Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHPS1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function . Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHPS1_HUMAN
GO:0043168 anion binding 45.4545 4 no
GO:0000166 nucleotide binding 43.1818 4 no
GO:0017076 purine nucleotide binding 43.1818 5 no
GO:0032555 purine ribonucleotide binding 43.1818 4 no
GO:0035639 purine ribonucleoside triphosphate binding 43.1818 4 no
GO:0003723 RNA binding 40.9091 4 no
GO:0016462 pyrophosphatase activity 34.0909 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 34.0909 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 34.0909 6 no
GO:0005524 ATP binding 29.5455 5 no
GO:0030554 adenyl nucleotide binding 29.5455 6 no
GO:0032559 adenyl ribonucleotide binding 29.5455 5 no
GO:0019900 kinase binding 27.2727 4 yes
GO:0045296 cadherin binding 27.2727 4 no
GO:0019901 protein kinase binding 25.0000 5 yes
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0016887 ATP hydrolysis activity 20.4545 7 no
GO:0044389 ubiquitin-like protein ligase binding 20.4545 4 no
GO:0017124 SH3 domain binding 13.6364 4 yes
GO:1990782 protein tyrosine kinase binding 13.6364 6 yes
GO:0019902 phosphatase binding 11.3636 4 yes
GO:0019903 protein phosphatase binding 11.3636 5 yes
GO:0030695 GTPase regulator activity 11.3636 4 yes
GO:0086080 protein binding involved in heterotypic cell-cell adhesion 4.5455 6 yes
GO:0098631 cell adhesion mediator activity 4.5455 4 yes
GO:0098632 cell-cell adhesion mediator activity 4.5455 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SHPS1_HUMAN
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0048522 positive regulation of cellular process 65.9091 4 yes
GO:0060255 regulation of macromolecule metabolic process 65.9091 4 yes
GO:0031323 regulation of cellular metabolic process 63.6364 4 yes
GO:0080090 regulation of primary metabolic process 63.6364 4 yes
GO:0010646 regulation of cell communication 59.0909 4 yes
GO:0009889 regulation of biosynthetic process 56.8182 4 yes
GO:0031326 regulation of cellular biosynthetic process 56.8182 5 yes
GO:0010556 regulation of macromolecule biosynthetic process 54.5455 5 yes
GO:0051128 regulation of cellular component organization 54.5455 4 yes
GO:0009966 regulation of signal transduction 52.2727 4 yes
GO:0010468 regulation of gene expression 50.0000 6 yes
GO:0042981 regulation of apoptotic process 47.7273 5 no
GO:0043067 regulation of programmed cell death 47.7273 4 no
GO:0051246 regulation of protein metabolic process 45.4545 5 yes
GO:0009893 positive regulation of metabolic process 43.1818 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 40.9091 5 no
GO:0031325 positive regulation of cellular metabolic process 40.9091 5 no
GO:0048584 positive regulation of response to stimulus 40.9091 4 no
GO:0006996 organelle organization 40.9091 4 no
GO:1902531 regulation of intracellular signal transduction 40.9091 5 yes
GO:0010604 positive regulation of macromolecule metabolic process 38.6364 5 no
GO:0043069 negative regulation of programmed cell death 36.3636 5 no
GO:0009891 positive regulation of biosynthetic process 36.3636 5 no
GO:0031328 positive regulation of cellular biosynthetic process 36.3636 6 no
GO:0009967 positive regulation of signal transduction 36.3636 5 no
GO:0010647 positive regulation of cell communication 36.3636 5 no
GO:0023056 positive regulation of signaling 36.3636 4 no
GO:0042127 regulation of cell population proliferation 36.3636 4 no
GO:0009892 negative regulation of metabolic process 36.3636 4 yes
GO:0010605 negative regulation of macromolecule metabolic process 36.3636 5 yes
GO:0022607 cellular component assembly 36.3636 4 no
GO:0043066 negative regulation of apoptotic process 36.3636 6 no
GO:0010557 positive regulation of macromolecule biosynthetic process 34.0909 6 no
GO:0051252 regulation of RNA metabolic process 34.0909 5 no
GO:0009890 negative regulation of biosynthetic process 34.0909 5 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 34.0909 6 yes
GO:0031324 negative regulation of cellular metabolic process 34.0909 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 34.0909 6 yes
GO:0006355 regulation of DNA-templated transcription 31.8182 7 no
GO:0044087 regulation of cellular component biogenesis 31.8182 4 no
GO:0045595 regulation of cell differentiation 31.8182 4 no
GO:2001141 regulation of RNA biosynthetic process 31.8182 6 no
GO:0031399 regulation of protein modification process 31.8182 6 yes
GO:0051240 positive regulation of multicellular organismal process 31.8182 4 yes
GO:0071310 cellular response to organic substance 31.8182 4 yes
GO:0008104 protein localization 31.8182 4 no
GO:0033043 regulation of organelle organization 29.5455 5 no
GO:2000026 regulation of multicellular organismal development 29.5455 4 no
GO:0051049 regulation of transport 29.5455 4 yes
GO:0051129 negative regulation of cellular component organization 29.5455 5 yes
GO:0051130 positive regulation of cellular component organization 29.5455 5 yes
GO:0080134 regulation of response to stress 29.5455 4 yes
GO:0031344 regulation of cell projection organization 27.2727 5 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 no
GO:0002684 positive regulation of immune system process 27.2727 4 yes
GO:0010648 negative regulation of cell communication 27.2727 5 yes
GO:0023057 negative regulation of signaling 27.2727 4 yes
GO:0032101 regulation of response to external stimulus 27.2727 4 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 25.0000 5 no
GO:0008284 positive regulation of cell population proliferation 25.0000 5 no
GO:0030334 regulation of cell migration 25.0000 5 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:2000145 regulation of cell motility 25.0000 4 no
GO:0009968 negative regulation of signal transduction 25.0000 5 yes
GO:0010629 negative regulation of gene expression 25.0000 7 yes
GO:0048585 negative regulation of response to stimulus 25.0000 4 yes
GO:0051050 positive regulation of transport 25.0000 4 yes
GO:0071702 organic substance transport 22.7273 4 no
GO:0071705 nitrogen compound transport 22.7273 4 no
GO:0032880 regulation of protein localization 22.7273 5 no
GO:0060341 regulation of cellular localization 22.7273 4 no
GO:0030030 cell projection organization 22.7273 4 no
GO:0030335 positive regulation of cell migration 22.7273 6 no
GO:0040017 positive regulation of locomotion 22.7273 4 no
GO:0120036 plasma membrane bounded cell projection organization 22.7273 5 no
GO:0141124 intracellular signaling cassette 22.7273 4 no
GO:1902533 positive regulation of intracellular signal transduction 22.7273 6 no
GO:2000147 positive regulation of cell motility 22.7273 5 no
GO:0010628 positive regulation of gene expression 22.7273 7 no
GO:0051247 positive regulation of protein metabolic process 22.7273 6 no
GO:0007010 cytoskeleton organization 22.7273 5 no
GO:0019220 regulation of phosphate metabolic process 22.7273 6 yes
GO:0033993 response to lipid 22.7273 4 yes
GO:0051174 regulation of phosphorus metabolic process 22.7273 5 yes
GO:0051248 negative regulation of protein metabolic process 22.7273 6 yes
GO:1901701 cellular response to oxygen-containing compound 22.7273 4 yes
GO:0015031 protein transport 22.7273 4 no
GO:0036211 protein modification process 20.4545 4 no
GO:0043412 macromolecule modification 20.4545 4 no
GO:0051726 regulation of cell cycle 20.4545 4 no
GO:0006357 regulation of transcription by RNA polymerase II 20.4545 8 no
GO:0009894 regulation of catabolic process 20.4545 4 no
GO:0060284 regulation of cell development 20.4545 5 no
GO:0051093 negative regulation of developmental process 20.4545 4 no
GO:0001932 regulation of protein phosphorylation 20.4545 7 yes
GO:0030155 regulation of cell adhesion 20.4545 4 yes
GO:0034097 response to cytokine 20.4545 4 yes
GO:0042325 regulation of phosphorylation 20.4545 7 yes
GO:0071396 cellular response to lipid 20.4545 5 yes
GO:0006886 intracellular protein transport 20.4545 4 no
GO:0014070 response to organic cyclic compound 20.4545 4 no
GO:0001817 regulation of cytokine production 18.1818 4 yes
GO:0031347 regulation of defense response 18.1818 5 yes
GO:0043408 regulation of MAPK cascade 18.1818 6 yes
GO:0051241 negative regulation of multicellular organismal process 18.1818 4 yes
GO:0071345 cellular response to cytokine stimulus 18.1818 5 yes
GO:0045785 positive regulation of cell adhesion 15.9091 5 yes
GO:0050865 regulation of cell activation 15.9091 4 yes
GO:1902532 negative regulation of intracellular signal transduction 15.9091 6 yes
GO:0002694 regulation of leukocyte activation 13.6364 4 yes
GO:0022407 regulation of cell-cell adhesion 13.6364 5 yes
GO:0034599 cellular response to oxidative stress 13.6364 4 yes
GO:0050863 regulation of T cell activation 13.6364 6 yes
GO:0050867 positive regulation of cell activation 13.6364 5 yes
GO:0051249 regulation of lymphocyte activation 13.6364 5 yes
GO:0062197 cellular response to chemical stress 13.6364 4 yes
GO:0000302 response to reactive oxygen species 11.3636 4 yes
GO:0002696 positive regulation of leukocyte activation 11.3636 5 yes
GO:0022409 positive regulation of cell-cell adhesion 11.3636 6 yes
GO:0031400 negative regulation of protein modification process 11.3636 7 yes
GO:0045428 regulation of nitric oxide biosynthetic process 11.3636 5 yes
GO:0050870 positive regulation of T cell activation 11.3636 7 yes
GO:0051251 positive regulation of lymphocyte activation 11.3636 6 yes
GO:0070372 regulation of ERK1 and ERK2 cascade 11.3636 7 yes
GO:0080164 regulation of nitric oxide metabolic process 11.3636 4 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 11.3636 6 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 11.3636 7 yes
GO:0002237 response to molecule of bacterial origin 9.0909 4 yes
GO:0032479 regulation of type I interferon production 9.0909 5 yes
GO:0032496 response to lipopolysaccharide 9.0909 4 yes
GO:0032649 regulation of type II interferon production 9.0909 5 yes
GO:0032680 regulation of tumor necrosis factor production 9.0909 6 yes
GO:0034341 response to type II interferon 9.0909 5 yes
GO:0034614 cellular response to reactive oxygen species 9.0909 5 yes
GO:0042542 response to hydrogen peroxide 9.0909 4 yes
GO:0046328 regulation of JNK cascade 9.0909 7 yes
GO:0051051 negative regulation of transport 9.0909 4 yes
GO:0071219 cellular response to molecule of bacterial origin 9.0909 4 yes
GO:0071222 cellular response to lipopolysaccharide 9.0909 5 yes
GO:0071346 cellular response to type II interferon 9.0909 6 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 9.0909 5 yes
GO:0001818 negative regulation of cytokine production 6.8182 5 yes
GO:0001933 negative regulation of protein phosphorylation 6.8182 8 yes
GO:0010563 negative regulation of phosphorus metabolic process 6.8182 6 yes
GO:0030100 regulation of endocytosis 6.8182 5 yes
GO:0032480 negative regulation of type I interferon production 6.8182 6 yes
GO:0032648 regulation of interferon-beta production 6.8182 6 yes
GO:0032651 regulation of interleukin-1 beta production 6.8182 6 yes
GO:0032652 regulation of interleukin-1 production 6.8182 5 yes
GO:0032675 regulation of interleukin-6 production 6.8182 5 yes
GO:0042326 negative regulation of phosphorylation 6.8182 8 yes
GO:0043409 negative regulation of MAPK cascade 6.8182 7 yes
GO:0045807 positive regulation of endocytosis 6.8182 5 yes
GO:0045936 negative regulation of phosphate metabolic process 6.8182 7 yes
GO:0050727 regulation of inflammatory response 6.8182 5 yes
GO:0050764 regulation of phagocytosis 6.8182 6 yes
GO:0050766 positive regulation of phagocytosis 6.8182 6 yes
GO:0060627 regulation of vesicle-mediated transport 6.8182 4 yes
GO:0070301 cellular response to hydrogen peroxide 6.8182 5 yes
GO:0070671 response to interleukin-12 6.8182 5 yes
GO:1903719 regulation of I-kappaB phosphorylation 6.8182 8 yes
GO:0031348 negative regulation of defense response 4.5455 5 yes
GO:0032102 negative regulation of response to external stimulus 4.5455 5 yes
GO:0032642 regulation of chemokine production 4.5455 5 yes
GO:0032682 negative regulation of chemokine production 4.5455 6 yes
GO:0032688 negative regulation of interferon-beta production 4.5455 7 yes
GO:0032715 negative regulation of interleukin-6 production 4.5455 6 yes
GO:0032720 negative regulation of tumor necrosis factor production 4.5455 7 yes
GO:0035696 monocyte extravasation 4.5455 4 yes
GO:0045019 negative regulation of nitric oxide biosynthetic process 4.5455 6 yes
GO:0045806 negative regulation of endocytosis 4.5455 5 yes
GO:0046329 negative regulation of JNK cascade 4.5455 8 yes
GO:0050728 negative regulation of inflammatory response 4.5455 6 yes
GO:0050765 negative regulation of phagocytosis 4.5455 6 yes
GO:0070373 negative regulation of ERK1 and ERK2 cascade 4.5455 8 yes
GO:0070555 response to interleukin-1 4.5455 5 yes
GO:0071347 cellular response to interleukin-1 4.5455 6 yes
GO:0071349 cellular response to interleukin-12 4.5455 6 yes
GO:0071640 regulation of macrophage inflammatory protein 1 alpha production 4.5455 6 yes
GO:0071641 negative regulation of macrophage inflammatory protein 1 alpha production 4.5455 7 yes
GO:0071649 regulation of chemokine (C-C motif) ligand 5 production 4.5455 6 yes
GO:0071650 negative regulation of chemokine (C-C motif) ligand 5 production 4.5455 7 yes
GO:1900015 regulation of cytokine production involved in inflammatory response 4.5455 5 yes
GO:1900016 negative regulation of cytokine production involved in inflammatory response 4.5455 6 yes
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production 4.5455 6 yes
GO:1903720 negative regulation of I-kappaB phosphorylation 4.5455 9 yes
GO:1904406 negative regulation of nitric oxide metabolic process 4.5455 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
PTN6_HUMAN [view interactions] Low throughput no no
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
NPHN_HUMAN [view interactions] Low throughput no no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
CD47_HUMAN [view interactions] Low throughput no no
MATK_HUMAN [view interactions] Low throughput no yes
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
NR0B2_HUMAN [view interactions] Low throughput no no
FBX2_HUMAN [view entry] [view interactions] Low throughput yes yes
SKP1_HUMAN [view interactions] Low throughput no yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
GHR_HUMAN [view interactions] Low throughput no yes
SHPS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CSF1_HUMAN [view interactions] High throughput no no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
SHIP1_HUMAN [view interactions] High throughput no no
HOME1_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
NOL3_HUMAN [view interactions] High throughput no yes
TRIM2_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
K1C15_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
TRI27_HUMAN [view interactions] High throughput no yes
K1C40_HUMAN [view interactions] High throughput no no
CCD57_HUMAN [view interactions] High throughput no yes
TRI23_HUMAN [view interactions] High throughput no yes
KRT34_HUMAN [view interactions] High throughput no no
DYLT1_HUMAN [view interactions] High throughput no no
HSF2B_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
SIRPG_HUMAN [view interactions] High throughput no no
RNF4_HUMAN [view interactions] High throughput no yes
BIP_HUMAN [view entry] [view interactions] High throughput yes yes
TCPZ_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
CALR_HUMAN [view entry] [view interactions] High throughput yes yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
ENPL_HUMAN [view entry] [view interactions] High throughput yes yes
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
SPT6H_HUMAN [view interactions] High throughput no yes
DDX6_HUMAN [view entry] [view interactions] High throughput yes yes
STAT1_HUMAN [view entry] [view interactions] High throughput yes no
ILK_HUMAN [view interactions] High throughput no no
PTPRA_HUMAN [view interactions] High throughput no yes
AKT1_HUMAN [view entry] [view interactions] High throughput yes yes
KTN1_HUMAN [view entry] [view interactions] High throughput yes yes
VIME_HUMAN [view entry] [view interactions] High throughput yes no
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
NOX4_HUMAN [view interactions] High throughput no no
TCTP_HUMAN [view entry] [view interactions] High throughput yes yes
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
SOS1_HUMAN [view entry] [view interactions] High throughput yes yes
DX39A_HUMAN [view interactions] High throughput no yes
SH21B_HUMAN [view interactions] High throughput no no
ERGI2_HUMAN [view interactions] High throughput no yes
F1142_HUMAN [view interactions] High throughput no yes
CLC4A_HUMAN [view interactions] High throughput no no
TRI67_HUMAN [view interactions] High throughput no no
ADA10_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
IF2P_HUMAN [view interactions] High throughput no yes
RS8_HUMAN [view entry] [view interactions] High throughput yes no
ELOA1_HUMAN [view interactions] High throughput no yes
FUBP1_HUMAN [view interactions] High throughput no yes
SAFB2_HUMAN [view interactions] High throughput no yes
DDX10_HUMAN [view interactions] High throughput no yes
TBX3_HUMAN [view interactions] High throughput no no
NEK1_HUMAN [view interactions] High throughput no yes
CDK16_HUMAN [view interactions] High throughput no yes
PTN7_HUMAN [view interactions] High throughput no no
PPM1B_HUMAN [view interactions] High throughput no yes
ARF4_HUMAN [view entry] [view interactions] High throughput yes no
GNL1_HUMAN [view entry] [view interactions] High throughput yes yes
MX1_HUMAN [view interactions] High throughput no yes
ACTN1_HUMAN [view entry] [view interactions] High throughput yes yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PROF1_HUMAN [view entry] [view interactions] High throughput yes yes
K22E_HUMAN [view interactions] High throughput no no
K1C10_HUMAN [view interactions] High throughput no no
NEXN_HUMAN [view interactions] High throughput no yes
NU1M_HUMAN [view interactions] High throughput no yes
PAHX_HUMAN [view interactions] High throughput no yes
NUCB1_HUMAN [view interactions] High throughput no yes
CO6A2_HUMAN [view interactions] High throughput no no
CD81_HUMAN [view interactions] High throughput no no
ARHG6_HUMAN [view interactions] High throughput no no
PSA6_HUMAN [view interactions] High throughput no yes
PRS8_HUMAN [view interactions] High throughput no yes
SMG7_HUMAN [view interactions] High throughput no no
HSP74_HUMAN [view entry] [view interactions] High throughput yes yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
STING_HUMAN [view interactions] High throughput no yes
MUC18_HUMAN [view interactions] High throughput no yes
SSR3_HUMAN [view interactions] High throughput no yes