Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

TRIM2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
227 Glu Val Charcot-Marie-Toothdisease,axonal,2R(CMT2R) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in TRIM2_HUMAN
GO:0003723 RNA binding 33.3333 4 no
GO:0000166 nucleotide binding 28.5714 4 no
GO:0005524 ATP binding 28.5714 5 no
GO:0017076 purine nucleotide binding 28.5714 5 no
GO:0030554 adenyl nucleotide binding 28.5714 6 no
GO:0032555 purine ribonucleotide binding 28.5714 4 no
GO:0032559 adenyl ribonucleotide binding 28.5714 5 no
GO:0035639 purine ribonucleoside triphosphate binding 28.5714 4 no
GO:0043168 anion binding 28.5714 4 no
GO:0004842 ubiquitin-protein transferase activity 23.8095 4 yes
GO:0016755 aminoacyltransferase activity 23.8095 4 yes
GO:0031625 ubiquitin protein ligase binding 23.8095 5 no
GO:0044389 ubiquitin-like protein ligase binding 23.8095 4 no
GO:0043169 cation binding 19.0476 4 yes
GO:0046872 metal ion binding 19.0476 5 yes
GO:0046914 transition metal ion binding 19.0476 6 yes
GO:0061630 ubiquitin protein ligase activity 19.0476 5 yes
GO:0061659 ubiquitin-like protein ligase activity 19.0476 4 yes
GO:0008270 zinc ion binding 14.2857 7 yes

Biological process

Term Name % Distance from top the of the tree Annotated in TRIM2_HUMAN
GO:0031323 regulation of cellular metabolic process 71.4286 4 yes
GO:0051246 regulation of protein metabolic process 66.6667 5 yes
GO:0060255 regulation of macromolecule metabolic process 66.6667 4 yes
GO:0080090 regulation of primary metabolic process 66.6667 4 yes
GO:0009889 regulation of biosynthetic process 61.9048 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 61.9048 5 yes
GO:0031326 regulation of cellular biosynthetic process 61.9048 5 yes
GO:0048523 negative regulation of cellular process 61.9048 4 yes
GO:0048522 positive regulation of cellular process 61.9048 4 no
GO:0010646 regulation of cell communication 57.1429 4 no
GO:0010468 regulation of gene expression 52.3810 6 yes
GO:0009893 positive regulation of metabolic process 47.6190 4 no
GO:0010604 positive regulation of macromolecule metabolic process 47.6190 5 no
GO:0031399 regulation of protein modification process 47.6190 6 no
GO:0051247 positive regulation of protein metabolic process 47.6190 6 no
GO:0009892 negative regulation of metabolic process 42.8571 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 42.8571 5 yes
GO:0036211 protein modification process 42.8571 4 yes
GO:0043412 macromolecule modification 42.8571 4 yes
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0031401 positive regulation of protein modification process 42.8571 7 no
GO:0051128 regulation of cellular component organization 42.8571 4 no
GO:0009890 negative regulation of biosynthetic process 38.0952 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 38.0952 6 yes
GO:0010629 negative regulation of gene expression 38.0952 7 yes
GO:0031324 negative regulation of cellular metabolic process 38.0952 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 38.0952 6 yes
GO:0001932 regulation of protein phosphorylation 38.0952 7 no
GO:0006996 organelle organization 38.0952 4 no
GO:0010647 positive regulation of cell communication 38.0952 5 no
GO:0019220 regulation of phosphate metabolic process 38.0952 6 no
GO:0022607 cellular component assembly 38.0952 4 no
GO:0023056 positive regulation of signaling 38.0952 4 no
GO:0031325 positive regulation of cellular metabolic process 38.0952 5 no
GO:0042325 regulation of phosphorylation 38.0952 7 no
GO:0051174 regulation of phosphorus metabolic process 38.0952 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 38.0952 5 no
GO:0009057 macromolecule catabolic process 33.3333 4 yes
GO:0051248 negative regulation of protein metabolic process 33.3333 6 yes
GO:0001934 positive regulation of protein phosphorylation 33.3333 8 no
GO:0010562 positive regulation of phosphorus metabolic process 33.3333 6 no
GO:0042327 positive regulation of phosphorylation 33.3333 8 no
GO:0045937 positive regulation of phosphate metabolic process 33.3333 7 no
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0051130 positive regulation of cellular component organization 33.3333 5 no
GO:0006508 proteolysis 28.5714 4 yes
GO:0016567 protein ubiquitination 28.5714 8 yes
GO:0019941 modification-dependent protein catabolic process 28.5714 6 yes
GO:0030163 protein catabolic process 28.5714 4 yes
GO:0032446 protein modification by small protein conjugation 28.5714 7 yes
GO:0042981 regulation of apoptotic process 28.5714 5 yes
GO:0043067 regulation of programmed cell death 28.5714 4 yes
GO:0043632 modification-dependent macromolecule catabolic process 28.5714 5 yes
GO:0043687 post-translational protein modification 28.5714 5 yes
GO:0051603 proteolysis involved in protein catabolic process 28.5714 5 yes
GO:0070647 protein modification by small protein conjugation or removal 28.5714 6 yes
GO:1901565 organonitrogen compound catabolic process 28.5714 4 yes
GO:0008104 protein localization 28.5714 4 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0031344 regulation of cell projection organization 28.5714 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 28.5714 6 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0071702 organic substance transport 28.5714 4 no
GO:0071705 nitrogen compound transport 28.5714 4 no
GO:0009894 regulation of catabolic process 28.5714 4 no
GO:0009891 positive regulation of biosynthetic process 28.5714 5 no
GO:0010557 positive regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0031328 positive regulation of cellular biosynthetic process 28.5714 6 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0050804 modulation of chemical synaptic transmission 28.5714 5 no
GO:0099177 regulation of trans-synaptic signaling 28.5714 4 no
GO:0000209 protein polyubiquitination 23.8095 9 yes
GO:0006417 regulation of translation 23.8095 6 yes
GO:0006511 ubiquitin-dependent protein catabolic process 23.8095 7 yes
GO:0010498 proteasomal protein catabolic process 23.8095 5 yes
GO:0010608 post-transcriptional regulation of gene expression 23.8095 7 yes
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 23.8095 6 yes
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010243 response to organonitrogen compound 23.8095 4 no
GO:0120036 plasma membrane bounded cell projection organization 23.8095 5 no
GO:0002684 positive regulation of immune system process 23.8095 4 no
GO:0015031 protein transport 23.8095 4 no
GO:0050776 regulation of immune response 23.8095 4 no
GO:0080134 regulation of response to stress 23.8095 4 no
GO:0051252 regulation of RNA metabolic process 23.8095 5 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:0017148 negative regulation of translation 19.0476 7 yes
GO:0043523 regulation of neuron apoptotic process 19.0476 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
TRIM3_HUMAN [view entry] [view interactions] Low throughput yes no
NFL_HUMAN [view entry] [view interactions] Low throughput yes yes
UB2D1_HUMAN [view interactions] Low throughput no yes
UB2D3_HUMAN [view interactions] Low throughput no yes
B2L11_HUMAN [view interactions] Low throughput no yes
HMN1_HUMAN [view interactions] Low throughput no no
MYO5A_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
SNAI1_HUMAN [view interactions] Low throughput no yes
P53_HUMAN [view interactions] Low throughput no no
TRIM2_HUMAN [view entry] [view interactions] Low throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
LRC8E_HUMAN [view interactions] High throughput no no
UBAC1_HUMAN [view interactions] High throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
VATG1_HUMAN [view entry] [view interactions] High throughput yes yes
MATR3_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
UBE2U_HUMAN [view interactions] High throughput no no
UB2D2_HUMAN [view interactions] High throughput no yes
UB2E1_HUMAN [view interactions] High throughput no yes
UB2E2_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
UB2E3_HUMAN [view interactions] High throughput no yes
UB2D4_HUMAN [view interactions] High throughput no yes
UBE2W_HUMAN [view interactions] High throughput no yes
CXB5_HUMAN [view interactions] High throughput no no
MAT1_HUMAN [view interactions] High throughput no yes
TRIM8_HUMAN [view interactions] High throughput no yes
CIB3_HUMAN [view interactions] High throughput no no
CDK20_HUMAN [view interactions] High throughput no yes
UBE2K_HUMAN [view interactions] High throughput no yes
SHPS1_HUMAN [view entry] [view interactions] High throughput yes yes
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
LCA5_HUMAN [view interactions] High throughput no no
DTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
OTUB2_HUMAN [view interactions] High throughput no no
TNAP3_HUMAN [view interactions] High throughput no yes
COG3_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD7_HUMAN [view interactions] High throughput no no
ELAV1_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
CFTR_HUMAN [view interactions] High throughput no no
VIR_HUMAN [view interactions] High throughput no yes
TIA1_HUMAN [view interactions] High throughput no no
MK01_HUMAN [view entry] [view interactions] High throughput yes yes
KLHL5_HUMAN [view interactions] High throughput no yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
UBE2C_HUMAN [view interactions] High throughput no yes
UBE2F_HUMAN [view interactions] High throughput no yes
UB2G1_HUMAN [view interactions] High throughput no yes
UBE2N_HUMAN [view entry] [view interactions] High throughput yes yes
ODPA_HUMAN [view entry] [view interactions] High throughput yes yes
NCDN_HUMAN [view entry] [view interactions] High throughput yes yes