Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KDIS_HUMAN

Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration . Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KDIS_HUMAN
GO:0043168 anion binding 38.1579 4 no
GO:0000166 nucleotide binding 36.8421 4 no
GO:0017076 purine nucleotide binding 36.8421 5 no
GO:0032555 purine ribonucleotide binding 35.5263 4 no
GO:0035639 purine ribonucleoside triphosphate binding 34.2105 4 no
GO:0019900 kinase binding 25.0000 4 no
GO:0019901 protein kinase binding 23.6842 5 no
GO:0016462 pyrophosphatase activity 23.6842 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 23.6842 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 23.6842 6 no
GO:0003924 GTPase activity 22.3684 7 no
GO:0005525 GTP binding 22.3684 5 no
GO:0019001 guanyl nucleotide binding 22.3684 6 no
GO:0032561 guanyl ribonucleotide binding 22.3684 5 no
GO:0019887 protein kinase regulator activity 2.6316 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KDIS_HUMAN
GO:0048522 positive regulation of cellular process 69.7368 4 yes
GO:0051128 regulation of cellular component organization 55.2632 4 yes
GO:0008104 protein localization 55.2632 4 no
GO:0010646 regulation of cell communication 48.6842 4 no
GO:0048523 negative regulation of cellular process 47.3684 4 no
GO:0060255 regulation of macromolecule metabolic process 46.0526 4 no
GO:0006996 organelle organization 43.4211 4 no
GO:0031323 regulation of cellular metabolic process 42.1053 4 no
GO:0022607 cellular component assembly 40.7895 4 no
GO:0009966 regulation of signal transduction 40.7895 4 no
GO:0010647 positive regulation of cell communication 38.1579 5 no
GO:0023056 positive regulation of signaling 38.1579 4 no
GO:0048584 positive regulation of response to stimulus 38.1579 4 no
GO:0080090 regulation of primary metabolic process 36.8421 4 no
GO:0009889 regulation of biosynthetic process 35.5263 4 no
GO:0009893 positive regulation of metabolic process 35.5263 4 no
GO:0010556 regulation of macromolecule biosynthetic process 35.5263 5 no
GO:0010604 positive regulation of macromolecule metabolic process 35.5263 5 no
GO:0031326 regulation of cellular biosynthetic process 35.5263 5 no
GO:0010468 regulation of gene expression 34.2105 6 no
GO:0051049 regulation of transport 34.2105 4 no
GO:0030030 cell projection organization 32.8947 4 yes
GO:0071702 organic substance transport 32.8947 4 no
GO:0071705 nitrogen compound transport 32.8947 4 no
GO:0060341 regulation of cellular localization 32.8947 4 no
GO:0009967 positive regulation of signal transduction 31.5789 5 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 no
GO:0032880 regulation of protein localization 31.5789 5 no
GO:0031325 positive regulation of cellular metabolic process 30.2632 5 no
GO:2000145 regulation of cell motility 30.2632 4 no
GO:0031344 regulation of cell projection organization 28.9474 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.9474 6 yes
GO:0030334 regulation of cell migration 28.9474 5 no
GO:0030155 regulation of cell adhesion 27.6316 4 no
GO:0051246 regulation of protein metabolic process 27.6316 5 no
GO:0120036 plasma membrane bounded cell projection organization 27.6316 5 no
GO:0051130 positive regulation of cellular component organization 26.3158 5 yes
GO:0015031 protein transport 26.3158 4 no
GO:0042127 regulation of cell population proliferation 26.3158 4 no
GO:0044087 regulation of cellular component biogenesis 26.3158 4 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0009892 negative regulation of metabolic process 23.6842 4 no
GO:0071310 cellular response to organic substance 23.6842 4 no
GO:1902533 positive regulation of intracellular signal transduction 23.6842 6 no
GO:0008284 positive regulation of cell population proliferation 22.3684 5 no
GO:0010605 negative regulation of macromolecule metabolic process 22.3684 5 no
GO:0031324 negative regulation of cellular metabolic process 22.3684 5 no
GO:0045595 regulation of cell differentiation 22.3684 4 no
GO:0045785 positive regulation of cell adhesion 22.3684 5 no
GO:0051094 positive regulation of developmental process 22.3684 4 no
GO:0051247 positive regulation of protein metabolic process 22.3684 6 no
GO:0060627 regulation of vesicle-mediated transport 22.3684 4 no
GO:0009891 positive regulation of biosynthetic process 22.3684 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 22.3684 6 no
GO:0031328 positive regulation of cellular biosynthetic process 22.3684 6 no
GO:0033043 regulation of organelle organization 22.3684 5 no
GO:0141124 intracellular signaling cassette 22.3684 4 no
GO:0031175 neuron projection development 21.0526 6 no
GO:0042981 regulation of apoptotic process 21.0526 5 no
GO:0043067 regulation of programmed cell death 21.0526 4 no
GO:2000026 regulation of multicellular organismal development 21.0526 4 no
GO:0022603 regulation of anatomical structure morphogenesis 21.0526 4 no
GO:0050804 modulation of chemical synaptic transmission 21.0526 5 no
GO:0099177 regulation of trans-synaptic signaling 21.0526 4 no
GO:0010975 regulation of neuron projection development 17.1053 7 yes
GO:0031346 positive regulation of cell projection organization 17.1053 6 yes
GO:0071363 cellular response to growth factor stimulus 9.2105 4 yes
GO:0010976 positive regulation of neuron projection development 7.8947 7 yes
GO:0048812 neuron projection morphogenesis 7.8947 5 yes
GO:0120039 plasma membrane bounded cell projection morphogenesis 7.8947 4 yes
GO:1990089 response to nerve growth factor 7.8947 4 yes
GO:1990090 cellular response to nerve growth factor stimulus 7.8947 5 yes
GO:0001701 in utero embryonic development 2.6316 6 yes
GO:0009792 embryo development ending in birth or egg hatching 2.6316 4 yes
GO:0038179 neurotrophin signaling pathway 2.6316 4 yes
GO:0038180 nerve growth factor signaling pathway 2.6316 5 yes
GO:0043009 chordate embryonic development 2.6316 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TNR16_HUMAN [view entry] [view interactions] Low throughput yes no
SEPT5_HUMAN [view interactions] Low throughput no no
MAGI2_HUMAN [view entry] [view interactions] Low throughput yes yes
NTRK1_HUMAN [view interactions] Low throughput no yes
CRKL_HUMAN [view entry] [view interactions] Low throughput yes yes
RPGF1_HUMAN [view interactions] Low throughput no yes
LRAD4_HUMAN [view interactions] High throughput no yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
GAK_HUMAN [view entry] [view interactions] High throughput yes yes
KINH_HUMAN [view entry] [view interactions] High throughput yes no
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB7A_HUMAN [view entry] [view interactions] High throughput yes yes
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
VAPA_HUMAN [view entry] [view interactions] High throughput yes yes
RENR_HUMAN [view entry] [view interactions] High throughput yes yes
MYEF2_HUMAN [view interactions] High throughput no no
GOT1B_HUMAN [view interactions] High throughput no yes
GTSE1_HUMAN [view interactions] High throughput no no
ACTB_HUMAN [view entry] [view interactions] High throughput yes no
BMR1A_HUMAN [view interactions] High throughput no no
FLOT1_HUMAN [view entry] [view interactions] High throughput yes yes
FLOT2_HUMAN [view entry] [view interactions] High throughput yes yes
COR1C_HUMAN [view entry] [view interactions] High throughput yes yes
SPAST_HUMAN [view interactions] High throughput no yes
TMED2_HUMAN [view interactions] High throughput no yes
RMD3_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
SMAP1_HUMAN [view interactions] High throughput no yes
PTN23_HUMAN [view entry] [view interactions] High throughput yes yes
FLNB_HUMAN [view interactions] High throughput no no
S53A1_HUMAN [view interactions] High throughput no yes
VSIG1_HUMAN [view interactions] High throughput no no
MRAP2_HUMAN [view interactions] High throughput no no
B4GA1_HUMAN [view interactions] High throughput no yes
CLMP_HUMAN [view entry] [view interactions] High throughput yes no
MAGE1_HUMAN [view entry] [view interactions] High throughput yes yes
CD79B_HUMAN [view interactions] High throughput no no
TNR1A_HUMAN [view interactions] High throughput no yes
DKKL1_HUMAN [view interactions] High throughput no no
CADH5_HUMAN [view interactions] High throughput no yes
MANS1_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
EGLN3_HUMAN [view interactions] High throughput no no
KCMF1_HUMAN [view interactions] High throughput no yes
VIR_HUMAN [view interactions] High throughput no yes
PTN3_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
LMBRL_HUMAN [view interactions] High throughput no no
PKHA4_HUMAN [view interactions] High throughput no yes
SNX27_HUMAN [view entry] [view interactions] High throughput yes no
EMC1_HUMAN [view interactions] High throughput no yes
EMC5_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
GP182_HUMAN [view interactions] High throughput no no
CSTN1_HUMAN [view entry] [view interactions] High throughput yes yes
TMEM9_HUMAN [view interactions] High throughput no no
IDD_HUMAN [view interactions] High throughput no no
FURIN_HUMAN [view interactions] High throughput no yes
TTMP_HUMAN [view interactions] High throughput no no
I27RA_HUMAN [view interactions] High throughput no no
TA2R_HUMAN [view interactions] High throughput no no
HIDE1_HUMAN [view interactions] High throughput no no
PBIP1_HUMAN [view entry] [view interactions] High throughput yes no
TTYH1_HUMAN [view entry] [view interactions] High throughput yes no
TMM74_HUMAN [view interactions] High throughput no no
APJ_HUMAN [view interactions] High throughput no yes
BACE2_HUMAN [view interactions] High throughput no yes
VSTM1_HUMAN [view interactions] High throughput no no
CML1_HUMAN [view interactions] High throughput no yes
CD226_HUMAN [view interactions] High throughput no yes
EFNA4_HUMAN [view interactions] High throughput no no
DLK1_HUMAN [view interactions] High throughput no no
PAAT_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOU_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND1_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
RND3_HUMAN [view interactions] High throughput no no
RHOV_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
CLCA_HUMAN [view entry] [view interactions] High throughput yes no
UTRN_HUMAN [view entry] [view interactions] High throughput yes yes
PARPT_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
CL16A_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
RN183_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
DNJC1_HUMAN [view interactions] High throughput no yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
AP2B1_HUMAN [view entry] [view interactions] High throughput yes yes
CK052_HUMAN [view interactions] High throughput no no
CAV1_HUMAN [view interactions] High throughput no no
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
E41LA_HUMAN [view interactions] High throughput no yes
EZRI_HUMAN [view entry] [view interactions] High throughput yes no
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
LYN_HUMAN [view entry] [view interactions] High throughput yes no
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
TMT1A_HUMAN [view interactions] High throughput no no
AFAD_HUMAN [view entry] [view interactions] High throughput yes yes
NU155_HUMAN [view interactions] High throughput no yes
OCLN_HUMAN [view interactions] High throughput no no
PARD3_HUMAN [view interactions] High throughput no yes
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB9A_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
SYNE3_HUMAN [view interactions] High throughput no no
VINC_HUMAN [view entry] [view interactions] High throughput yes no
ZFPL1_HUMAN [view interactions] High throughput no yes
ZYX_HUMAN [view interactions] High throughput no no
TAXB1_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
PHLP1_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
SAR1B_HUMAN [view interactions] High throughput no yes
AR13B_HUMAN [view interactions] High throughput no yes
GSK3A_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
HIF1N_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
FINC_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
DAG1_HUMAN [view entry] [view interactions] High throughput yes no
GCP60_HUMAN [view interactions] High throughput no yes
UFO_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
SCN2A_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
PHOCN_HUMAN [view entry] [view interactions] High throughput yes yes
CDC73_HUMAN [view interactions] High throughput no yes
ESR1_HUMAN [view interactions] High throughput no no
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
MYC_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
BET1_HUMAN [view interactions] High throughput no no
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
KCNJ2_HUMAN [view entry] [view interactions] High throughput yes yes
DYRK2_HUMAN [view interactions] High throughput no yes
CSF1R_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
EPHA2_HUMAN [view interactions] High throughput no no
EPHA3_HUMAN [view interactions] High throughput no yes
EPHA5_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
FGFR2_HUMAN [view interactions] High throughput no yes
FGFR4_HUMAN [view interactions] High throughput no no
NTRK2_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
PGFRA_HUMAN [view interactions] High throughput no no
RYK_HUMAN [view entry] [view interactions] High throughput yes no
STYK1_HUMAN [view interactions] High throughput no yes
CFTR_HUMAN [view interactions] High throughput no no
KCNK3_HUMAN [view interactions] High throughput no no
KRT34_HUMAN [view interactions] High throughput no no
FHL3_HUMAN [view interactions] High throughput no no
LGR4_HUMAN [view interactions] High throughput no yes
DPA1_HUMAN [view interactions] High throughput no yes
CEA21_HUMAN [view interactions] High throughput no yes
CGRF1_HUMAN [view interactions] High throughput no yes
TXD15_HUMAN [view interactions] High throughput no yes
VSIG4_HUMAN [view interactions] High throughput no no
EVA1C_HUMAN [view interactions] High throughput no yes
FAF2_HUMAN [view interactions] High throughput no yes