Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TRIM3_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Probably involved in vesicular trafficking via its association with the CART complex (PubMed). The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed). Positively regulates motility of microtubule-dependent motor protein KIF21B . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TRIM3_HUMAN
GO:0003723 RNA binding 37.5000 4 no
GO:0043169 cation binding 30.0000 4 yes
GO:0046872 metal ion binding 30.0000 5 yes
GO:0000166 nucleotide binding 30.0000 4 no
GO:0017076 purine nucleotide binding 30.0000 5 no
GO:0032555 purine ribonucleotide binding 30.0000 4 no
GO:0035639 purine ribonucleoside triphosphate binding 30.0000 4 no
GO:0043168 anion binding 30.0000 4 no
GO:0005524 ATP binding 27.5000 5 no
GO:0030554 adenyl nucleotide binding 27.5000 6 no
GO:0032559 adenyl ribonucleotide binding 27.5000 5 no
GO:0016755 aminoacyltransferase activity 20.0000 4 yes
GO:0004842 ubiquitin-protein transferase activity 17.5000 4 yes
GO:0008270 zinc ion binding 15.0000 7 yes
GO:0046914 transition metal ion binding 15.0000 6 yes
GO:0061630 ubiquitin protein ligase activity 15.0000 5 yes
GO:0061659 ubiquitin-like protein ligase activity 15.0000 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TRIM3_HUMAN
GO:0060255 regulation of macromolecule metabolic process 72.5000 4 yes
GO:0080090 regulation of primary metabolic process 72.5000 4 yes
GO:0031323 regulation of cellular metabolic process 70.0000 4 yes
GO:0009889 regulation of biosynthetic process 65.0000 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 65.0000 5 yes
GO:0031326 regulation of cellular biosynthetic process 65.0000 5 yes
GO:0048522 positive regulation of cellular process 65.0000 4 yes
GO:0010468 regulation of gene expression 62.5000 6 yes
GO:0010646 regulation of cell communication 57.5000 4 yes
GO:0051246 regulation of protein metabolic process 55.0000 5 yes
GO:0048523 negative regulation of cellular process 55.0000 4 yes
GO:0009966 regulation of signal transduction 50.0000 4 yes
GO:0006996 organelle organization 45.0000 4 no
GO:0009893 positive regulation of metabolic process 45.0000 4 no
GO:0010604 positive regulation of macromolecule metabolic process 45.0000 5 no
GO:0022607 cellular component assembly 42.5000 4 no
GO:0031399 regulation of protein modification process 42.5000 6 no
GO:0009892 negative regulation of metabolic process 42.5000 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 42.5000 5 yes
GO:0010647 positive regulation of cell communication 42.5000 5 yes
GO:0023056 positive regulation of signaling 42.5000 4 yes
GO:0036211 protein modification process 42.5000 4 yes
GO:0043412 macromolecule modification 42.5000 4 yes
GO:0051128 regulation of cellular component organization 40.0000 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.0000 5 no
GO:0031324 negative regulation of cellular metabolic process 40.0000 5 yes
GO:0031325 positive regulation of cellular metabolic process 37.5000 5 no
GO:0051252 regulation of RNA metabolic process 37.5000 5 no
GO:0009890 negative regulation of biosynthetic process 37.5000 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 37.5000 6 yes
GO:0031327 negative regulation of cellular biosynthetic process 37.5000 6 yes
GO:0048584 positive regulation of response to stimulus 37.5000 4 yes
GO:0071702 organic substance transport 35.0000 4 yes
GO:0019220 regulation of phosphate metabolic process 35.0000 6 no
GO:0051174 regulation of phosphorus metabolic process 35.0000 5 no
GO:0051247 positive regulation of protein metabolic process 35.0000 6 no
GO:0042325 regulation of phosphorylation 32.5000 7 no
GO:0008104 protein localization 32.5000 4 yes
GO:0009967 positive regulation of signal transduction 32.5000 5 yes
GO:0051248 negative regulation of protein metabolic process 30.0000 6 yes
GO:0071705 nitrogen compound transport 30.0000 4 yes
GO:0001932 regulation of protein phosphorylation 30.0000 7 no
GO:0031401 positive regulation of protein modification process 30.0000 7 no
GO:1902531 regulation of intracellular signal transduction 30.0000 5 no
GO:0009891 positive regulation of biosynthetic process 30.0000 5 no
GO:0031328 positive regulation of cellular biosynthetic process 30.0000 6 no
GO:0044087 regulation of cellular component biogenesis 30.0000 4 no
GO:0009894 regulation of catabolic process 30.0000 4 no
GO:0010629 negative regulation of gene expression 30.0000 7 yes
GO:0006355 regulation of DNA-templated transcription 27.5000 7 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.5000 6 no
GO:0048585 negative regulation of response to stimulus 27.5000 4 no
GO:2001141 regulation of RNA biosynthetic process 27.5000 6 no
GO:0050804 modulation of chemical synaptic transmission 27.5000 5 no
GO:0099177 regulation of trans-synaptic signaling 27.5000 4 no
GO:0007010 cytoskeleton organization 25.0000 5 no
GO:0010562 positive regulation of phosphorus metabolic process 25.0000 6 no
GO:0042327 positive regulation of phosphorylation 25.0000 8 no
GO:0045937 positive regulation of phosphate metabolic process 25.0000 7 no
GO:0009968 negative regulation of signal transduction 25.0000 5 no
GO:0010648 negative regulation of cell communication 25.0000 5 no
GO:0023057 negative regulation of signaling 25.0000 4 no
GO:0070647 protein modification by small protein conjugation or removal 22.5000 6 yes
GO:0001934 positive regulation of protein phosphorylation 22.5000 8 no
GO:0006796 phosphate-containing compound metabolic process 22.5000 4 no
GO:0030030 cell projection organization 22.5000 4 no
GO:0006357 regulation of transcription by RNA polymerase II 22.5000 8 no
GO:0042981 regulation of apoptotic process 22.5000 5 no
GO:0043067 regulation of programmed cell death 22.5000 4 no
GO:0045595 regulation of cell differentiation 22.5000 4 no
GO:0051049 regulation of transport 22.5000 4 no
GO:0051130 positive regulation of cellular component organization 22.5000 5 no
GO:0009057 macromolecule catabolic process 22.5000 4 yes
GO:0010608 post-transcriptional regulation of gene expression 22.5000 7 yes
GO:0015031 protein transport 22.5000 4 yes
GO:0032446 protein modification by small protein conjugation 22.5000 7 yes
GO:0043687 post-translational protein modification 22.5000 5 yes
GO:0080134 regulation of response to stress 20.0000 4 yes
GO:0006417 regulation of translation 20.0000 6 yes
GO:0051603 proteolysis involved in protein catabolic process 17.5000 5 yes
GO:0006508 proteolysis 17.5000 4 yes
GO:0006511 ubiquitin-dependent protein catabolic process 17.5000 7 yes
GO:0016567 protein ubiquitination 17.5000 8 yes
GO:0017148 negative regulation of translation 17.5000 7 yes
GO:0019941 modification-dependent protein catabolic process 17.5000 6 yes
GO:0032101 regulation of response to external stimulus 17.5000 4 yes
GO:0043632 modification-dependent macromolecule catabolic process 17.5000 5 yes
GO:1901565 organonitrogen compound catabolic process 15.0000 4 yes
GO:0030163 protein catabolic process 15.0000 4 yes
GO:0000209 protein polyubiquitination 12.5000 9 yes
GO:0010498 proteasomal protein catabolic process 12.5000 5 yes
GO:0031347 regulation of defense response 12.5000 5 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 12.5000 6 yes
GO:0050776 regulation of immune response 10.0000 4 yes
GO:0007399 nervous system development 10.0000 4 yes
GO:0032103 positive regulation of response to external stimulus 10.0000 5 yes
GO:0050778 positive regulation of immune response 7.5000 5 yes
GO:0070534 protein K63-linked ubiquitination 7.5000 10 yes
GO:0002684 positive regulation of immune system process 7.5000 4 yes
GO:0002831 regulation of response to biotic stimulus 7.5000 4 yes
GO:0031349 positive regulation of defense response 7.5000 5 yes
GO:0045088 regulation of innate immune response 7.5000 5 yes
GO:0062207 regulation of pattern recognition receptor signaling pathway 5.0000 5 yes
GO:0062208 positive regulation of pattern recognition receptor signaling pathway 5.0000 6 yes
GO:0002833 positive regulation of response to biotic stimulus 5.0000 5 yes
GO:0034139 regulation of toll-like receptor 3 signaling pathway 5.0000 7 yes
GO:0034141 positive regulation of toll-like receptor 3 signaling pathway 5.0000 7 yes
GO:0039531 regulation of cytoplasmic pattern recognition receptor signaling pathway 5.0000 6 yes
GO:0045089 positive regulation of innate immune response 5.0000 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
MYO5B_HUMAN [view entry] [view interactions] Low throughput yes yes
TRIM2_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2D1_HUMAN [view interactions] Low throughput no yes
TRIM3_HUMAN [view entry] [view interactions] Low throughput yes no
ACTN4_HUMAN [view entry] [view interactions] Low throughput yes yes
KI21B_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC9_HUMAN [view entry] [view interactions] Low throughput yes yes
LST2_HUMAN [view interactions] Low throughput no yes
HGS_HUMAN [view entry] [view interactions] Low throughput yes yes
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
CDN1A_HUMAN [view interactions] Low throughput no no
IMB1_HUMAN [view entry] [view interactions] Low throughput yes yes
NOTC1_HUMAN [view entry] [view interactions] Low throughput yes yes
IMA3_HUMAN [view interactions] Low throughput no yes
BECN1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
ESR1_HUMAN [view interactions] Low throughput no no
SAE1_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2D2_HUMAN [view interactions] Low throughput no yes
UB2E1_HUMAN [view interactions] Low throughput no yes
TRPM7_HUMAN [view interactions] High throughput no no
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
CYFP1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HUWE1_HUMAN [view interactions] High throughput no yes
MYOME_HUMAN [view interactions] High throughput no no
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
UB2G2_HUMAN [view interactions] High throughput no yes
UBE2U_HUMAN [view interactions] High throughput no no
LNX1_HUMAN [view entry] [view interactions] High throughput yes yes
RO52_HUMAN [view interactions] High throughput no yes
UB2E2_HUMAN [view interactions] High throughput no yes
LRC8E_HUMAN [view interactions] High throughput no no
CEP70_HUMAN [view interactions] High throughput no yes
KC1E_HUMAN [view entry] [view interactions] High throughput yes yes
ARLY_HUMAN [view interactions] High throughput no no
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2Z_HUMAN [view interactions] High throughput no yes
ROP1A_HUMAN [view interactions] High throughput no no
DNMT1_HUMAN [view interactions] High throughput no no
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
TEAD2_HUMAN [view interactions] High throughput no no
UB2D4_HUMAN [view interactions] High throughput no yes
TNAP3_HUMAN [view interactions] High throughput no yes
UBP32_HUMAN [view interactions] High throughput no yes
TEAD1_HUMAN [view interactions] High throughput no no
KCTD7_HUMAN [view interactions] High throughput no no
HECW2_HUMAN [view entry] [view interactions] High throughput yes no
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
PRP6_HUMAN [view interactions] High throughput no yes
DDX17_HUMAN [view entry] [view interactions] High throughput yes yes
U2AF2_HUMAN [view interactions] High throughput no yes
SERB1_HUMAN [view interactions] High throughput no yes
RL6_HUMAN [view entry] [view interactions] High throughput yes yes
PABP4_HUMAN [view entry] [view interactions] High throughput yes yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
DPYL2_HUMAN [view entry] [view interactions] High throughput yes yes
INS_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
GPM6A_HUMAN [view entry] [view interactions] High throughput yes no
TMIE_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
FOXA1_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
RAF1_HUMAN [view entry] [view interactions] High throughput yes no
TRI67_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
UB2D3_HUMAN [view interactions] High throughput no yes
UBE2W_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2K_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes