DDX17_HUMAN
Evidence for PS localization
Functions
As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed, PubMed, PubMed, PubMed). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed). This function requires the RNA helicase activity (PubMed, PubMed, PubMed, PubMed). Affects NFAT5 and histone macro-H2A.1/MACROH2A1 alternative splicing in a CDK9-dependent manner (PubMed, PubMed). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed). Binds pri-microRNAs on the 3 segment flanking the stem loop via the 5-[ACG]CAUC[ACU]-3 consensus sequence (PubMed). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed, PubMed). May be involved not only in microRNA primary transcript processing, but also stabilization . Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed). Enhances NFAT5 transcriptional activity (PubMed). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed, PubMed, PubMed). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed). Coactivates MMP7 transcription (PubMed). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed, PubMed). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed, PubMed, PubMed, PubMed). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed, PubMed). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DDX17_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 47.3684 | 4 | yes |
| GO:0046872 | metal ion binding | 25.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.3684 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 21.0526 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 21.0526 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 21.0526 | 4 | yes |
| GO:0005524 | ATP binding | 19.7368 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 19.7368 | 5 | yes |
| GO:0016462 | pyrophosphatase activity | 13.1579 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 13.1579 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 13.1579 | 6 | yes |
| GO:0016887 | ATP hydrolysis activity | 11.8421 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DDX17_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 69.7368 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 68.4211 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 67.1053 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 67.1053 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 67.1053 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 57.8947 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 55.2632 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 52.6316 | 4 | yes |
| GO:0010468 | regulation of gene expression | 52.6316 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 52.6316 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 51.3158 | 5 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 48.6842 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 47.3684 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 44.7368 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 44.7368 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 43.4211 | 4 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 43.4211 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 43.4211 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 42.1053 | 5 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 42.1053 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 42.1053 | 5 | yes |
| GO:0010646 | regulation of cell communication | 42.1053 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.7895 | 4 | no |
| GO:0009966 | regulation of signal transduction | 39.4737 | 4 | no |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0006996 | organelle organization | 35.5263 | 4 | no |
| GO:0043412 | macromolecule modification | 34.2105 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 32.8947 | 6 | yes |
| GO:0090304 | nucleic acid metabolic process | 32.8947 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 32.8947 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 32.8947 | 6 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 31.5789 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 31.5789 | 6 | yes |
| GO:0036211 | protein modification process | 31.5789 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.5789 | 6 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 30.2632 | 7 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 28.9474 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 28.9474 | 6 | yes |
| GO:0016070 | RNA metabolic process | 28.9474 | 5 | yes |
| GO:0008104 | protein localization | 28.9474 | 4 | no |
| GO:0010941 | regulation of cell death | 28.9474 | 4 | no |
| GO:0009894 | regulation of catabolic process | 28.9474 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
| GO:0006396 | RNA processing | 27.6316 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 27.6316 | 6 | yes |
| GO:0051248 | negative regulation of protein metabolic process | 27.6316 | 6 | no |
| GO:0033043 | regulation of organelle organization | 27.6316 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 26.3158 | 5 | no |
| GO:0010628 | positive regulation of gene expression | 26.3158 | 6 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 25.0000 | 6 | yes |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 25.0000 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051726 | regulation of cell cycle | 25.0000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 23.6842 | 4 | no |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 23.6842 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.6842 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.6842 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 23.6842 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 22.3684 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 22.3684 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 22.3684 | 7 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 22.3684 | 8 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 22.3684 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.3684 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.3684 | 5 | no |
| GO:0010564 | regulation of cell cycle process | 22.3684 | 5 | no |
| GO:0071702 | organic substance transport | 21.0526 | 4 | no |
| GO:0071705 | nitrogen compound transport | 21.0526 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 21.0526 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.0526 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.0526 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.0526 | 7 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0016071 | mRNA metabolic process | 19.7368 | 6 | yes |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 19.7368 | 8 | yes |
| GO:0006397 | mRNA processing | 18.4211 | 7 | yes |
| GO:0008380 | RNA splicing | 18.4211 | 7 | yes |
| GO:1903311 | regulation of mRNA metabolic process | 17.1053 | 6 | yes |
| GO:0000375 | RNA splicing, via transesterification reactions | 14.4737 | 8 | yes |
| GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 14.4737 | 9 | yes |
| GO:0000398 | mRNA splicing, via spliceosome | 14.4737 | 8 | yes |
| GO:0034660 | ncRNA metabolic process | 14.4737 | 6 | yes |
| GO:0043484 | regulation of RNA splicing | 13.1579 | 6 | yes |
| GO:0034470 | ncRNA processing | 11.8421 | 7 | yes |
| GO:0048024 | regulation of mRNA splicing, via spliceosome | 10.5263 | 7 | yes |
| GO:0050684 | regulation of mRNA processing | 10.5263 | 7 | yes |
| GO:0000381 | regulation of alternative mRNA splicing, via spliceosome | 7.8947 | 8 | yes |
| GO:0010586 | miRNA metabolic process | 6.5789 | 7 | yes |
| GO:0016072 | rRNA metabolic process | 6.5789 | 7 | yes |
| GO:0051607 | defense response to virus | 6.5789 | 4 | yes |
| GO:0140546 | defense response to symbiont | 6.5789 | 4 | yes |
| GO:0000380 | alternative mRNA splicing, via spliceosome | 5.2632 | 9 | yes |
| GO:0001837 | epithelial to mesenchymal transition | 5.2632 | 5 | yes |
| GO:0030518 | intracellular steroid hormone receptor signaling pathway | 5.2632 | 4 | yes |
| GO:0043401 | steroid hormone mediated signaling pathway | 5.2632 | 4 | yes |
| GO:0045445 | myoblast differentiation | 5.2632 | 4 | yes |
| GO:0048762 | mesenchymal cell differentiation | 5.2632 | 4 | yes |
| GO:0006364 | rRNA processing | 3.9474 | 8 | yes |
| GO:0030520 | intracellular estrogen receptor signaling pathway | 3.9474 | 5 | yes |
| GO:0030521 | androgen receptor signaling pathway | 3.9474 | 5 | yes |
| GO:2001014 | regulation of skeletal muscle cell differentiation | 3.9474 | 5 | yes |
| GO:0031047 | gene silencing by RNA | 2.6316 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DDX17_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 3.9474 | 4 | no |
| DOID:331 | central nervous system disease | 3.9474 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.6316 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.6316 | 5 | no |
| DOID:114 | heart disease | 2.6316 | 3 | no |
| DOID:2843 | long QT syndrome | 2.6316 | 6 | no |
| DOID:37 | skin disease | 2.6316 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RU17_HUMAN | [view interactions] | Low throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SREK1_HUMAN | [view interactions] | Low throughput | no | yes |
| CTCF_HUMAN | [view interactions] | Low throughput | no | yes |
| NFAT5_HUMAN | [view interactions] | Low throughput | no | yes |
| RNC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| YAP1_HUMAN | [view interactions] | Low throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZCCHV_HUMAN | [view interactions] | Low throughput | no | yes |
| TTP_HUMAN | [view interactions] | Low throughput | no | yes |
| DCP1A_HUMAN | [view interactions] | Low throughput | no | yes |
| DCP2_HUMAN | [view interactions] | Low throughput | no | yes |
| KLF4_HUMAN | [view interactions] | Low throughput | no | no |
| MYOD1_HUMAN | [view interactions] | Low throughput | no | no |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| ESR1_HUMAN | [view interactions] | Low throughput | no | no |
| DGCR8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| EXOS3_HUMAN | [view interactions] | Low throughput | no | yes |
| EXOS5_HUMAN | [view interactions] | Low throughput | no | yes |
| XRCC5_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| FOS_HUMAN | [view interactions] | Low throughput | no | yes |
| MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
| KAT2B_HUMAN | [view interactions] | Low throughput | no | yes |
| CBP_HUMAN | [view interactions] | Low throughput | no | yes |
| EP300_HUMAN | [view interactions] | Low throughput | no | yes |
| MBNL1_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC2_HUMAN | [view interactions] | Low throughput | no | yes |
| HDAC3_HUMAN | [view interactions] | Low throughput | no | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBP56_HUMAN | [view interactions] | High throughput | no | yes |
| RPB1_HUMAN | [view interactions] | High throughput | no | no |
| RU1C_HUMAN | [view interactions] | High throughput | no | yes |
| ARAF_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT7B_HUMAN | [view interactions] | High throughput | no | no |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| NFX1_HUMAN | [view interactions] | High throughput | no | yes |
| BRD7_HUMAN | [view interactions] | High throughput | no | yes |
| ERCC6_HUMAN | [view interactions] | High throughput | no | no |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| CMTR1_HUMAN | [view interactions] | High throughput | no | yes |
| ARI2_HUMAN | [view interactions] | High throughput | no | no |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ZCH18_HUMAN | [view interactions] | High throughput | no | yes |
| NIPBL_HUMAN | [view interactions] | High throughput | no | yes |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| LRC31_HUMAN | [view interactions] | High throughput | no | no |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| AURKB_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| U2AF2_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| SF01_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| WBP11_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM45_HUMAN | [view interactions] | High throughput | no | yes |
| RBM4_HUMAN | [view interactions] | High throughput | no | yes |
| CIC_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH3_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| RIN3_HUMAN | [view interactions] | High throughput | no | yes |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| TMM79_HUMAN | [view interactions] | High throughput | no | no |
| AIRE_HUMAN | [view interactions] | High throughput | no | no |
| UFL1_HUMAN | [view interactions] | High throughput | no | yes |
| MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDRGK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
| FZR1_HUMAN | [view interactions] | High throughput | no | no |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| GBRL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAGE4_HUMAN | [view interactions] | High throughput | no | no |
| GBRAP_HUMAN | [view interactions] | High throughput | no | no |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBTB2_HUMAN | [view interactions] | High throughput | no | yes |
| MGN_HUMAN | [view interactions] | High throughput | no | yes |
| MAEA_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| NALP7_HUMAN | [view interactions] | High throughput | no | no |
| ZN363_HUMAN | [view interactions] | High throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | High throughput | no | no |
| RBCC1_HUMAN | [view interactions] | High throughput | no | no |
| THOC7_HUMAN | [view interactions] | High throughput | no | yes |
| DDX3X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MATR3_HUMAN | [view interactions] | High throughput | no | yes |
| ZEB1_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| UBA5_HUMAN | [view interactions] | High throughput | no | yes |
| ATG13_HUMAN | [view interactions] | High throughput | no | no |
| SRSF1_HUMAN | [view interactions] | High throughput | no | yes |
| CN119_HUMAN | [view interactions] | High throughput | no | yes |
| RNPS1_HUMAN | [view interactions] | High throughput | no | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX41_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| DDX21_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| EMC9_HUMAN | [view interactions] | High throughput | no | no |
| HNRPD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ILF3_HUMAN | [view interactions] | High throughput | no | yes |
| MET14_HUMAN | [view interactions] | High throughput | no | yes |
| PDZD8_HUMAN | [view interactions] | High throughput | no | yes |
| DICER_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| RSMB_HUMAN | [view interactions] | High throughput | no | yes |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SSRP1_HUMAN | [view interactions] | High throughput | no | yes |
| CRY1_HUMAN | [view interactions] | High throughput | no | yes |
| SPT5H_HUMAN | [view interactions] | High throughput | no | yes |
| PTK6_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| APBB1_HUMAN | [view interactions] | High throughput | no | yes |
| NCBP3_HUMAN | [view interactions] | High throughput | no | yes |
| PIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NCBP1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WBP2_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM28_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOP1_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| ACINU_HUMAN | [view interactions] | High throughput | no | yes |
| MEX3C_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DSRAD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P3H1_HUMAN | [view interactions] | High throughput | no | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM1_HUMAN | [view interactions] | High throughput | no | no |
| SF3A2_HUMAN | [view interactions] | High throughput | no | yes |
| KPRA_HUMAN | [view interactions] | High throughput | no | no |
| ATX2_HUMAN | [view interactions] | High throughput | no | yes |
| SMN_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| DHX15_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| EF1A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KHDR1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PLK1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| PTBP1_HUMAN | [view interactions] | High throughput | no | no |
| RTF2_HUMAN | [view interactions] | High throughput | no | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MECP2_HUMAN | [view interactions] | High throughput | no | yes |
| TXLNA_HUMAN | [view interactions] | High throughput | no | yes |
| RYBP_HUMAN | [view interactions] | High throughput | no | no |
| TXLNG_HUMAN | [view interactions] | High throughput | no | no |
| AUTS2_HUMAN | [view interactions] | High throughput | no | yes |
| ILK_HUMAN | [view interactions] | High throughput | no | no |
| AURKA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NOSIP_HUMAN | [view interactions] | High throughput | no | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARVA_HUMAN | [view interactions] | High throughput | no | yes |
| BYST_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBM15_HUMAN | [view interactions] | High throughput | no | yes |
| PLPHP_HUMAN | [view interactions] | High throughput | no | yes |
| RBM10_HUMAN | [view interactions] | High throughput | no | yes |
| SYQ_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| DRC4_HUMAN | [view interactions] | High throughput | no | yes |
| YLPM1_HUMAN | [view interactions] | High throughput | no | yes |
| DDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNX1_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| HNRL1_HUMAN | [view interactions] | High throughput | no | yes |
| VINEX_HUMAN | [view interactions] | High throughput | no | no |
| AATF_HUMAN | [view interactions] | High throughput | no | yes |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CATIN_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CWC22_HUMAN | [view interactions] | High throughput | no | yes |
| CEBPZ_HUMAN | [view interactions] | High throughput | no | no |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| PYRG1_HUMAN | [view interactions] | High throughput | no | no |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| LSG1_HUMAN | [view interactions] | High throughput | no | yes |
| CAND1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUCL_HUMAN | [view interactions] | High throughput | no | yes |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| PAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| SMU1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL2_HUMAN | [view interactions] | High throughput | no | yes |
| CI114_HUMAN | [view interactions] | High throughput | no | yes |
| NEDD8_HUMAN | [view interactions] | High throughput | no | yes |
| TRM1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX27_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| GNL3_HUMAN | [view interactions] | High throughput | no | yes |
| NFKB1_HUMAN | [view interactions] | High throughput | no | yes |
| NOP14_HUMAN | [view interactions] | High throughput | no | yes |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPWD1_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view interactions] | High throughput | no | yes |
| PRP18_HUMAN | [view interactions] | High throughput | no | yes |
| CENPA_HUMAN | [view interactions] | High throughput | no | no |
| PR40A_HUMAN | [view interactions] | High throughput | no | yes |
| NBEL2_HUMAN | [view interactions] | High throughput | no | no |
| PWP2_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| SDA1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SF3A3_HUMAN | [view interactions] | High throughput | no | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| MINT_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| RBM14_HUMAN | [view interactions] | High throughput | no | yes |
| TRIR_HUMAN | [view interactions] | High throughput | no | yes |
| RBM5_HUMAN | [view interactions] | High throughput | no | yes |
| TTC4_HUMAN | [view interactions] | High throughput | no | yes |
| FXR2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR43_HUMAN | [view interactions] | High throughput | no | yes |
| ASXL1_HUMAN | [view interactions] | High throughput | no | no |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| SNRPA_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| SFPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DPPA3_HUMAN | [view interactions] | High throughput | no | no |
| RBM7_HUMAN | [view interactions] | High throughput | no | yes |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| ECHB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| PRP6_HUMAN | [view interactions] | High throughput | no | yes |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PROF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| NBR1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| MEPCE_HUMAN | [view interactions] | High throughput | no | yes |
| CR3L4_HUMAN | [view interactions] | High throughput | no | no |
| TAD2A_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| VHL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMRCD_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3K1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| ISG15_HUMAN | [view interactions] | High throughput | no | no |
| CDK2_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| IGSF8_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ICAM1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| LGR4_HUMAN | [view interactions] | High throughput | no | yes |
| NS1BP_HUMAN | [view interactions] | High throughput | no | yes |
| SPRTN_HUMAN | [view interactions] | High throughput | no | yes |
| CP250_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC8_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| KS6B2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CCDC9_HUMAN | [view interactions] | High throughput | no | yes |
| CRY2_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| MCM5_HUMAN | [view interactions] | High throughput | no | no |
| SENP3_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| FNBP4_HUMAN | [view interactions] | High throughput | no | yes |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY1A_HUMAN | [view interactions] | High throughput | no | no |
| AMY1C_HUMAN | [view interactions] | High throughput | no | no |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| AMPD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CYLD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IN80B_HUMAN | [view interactions] | High throughput | no | no |
| BRCA1_HUMAN | [view interactions] | High throughput | no | yes |
| MTF1_HUMAN | [view interactions] | High throughput | no | no |
| FBX7_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIE_HUMAN | [view interactions] | High throughput | no | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| PRP8_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP2_HUMAN | [view interactions] | High throughput | no | yes |
| CHD3_HUMAN | [view interactions] | High throughput | no | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| RNF31_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| RIOK1_HUMAN | [view interactions] | High throughput | no | yes |
| HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
| LARP7_HUMAN | [view interactions] | High throughput | no | yes |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| SNAI1_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| REST_HUMAN | [view interactions] | High throughput | no | yes |
| CNTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAF1_HUMAN | [view interactions] | High throughput | no | yes |
| KIN17_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| ZFY21_HUMAN | [view interactions] | High throughput | no | yes |
| XRCC6_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |