PLXA3_HUMAN
Evidence for PS localization
Functions
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLXA3_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 30.0000 | 4 | no |
| GO:0016301 | kinase activity | 26.6667 | 4 | no |
| GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 26.6667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 26.6667 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.6667 | 4 | no |
| GO:0017154 | semaphorin receptor activity | 23.3333 | 4 | yes |
| GO:0019900 | kinase binding | 23.3333 | 4 | no |
| GO:0019901 | protein kinase binding | 23.3333 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 23.3333 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLXA3_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 83.3333 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 73.3333 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 63.3333 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 50.0000 | 4 | yes |
| GO:0030030 | cell projection organization | 50.0000 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 50.0000 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 50.0000 | 4 | no |
| GO:0031175 | neuron projection development | 46.6667 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 46.6667 | 5 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 46.6667 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 46.6667 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 46.6667 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 46.6667 | 4 | no |
| GO:0010975 | regulation of neuron projection development | 43.3333 | 7 | yes |
| GO:0030155 | regulation of cell adhesion | 43.3333 | 4 | yes |
| GO:2000145 | regulation of cell motility | 43.3333 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 43.3333 | 4 | no |
| GO:0007411 | axon guidance | 40.0000 | 8 | yes |
| GO:0030334 | regulation of cell migration | 40.0000 | 5 | yes |
| GO:0051094 | positive regulation of developmental process | 40.0000 | 4 | yes |
| GO:0097485 | neuron projection guidance | 40.0000 | 7 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0045597 | positive regulation of cell differentiation | 36.6667 | 5 | yes |
| GO:0048585 | negative regulation of response to stimulus | 36.6667 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 36.6667 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 36.6667 | 5 | yes |
| GO:0060284 | regulation of cell development | 36.6667 | 5 | yes |
| GO:0009966 | regulation of signal transduction | 36.6667 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.6667 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.6667 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 36.6667 | 5 | no |
| GO:0001558 | regulation of cell growth | 33.3333 | 4 | yes |
| GO:0022604 | regulation of cell morphogenesis | 33.3333 | 5 | yes |
| GO:0031346 | positive regulation of cell projection organization | 33.3333 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 33.3333 | 5 | yes |
| GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 33.3333 | 6 | no |
| GO:0051049 | regulation of transport | 33.3333 | 4 | no |
| GO:0006996 | organelle organization | 33.3333 | 4 | no |
| GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
| GO:0008360 | regulation of cell shape | 30.0000 | 6 | yes |
| GO:0050767 | regulation of neurogenesis | 30.0000 | 6 | yes |
| GO:0051129 | negative regulation of cellular component organization | 30.0000 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 30.0000 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 30.0000 | 4 | yes |
| GO:0051960 | regulation of nervous system development | 30.0000 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 30.0000 | 5 | yes |
| GO:0071526 | semaphorin-plexin signaling pathway | 30.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0043412 | macromolecule modification | 30.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.0000 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 30.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.0000 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 30.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 30.0000 | 5 | no |
| GO:0030516 | regulation of axon extension | 26.6667 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 26.6667 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 26.6667 | 4 | yes |
| GO:0045596 | negative regulation of cell differentiation | 26.6667 | 5 | yes |
| GO:0050919 | negative chemotaxis | 26.6667 | 4 | yes |
| GO:0051093 | negative regulation of developmental process | 26.6667 | 4 | yes |
| GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 26.6667 | 5 | yes |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0036211 | protein modification process | 26.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0060548 | negative regulation of cell death | 26.6667 | 5 | no |
| GO:0010720 | positive regulation of cell development | 23.3333 | 6 | yes |
| GO:0010721 | negative regulation of cell development | 23.3333 | 6 | yes |
| GO:0010977 | negative regulation of neuron projection development | 23.3333 | 7 | yes |
| GO:0033043 | regulation of organelle organization | 23.3333 | 5 | yes |
| GO:0040013 | negative regulation of locomotion | 23.3333 | 4 | yes |
| GO:0045926 | negative regulation of growth | 23.3333 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 23.3333 | 5 | yes |
| GO:0050920 | regulation of chemotaxis | 23.3333 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 23.3333 | 6 | yes |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 23.3333 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 23.3333 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.3333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 23.3333 | 6 | no |
| GO:0023056 | positive regulation of signaling | 23.3333 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 23.3333 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 23.3333 | 5 | no |
| GO:0008104 | protein localization | 23.3333 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 23.3333 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 23.3333 | 5 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 23.3333 | 6 | no |
| GO:0043066 | negative regulation of apoptotic process | 23.3333 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 23.3333 | 6 | no |
| GO:0021612 | facial nerve structural organization | 20.0000 | 4 | yes |
| GO:0030308 | negative regulation of cell growth | 20.0000 | 5 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 20.0000 | 5 | yes |
| GO:0043087 | regulation of GTPase activity | 20.0000 | 5 | yes |
| GO:0048841 | regulation of axon extension involved in axon guidance | 20.0000 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 20.0000 | 6 | yes |
| GO:0050769 | positive regulation of neurogenesis | 20.0000 | 6 | yes |
| GO:0050771 | negative regulation of axonogenesis | 20.0000 | 6 | yes |
| GO:0050772 | positive regulation of axonogenesis | 20.0000 | 6 | yes |
| GO:0051961 | negative regulation of nervous system development | 20.0000 | 5 | yes |
| GO:0051962 | positive regulation of nervous system development | 20.0000 | 5 | yes |
| GO:1990138 | neuron projection extension | 20.0000 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 16.6667 | 5 | yes |
| GO:0008045 | motor neuron axon guidance | 16.6667 | 9 | yes |
| GO:0010638 | positive regulation of organelle organization | 16.6667 | 6 | yes |
| GO:0021637 | trigeminal nerve structural organization | 16.6667 | 4 | yes |
| GO:0030517 | negative regulation of axon extension | 16.6667 | 6 | yes |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | 16.6667 | 6 | yes |
| GO:0050922 | negative regulation of chemotaxis | 16.6667 | 5 | yes |
| GO:0021785 | branchiomotor neuron axon guidance | 13.3333 | 10 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 13.3333 | 7 | yes |
| GO:0021954 | central nervous system neuron development | 10.0000 | 5 | yes |
| GO:0048666 | neuron development | 10.0000 | 4 | yes |
| GO:0021860 | pyramidal neuron development | 6.6667 | 7 | yes |
| GO:0021884 | forebrain neuron development | 6.6667 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| PLXA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MTG16_HUMAN | [view interactions] | Low throughput | no | yes |
| POLK_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| USF1_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5_HUMAN | [view interactions] | High throughput | no | yes |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| HLAE_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| EP3A_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAH6_HUMAN | [view interactions] | High throughput | no | no |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| SG2A1_HUMAN | [view interactions] | High throughput | no | no |
| GLT10_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| SPXN_HUMAN | [view interactions] | High throughput | no | no |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| IGLL5_HUMAN | [view interactions] | High throughput | no | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| C1QB_HUMAN | [view interactions] | High throughput | no | no |
| FMOD_HUMAN | [view interactions] | High throughput | no | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| KLK3_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| CRIS2_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| APOM_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| SEM5B_HUMAN | [view interactions] | High throughput | no | yes |
| SEM6D_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| MED22_HUMAN | [view interactions] | High throughput | no | no |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| CCN1_HUMAN | [view interactions] | High throughput | no | yes |
| SPS2L_HUMAN | [view interactions] | High throughput | no | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSF2_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| FIGN_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBF_HUMAN | [view interactions] | High throughput | no | yes |
| OAZ1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MKNK2_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM7A_HUMAN | [view interactions] | Computational | no | yes |
| SEM3F_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SEM4F_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SEM3A_HUMAN | [view interactions] | Computational | no | no |
| SEM4D_HUMAN | [view interactions] | Computational | no | yes |
| SEM6C_HUMAN | [view interactions] | Computational | no | no |
| SEM6B_HUMAN | [view interactions] | Computational | no | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LIMK1_HUMAN | [view interactions] | Computational | no | yes |
| SEM5A_HUMAN | [view interactions] | Computational | no | yes |
| PLXA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RHOD_HUMAN | [view interactions] | Computational | no | no |
| RRAS_HUMAN | [view interactions] | Computational | no | yes |
| NRP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FES_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SEM3C_HUMAN | [view interactions] | Computational | no | no |
| SEM3D_HUMAN | [view interactions] | Computational | no | no |
| SEM3B_HUMAN | [view interactions] | Computational | no | yes |
| PLXA2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| NRP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLXA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RND1_HUMAN | [view interactions] | Computational | no | no |
| SEM3G_HUMAN | [view interactions] | Computational | no | no |
| FYN_HUMAN | [view entry] [view interactions] | Computational | yes | no |