PLXA3_HUMAN
Evidence for PS localization
Functions
Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLXA3_HUMAN |
|---|---|---|---|---|
| GO:0017154 | semaphorin receptor activity | 9.0909 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLXA3_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 68.1818 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 59.0909 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 45.4545 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 40.9091 | 4 | no |
| GO:0010646 | regulation of cell communication | 40.9091 | 4 | no |
| GO:0009966 | regulation of signal transduction | 36.3636 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:2000026 | regulation of multicellular organismal development | 31.8182 | 4 | yes |
| GO:0009894 | regulation of catabolic process | 31.8182 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 31.8182 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.8182 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.8182 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.8182 | 5 | no |
| GO:0022607 | cellular component assembly | 31.8182 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 27.2727 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 27.2727 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 27.2727 | 4 | no |
| GO:0008104 | protein localization | 27.2727 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 27.2727 | 6 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0043933 | protein-containing complex organization | 27.2727 | 4 | no |
| GO:0030030 | cell projection organization | 22.7273 | 4 | yes |
| GO:0045595 | regulation of cell differentiation | 22.7273 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 22.7273 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 22.7273 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 22.7273 | 4 | yes |
| GO:0051241 | negative regulation of multicellular organismal process | 22.7273 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 22.7273 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 22.7273 | 5 | no |
| GO:0010468 | regulation of gene expression | 22.7273 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.7273 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.7273 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.7273 | 5 | no |
| GO:0023056 | positive regulation of signaling | 22.7273 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.7273 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.7273 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 22.7273 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 22.7273 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.7273 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 22.7273 | 6 | no |
| GO:0065003 | protein-containing complex assembly | 22.7273 | 5 | no |
| GO:0043412 | macromolecule modification | 22.7273 | 4 | no |
| GO:0001558 | regulation of cell growth | 18.1818 | 4 | yes |
| GO:0007411 | axon guidance | 18.1818 | 8 | yes |
| GO:0010975 | regulation of neuron projection development | 18.1818 | 7 | yes |
| GO:0010977 | negative regulation of neuron projection development | 18.1818 | 7 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 18.1818 | 4 | yes |
| GO:0030155 | regulation of cell adhesion | 18.1818 | 4 | yes |
| GO:0031175 | neuron projection development | 18.1818 | 6 | yes |
| GO:0031344 | regulation of cell projection organization | 18.1818 | 5 | yes |
| GO:0031345 | negative regulation of cell projection organization | 18.1818 | 6 | yes |
| GO:0045596 | negative regulation of cell differentiation | 18.1818 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 18.1818 | 5 | yes |
| GO:0045926 | negative regulation of growth | 18.1818 | 4 | yes |
| GO:0048640 | negative regulation of developmental growth | 18.1818 | 5 | yes |
| GO:0051093 | negative regulation of developmental process | 18.1818 | 4 | yes |
| GO:0051129 | negative regulation of cellular component organization | 18.1818 | 5 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 18.1818 | 4 | yes |
| GO:0097485 | neuron projection guidance | 18.1818 | 7 | yes |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 18.1818 | 6 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 18.1818 | 5 | yes |
| GO:0010721 | negative regulation of cell development | 13.6364 | 6 | yes |
| GO:0030308 | negative regulation of cell growth | 13.6364 | 5 | yes |
| GO:0030334 | regulation of cell migration | 13.6364 | 5 | yes |
| GO:0040013 | negative regulation of locomotion | 13.6364 | 4 | yes |
| GO:0048666 | neuron development | 13.6364 | 4 | yes |
| GO:0050767 | regulation of neurogenesis | 13.6364 | 6 | yes |
| GO:0050768 | negative regulation of neurogenesis | 13.6364 | 6 | yes |
| GO:0050770 | regulation of axonogenesis | 13.6364 | 5 | yes |
| GO:0050771 | negative regulation of axonogenesis | 13.6364 | 6 | yes |
| GO:0050919 | negative chemotaxis | 13.6364 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 13.6364 | 5 | yes |
| GO:0051960 | regulation of nervous system development | 13.6364 | 5 | yes |
| GO:0051961 | negative regulation of nervous system development | 13.6364 | 5 | yes |
| GO:0060284 | regulation of cell development | 13.6364 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 13.6364 | 5 | yes |
| GO:2000145 | regulation of cell motility | 13.6364 | 4 | yes |
| GO:0001764 | neuron migration | 9.0909 | 4 | yes |
| GO:0007162 | negative regulation of cell adhesion | 9.0909 | 5 | yes |
| GO:0008045 | motor neuron axon guidance | 9.0909 | 9 | yes |
| GO:0010638 | positive regulation of organelle organization | 9.0909 | 6 | yes |
| GO:0010720 | positive regulation of cell development | 9.0909 | 6 | yes |
| GO:0021612 | facial nerve structural organization | 9.0909 | 4 | yes |
| GO:0021628 | olfactory nerve formation | 9.0909 | 4 | yes |
| GO:0021637 | trigeminal nerve structural organization | 9.0909 | 4 | yes |
| GO:0021785 | branchiomotor neuron axon guidance | 9.0909 | 10 | yes |
| GO:0021828 | gonadotrophin-releasing hormone neuronal migration to the hypothalamus | 9.0909 | 5 | yes |
| GO:0021855 | hypothalamus cell migration | 9.0909 | 4 | yes |
| GO:0021856 | hypothalamic tangential migration using cell-axon interactions | 9.0909 | 5 | yes |
| GO:0021860 | pyramidal neuron development | 9.0909 | 7 | yes |
| GO:0021884 | forebrain neuron development | 9.0909 | 6 | yes |
| GO:0021954 | central nervous system neuron development | 9.0909 | 5 | yes |
| GO:0022604 | regulation of cell morphogenesis | 9.0909 | 5 | yes |
| GO:0030516 | regulation of axon extension | 9.0909 | 5 | yes |
| GO:0030517 | negative regulation of axon extension | 9.0909 | 6 | yes |
| GO:0031346 | positive regulation of cell projection organization | 9.0909 | 6 | yes |
| GO:0032101 | regulation of response to external stimulus | 9.0909 | 4 | yes |
| GO:0032102 | negative regulation of response to external stimulus | 9.0909 | 5 | yes |
| GO:0033043 | regulation of organelle organization | 9.0909 | 5 | yes |
| GO:0048675 | axon extension | 9.0909 | 5 | yes |
| GO:0048841 | regulation of axon extension involved in axon guidance | 9.0909 | 6 | yes |
| GO:0048843 | negative regulation of axon extension involved in axon guidance | 9.0909 | 6 | yes |
| GO:0048846 | axon extension involved in axon guidance | 9.0909 | 6 | yes |
| GO:0050769 | positive regulation of neurogenesis | 9.0909 | 6 | yes |
| GO:0050772 | positive regulation of axonogenesis | 9.0909 | 6 | yes |
| GO:0050920 | regulation of chemotaxis | 9.0909 | 4 | yes |
| GO:0050922 | negative regulation of chemotaxis | 9.0909 | 5 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 9.0909 | 6 | yes |
| GO:0051495 | positive regulation of cytoskeleton organization | 9.0909 | 7 | yes |
| GO:0051962 | positive regulation of nervous system development | 9.0909 | 5 | yes |
| GO:0071526 | semaphorin-plexin signaling pathway | 9.0909 | 4 | yes |
| GO:1902284 | neuron projection extension involved in neuron projection guidance | 9.0909 | 5 | yes |
| GO:1902285 | semaphorin-plexin signaling pathway involved in neuron projection guidance | 9.0909 | 5 | yes |
| GO:1902287 | semaphorin-plexin signaling pathway involved in axon guidance | 9.0909 | 6 | yes |
| GO:1990138 | neuron projection extension | 9.0909 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MTG16_HUMAN | [view interactions] | Low throughput | no | yes |
| PLXA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DPYL2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CSK2B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP2AB_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF4B_HUMAN | [view interactions] | High throughput | no | no |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF1C_HUMAN | [view interactions] | High throughput | no | yes |
| KLC4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC6_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| PAR6A_HUMAN | [view interactions] | High throughput | no | yes |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| MED22_HUMAN | [view interactions] | High throughput | no | no |
| ERF3A_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA3_HUMAN | [view interactions] | High throughput | no | no |
| CCN1_HUMAN | [view interactions] | High throughput | no | yes |
| SPS2L_HUMAN | [view interactions] | High throughput | no | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HSF2_HUMAN | [view interactions] | High throughput | no | no |
| TPX2_HUMAN | [view interactions] | High throughput | no | yes |
| FIGN_HUMAN | [view interactions] | High throughput | no | yes |
| NDC80_HUMAN | [view interactions] | High throughput | no | no |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| MLH1_HUMAN | [view interactions] | High throughput | no | yes |
| PCDBF_HUMAN | [view interactions] | High throughput | no | yes |
| OAZ1_HUMAN | [view interactions] | High throughput | no | yes |
| EXOS2_HUMAN | [view interactions] | High throughput | no | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MKNK2_HUMAN | [view interactions] | High throughput | no | yes |
| KI21A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| POLK_HUMAN | [view interactions] | High throughput | no | no |
| GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTB_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNTRB_HUMAN | [view interactions] | High throughput | no | yes |
| USF1_HUMAN | [view interactions] | High throughput | no | yes |
| ARP5_HUMAN | [view interactions] | High throughput | no | yes |
| SG1D1_HUMAN | [view interactions] | High throughput | no | no |
| HLAE_HUMAN | [view interactions] | High throughput | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| PTPRK_HUMAN | [view interactions] | High throughput | no | no |
| SG2A2_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CA054_HUMAN | [view interactions] | High throughput | no | yes |
| NKG2A_HUMAN | [view interactions] | High throughput | no | no |
| CL12B_HUMAN | [view interactions] | High throughput | no | no |
| EP3A_HUMAN | [view interactions] | High throughput | no | no |
| FBX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAH6_HUMAN | [view interactions] | High throughput | no | no |
| CST9L_HUMAN | [view interactions] | High throughput | no | no |
| HDBP1_HUMAN | [view interactions] | High throughput | no | no |
| HYOU1_HUMAN | [view interactions] | High throughput | no | yes |
| EP3B_HUMAN | [view interactions] | High throughput | no | no |
| CEAM8_HUMAN | [view interactions] | High throughput | no | no |
| SG2A1_HUMAN | [view interactions] | High throughput | no | no |
| GLT10_HUMAN | [view interactions] | High throughput | no | no |
| DB135_HUMAN | [view interactions] | High throughput | no | no |
| SPXN_HUMAN | [view interactions] | High throughput | no | no |
| SIA8D_HUMAN | [view interactions] | High throughput | no | yes |
| IGLL5_HUMAN | [view interactions] | High throughput | no | no |
| SIRPD_HUMAN | [view interactions] | High throughput | no | no |
| TAZ_HUMAN | [view interactions] | High throughput | no | yes |
| C1QB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FMOD_HUMAN | [view interactions] | High throughput | no | no |
| PCDB3_HUMAN | [view interactions] | High throughput | no | no |
| CLC2B_HUMAN | [view interactions] | High throughput | no | yes |
| LYPD4_HUMAN | [view interactions] | High throughput | no | no |
| DQA1_HUMAN | [view interactions] | High throughput | no | yes |
| PTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MFAP4_HUMAN | [view interactions] | High throughput | no | no |
| BTNL2_HUMAN | [view interactions] | High throughput | no | no |
| FIBIN_HUMAN | [view interactions] | High throughput | no | yes |
| PSPC_HUMAN | [view interactions] | High throughput | no | no |
| SDF2L_HUMAN | [view interactions] | High throughput | no | yes |
| KLK3_HUMAN | [view interactions] | High throughput | no | no |
| ASIC4_HUMAN | [view interactions] | High throughput | no | no |
| CRIS2_HUMAN | [view interactions] | High throughput | no | no |
| DNSL1_HUMAN | [view interactions] | High throughput | no | yes |
| GGH_HUMAN | [view interactions] | High throughput | no | yes |
| NRG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T106A_HUMAN | [view interactions] | High throughput | no | no |
| LYZL1_HUMAN | [view interactions] | High throughput | no | no |
| IL5RA_HUMAN | [view interactions] | High throughput | no | no |
| LY86_HUMAN | [view interactions] | High throughput | no | no |
| ISLR_HUMAN | [view interactions] | High throughput | no | no |
| HLAG_HUMAN | [view interactions] | High throughput | no | no |
| CBLN4_HUMAN | [view interactions] | High throughput | no | no |
| IDS_HUMAN | [view interactions] | High throughput | no | yes |
| APOM_HUMAN | [view interactions] | High throughput | no | no |
| SLUR1_HUMAN | [view interactions] | High throughput | no | no |
| EPHA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BRID5_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| PLXD1_HUMAN | [view interactions] | High throughput | no | yes |
| PLXB2_HUMAN | [view interactions] | High throughput | no | yes |
| SEM5B_HUMAN | [view interactions] | High throughput | no | yes |
| SEM6D_HUMAN | [view interactions] | High throughput | no | no |
| LYRIC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SEM6A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |