 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 32.8571 | 5 | no |
| GO:0071705 | nitrogen compound transport | 31.4286 | 4 | no |
| GO:0051049 | regulation of transport | 31.4286 | 4 | no |
| GO:0098657 | import into cell | 30.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.0000 | 6 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0015031 | protein transport | 28.5714 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.7143 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 25.7143 | 5 | no |
| GO:0023056 | positive regulation of signaling | 25.7143 | 4 | no |
| GO:0043933 | protein-containing complex organization | 24.2857 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 24.2857 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.2857 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.2857 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.8571 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 22.8571 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 22.8571 | 7 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.8571 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.8571 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 22.8571 | 6 | no |
| GO:0009967 | positive regulation of signal transduction | 22.8571 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.8571 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.4286 | 5 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0006898 | receptor-mediated endocytosis | 20.0000 | 4 | yes |
| GO:0031344 | regulation of cell projection organization | 20.0000 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.0000 | 6 | yes |
| GO:0065003 | protein-containing complex assembly | 18.5714 | 5 | yes |
| GO:0010975 | regulation of neuron projection development | 15.7143 | 7 | yes |
| GO:0072583 | clathrin-dependent endocytosis | 15.7143 | 5 | yes |
| GO:0016310 | phosphorylation | 11.4286 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 11.4286 | 6 | yes |
| GO:0048268 | clathrin coat assembly | 11.4286 | 6 | yes |
| GO:0072657 | protein localization to membrane | 11.4286 | 4 | yes |
| GO:0010977 | negative regulation of neuron projection development | 10.0000 | 7 | yes |
| GO:0033365 | protein localization to organelle | 10.0000 | 5 | yes |
| GO:0022411 | cellular component disassembly | 8.5714 | 4 | yes |
| GO:0006892 | post-Golgi vesicle-mediated transport | 7.1429 | 4 | yes |
| GO:0007030 | Golgi organization | 7.1429 | 5 | yes |
| GO:0007034 | vacuolar transport | 7.1429 | 4 | yes |
| GO:0007041 | lysosomal transport | 7.1429 | 5 | yes |
| GO:0016482 | cytosolic transport | 7.1429 | 4 | yes |
| GO:0051084 | de novo post-translational protein folding | 7.1429 | 4 | yes |
| GO:0051085 | chaperone cofactor-dependent protein refolding | 7.1429 | 4 | yes |
| GO:0032984 | protein-containing complex disassembly | 5.7143 | 5 | yes |
| GO:0051261 | protein depolymerization | 5.7143 | 6 | yes |
| GO:0072318 | clathrin coat disassembly | 5.7143 | 8 | yes |
| GO:0072319 | vesicle uncoating | 5.7143 | 7 | yes |
| GO:1990778 | protein localization to cell periphery | 5.7143 | 5 | yes |
| GO:0007029 | endoplasmic reticulum organization | 4.2857 | 5 | yes |
| GO:0016191 | synaptic vesicle uncoating | 4.2857 | 9 | yes |
| GO:0072659 | protein localization to plasma membrane | 4.2857 | 5 | yes |
| GO:0006896 | Golgi to vacuole transport | 2.8571 | 5 | yes |
| GO:0034067 | protein localization to Golgi apparatus | 2.8571 | 6 | yes |
| GO:0090160 | Golgi to lysosome transport | 2.8571 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| I12R2_HUMAN | [view interactions] | Low throughput | no | no |
| AT132_HUMAN | [view interactions] | Low throughput | no | yes |
| BAG5_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| DYN2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ANDR_HUMAN | [view interactions] | Low throughput | no | no |
| CDK5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CCNG1_HUMAN | [view interactions] | Low throughput | no | yes |
| GAK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7L_HUMAN | [view interactions] | High throughput | no | yes |
| 2AAA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GTSE1_HUMAN | [view interactions] | High throughput | no | no |
| PICAL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC16A_HUMAN | [view interactions] | High throughput | no | yes |
| USO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHKG2_HUMAN | [view interactions] | High throughput | no | no |
| DAB2_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| HIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTT1_HUMAN | [view interactions] | High throughput | no | no |
| PLXA3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FEM1B_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| P3C2A_HUMAN | [view interactions] | High throughput | no | yes |
| FA83B_HUMAN | [view interactions] | High throughput | no | no |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S53A1_HUMAN | [view interactions] | High throughput | no | yes |
| FA83H_HUMAN | [view interactions] | High throughput | no | yes |
| EDRF1_HUMAN | [view interactions] | High throughput | no | no |
| PSA5_HUMAN | [view interactions] | High throughput | no | yes |
| CBPM_HUMAN | [view interactions] | High throughput | no | no |
| INF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STON2_HUMAN | [view interactions] | High throughput | no | yes |
| PUS7L_HUMAN | [view interactions] | High throughput | no | yes |
| SP1_HUMAN | [view interactions] | High throughput | no | yes |
| CLH2_HUMAN | [view interactions] | High throughput | no | no |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| STALP_HUMAN | [view interactions] | High throughput | no | yes |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPN4_HUMAN | [view interactions] | High throughput | no | yes |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| HIP1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AFAP1_HUMAN | [view interactions] | High throughput | no | yes |
| GOGB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEN1A_HUMAN | [view interactions] | High throughput | no | no |
| CE162_HUMAN | [view interactions] | High throughput | no | yes |
| ZN106_HUMAN | [view interactions] | High throughput | no | no |
| ACK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F174A_HUMAN | [view interactions] | High throughput | no | yes |
| C5AR2_HUMAN | [view interactions] | High throughput | no | yes |
| STABP_HUMAN | [view interactions] | High throughput | no | yes |
| HPBP1_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CBLC_HUMAN | [view interactions] | High throughput | no | yes |
| GPX7_HUMAN | [view interactions] | High throughput | no | no |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCRL_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| MB212_HUMAN | [view interactions] | High throughput | no | no |
| IRAK1_HUMAN | [view interactions] | High throughput | no | yes |
| WNK3_HUMAN | [view interactions] | High throughput | no | no |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| ICOS_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
| AXIN1_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MFHA1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| AP2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUMB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNK1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AAK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WNK1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CPSF7_HUMAN | [view interactions] | High throughput | no | yes |
| PAR10_HUMAN | [view interactions] | High throughput | no | yes |
| RABX5_HUMAN | [view interactions] | High throughput | no | no |
| CLASR_HUMAN | [view interactions] | High throughput | no | yes |
| PALS1_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RN181_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| PTPRO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| LGI1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NIPA3_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| TGFA_HUMAN | [view interactions] | High throughput | no | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| S10A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EFMT2_HUMAN | [view interactions] | High throughput | no | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| UBXN6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CIB2_HUMAN | [view interactions] | High throughput | no | yes |
| PPM1M_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| CIA2A_HUMAN | [view interactions] | High throughput | no | yes |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| PAAT_HUMAN | [view interactions] | High throughput | no | yes |
| AUXI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSG11_HUMAN | [view interactions] | High throughput | no | no |
| SAHH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| RBM42_HUMAN | [view interactions] | High throughput | no | yes |
| RL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| ATG5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MED16_HUMAN | [view interactions] | High throughput | no | yes |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RB_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPM1B_HUMAN | [view interactions] | High throughput | no | yes |
| ALMS1_HUMAN | [view interactions] | High throughput | no | no |
| APC1_HUMAN | [view interactions] | High throughput | no | no |
| ARHGC_HUMAN | [view interactions] | High throughput | no | yes |
| EMAL3_HUMAN | [view interactions] | High throughput | no | no |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| OSBL6_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA1_HUMAN | [view interactions] | High throughput | no | yes |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| RN183_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| CBPD_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| ARP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANC2_HUMAN | [view interactions] | High throughput | no | no |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEX14_HUMAN | [view interactions] | High throughput | no | yes |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| SYNE3_HUMAN | [view interactions] | High throughput | no | no |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |