SAR1A_HUMAN
Evidence for PS localization
Functions
Involved in transport from the endoplasmic reticulum to the Golgi apparatus . Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in SAR1A_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.5455 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 29.5455 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 29.5455 | 4 | yes |
| GO:0046872 | metal ion binding | 27.2727 | 4 | no |
| GO:0005525 | GTP binding | 25.0000 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 25.0000 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 25.0000 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 25.0000 | 6 | yes |
| GO:0019001 | guanyl nucleotide binding | 25.0000 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 25.0000 | 5 | yes |
| GO:0003924 | GTPase activity | 22.7273 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in SAR1A_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.5455 | 4 | yes |
| GO:0006996 | organelle organization | 45.4545 | 4 | yes |
| GO:0071702 | organic substance transport | 45.4545 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 45.4545 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.1818 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 43.1818 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.1818 | 4 | no |
| GO:0008104 | protein localization | 40.9091 | 4 | yes |
| GO:0015031 | protein transport | 38.6364 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 36.3636 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 34.0909 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 34.0909 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 34.0909 | 4 | no |
| GO:0010468 | regulation of gene expression | 34.0909 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.0909 | 5 | no |
| GO:0051049 | regulation of transport | 31.8182 | 4 | yes |
| GO:0022607 | cellular component assembly | 31.8182 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 31.8182 | 5 | no |
| GO:0006886 | intracellular protein transport | 29.5455 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.5455 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 29.5455 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 27.2727 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 27.2727 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 27.2727 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 27.2727 | 5 | no |
| GO:0061024 | membrane organization | 25.0000 | 4 | yes |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.7273 | 4 | yes |
| GO:0010941 | regulation of cell death | 22.7273 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.4545 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 20.4545 | 6 | no |
| GO:0036211 | protein modification process | 20.4545 | 4 | no |
| GO:0043412 | macromolecule modification | 20.4545 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.4545 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4545 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 20.4545 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.4545 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 20.4545 | 5 | no |
| GO:0071310 | cellular response to organic substance | 20.4545 | 4 | no |
| GO:0023056 | positive regulation of signaling | 20.4545 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.4545 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.4545 | 6 | no |
| GO:0048193 | Golgi vesicle transport | 18.1818 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 18.1818 | 4 | yes |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 15.9091 | 4 | yes |
| GO:0016050 | vesicle organization | 15.9091 | 5 | yes |
| GO:0032880 | regulation of protein localization | 15.9091 | 5 | yes |
| GO:0035459 | vesicle cargo loading | 15.9091 | 4 | yes |
| GO:0060627 | regulation of vesicle-mediated transport | 15.9091 | 4 | yes |
| GO:0090110 | COPII-coated vesicle cargo loading | 15.9091 | 4 | yes |
| GO:0032386 | regulation of intracellular transport | 13.6364 | 5 | yes |
| GO:0032388 | positive regulation of intracellular transport | 13.6364 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 13.6364 | 5 | yes |
| GO:0051223 | regulation of protein transport | 13.6364 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 13.6364 | 6 | yes |
| GO:1903829 | positive regulation of protein localization | 13.6364 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 13.6364 | 6 | yes |
| GO:0033157 | regulation of intracellular protein transport | 11.3636 | 6 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 11.3636 | 5 | yes |
| GO:0090316 | positive regulation of intracellular protein transport | 11.3636 | 6 | yes |
| GO:0003400 | regulation of COPII vesicle coating | 4.5455 | 6 | yes |
| GO:0060628 | regulation of ER to Golgi vesicle-mediated transport | 4.5455 | 5 | yes |
| GO:0070861 | regulation of protein exit from endoplasmic reticulum | 4.5455 | 7 | yes |
| GO:0070863 | positive regulation of protein exit from endoplasmic reticulum | 4.5455 | 7 | yes |
| GO:0090113 | regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis | 4.5455 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SAR1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SC23A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ATF6A_HUMAN | [view interactions] | Low throughput | no | yes |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| S23IP_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| MA1B1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC10_HUMAN | [view interactions] | High throughput | no | no |
| VPS45_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| SC24A_HUMAN | [view interactions] | High throughput | no | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| NPRL2_HUMAN | [view interactions] | High throughput | no | yes |
| S39A9_HUMAN | [view interactions] | High throughput | no | yes |
| TSC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC24C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEPD5_HUMAN | [view interactions] | High throughput | no | yes |
| TSC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPRL3_HUMAN | [view interactions] | High throughput | no | yes |
| SC31A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPD52_HUMAN | [view interactions] | High throughput | no | yes |
| HEM3_HUMAN | [view interactions] | High throughput | no | yes |
| C1TC_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PTBP1_HUMAN | [view interactions] | High throughput | no | no |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| OPTN_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| PSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TRAF3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VKOR1_HUMAN | [view interactions] | High throughput | no | yes |
| MIP_HUMAN | [view interactions] | High throughput | no | no |
| B2CL2_HUMAN | [view interactions] | High throughput | no | yes |
| TMM60_HUMAN | [view interactions] | High throughput | no | no |
| S38A7_HUMAN | [view interactions] | High throughput | no | yes |
| GLPA_HUMAN | [view interactions] | High throughput | no | no |
| FAM3C_HUMAN | [view interactions] | High throughput | no | yes |
| ORML1_HUMAN | [view interactions] | High throughput | no | no |
| PLPP4_HUMAN | [view interactions] | High throughput | no | yes |
| GIMA1_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP5_HUMAN | [view interactions] | High throughput | no | no |
| ZNT8_HUMAN | [view interactions] | High throughput | no | no |
| RMD2_HUMAN | [view interactions] | High throughput | no | yes |
| EMP3_HUMAN | [view interactions] | High throughput | no | no |
| VAMP4_HUMAN | [view interactions] | High throughput | no | yes |
| ERG28_HUMAN | [view interactions] | High throughput | no | yes |
| HMOX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNC50_HUMAN | [view interactions] | High throughput | no | yes |
| TM109_HUMAN | [view interactions] | High throughput | no | yes |
| TM107_HUMAN | [view interactions] | High throughput | no | yes |
| ALG8_HUMAN | [view interactions] | High throughput | no | yes |
| TTMP_HUMAN | [view interactions] | High throughput | no | no |
| TTPA_HUMAN | [view interactions] | High throughput | no | no |
| SMIM1_HUMAN | [view interactions] | High throughput | no | yes |
| PLP2_HUMAN | [view interactions] | High throughput | no | yes |
| TM243_HUMAN | [view interactions] | High throughput | no | no |
| TM254_HUMAN | [view interactions] | High throughput | no | yes |
| CD53_HUMAN | [view interactions] | High throughput | no | yes |
| UBIA1_HUMAN | [view interactions] | High throughput | no | no |
| LHPL5_HUMAN | [view interactions] | High throughput | no | no |
| PPLA_HUMAN | [view interactions] | High throughput | no | no |
| NRM_HUMAN | [view interactions] | High throughput | no | no |
| SNP47_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRAC_HUMAN | [view interactions] | High throughput | no | no |
| AQP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM267_HUMAN | [view interactions] | High throughput | no | no |
| SGMR2_HUMAN | [view interactions] | High throughput | no | no |
| SERP1_HUMAN | [view interactions] | High throughput | no | no |
| UPK1B_HUMAN | [view interactions] | High throughput | no | no |
| MSPD3_HUMAN | [view interactions] | High throughput | no | no |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| MIRO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM187_HUMAN | [view interactions] | High throughput | no | no |
| JAGN1_HUMAN | [view interactions] | High throughput | no | no |
| STX8_HUMAN | [view interactions] | High throughput | no | yes |
| AQP3_HUMAN | [view interactions] | High throughput | no | no |
| TMM42_HUMAN | [view interactions] | High throughput | no | no |
| VAMP3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM218_HUMAN | [view interactions] | High throughput | no | no |
| SC22A_HUMAN | [view interactions] | High throughput | no | no |
| GRM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAT8_HUMAN | [view interactions] | High throughput | no | no |
| ASGR1_HUMAN | [view interactions] | High throughput | no | no |
| AGRE2_HUMAN | [view interactions] | High throughput | no | no |
| PLLP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AQP10_HUMAN | [view interactions] | High throughput | no | no |
| CLDN2_HUMAN | [view interactions] | High throughput | no | no |
| MARH5_HUMAN | [view interactions] | High throughput | no | no |
| S35A1_HUMAN | [view interactions] | High throughput | no | no |
| CXB2_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TR1L1_HUMAN | [view interactions] | High throughput | no | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| TECT3_HUMAN | [view interactions] | High throughput | no | yes |
| BET1_HUMAN | [view interactions] | High throughput | no | no |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UFO_HUMAN | [view interactions] | High throughput | no | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| VGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| TIE2_HUMAN | [view interactions] | High throughput | no | no |
| PPGB_HUMAN | [view interactions] | High throughput | no | yes |
| AIG1_HUMAN | [view interactions] | High throughput | no | no |
| CXL16_HUMAN | [view interactions] | High throughput | no | no |
| CLD19_HUMAN | [view interactions] | High throughput | no | no |
| CKLF5_HUMAN | [view interactions] | High throughput | no | yes |
| CLC7A_HUMAN | [view interactions] | High throughput | no | no |
| CO4A5_HUMAN | [view interactions] | High throughput | no | no |
| EST1_HUMAN | [view interactions] | High throughput | no | no |
| LAT_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| DTNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| SC23B_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| SC5A5_HUMAN | [view interactions] | High throughput | no | no |
| RN185_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COPG2_HUMAN | [view interactions] | High throughput | no | yes |
| SEC13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YIPF5_HUMAN | [view interactions] | High throughput | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MA1A1_HUMAN | [view interactions] | High throughput | no | yes |
| MOGS_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5A_HUMAN | [view interactions] | High throughput | no | yes |
| ARFG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARM1_HUMAN | [view interactions] | High throughput | no | yes |
| B4GT1_HUMAN | [view interactions] | High throughput | no | yes |
| DCAF7_HUMAN | [view interactions] | High throughput | no | yes |
| FUT8_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| NCOR1_HUMAN | [view interactions] | High throughput | no | yes |
| IF2B1_HUMAN | [view interactions] | High throughput | no | no |
| S39A7_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| TBL1R_HUMAN | [view interactions] | High throughput | no | yes |
| ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
| CHRC1_HUMAN | [view interactions] | High throughput | no | no |
| S39A3_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CUL5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| SC31B_HUMAN | [view interactions] | Computational | no | yes |
| KLH12_HUMAN | [view interactions] | Computational | no | no |
| RAB1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SC24D_HUMAN | [view interactions] | Computational | no | yes |
| SC16B_HUMAN | [view interactions] | Computational | no | no |
| SMAD2_HUMAN | [view interactions] | Computational | no | yes |
| TMED7_HUMAN | [view interactions] | Computational | no | yes |
| TGFB3_HUMAN | [view interactions] | Computational | no | no |
| SC16A_HUMAN | [view interactions] | Computational | no | yes |
| PDCD6_HUMAN | [view interactions] | Computational | no | no |
| PEF1_HUMAN | [view interactions] | Computational | no | no |
| PREB_HUMAN | [view interactions] | Computational | no | yes |
| TGFR2_HUMAN | [view interactions] | Computational | no | no |
| SMAD7_HUMAN | [view interactions] | Computational | no | yes |
| TGFR1_HUMAN | [view interactions] | Computational | no | no |
| ANR40_HUMAN | [view interactions] | Computational | no | yes |
| TGFB2_HUMAN | [view interactions] | Computational | no | no |