KDIS_HUMAN
Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration . Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in KDIS_HUMAN |
---|---|---|---|---|
GO:0043168 | anion binding | 38.1579 | 4 | no |
GO:0000166 | nucleotide binding | 36.8421 | 4 | no |
GO:0017076 | purine nucleotide binding | 36.8421 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 35.5263 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 34.2105 | 4 | no |
GO:0019900 | kinase binding | 25.0000 | 4 | no |
GO:0019901 | protein kinase binding | 23.6842 | 5 | no |
GO:0016462 | pyrophosphatase activity | 23.6842 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 23.6842 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 23.6842 | 6 | no |
GO:0003924 | GTPase activity | 22.3684 | 7 | no |
GO:0005525 | GTP binding | 22.3684 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 22.3684 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 22.3684 | 5 | no |
GO:0019887 | protein kinase regulator activity | 2.6316 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in KDIS_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 69.7368 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 55.2632 | 4 | yes |
GO:0008104 | protein localization | 55.2632 | 4 | no |
GO:0010646 | regulation of cell communication | 48.6842 | 4 | no |
GO:0048523 | negative regulation of cellular process | 47.3684 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 46.0526 | 4 | no |
GO:0006996 | organelle organization | 43.4211 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 42.1053 | 4 | no |
GO:0022607 | cellular component assembly | 40.7895 | 4 | no |
GO:0009966 | regulation of signal transduction | 40.7895 | 4 | no |
GO:0010647 | positive regulation of cell communication | 38.1579 | 5 | no |
GO:0023056 | positive regulation of signaling | 38.1579 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 38.1579 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 36.8421 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 35.5263 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 35.5263 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 35.5263 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 35.5263 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 35.5263 | 5 | no |
GO:0010468 | regulation of gene expression | 34.2105 | 6 | no |
GO:0051049 | regulation of transport | 34.2105 | 4 | no |
GO:0030030 | cell projection organization | 32.8947 | 4 | yes |
GO:0071702 | organic substance transport | 32.8947 | 4 | no |
GO:0071705 | nitrogen compound transport | 32.8947 | 4 | no |
GO:0060341 | regulation of cellular localization | 32.8947 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 31.5789 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.5789 | 5 | no |
GO:0032880 | regulation of protein localization | 31.5789 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 30.2632 | 5 | no |
GO:2000145 | regulation of cell motility | 30.2632 | 4 | no |
GO:0031344 | regulation of cell projection organization | 28.9474 | 5 | yes |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.9474 | 6 | yes |
GO:0030334 | regulation of cell migration | 28.9474 | 5 | no |
GO:0030155 | regulation of cell adhesion | 27.6316 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 27.6316 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 27.6316 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 26.3158 | 5 | yes |
GO:0015031 | protein transport | 26.3158 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 26.3158 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 26.3158 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 25.0000 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 23.6842 | 4 | no |
GO:0071310 | cellular response to organic substance | 23.6842 | 4 | no |
GO:1902533 | positive regulation of intracellular signal transduction | 23.6842 | 6 | no |
GO:0008284 | positive regulation of cell population proliferation | 22.3684 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 22.3684 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 22.3684 | 5 | no |
GO:0045595 | regulation of cell differentiation | 22.3684 | 4 | no |
GO:0045785 | positive regulation of cell adhesion | 22.3684 | 5 | no |
GO:0051094 | positive regulation of developmental process | 22.3684 | 4 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.3684 | 6 | no |
GO:0060627 | regulation of vesicle-mediated transport | 22.3684 | 4 | no |
GO:0009891 | positive regulation of biosynthetic process | 22.3684 | 5 | no |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.3684 | 6 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 22.3684 | 6 | no |
GO:0033043 | regulation of organelle organization | 22.3684 | 5 | no |
GO:0141124 | intracellular signaling cassette | 22.3684 | 4 | no |
GO:0031175 | neuron projection development | 21.0526 | 6 | no |
GO:0042981 | regulation of apoptotic process | 21.0526 | 5 | no |
GO:0043067 | regulation of programmed cell death | 21.0526 | 4 | no |
GO:2000026 | regulation of multicellular organismal development | 21.0526 | 4 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 21.0526 | 4 | no |
GO:0050804 | modulation of chemical synaptic transmission | 21.0526 | 5 | no |
GO:0099177 | regulation of trans-synaptic signaling | 21.0526 | 4 | no |
GO:0010975 | regulation of neuron projection development | 17.1053 | 7 | yes |
GO:0031346 | positive regulation of cell projection organization | 17.1053 | 6 | yes |
GO:0071363 | cellular response to growth factor stimulus | 9.2105 | 4 | yes |
GO:0010976 | positive regulation of neuron projection development | 7.8947 | 7 | yes |
GO:0048812 | neuron projection morphogenesis | 7.8947 | 5 | yes |
GO:0120039 | plasma membrane bounded cell projection morphogenesis | 7.8947 | 4 | yes |
GO:1990089 | response to nerve growth factor | 7.8947 | 4 | yes |
GO:1990090 | cellular response to nerve growth factor stimulus | 7.8947 | 5 | yes |
GO:0001701 | in utero embryonic development | 2.6316 | 6 | yes |
GO:0009792 | embryo development ending in birth or egg hatching | 2.6316 | 4 | yes |
GO:0038179 | neurotrophin signaling pathway | 2.6316 | 4 | yes |
GO:0038180 | nerve growth factor signaling pathway | 2.6316 | 5 | yes |
GO:0043009 | chordate embryonic development | 2.6316 | 5 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
TNR16_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SEPT5_HUMAN | [view interactions] | Low throughput | no | no |
MAGI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
NTRK1_HUMAN | [view interactions] | Low throughput | no | yes |
CRKL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RPGF1_HUMAN | [view interactions] | Low throughput | no | yes |
LRAD4_HUMAN | [view interactions] | High throughput | no | yes |
CLH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KINH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VAPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYEF2_HUMAN | [view interactions] | High throughput | no | no |
GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
GTSE1_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SPAST_HUMAN | [view interactions] | High throughput | no | yes |
TMED2_HUMAN | [view interactions] | High throughput | no | yes |
RMD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMAP1_HUMAN | [view interactions] | High throughput | no | yes |
PTN23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
S53A1_HUMAN | [view interactions] | High throughput | no | yes |
VSIG1_HUMAN | [view interactions] | High throughput | no | no |
MRAP2_HUMAN | [view interactions] | High throughput | no | no |
B4GA1_HUMAN | [view interactions] | High throughput | no | yes |
CLMP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MAGE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD79B_HUMAN | [view interactions] | High throughput | no | no |
TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
DKKL1_HUMAN | [view interactions] | High throughput | no | no |
CADH5_HUMAN | [view interactions] | High throughput | no | yes |
MANS1_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
KCMF1_HUMAN | [view interactions] | High throughput | no | yes |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
PTN3_HUMAN | [view interactions] | High throughput | no | yes |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LMBRL_HUMAN | [view interactions] | High throughput | no | no |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
SNX27_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EMC1_HUMAN | [view interactions] | High throughput | no | yes |
EMC5_HUMAN | [view interactions] | High throughput | no | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
GP182_HUMAN | [view interactions] | High throughput | no | no |
CSTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMEM9_HUMAN | [view interactions] | High throughput | no | no |
IDD_HUMAN | [view interactions] | High throughput | no | no |
FURIN_HUMAN | [view interactions] | High throughput | no | yes |
TTMP_HUMAN | [view interactions] | High throughput | no | no |
I27RA_HUMAN | [view interactions] | High throughput | no | no |
TA2R_HUMAN | [view interactions] | High throughput | no | no |
HIDE1_HUMAN | [view interactions] | High throughput | no | no |
PBIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TTYH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TMM74_HUMAN | [view interactions] | High throughput | no | no |
APJ_HUMAN | [view interactions] | High throughput | no | yes |
BACE2_HUMAN | [view interactions] | High throughput | no | yes |
VSTM1_HUMAN | [view interactions] | High throughput | no | no |
CML1_HUMAN | [view interactions] | High throughput | no | yes |
CD226_HUMAN | [view interactions] | High throughput | no | yes |
EFNA4_HUMAN | [view interactions] | High throughput | no | no |
DLK1_HUMAN | [view interactions] | High throughput | no | no |
PAAT_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RHOQ_HUMAN | [view interactions] | High throughput | no | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RHOD_HUMAN | [view interactions] | High throughput | no | no |
RHOF_HUMAN | [view interactions] | High throughput | no | no |
RHOU_HUMAN | [view interactions] | High throughput | no | no |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RND1_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
RND3_HUMAN | [view interactions] | High throughput | no | no |
RHOV_HUMAN | [view interactions] | High throughput | no | no |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
CLCA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
UTRN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PARPT_HUMAN | [view interactions] | High throughput | no | no |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
CL16A_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TIA1_HUMAN | [view interactions] | High throughput | no | no |
RN183_HUMAN | [view interactions] | High throughput | no | no |
LEG9_HUMAN | [view interactions] | High throughput | no | yes |
DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
AP2B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CK052_HUMAN | [view interactions] | High throughput | no | no |
CAV1_HUMAN | [view interactions] | High throughput | no | no |
CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
E41LA_HUMAN | [view interactions] | High throughput | no | yes |
EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXD3_HUMAN | [view interactions] | High throughput | no | no |
LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
LAMP3_HUMAN | [view interactions] | High throughput | no | no |
LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LCK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMT1A_HUMAN | [view interactions] | High throughput | no | no |
AFAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NU155_HUMAN | [view interactions] | High throughput | no | yes |
OCLN_HUMAN | [view interactions] | High throughput | no | no |
PARD3_HUMAN | [view interactions] | High throughput | no | yes |
PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STX6_HUMAN | [view interactions] | High throughput | no | yes |
STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNE3_HUMAN | [view interactions] | High throughput | no | no |
VINC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
ZYX_HUMAN | [view interactions] | High throughput | no | no |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
RNF43_HUMAN | [view interactions] | High throughput | no | yes |
ATG9A_HUMAN | [view interactions] | High throughput | no | yes |
PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAR1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
AR13B_HUMAN | [view interactions] | High throughput | no | yes |
GSK3A_HUMAN | [view interactions] | High throughput | no | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HIF1N_HUMAN | [view interactions] | High throughput | no | yes |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DAG1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
GCP60_HUMAN | [view interactions] | High throughput | no | yes |
UFO_HUMAN | [view interactions] | High throughput | no | no |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCN2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDC73_HUMAN | [view interactions] | High throughput | no | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
TMM17_HUMAN | [view interactions] | High throughput | no | yes |
BET1_HUMAN | [view interactions] | High throughput | no | no |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LAMP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCNJ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYRK2_HUMAN | [view interactions] | High throughput | no | yes |
CSF1R_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
EPHA3_HUMAN | [view interactions] | High throughput | no | yes |
EPHA5_HUMAN | [view interactions] | High throughput | no | no |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
FGFR2_HUMAN | [view interactions] | High throughput | no | yes |
FGFR4_HUMAN | [view interactions] | High throughput | no | no |
NTRK2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PGFRA_HUMAN | [view interactions] | High throughput | no | no |
RYK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
STYK1_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
KCNK3_HUMAN | [view interactions] | High throughput | no | no |
KRT34_HUMAN | [view interactions] | High throughput | no | no |
FHL3_HUMAN | [view interactions] | High throughput | no | no |
LGR4_HUMAN | [view interactions] | High throughput | no | yes |
DPA1_HUMAN | [view interactions] | High throughput | no | yes |
CEA21_HUMAN | [view interactions] | High throughput | no | yes |
CGRF1_HUMAN | [view interactions] | High throughput | no | yes |
TXD15_HUMAN | [view interactions] | High throughput | no | yes |
VSIG4_HUMAN | [view interactions] | High throughput | no | no |
EVA1C_HUMAN | [view interactions] | High throughput | no | yes |
FAF2_HUMAN | [view interactions] | High throughput | no | yes |