Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TRIM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
227 Glu Val Charcot-Marie-Toothdisease2R(CMT2R) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TRIM2_HUMAN
GO:0003723 RNA binding 31.5789 4 no
GO:0005524 ATP binding 26.3158 5 no
GO:0017076 purine nucleotide binding 26.3158 4 no
GO:0030554 adenyl nucleotide binding 26.3158 5 no
GO:0032555 purine ribonucleotide binding 26.3158 4 no
GO:0032559 adenyl ribonucleotide binding 26.3158 5 no
GO:0035639 purine ribonucleoside triphosphate binding 26.3158 4 no
GO:0046872 metal ion binding 21.0526 4 yes
GO:0046914 transition metal ion binding 21.0526 5 yes
GO:0042803 protein homodimerization activity 21.0526 4 no
GO:0019900 kinase binding 21.0526 4 no
GO:0019901 protein kinase binding 21.0526 5 no
GO:0004842 ubiquitin-protein transferase activity 15.7895 4 yes
GO:0008270 zinc ion binding 15.7895 6 yes
GO:0061630 ubiquitin protein ligase activity 15.7895 5 yes
GO:0061659 ubiquitin-like protein ligase activity 15.7895 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TRIM2_HUMAN
GO:0031323 regulation of cellular metabolic process 52.6316 4 no
GO:0048522 positive regulation of cellular process 52.6316 4 no
GO:0010646 regulation of cell communication 47.3684 4 no
GO:0051171 regulation of nitrogen compound metabolic process 47.3684 4 no
GO:0051246 regulation of protein metabolic process 47.3684 5 no
GO:0060255 regulation of macromolecule metabolic process 47.3684 4 no
GO:0080090 regulation of primary metabolic process 47.3684 4 no
GO:0001932 regulation of protein phosphorylation 42.1053 7 no
GO:0009893 positive regulation of metabolic process 42.1053 4 no
GO:0010604 positive regulation of macromolecule metabolic process 42.1053 5 no
GO:0019220 regulation of phosphate metabolic process 42.1053 6 no
GO:0031325 positive regulation of cellular metabolic process 42.1053 5 no
GO:0031399 regulation of protein modification process 42.1053 6 no
GO:0042325 regulation of phosphorylation 42.1053 7 no
GO:0051173 positive regulation of nitrogen compound metabolic process 42.1053 5 no
GO:0051174 regulation of phosphorus metabolic process 42.1053 5 no
GO:0051247 positive regulation of protein metabolic process 42.1053 6 no
GO:0010468 regulation of gene expression 42.1053 5 no
GO:0048523 negative regulation of cellular process 42.1053 4 no
GO:0010941 regulation of cell death 36.8421 4 yes
GO:0036211 protein modification process 36.8421 4 yes
GO:0043412 macromolecule modification 36.8421 4 yes
GO:0008104 protein localization 36.8421 4 no
GO:0001934 positive regulation of protein phosphorylation 36.8421 8 no
GO:0009966 regulation of signal transduction 36.8421 4 no
GO:0010562 positive regulation of phosphorus metabolic process 36.8421 6 no
GO:0022607 cellular component assembly 36.8421 4 no
GO:0030030 cell projection organization 36.8421 4 no
GO:0031401 positive regulation of protein modification process 36.8421 7 no
GO:0042327 positive regulation of phosphorylation 36.8421 8 no
GO:0045937 positive regulation of phosphate metabolic process 36.8421 7 no
GO:0051128 regulation of cellular component organization 36.8421 4 no
GO:0009889 regulation of biosynthetic process 36.8421 4 no
GO:0031326 regulation of cellular biosynthetic process 36.8421 5 no
GO:0042981 regulation of apoptotic process 31.5789 6 yes
GO:0043067 regulation of programmed cell death 31.5789 5 yes
GO:1901214 regulation of neuron death 31.5789 5 yes
GO:0071702 organic substance transport 31.5789 4 no
GO:0071705 nitrogen compound transport 31.5789 4 no
GO:0006996 organelle organization 31.5789 4 no
GO:0010647 positive regulation of cell communication 31.5789 5 no
GO:0023056 positive regulation of signaling 31.5789 4 no
GO:0080134 regulation of response to stress 31.5789 4 no
GO:1902531 regulation of intracellular signal transduction 31.5789 5 no
GO:0009892 negative regulation of metabolic process 31.5789 4 no
GO:0010556 regulation of macromolecule biosynthetic process 31.5789 5 no
GO:0010605 negative regulation of macromolecule metabolic process 31.5789 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.5789 5 no
GO:0031324 negative regulation of cellular metabolic process 31.5789 5 no
GO:0051049 regulation of transport 31.5789 4 no
GO:0051172 negative regulation of nitrogen compound metabolic process 31.5789 5 no
GO:0009057 macromolecule catabolic process 26.3158 4 yes
GO:0043523 regulation of neuron apoptotic process 26.3158 6 yes
GO:0015031 protein transport 26.3158 4 no
GO:0009894 regulation of catabolic process 26.3158 4 no
GO:0031344 regulation of cell projection organization 26.3158 5 no
GO:0032990 cell part morphogenesis 26.3158 4 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0048812 neuron projection morphogenesis 26.3158 7 no
GO:0048858 cell projection morphogenesis 26.3158 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 26.3158 6 no
GO:0120036 plasma membrane bounded cell projection organization 26.3158 5 no
GO:0120039 plasma membrane bounded cell projection morphogenesis 26.3158 6 no
GO:0009891 positive regulation of biosynthetic process 26.3158 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 26.3158 6 no
GO:0010628 positive regulation of gene expression 26.3158 6 no
GO:0010629 negative regulation of gene expression 26.3158 6 no
GO:0031328 positive regulation of cellular biosynthetic process 26.3158 6 no
GO:0050804 modulation of chemical synaptic transmission 26.3158 5 no
GO:0051050 positive regulation of transport 26.3158 4 no
GO:0051130 positive regulation of cellular component organization 26.3158 5 no
GO:0051248 negative regulation of protein metabolic process 26.3158 6 no
GO:0099177 regulation of trans-synaptic signaling 26.3158 4 no
GO:0010243 response to organonitrogen compound 26.3158 4 no
GO:0051338 regulation of transferase activity 26.3158 4 no
GO:0071310 cellular response to organic substance 26.3158 4 no
GO:0043933 protein-containing complex organization 26.3158 4 no
GO:0065003 protein-containing complex assembly 26.3158 5 no
GO:0006508 proteolysis 21.0526 4 yes
GO:0016567 protein ubiquitination 21.0526 7 yes
GO:0019941 modification-dependent protein catabolic process 21.0526 6 yes
GO:0030163 protein catabolic process 21.0526 4 yes
GO:0032446 protein modification by small protein conjugation 21.0526 6 yes
GO:0043632 modification-dependent macromolecule catabolic process 21.0526 5 yes
GO:0044265 cellular macromolecule catabolic process 21.0526 4 yes
GO:0051603 proteolysis involved in protein catabolic process 21.0526 5 yes
GO:0070647 protein modification by small protein conjugation or removal 21.0526 5 yes
GO:1901565 organonitrogen compound catabolic process 21.0526 4 yes
GO:0033365 protein localization to organelle 21.0526 5 no
GO:0031329 regulation of cellular catabolic process 21.0526 5 no
GO:0072657 protein localization to membrane 21.0526 4 no
GO:0080135 regulation of cellular response to stress 21.0526 4 no
GO:0010648 negative regulation of cell communication 21.0526 5 no
GO:0023057 negative regulation of signaling 21.0526 4 no
GO:0060627 regulation of vesicle-mediated transport 21.0526 4 no
GO:1901699 cellular response to nitrogen compound 21.0526 4 no
GO:0032101 regulation of response to external stimulus 21.0526 4 no
GO:0043085 positive regulation of catalytic activity 21.0526 4 no
GO:0050776 regulation of immune response 21.0526 4 no
GO:0051347 positive regulation of transferase activity 21.0526 5 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:1901701 cellular response to oxygen-containing compound 21.0526 4 no
GO:0043549 regulation of kinase activity 21.0526 5 no
GO:0045859 regulation of protein kinase activity 21.0526 6 no
GO:0060548 negative regulation of cell death 21.0526 5 no
GO:0001817 regulation of cytokine production 21.0526 4 no
GO:0000209 protein polyubiquitination 15.7895 8 yes
GO:0006511 ubiquitin-dependent protein catabolic process 15.7895 7 yes
GO:0010498 proteasomal protein catabolic process 15.7895 5 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 15.7895 6 yes

Disease

Term Name % Distance from top the of the tree Annotated in TRIM2_HUMAN
DOID:0050539 Charcot-Marie-Tooth disease type 2 10.5263 7 yes
DOID:0110161 Charcot-Marie-Tooth disease type 2R 10.5263 8 yes
DOID:10595 Charcot-Marie-Tooth disease 10.5263 6 yes
DOID:440 neuromuscular disease 10.5263 5 yes
DOID:574 peripheral nervous system disease 10.5263 3 yes
DOID:870 neuropathy 10.5263 4 yes

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
B2L11_HUMAN [view interactions] Low throughput no yes
HMN1_HUMAN [view interactions] Low throughput no no
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
SNAI1_HUMAN [view interactions] Low throughput no yes
TRIM2_HUMAN [view entry] [view interactions] Low throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
LRC8E_HUMAN [view interactions] High throughput no no
UBAC1_HUMAN [view interactions] High throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
TRIM3_HUMAN [view entry] [view interactions] High throughput yes no
MATR3_HUMAN [view interactions] High throughput no yes
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
UBE2U_HUMAN [view interactions] High throughput no no
UB2D1_HUMAN [view interactions] High throughput no yes
UB2D2_HUMAN [view interactions] High throughput no yes
UB2D3_HUMAN [view interactions] High throughput no yes
UB2E1_HUMAN [view interactions] High throughput no yes
UB2E2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
UB2E3_HUMAN [view interactions] High throughput no yes
UB2D4_HUMAN [view interactions] High throughput no yes
UBE2W_HUMAN [view interactions] High throughput no yes
CXB5_HUMAN [view interactions] High throughput no no
MAT1_HUMAN [view interactions] High throughput no yes
TRIM8_HUMAN [view interactions] High throughput no yes
CIB3_HUMAN [view interactions] High throughput no no
CDK20_HUMAN [view interactions] High throughput no yes
UBE2K_HUMAN [view interactions] High throughput no yes
SHPS1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
LCA5_HUMAN [view interactions] High throughput no no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
OTUB2_HUMAN [view interactions] High throughput no no
TNAP3_HUMAN [view interactions] High throughput no yes
COG3_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD7_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
VIR_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL5_HUMAN [view interactions] High throughput no yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes