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DDX17_HUMAN

As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed, PubMed, PubMed, PubMed). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed). This function requires the RNA helicase activity (PubMed, PubMed, PubMed, PubMed). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed, PubMed). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed). Binds pri-microRNAs on the 3 segment flanking the stem loop via the 5-[ACG]CAUC[ACU]-3 consensus sequence (PubMed). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed, PubMed). May be involved not only in microRNA primary transcript processing, but also stabilization . Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed). Enhances NFAT5 transcriptional activity (PubMed). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed, PubMed, PubMed). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed). Coactivates MMP7 transcription (PubMed). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed, PubMed). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed, PubMed, PubMed, PubMed). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed, PubMed). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed). [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in DDX17_HUMAN
GO:0003723 RNA binding 43.7500 4 yes
GO:0043169 cation binding 31.2500 4 no
GO:0046872 metal ion binding 31.2500 5 no
GO:0043168 anion binding 23.9583 4 yes
GO:0044389 ubiquitin-like protein ligase binding 21.8750 4 no
GO:0000166 nucleotide binding 20.8333 4 yes
GO:0017076 purine nucleotide binding 20.8333 5 yes
GO:0032555 purine ribonucleotide binding 20.8333 4 yes
GO:0031625 ubiquitin protein ligase binding 20.8333 5 no
GO:0035639 purine ribonucleoside triphosphate binding 19.7917 4 yes
GO:0030554 adenyl nucleotide binding 18.7500 6 yes
GO:0032559 adenyl ribonucleotide binding 18.7500 5 yes
GO:0003729 mRNA binding 17.7083 5 yes
GO:0005524 ATP binding 17.7083 5 yes
GO:0016462 pyrophosphatase activity 12.5000 5 yes
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 12.5000 4 yes
GO:0017111 ribonucleoside triphosphate phosphatase activity 12.5000 6 yes
GO:0016887 ATP hydrolysis activity 10.4167 7 yes
GO:0003730 mRNA 3-UTR binding 9.3750 6 yes

Biological process

Term Name % Distance from top the of the tree Annotated in DDX17_HUMAN
GO:0060255 regulation of macromolecule metabolic process 69.7917 4 yes
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0031323 regulation of cellular metabolic process 64.5833 4 yes
GO:0009889 regulation of biosynthetic process 56.2500 4 yes
GO:0010468 regulation of gene expression 56.2500 6 yes
GO:0010556 regulation of macromolecule biosynthetic process 56.2500 5 yes
GO:0031326 regulation of cellular biosynthetic process 56.2500 5 yes
GO:0048523 negative regulation of cellular process 55.2083 4 yes
GO:0009893 positive regulation of metabolic process 53.1250 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 50.0000 5 yes
GO:0009892 negative regulation of metabolic process 47.9167 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 46.8750 5 yes
GO:0010646 regulation of cell communication 46.8750 4 no
GO:0031325 positive regulation of cellular metabolic process 45.8333 5 yes
GO:0051246 regulation of protein metabolic process 44.7917 5 no
GO:0031324 negative regulation of cellular metabolic process 43.7500 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 42.7083 5 yes
GO:0009966 regulation of signal transduction 42.7083 4 no
GO:0051252 regulation of RNA metabolic process 41.6667 5 yes
GO:0022607 cellular component assembly 41.6667 4 no
GO:0051128 regulation of cellular component organization 40.6250 4 no
GO:0009891 positive regulation of biosynthetic process 39.5833 5 yes
GO:0009890 negative regulation of biosynthetic process 38.5417 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 38.5417 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 38.5417 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 38.5417 6 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 36.4583 6 yes
GO:0006355 regulation of DNA-templated transcription 33.3333 7 yes
GO:2001141 regulation of RNA biosynthetic process 33.3333 6 yes
GO:0008104 protein localization 32.2917 4 no
GO:0051247 positive regulation of protein metabolic process 32.2917 6 no
GO:0090304 nucleic acid metabolic process 31.2500 4 yes
GO:0006996 organelle organization 31.2500 4 no
GO:0043412 macromolecule modification 31.2500 4 no
GO:0043933 protein-containing complex organization 31.2500 4 no
GO:1902531 regulation of intracellular signal transduction 31.2500 5 no
GO:0009894 regulation of catabolic process 31.2500 4 no
GO:0006357 regulation of transcription by RNA polymerase II 30.2083 8 yes
GO:0036211 protein modification process 29.1667 4 no
GO:0010629 negative regulation of gene expression 28.1250 7 yes
GO:0016070 RNA metabolic process 27.0833 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 27.0833 5 yes
GO:0043067 regulation of programmed cell death 27.0833 4 no
GO:0048584 positive regulation of response to stimulus 27.0833 4 no
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 26.0417 5 no
GO:0010647 positive regulation of cell communication 26.0417 5 no
GO:0023056 positive regulation of signaling 26.0417 4 no
GO:0042981 regulation of apoptotic process 26.0417 5 no
GO:0010628 positive regulation of gene expression 25.0000 7 no
GO:0045595 regulation of cell differentiation 23.9583 4 yes
GO:0051254 positive regulation of RNA metabolic process 23.9583 6 yes
GO:0044087 regulation of cellular component biogenesis 23.9583 4 no
GO:0065003 protein-containing complex assembly 23.9583 5 no
GO:0010648 negative regulation of cell communication 23.9583 5 no
GO:0023057 negative regulation of signaling 23.9583 4 no
GO:0048585 negative regulation of response to stimulus 23.9583 4 no
GO:0051253 negative regulation of RNA metabolic process 23.9583 6 no
GO:0071310 cellular response to organic substance 23.9583 4 no
GO:0009968 negative regulation of signal transduction 22.9167 5 no
GO:0031399 regulation of protein modification process 22.9167 6 no
GO:0006396 RNA processing 21.8750 6 yes
GO:0045893 positive regulation of DNA-templated transcription 21.8750 8 yes
GO:1902680 positive regulation of RNA biosynthetic process 21.8750 7 yes
GO:0009057 macromolecule catabolic process 21.8750 4 no
GO:0030162 regulation of proteolysis 21.8750 6 no
GO:0033043 regulation of organelle organization 21.8750 5 no
GO:0009967 positive regulation of signal transduction 21.8750 5 no
GO:0051049 regulation of transport 21.8750 4 no
GO:0051248 negative regulation of protein metabolic process 21.8750 6 no
GO:0080134 regulation of response to stress 21.8750 4 no
GO:0051130 positive regulation of cellular component organization 20.8333 5 no
GO:0051726 regulation of cell cycle 20.8333 4 no
GO:0071702 organic substance transport 20.8333 4 no
GO:0071705 nitrogen compound transport 20.8333 4 no
GO:0045944 positive regulation of transcription by RNA polymerase II 18.7500 9 yes
GO:0016071 mRNA metabolic process 17.7083 6 yes
GO:0006397 mRNA processing 15.6250 7 yes
GO:0008380 RNA splicing 15.6250 7 yes
GO:0000375 RNA splicing, via transesterification reactions 13.5417 8 yes
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 13.5417 9 yes
GO:0000398 mRNA splicing, via spliceosome 13.5417 8 yes
GO:1903311 regulation of mRNA metabolic process 12.5000 6 yes
GO:0140546 defense response to symbiont 11.4583 4 yes
GO:0043484 regulation of RNA splicing 9.3750 6 yes
GO:0141188 nucleic acid catabolic process 9.3750 5 yes
GO:0048024 regulation of mRNA splicing, via spliceosome 7.2917 7 yes
GO:0050684 regulation of mRNA processing 7.2917 7 yes
GO:0000381 regulation of alternative mRNA splicing, via spliceosome 6.2500 8 yes
GO:0051607 defense response to virus 6.2500 4 yes
GO:0000380 alternative mRNA splicing, via spliceosome 5.2083 9 yes
GO:0001837 epithelial to mesenchymal transition 5.2083 5 yes
GO:0010586 miRNA metabolic process 5.2083 6 yes
GO:0016072 rRNA metabolic process 5.2083 6 yes
GO:0045445 myoblast differentiation 5.2083 4 yes
GO:0048762 mesenchymal cell differentiation 5.2083 4 yes
GO:0006364 rRNA processing 4.1667 6 yes
GO:0030518 intracellular steroid hormone receptor signaling pathway 4.1667 5 yes
GO:0031047 regulatory ncRNA-mediated gene silencing 4.1667 8 yes
GO:0043401 steroid hormone mediated signaling pathway 4.1667 4 yes
GO:0141193 nuclear receptor signaling pathway 4.1667 4 yes
GO:0030520 intracellular estrogen receptor signaling pathway 3.1250 6 yes
GO:0030521 androgen receptor signaling pathway 3.1250 6 yes
GO:2001014 regulation of skeletal muscle cell differentiation 3.1250 5 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
HDAC1_HUMAN [view interactions] Low throughput no no
FOS_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
KAT2B_HUMAN [view interactions] Low throughput no yes
CBP_HUMAN [view interactions] Low throughput no yes
EP300_HUMAN [view interactions] Low throughput no yes
MBNL1_HUMAN [view interactions] Low throughput no yes
HDAC2_HUMAN [view interactions] Low throughput no yes
HDAC3_HUMAN [view interactions] Low throughput no yes
RU17_HUMAN [view interactions] Low throughput no yes
DDX5_HUMAN [view entry] [view interactions] Low throughput yes yes
SREK1_HUMAN [view interactions] Low throughput no yes
CTCF_HUMAN [view interactions] Low throughput no yes
NFAT5_HUMAN [view interactions] Low throughput no yes
RNC_HUMAN [view entry] [view interactions] Low throughput yes no
YAP1_HUMAN [view interactions] Low throughput no yes
WWTR1_HUMAN [view interactions] Low throughput no yes
ZCCHV_HUMAN [view interactions] Low throughput no yes
TTP_HUMAN [view interactions] Low throughput no yes
DCP1A_HUMAN [view interactions] Low throughput no yes
DCP2_HUMAN [view interactions] Low throughput no yes
KLF4_HUMAN [view interactions] Low throughput no no
MYOD1_HUMAN [view interactions] Low throughput no no
P53_HUMAN [view interactions] Low throughput no no
ESR1_HUMAN [view interactions] Low throughput no no
DGCR8_HUMAN [view entry] [view interactions] Low throughput yes yes
EXOS5_HUMAN [view interactions] Low throughput no yes
EXOS3_HUMAN [view interactions] Low throughput no yes
LN28A_HUMAN [view interactions] Low throughput no no
XRCC5_HUMAN [view interactions] Low throughput no yes
CUL1_HUMAN [view interactions] High throughput no yes
WBP2_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
PTPRD_HUMAN [view entry] [view interactions] High throughput yes no
CUL2_HUMAN [view interactions] High throughput no yes
OTUD4_HUMAN [view interactions] High throughput no yes
NEDD8_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
UBP7_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
CSK21_HUMAN [view entry] [view interactions] High throughput yes yes
NFKB1_HUMAN [view interactions] High throughput no yes
SRSF3_HUMAN [view interactions] High throughput no yes
PP1R7_HUMAN [view entry] [view interactions] High throughput yes yes
SF3A1_HUMAN [view interactions] High throughput no yes
NOTC1_HUMAN [view entry] [view interactions] High throughput yes yes
ACINU_HUMAN [view interactions] High throughput no yes
CENPA_HUMAN [view interactions] High throughput no no
CH60_HUMAN [view entry] [view interactions] High throughput yes yes
NBEL2_HUMAN [view interactions] High throughput no no
DSRAD_HUMAN [view entry] [view interactions] High throughput yes yes
TIFAB_HUMAN [view interactions] High throughput no no
RBP2_HUMAN [view interactions] High throughput no yes
DISC1_HUMAN [view entry] [view interactions] High throughput yes no
IF5A1_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
P3H1_HUMAN [view interactions] High throughput no yes
NECD_HUMAN [view interactions] High throughput no no
LSM1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
KPRA_HUMAN [view interactions] High throughput no no
RBM14_HUMAN [view interactions] High throughput no yes
ATX2_HUMAN [view interactions] High throughput no yes
RBM5_HUMAN [view interactions] High throughput no yes
ATX2L_HUMAN [view interactions] High throughput no no
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
DHX15_HUMAN [view interactions] High throughput no yes
ASXL1_HUMAN [view interactions] High throughput no no
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
SNRPA_HUMAN [view interactions] High throughput no yes
ROA3_HUMAN [view entry] [view interactions] High throughput yes yes
SFPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR1_HUMAN [view interactions] High throughput no yes
RBM7_HUMAN [view interactions] High throughput no yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
ECHB_HUMAN [view entry] [view interactions] High throughput yes yes
PLK1_HUMAN [view interactions] High throughput no yes
PRP6_HUMAN [view interactions] High throughput no yes
PTBP1_HUMAN [view interactions] High throughput no no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
RTF2_HUMAN [view interactions] High throughput no yes
SBDS_HUMAN [view interactions] High throughput no yes
ROA1_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPQ_HUMAN [view entry] [view interactions] High throughput yes yes
KHDR2_HUMAN [view interactions] High throughput no yes
TXLNA_HUMAN [view interactions] High throughput no yes
MEPCE_HUMAN [view interactions] High throughput no yes
TXLNG_HUMAN [view interactions] High throughput no no
ILK_HUMAN [view interactions] High throughput no no
NOSIP_HUMAN [view interactions] High throughput no yes
PARVA_HUMAN [view interactions] High throughput no yes
PLEC_HUMAN [view entry] [view interactions] High throughput yes yes
PLPHP_HUMAN [view interactions] High throughput no yes
CR3L4_HUMAN [view interactions] High throughput no no
SYQ_HUMAN [view interactions] High throughput no yes
TAD2A_HUMAN [view interactions] High throughput no no
SMRC2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
YLPM1_HUMAN [view interactions] High throughput no yes
HDAC5_HUMAN [view interactions] High throughput no yes
DDX1_HUMAN [view entry] [view interactions] High throughput yes yes
VHL_HUMAN [view entry] [view interactions] High throughput yes yes
HNRPU_HUMAN [view interactions] High throughput no yes
SMRCD_HUMAN [view interactions] High throughput no yes
HNRL1_HUMAN [view interactions] High throughput no yes
AATF_HUMAN [view interactions] High throughput no yes
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
CATIN_HUMAN [view interactions] High throughput no yes
SH3K1_HUMAN [view entry] [view interactions] High throughput yes yes
CWC22_HUMAN [view interactions] High throughput no yes
TFE2_HUMAN [view interactions] High throughput no no
CEBPZ_HUMAN [view interactions] High throughput no no
ISG15_HUMAN [view interactions] High throughput no no
PYRG1_HUMAN [view interactions] High throughput no no
CDK2_HUMAN [view interactions] High throughput no yes
LSG1_HUMAN [view interactions] High throughput no yes
NUCL_HUMAN [view interactions] High throughput no yes
PAXB1_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
SMU1_HUMAN [view interactions] High throughput no yes
FINC_HUMAN [view interactions] High throughput no yes
CI114_HUMAN [view interactions] High throughput no yes
ITA4_HUMAN [view interactions] High throughput no no
TRM1_HUMAN [view interactions] High throughput no yes
CD81_HUMAN [view interactions] High throughput no no
DDX27_HUMAN [view interactions] High throughput no no
IGSF8_HUMAN [view entry] [view interactions] High throughput yes no
GNL3_HUMAN [view interactions] High throughput no yes
ICAM1_HUMAN [view interactions] High throughput no no
NOP14_HUMAN [view interactions] High throughput no yes
CALM2_HUMAN [view entry] [view interactions] High throughput yes yes
PPWD1_HUMAN [view interactions] High throughput no yes
CALM1_HUMAN [view entry] [view interactions] High throughput yes yes
PRP18_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
PR40A_HUMAN [view interactions] High throughput no no
RFA1_HUMAN [view interactions] High throughput no yes
PWP2_HUMAN [view interactions] High throughput no no
RFA2_HUMAN [view interactions] High throughput no yes
SDA1_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes
SF3A3_HUMAN [view interactions] High throughput no yes
WWOX_HUMAN [view interactions] High throughput no yes
MINT_HUMAN [view interactions] High throughput no yes
LGR4_HUMAN [view interactions] High throughput no yes
TFP11_HUMAN [view interactions] High throughput no no
NS1BP_HUMAN [view interactions] High throughput no yes
TRIR_HUMAN [view interactions] High throughput no yes
SPRTN_HUMAN [view interactions] High throughput no yes
TTC4_HUMAN [view interactions] High throughput no yes
CP250_HUMAN [view interactions] High throughput no no
WDR43_HUMAN [view interactions] High throughput no yes
CUL7_HUMAN [view interactions] High throughput no yes
HNRDL_HUMAN [view interactions] High throughput no yes
OBSL1_HUMAN [view interactions] High throughput no yes
HNRPR_HUMAN [view interactions] High throughput no yes
CCDC8_HUMAN [view interactions] High throughput no yes
CHM2A_HUMAN [view interactions] High throughput no yes
EED_HUMAN [view interactions] High throughput no yes
AGAL_HUMAN [view interactions] High throughput no yes
KS6B2_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
NTRK1_HUMAN [view interactions] High throughput no yes
PYGB_HUMAN [view entry] [view interactions] High throughput yes no
EWS_HUMAN [view interactions] High throughput no yes
AL1B1_HUMAN [view interactions] High throughput no yes
CCDC9_HUMAN [view interactions] High throughput no yes
AL9A1_HUMAN [view interactions] High throughput no yes
CRY2_HUMAN [view interactions] High throughput no yes
HNRPM_HUMAN [view entry] [view interactions] High throughput yes yes
FBXW7_HUMAN [view interactions] High throughput no yes
THOP1_HUMAN [view interactions] High throughput no yes
MCM2_HUMAN [view interactions] High throughput no no
SYRC_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
WDR4_HUMAN [view interactions] High throughput no no
SENP3_HUMAN [view interactions] High throughput no yes
ILF2_HUMAN [view interactions] High throughput no yes
RC3H1_HUMAN [view interactions] High throughput no yes
FKBP5_HUMAN [view interactions] High throughput no yes
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
TRI25_HUMAN [view interactions] High throughput no yes
WWP2_HUMAN [view interactions] High throughput no no
TRXR1_HUMAN [view interactions] High throughput no yes
FNBP4_HUMAN [view interactions] High throughput no yes
TRUB1_HUMAN [view interactions] High throughput no no
AMY1B_HUMAN [view interactions] High throughput no no
SRPK1_HUMAN [view interactions] High throughput no yes
AMY1A_HUMAN [view interactions] High throughput no no
RALY_HUMAN [view interactions] High throughput no yes
AMY1C_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
NIF3L_HUMAN [view interactions] High throughput no yes
ACTC_HUMAN [view interactions] High throughput no no
AMPD2_HUMAN [view entry] [view interactions] High throughput yes yes
DPPA3_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
LEG9_HUMAN [view interactions] High throughput no yes
CYLD_HUMAN [view entry] [view interactions] High throughput yes yes
NAA40_HUMAN [view interactions] High throughput no no
IN80B_HUMAN [view interactions] High throughput no no
NRP1_HUMAN [view entry] [view interactions] High throughput yes yes
BRCA1_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
MTF1_HUMAN [view interactions] High throughput no no
SAR1A_HUMAN [view entry] [view interactions] High throughput yes yes
FBX7_HUMAN [view interactions] High throughput no yes
STXB1_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
PPIE_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
DCA12_HUMAN [view interactions] High throughput no yes
LAP2A_HUMAN [view interactions] High throughput no yes
NLE1_HUMAN [view interactions] High throughput no yes
PRP8_HUMAN [view interactions] High throughput no yes
NUP43_HUMAN [view interactions] High throughput no yes
U5S1_HUMAN [view interactions] High throughput no yes
COP1_HUMAN [view interactions] High throughput no no
AAR2_HUMAN [view interactions] High throughput no no
SNR40_HUMAN [view interactions] High throughput no yes
PIHD1_HUMAN [view interactions] High throughput no yes
TLE2_HUMAN [view interactions] High throughput no yes
TNIP2_HUMAN [view interactions] High throughput no yes
TLE3_HUMAN [view interactions] High throughput no yes
CHD3_HUMAN [view interactions] High throughput no yes
RFA4_HUMAN [view interactions] High throughput no yes
CHD4_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
RNF31_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
RIOK1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
LARP7_HUMAN [view interactions] High throughput no yes
RUNX1_HUMAN [view interactions] High throughput no yes
SNAI1_HUMAN [view interactions] High throughput no yes
AGR2_HUMAN [view interactions] High throughput no no
RECQ4_HUMAN [view interactions] High throughput no yes
REST_HUMAN [view interactions] High throughput no yes
CNTP1_HUMAN [view entry] [view interactions] High throughput yes yes
CDK9_HUMAN [view interactions] High throughput no yes
RC3H2_HUMAN [view interactions] High throughput no yes
PHB1_HUMAN [view entry] [view interactions] High throughput yes yes
FAF1_HUMAN [view interactions] High throughput no yes
KIN17_HUMAN [view interactions] High throughput no no
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
NR2C2_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
PPARG_HUMAN [view interactions] High throughput no yes
ZFY21_HUMAN [view interactions] High throughput no yes
XRCC6_HUMAN [view interactions] High throughput no yes
TRPV1_HUMAN [view entry] [view interactions] High throughput yes no
ATX1_HUMAN [view interactions] High throughput no yes
H4_HUMAN [view interactions] High throughput no yes
TRIM3_HUMAN [view entry] [view interactions] High throughput yes no
TIA1_HUMAN [view interactions] High throughput no no
PSDE_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
TIP_HUMAN [view entry] [view interactions] High throughput yes yes
RBP56_HUMAN [view interactions] High throughput no yes
RPB1_HUMAN [view interactions] High throughput no no
RU1C_HUMAN [view interactions] High throughput no yes
ARAF_HUMAN [view interactions] High throughput no yes
ZBT7B_HUMAN [view interactions] High throughput no no
BIRC3_HUMAN [view interactions] High throughput no no
NFX1_HUMAN [view interactions] High throughput no yes
BRD7_HUMAN [view interactions] High throughput no yes
ERCC6_HUMAN [view interactions] High throughput no no
SOX2_HUMAN [view interactions] High throughput no yes
TIF1B_HUMAN [view interactions] High throughput no yes
SF3B4_HUMAN [view interactions] High throughput no yes
CMTR1_HUMAN [view interactions] High throughput no yes
U2AF2_HUMAN [view interactions] High throughput no yes
ARI2_HUMAN [view interactions] High throughput no no
SF01_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
WBP11_HUMAN [view interactions] High throughput no yes
PINK1_HUMAN [view interactions] High throughput no yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
TFCP2_HUMAN [view interactions] High throughput no no
ZCH18_HUMAN [view interactions] High throughput no yes
HNRPK_HUMAN [view entry] [view interactions] High throughput yes yes
NIPBL_HUMAN [view interactions] High throughput no yes
RBM4_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
HNRH3_HUMAN [view interactions] High throughput no no
LRC31_HUMAN [view interactions] High throughput no no
DUX4_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
CF418_HUMAN [view interactions] High throughput no yes
ANLN_HUMAN [view interactions] High throughput no yes
2ABB_HUMAN [view interactions] High throughput no yes
AURKB_HUMAN [view interactions] High throughput no yes
AIRE_HUMAN [view interactions] High throughput no no
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
MLP3A_HUMAN [view entry] [view interactions] High throughput yes yes
CHM4C_HUMAN [view interactions] High throughput no yes
MLP3B_HUMAN [view interactions] High throughput no yes
ECT2_HUMAN [view interactions] High throughput no no
GBRL2_HUMAN [view entry] [view interactions] High throughput yes yes
KIF14_HUMAN [view interactions] High throughput no no
GBRL1_HUMAN [view interactions] High throughput no yes
KI20A_HUMAN [view interactions] High throughput no yes
GBRAP_HUMAN [view entry] [view interactions] High throughput yes no
KIF23_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
IF4A3_HUMAN [view entry] [view interactions] High throughput yes yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
MGN_HUMAN [view interactions] High throughput no yes
BRD4_HUMAN [view interactions] High throughput no yes
NUPR1_HUMAN [view interactions] High throughput no no
CIC_HUMAN [view interactions] High throughput no yes
RBM39_HUMAN [view interactions] High throughput no yes
TRPM7_HUMAN [view interactions] High throughput no no
F16P1_HUMAN [view interactions] High throughput no no
THOC7_HUMAN [view interactions] High throughput no yes
RIN3_HUMAN [view interactions] High throughput no yes
MATR3_HUMAN [view interactions] High throughput no yes
TMM79_HUMAN [view interactions] High throughput no no
FUS_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
UBA5_HUMAN [view interactions] High throughput no yes
DDRGK_HUMAN [view entry] [view interactions] High throughput yes yes
SRSF1_HUMAN [view interactions] High throughput no yes
FZR1_HUMAN [view interactions] High throughput no no
RNPS1_HUMAN [view interactions] High throughput no yes
WDR5_HUMAN [view interactions] High throughput no no
DDX41_HUMAN [view interactions] High throughput no yes
PAGE4_HUMAN [view interactions] High throughput no no
NUDC2_HUMAN [view entry] [view interactions] High throughput yes yes
ZBTB2_HUMAN [view interactions] High throughput no yes
MAEA_HUMAN [view interactions] High throughput no yes
UBP11_HUMAN [view interactions] High throughput no yes
JMJD6_HUMAN [view interactions] High throughput no yes
BTF3_HUMAN [view interactions] High throughput no yes
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
NALP7_HUMAN [view interactions] High throughput no no
MET14_HUMAN [view interactions] High throughput no yes
ZN363_HUMAN [view interactions] High throughput no yes
DICER_HUMAN [view entry] [view interactions] High throughput yes yes
RBCC1_HUMAN [view interactions] High throughput no no
NEK4_HUMAN [view interactions] High throughput no yes
DDX3X_HUMAN [view entry] [view interactions] High throughput yes yes
PRD16_HUMAN [view interactions] High throughput no no
ZEB1_HUMAN [view interactions] High throughput no yes
MECOM_HUMAN [view interactions] High throughput no yes
BAG1_HUMAN [view interactions] High throughput no yes
CRY1_HUMAN [view interactions] High throughput no yes
ATG13_HUMAN [view interactions] High throughput no no
PTK6_HUMAN [view interactions] High throughput no yes
CN119_HUMAN [view interactions] High throughput no yes
MSPD2_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
NCBP3_HUMAN [view interactions] High throughput no yes
CPSF6_HUMAN [view interactions] High throughput no yes
NCBP1_HUMAN [view interactions] High throughput no yes
DDX21_HUMAN [view interactions] High throughput no yes
DHX9_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
EMC9_HUMAN [view interactions] High throughput no no
ZBT18_HUMAN [view interactions] High throughput no yes
HNRPD_HUMAN [view entry] [view interactions] High throughput yes yes
RBM45_HUMAN [view interactions] High throughput no yes
HNRPL_HUMAN [view interactions] High throughput no yes
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
ILF3_HUMAN [view interactions] High throughput no yes
NEK10_HUMAN [view interactions] High throughput no no
PDZD8_HUMAN [view interactions] High throughput no yes
VCAM1_HUMAN [view interactions] High throughput no no
PSPC1_HUMAN [view interactions] High throughput no yes
RBM28_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
TOP1_HUMAN [view interactions] High throughput no yes
RSMB_HUMAN [view interactions] High throughput no yes
SSRP1_HUMAN [view interactions] High throughput no yes
SPT5H_HUMAN [view interactions] High throughput no yes
MEX3C_HUMAN [view interactions] High throughput no yes
TRI31_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
ANM1_HUMAN [view interactions] High throughput no yes
CALM3_HUMAN [view entry] [view interactions] High throughput yes yes
FOXC1_HUMAN [view interactions] High throughput no no
SF3A2_HUMAN [view interactions] High throughput no yes
KAPCB_HUMAN [view entry] [view interactions] High throughput yes yes
MYCN_HUMAN [view interactions] High throughput no no
SMN_HUMAN [view interactions] High throughput no yes
IF2B3_HUMAN [view interactions] High throughput no no
SNW1_HUMAN [view interactions] High throughput no yes
IKZF1_HUMAN [view interactions] High throughput no no
CDC5L_HUMAN [view interactions] High throughput no yes
IKZF3_HUMAN [view interactions] High throughput no no
ANXA1_HUMAN [view entry] [view interactions] High throughput yes no
AIMP2_HUMAN [view interactions] High throughput no yes
HDAC6_HUMAN [view interactions] High throughput no yes
JUN_HUMAN [view interactions] High throughput no yes
RNF43_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
OVOL2_HUMAN [view interactions] High throughput no no
PKHA7_HUMAN [view interactions] High throughput no yes
ZRAN1_HUMAN [view interactions] High throughput no yes
BAP1_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
LITD1_HUMAN [view interactions] High throughput no no
MEN1_HUMAN [view interactions] High throughput no yes
MECP2_HUMAN [view interactions] High throughput no yes
ANDR_HUMAN [view interactions] High throughput no no
RYBP_HUMAN [view interactions] High throughput no no
LOXL2_HUMAN [view interactions] High throughput no yes
AUTS2_HUMAN [view interactions] High throughput no yes
R113A_HUMAN [view interactions] High throughput no yes
DX39B_HUMAN [view interactions] High throughput no no
RIMS1_HUMAN [view entry] [view interactions] High throughput yes yes
ACE2_HUMAN [view interactions] High throughput no no
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CDK7_HUMAN [view interactions] High throughput no yes
HCN1_HUMAN [view entry] [view interactions] High throughput yes yes
CCNF_HUMAN [view interactions] High throughput no no
DYR1A_HUMAN [view interactions] High throughput no yes
RUFY1_HUMAN [view interactions] High throughput no yes
CEP63_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
CP135_HUMAN [view interactions] High throughput no no
TRI33_HUMAN [view interactions] High throughput no yes
CE192_HUMAN [view interactions] High throughput no yes
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
CP110_HUMAN [view interactions] High throughput no yes
FBW1A_HUMAN [view interactions] High throughput no yes
ODFP2_HUMAN [view interactions] High throughput no no
MBD5_HUMAN [view interactions] High throughput no no
POC5_HUMAN [view interactions] High throughput no yes
MBD6_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
ASXL2_HUMAN [view interactions] High throughput no no
HAKAI_HUMAN [view interactions] High throughput no yes
UBP48_HUMAN [view interactions] High throughput no yes
AURKA_HUMAN [view entry] [view interactions] High throughput yes no
RHG24_HUMAN [view interactions] High throughput no yes
GRB2_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2O_HUMAN [view interactions] High throughput no yes
BYST_HUMAN [view interactions] High throughput no yes
GCSP_HUMAN [view interactions] High throughput no yes
RBM15_HUMAN [view interactions] High throughput no yes
PIAS1_HUMAN [view entry] [view interactions] High throughput yes yes
RBM10_HUMAN [view interactions] High throughput no yes
CBL_HUMAN [view interactions] High throughput no yes
HNRH1_HUMAN [view entry] [view interactions] High throughput yes yes
EZH2_HUMAN [view interactions] High throughput no no
DRC4_HUMAN [view interactions] High throughput no yes
MIDN_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
SMC5_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
KAT6A_HUMAN [view interactions] High throughput no yes
VINEX_HUMAN [view interactions] High throughput no no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
B3GN2_HUMAN [view interactions] High throughput no yes
ZWINT_HUMAN [view entry] [view interactions] High throughput yes no
UBE2H_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
TNIP1_HUMAN [view interactions] High throughput no yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
HDGF_HUMAN [view interactions] High throughput no yes
APBB1_HUMAN [view entry] [view interactions] High throughput yes yes
YBOX1_HUMAN [view interactions] High throughput no yes
PIN1_HUMAN [view entry] [view interactions] High throughput yes yes
CAND1_HUMAN [view entry] [view interactions] High throughput yes no
A4_HUMAN [view entry] [view interactions] High throughput yes yes