Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

JAK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of Tyr-41 of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed). [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

Position Amino acid Mutation Disease Overlap with binding region
607 Lys Asn Leukemia,acutemyelogenous(AML) -
617 Val Phe Leukemia,acutemyelogenous(AML) -
617 Val Phe Polycythemiavera(PV) -
617 Val Phe Thrombocythemia3(THCYT3) -
617 Val Ile Thrombocythemia3(THCYT3) -

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in JAK2_HUMAN
GO:0019900 kinase binding 46.1538 4 yes
GO:0019901 protein kinase binding 44.2308 5 yes
GO:0000166 nucleotide binding 42.3077 4 yes
GO:0043168 anion binding 42.3077 4 yes
GO:0005524 ATP binding 40.3846 5 yes
GO:0017076 purine nucleotide binding 40.3846 5 yes
GO:0030554 adenyl nucleotide binding 40.3846 6 yes
GO:0032555 purine ribonucleotide binding 40.3846 4 yes
GO:0032559 adenyl ribonucleotide binding 40.3846 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 40.3846 4 yes
GO:0043169 cation binding 34.6154 4 yes
GO:0003723 RNA binding 34.6154 4 no
GO:0046872 metal ion binding 32.6923 5 yes
GO:0016301 kinase activity 30.7692 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 30.7692 4 yes
GO:0004713 protein tyrosine kinase activity 25.0000 4 yes
GO:0044389 ubiquitin-like protein ligase binding 25.0000 4 no
GO:0031625 ubiquitin protein ligase binding 23.0769 5 no
GO:0004715 non-membrane spanning protein tyrosine kinase activity 17.3077 5 yes
GO:0005126 cytokine receptor binding 15.3846 4 yes
GO:0042169 SH2 domain binding 11.5385 4 yes
GO:0070851 growth factor receptor binding 11.5385 4 yes
GO:0001664 G protein-coupled receptor binding 9.6154 4 yes
GO:0020037 heme binding 5.7692 4 yes
GO:0035173 histone kinase activity 5.7692 4 yes
GO:0051427 hormone receptor binding 5.7692 4 yes
GO:0051428 peptide hormone receptor binding 5.7692 5 yes
GO:0140996 histone H3 kinase activity 5.7692 5 yes
GO:0005131 growth hormone receptor binding 3.8462 5 yes
GO:0005143 interleukin-12 receptor binding 3.8462 5 yes
GO:0031701 angiotensin receptor binding 3.8462 5 yes
GO:0031702 type 1 angiotensin receptor binding 3.8462 6 yes
GO:0033130 acetylcholine receptor binding 3.8462 4 yes
GO:0035401 histone H3Y41 kinase activity 3.8462 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in JAK2_HUMAN
GO:0031323 regulation of cellular metabolic process 82.6923 4 yes
GO:0048522 positive regulation of cellular process 82.6923 4 yes
GO:0060255 regulation of macromolecule metabolic process 82.6923 4 yes
GO:0080090 regulation of primary metabolic process 80.7692 4 yes
GO:0048523 negative regulation of cellular process 75.0000 4 yes
GO:0010646 regulation of cell communication 73.0769 4 yes
GO:0009966 regulation of signal transduction 71.1538 4 yes
GO:0009893 positive regulation of metabolic process 69.2308 4 yes
GO:0009889 regulation of biosynthetic process 67.3077 4 yes
GO:0010604 positive regulation of macromolecule metabolic process 65.3846 5 yes
GO:0031325 positive regulation of cellular metabolic process 65.3846 5 yes
GO:0031326 regulation of cellular biosynthetic process 65.3846 5 yes
GO:0048584 positive regulation of response to stimulus 63.4615 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 61.5385 5 yes
GO:1902531 regulation of intracellular signal transduction 61.5385 5 yes
GO:0051246 regulation of protein metabolic process 59.6154 5 yes
GO:0036211 protein modification process 57.6923 4 yes
GO:0043412 macromolecule modification 57.6923 4 yes
GO:0010468 regulation of gene expression 55.7692 6 yes
GO:0019220 regulation of phosphate metabolic process 55.7692 6 yes
GO:0031399 regulation of protein modification process 55.7692 6 yes
GO:0051174 regulation of phosphorus metabolic process 55.7692 5 yes
GO:0009967 positive regulation of signal transduction 53.8462 5 yes
GO:0010647 positive regulation of cell communication 53.8462 5 yes
GO:0023056 positive regulation of signaling 53.8462 4 yes
GO:0009892 negative regulation of metabolic process 53.8462 4 no
GO:0042981 regulation of apoptotic process 53.8462 5 yes
GO:0043067 regulation of programmed cell death 53.8462 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 51.9231 5 yes
GO:0010605 negative regulation of macromolecule metabolic process 51.9231 5 no
GO:0051240 positive regulation of multicellular organismal process 51.9231 4 yes
GO:0042325 regulation of phosphorylation 50.0000 7 yes
GO:0051247 positive regulation of protein metabolic process 50.0000 6 yes
GO:0031401 positive regulation of protein modification process 48.0769 7 yes
GO:0031324 negative regulation of cellular metabolic process 48.0769 5 no
GO:0001932 regulation of protein phosphorylation 48.0769 7 yes
GO:0006796 phosphate-containing compound metabolic process 46.1538 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 46.1538 6 yes
GO:0042127 regulation of cell population proliferation 46.1538 4 yes
GO:0045937 positive regulation of phosphate metabolic process 46.1538 7 yes
GO:0051049 regulation of transport 46.1538 4 yes
GO:0080134 regulation of response to stress 44.2308 4 yes
GO:0009891 positive regulation of biosynthetic process 44.2308 5 yes
GO:0042327 positive regulation of phosphorylation 44.2308 8 yes
GO:0043085 positive regulation of catalytic activity 44.2308 4 yes
GO:0045595 regulation of cell differentiation 44.2308 4 yes
GO:1902533 positive regulation of intracellular signal transduction 42.3077 6 yes
GO:0031328 positive regulation of cellular biosynthetic process 42.3077 6 yes
GO:0032101 regulation of response to external stimulus 42.3077 4 yes
GO:0001934 positive regulation of protein phosphorylation 42.3077 8 yes
GO:0007167 enzyme-linked receptor protein signaling pathway 40.3846 4 yes
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway 40.3846 5 yes
GO:0051128 regulation of cellular component organization 40.3846 4 no
GO:0141124 intracellular signaling cassette 40.3846 4 no
GO:0043408 regulation of MAPK cascade 40.3846 6 yes
GO:0071310 cellular response to organic substance 38.4615 4 yes
GO:0008284 positive regulation of cell population proliferation 38.4615 5 yes
GO:0010557 positive regulation of macromolecule biosynthetic process 38.4615 6 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 38.4615 5 yes
GO:0051094 positive regulation of developmental process 38.4615 4 yes
GO:0051252 regulation of RNA metabolic process 38.4615 5 yes
GO:0048585 negative regulation of response to stimulus 36.5385 4 no
GO:0006355 regulation of DNA-templated transcription 34.6154 7 yes
GO:0022607 cellular component assembly 34.6154 4 yes
GO:2001141 regulation of RNA biosynthetic process 34.6154 6 yes
GO:0010648 negative regulation of cell communication 34.6154 5 no
GO:0023057 negative regulation of signaling 34.6154 4 no
GO:0043066 negative regulation of apoptotic process 34.6154 6 yes
GO:0043069 negative regulation of programmed cell death 34.6154 5 yes
GO:0043549 regulation of kinase activity 34.6154 5 yes
GO:0045859 regulation of protein kinase activity 34.6154 6 yes
GO:0051338 regulation of transferase activity 34.6154 4 yes
GO:0016310 phosphorylation 32.6923 5 yes
GO:0031347 regulation of defense response 32.6923 5 yes
GO:0051248 negative regulation of protein metabolic process 32.6923 6 no
GO:0009890 negative regulation of biosynthetic process 32.6923 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 32.6923 6 no
GO:0031327 negative regulation of cellular biosynthetic process 32.6923 6 no
GO:0006996 organelle organization 32.6923 4 no
GO:0043410 positive regulation of MAPK cascade 32.6923 7 yes
GO:0051336 regulation of hydrolase activity 32.6923 4 yes
GO:0002684 positive regulation of immune system process 32.6923 4 yes
GO:0010243 response to organonitrogen compound 30.7692 4 yes
GO:0009894 regulation of catabolic process 30.7692 4 no
GO:0050776 regulation of immune response 30.7692 4 yes
GO:0060341 regulation of cellular localization 30.7692 4 yes
GO:0006468 protein phosphorylation 28.8462 5 yes
GO:0009059 macromolecule biosynthetic process 28.8462 4 yes
GO:1901701 cellular response to oxygen-containing compound 28.8462 4 yes
GO:0018193 peptidyl-amino acid modification 28.8462 5 yes
GO:0030155 regulation of cell adhesion 28.8462 4 yes
GO:0009968 negative regulation of signal transduction 28.8462 5 no
GO:2000026 regulation of multicellular organismal development 28.8462 4 no
GO:0032880 regulation of protein localization 28.8462 5 yes
GO:0033674 positive regulation of kinase activity 28.8462 6 yes
GO:0043933 protein-containing complex organization 28.8462 4 yes
GO:0045597 positive regulation of cell differentiation 28.8462 5 yes
GO:0045860 positive regulation of protein kinase activity 28.8462 7 yes
GO:0051050 positive regulation of transport 28.8462 4 yes
GO:0051347 positive regulation of transferase activity 28.8462 5 yes
GO:0010628 positive regulation of gene expression 26.9231 7 yes
GO:0030162 regulation of proteolysis 26.9231 6 yes
GO:0051345 positive regulation of hydrolase activity 26.9231 5 yes
GO:0001817 regulation of cytokine production 26.9231 4 yes
GO:0090304 nucleic acid metabolic process 25.0000 4 yes
GO:0022407 regulation of cell-cell adhesion 25.0000 5 yes
GO:2000145 regulation of cell motility 25.0000 4 yes
GO:0010563 negative regulation of phosphorus metabolic process 25.0000 6 no
GO:0031400 negative regulation of protein modification process 25.0000 7 no
GO:0034762 regulation of transmembrane transport 25.0000 4 no
GO:0045936 negative regulation of phosphate metabolic process 25.0000 7 no
GO:0044087 regulation of cellular component biogenesis 25.0000 4 no
GO:0033993 response to lipid 25.0000 4 yes
GO:0034097 response to cytokine 25.0000 4 yes
GO:0043687 post-translational protein modification 25.0000 5 yes
GO:0045785 positive regulation of cell adhesion 25.0000 5 yes
GO:0051254 positive regulation of RNA metabolic process 25.0000 6 yes
GO:0065003 protein-containing complex assembly 23.0769 5 yes
GO:0070201 regulation of establishment of protein localization 23.0769 6 yes
GO:0071396 cellular response to lipid 23.0769 5 yes
GO:0030334 regulation of cell migration 23.0769 5 yes
GO:0030335 positive regulation of cell migration 23.0769 6 yes
GO:2000147 positive regulation of cell motility 23.0769 5 yes
GO:0002831 regulation of response to biotic stimulus 23.0769 4 no
GO:0051130 positive regulation of cellular component organization 23.0769 5 no
GO:0008104 protein localization 23.0769 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.0769 4 no
GO:0051726 regulation of cell cycle 23.0769 4 no
GO:0044057 regulation of system process 23.0769 4 no
GO:0040017 positive regulation of locomotion 23.0769 4 yes
GO:0050778 positive regulation of immune response 23.0769 5 yes
GO:0050865 regulation of cell activation 23.0769 4 yes
GO:0008285 negative regulation of cell population proliferation 21.1538 5 yes
GO:0014070 response to organic cyclic compound 21.1538 4 yes
GO:1902680 positive regulation of RNA biosynthetic process 21.1538 7 yes
GO:0018108 peptidyl-tyrosine phosphorylation 21.1538 6 yes
GO:0018212 peptidyl-tyrosine modification 21.1538 6 yes
GO:1903037 regulation of leukocyte cell-cell adhesion 21.1538 6 yes
GO:0019221 cytokine-mediated signaling pathway 21.1538 4 yes
GO:0030030 cell projection organization 21.1538 4 yes
GO:0032103 positive regulation of response to external stimulus 21.1538 5 no
GO:0060284 regulation of cell development 21.1538 5 no
GO:0070372 regulation of ERK1 and ERK2 cascade 21.1538 7 no
GO:1902532 negative regulation of intracellular signal transduction 21.1538 6 no
GO:0010629 negative regulation of gene expression 21.1538 7 no
GO:0009057 macromolecule catabolic process 21.1538 4 no
GO:0051051 negative regulation of transport 21.1538 4 no
GO:0045862 positive regulation of proteolysis 21.1538 7 yes
GO:0045893 positive regulation of DNA-templated transcription 21.1538 8 yes
GO:0050863 regulation of T cell activation 21.1538 6 yes
GO:0051249 regulation of lymphocyte activation 21.1538 5 yes
GO:0002694 regulation of leukocyte activation 21.1538 4 yes
GO:0002696 positive regulation of leukocyte activation 19.2308 5 yes
GO:0006357 regulation of transcription by RNA polymerase II 19.2308 8 yes
GO:0120036 plasma membrane bounded cell projection organization 19.2308 5 yes
GO:0141187 nucleic acid biosynthetic process 19.2308 5 yes
GO:1901362 organic cyclic compound biosynthetic process 19.2308 4 yes
GO:1903039 positive regulation of leukocyte cell-cell adhesion 19.2308 7 yes
GO:0022409 positive regulation of cell-cell adhesion 19.2308 6 yes
GO:1903829 positive regulation of protein localization 19.2308 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 19.2308 4 yes
GO:0046777 protein autophosphorylation 19.2308 6 yes
GO:0050730 regulation of peptidyl-tyrosine phosphorylation 19.2308 8 yes
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 19.2308 9 yes
GO:0050867 positive regulation of cell activation 19.2308 5 yes
GO:0050870 positive regulation of T cell activation 19.2308 7 yes
GO:0051223 regulation of protein transport 19.2308 5 yes
GO:0051251 positive regulation of lymphocyte activation 19.2308 6 yes
GO:0052547 regulation of peptidase activity 19.2308 5 yes
GO:0001819 positive regulation of cytokine production 19.2308 5 yes
GO:0052548 regulation of endopeptidase activity 19.2308 6 yes
GO:0071345 cellular response to cytokine stimulus 17.3077 5 yes
GO:0140546 defense response to symbiont 17.3077 4 yes
GO:2001233 regulation of apoptotic signaling pathway 17.3077 5 yes
GO:0032870 cellular response to hormone stimulus 17.3077 4 yes
GO:0050727 regulation of inflammatory response 17.3077 5 yes
GO:0051046 regulation of secretion 17.3077 5 yes
GO:0006915 apoptotic process 15.3846 4 yes
GO:0010950 positive regulation of endopeptidase activity 15.3846 7 yes
GO:0010952 positive regulation of peptidase activity 15.3846 6 yes
GO:1903530 regulation of secretion by cell 15.3846 4 yes
GO:1904951 positive regulation of establishment of protein localization 15.3846 6 yes
GO:0031175 neuron projection development 15.3846 6 yes
GO:0032386 regulation of intracellular transport 15.3846 5 yes
GO:0043065 positive regulation of apoptotic process 15.3846 6 yes
GO:0043068 positive regulation of programmed cell death 15.3846 5 yes
GO:0045944 positive regulation of transcription by RNA polymerase II 15.3846 9 yes
GO:0051896 regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 15.3846 6 yes
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 15.3846 7 yes
GO:0070663 regulation of leukocyte proliferation 13.4615 5 yes
GO:0071407 cellular response to organic cyclic compound 13.4615 5 yes
GO:0080164 regulation of nitric oxide metabolic process 13.4615 4 yes
GO:0097435 supramolecular fiber organization 13.4615 4 yes
GO:0099177 regulation of trans-synaptic signaling 13.4615 4 yes
GO:0016070 RNA metabolic process 13.4615 5 yes
GO:2000116 regulation of cysteine-type endopeptidase activity 13.4615 7 yes
GO:0045428 regulation of nitric oxide biosynthetic process 13.4615 5 yes
GO:0050804 modulation of chemical synaptic transmission 13.4615 5 yes
GO:0060396 growth hormone receptor signaling pathway 11.5385 6 yes
GO:0070665 positive regulation of leukocyte proliferation 11.5385 6 yes
GO:0007162 negative regulation of cell adhesion 11.5385 5 yes
GO:0010810 regulation of cell-substrate adhesion 11.5385 5 yes
GO:0032774 RNA biosynthetic process 11.5385 5 yes
GO:0032944 regulation of mononuclear cell proliferation 11.5385 6 yes
GO:0033157 regulation of intracellular protein transport 11.5385 6 yes
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 11.5385 8 yes
GO:0046822 regulation of nucleocytoplasmic transport 11.5385 6 yes
GO:0050670 regulation of lymphocyte proliferation 11.5385 6 yes
GO:0051047 positive regulation of secretion 11.5385 5 yes
GO:0051222 positive regulation of protein transport 11.5385 5 yes
GO:0060397 growth hormone receptor signaling pathway via JAK-STAT 9.6154 7 yes
GO:0071219 cellular response to molecule of bacterial origin 9.6154 4 yes
GO:0071222 cellular response to lipopolysaccharide 9.6154 5 yes
GO:0071383 cellular response to steroid hormone stimulus 9.6154 5 yes
GO:0010656 negative regulation of muscle cell apoptotic process 9.6154 7 yes
GO:0010660 regulation of muscle cell apoptotic process 9.6154 6 yes
GO:1900180 regulation of protein localization to nucleus 9.6154 6 yes
GO:1900182 positive regulation of protein localization to nucleus 9.6154 6 yes
GO:1901654 response to ketone 9.6154 4 yes
GO:1901655 cellular response to ketone 9.6154 5 yes
GO:1903532 positive regulation of secretion by cell 9.6154 5 yes
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production 9.6154 5 yes
GO:1904407 positive regulation of nitric oxide metabolic process 9.6154 5 yes
GO:0030099 myeloid cell differentiation 9.6154 4 yes
GO:2001056 positive regulation of cysteine-type endopeptidase activity 9.6154 8 yes
GO:0032147 activation of protein kinase activity 9.6154 8 yes
GO:0032496 response to lipopolysaccharide 9.6154 4 yes
GO:0032680 regulation of tumor necrosis factor production 9.6154 6 yes
GO:0033209 tumor necrosis factor-mediated signaling pathway 9.6154 5 yes
GO:0042129 regulation of T cell proliferation 9.6154 7 yes
GO:0043523 regulation of neuron apoptotic process 9.6154 6 yes
GO:0045429 positive regulation of nitric oxide biosynthetic process 9.6154 6 yes
GO:0046883 regulation of hormone secretion 9.6154 4 yes
GO:0048008 platelet-derived growth factor receptor signaling pathway 9.6154 6 yes
GO:0048545 response to steroid hormone 9.6154 4 yes
GO:0048660 regulation of smooth muscle cell proliferation 9.6154 5 yes
GO:0048661 positive regulation of smooth muscle cell proliferation 9.6154 6 yes
GO:0050708 regulation of protein secretion 9.6154 5 yes
GO:0002237 response to molecule of bacterial origin 9.6154 4 yes
GO:0002791 regulation of peptide secretion 7.6923 6 yes
GO:0060429 epithelium development 7.6923 4 yes
GO:0006351 DNA-templated transcription 7.6923 6 yes
GO:0070102 interleukin-6-mediated signaling pathway 7.6923 5 yes
GO:0006366 transcription by RNA polymerase II 7.6923 7 yes
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 7.6923 10 yes
GO:0007015 actin filament organization 7.6923 5 yes
GO:0007259 cell surface receptor signaling pathway via JAK-STAT 7.6923 5 yes
GO:0090087 regulation of peptide transport 7.6923 5 yes
GO:0090276 regulation of peptide hormone secretion 7.6923 5 yes
GO:0010543 regulation of platelet activation 7.6923 5 yes
GO:0090316 positive regulation of intracellular protein transport 7.6923 6 yes
GO:0090330 regulation of platelet aggregation 7.6923 6 yes
GO:0097696 cell surface receptor signaling pathway via STAT 7.6923 4 yes
GO:0120161 regulation of cold-induced thermogenesis 7.6923 4 yes
GO:0120162 positive regulation of cold-induced thermogenesis 7.6923 5 yes
GO:0140888 interferon-mediated signaling pathway 7.6923 5 yes
GO:0022408 negative regulation of cell-cell adhesion 7.6923 6 yes
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production 7.6923 6 yes
GO:1904035 regulation of epithelial cell apoptotic process 7.6923 6 yes
GO:0030097 hemopoiesis 7.6923 4 yes
GO:1904892 regulation of receptor signaling pathway via STAT 7.6923 5 yes
GO:0031960 response to corticosteroid 7.6923 5 yes
GO:0032388 positive regulation of intracellular transport 7.6923 5 yes
GO:0032651 regulation of interleukin-1 beta production 7.6923 6 yes
GO:0032652 regulation of interleukin-1 production 7.6923 5 yes
GO:0032760 positive regulation of tumor necrosis factor production 7.6923 7 yes
GO:0032946 positive regulation of mononuclear cell proliferation 7.6923 7 yes
GO:0034110 regulation of homotypic cell-cell adhesion 7.6923 6 yes
GO:0042102 positive regulation of T cell proliferation 7.6923 8 yes
GO:0042509 regulation of tyrosine phosphorylation of STAT protein 7.6923 9 yes
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein 7.6923 10 yes
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 7.6923 9 yes
GO:0046425 regulation of receptor signaling pathway via JAK-STAT 7.6923 6 yes
GO:0046824 positive regulation of nucleocytoplasmic transport 7.6923 6 yes
GO:0046887 positive regulation of hormone secretion 7.6923 5 yes
GO:0050671 positive regulation of lymphocyte proliferation 7.6923 7 yes
GO:0050796 regulation of insulin secretion 7.6923 6 yes
GO:0060333 type II interferon-mediated signaling pathway 7.6923 6 yes
GO:0002819 regulation of adaptive immune response 5.7692 5 yes
GO:0002821 positive regulation of adaptive immune response 5.7692 6 yes
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5.7692 6 yes
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 5.7692 7 yes
GO:0070671 response to interleukin-12 5.7692 5 yes
GO:0071384 cellular response to corticosteroid stimulus 5.7692 6 yes
GO:0071385 cellular response to glucocorticoid stimulus 5.7692 7 yes
GO:0007498 mesoderm development 5.7692 4 yes
GO:0071548 response to dexamethasone 5.7692 5 yes
GO:0071549 cellular response to dexamethasone stimulus 5.7692 6 yes
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.7692 5 yes
GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.7692 6 yes
GO:0097191 extrinsic apoptotic signaling pathway 5.7692 4 yes
GO:0098586 cellular response to virus 5.7692 4 yes
GO:0010662 regulation of striated muscle cell apoptotic process 5.7692 7 yes
GO:0010664 negative regulation of striated muscle cell apoptotic process 5.7692 8 yes
GO:0010665 regulation of cardiac muscle cell apoptotic process 5.7692 8 yes
GO:0010667 negative regulation of cardiac muscle cell apoptotic process 5.7692 9 yes
GO:0141193 nuclear receptor signaling pathway 5.7692 4 yes
GO:0010811 positive regulation of cell-substrate adhesion 5.7692 6 yes
GO:1904037 positive regulation of epithelial cell apoptotic process 5.7692 7 yes
GO:1904705 regulation of vascular associated smooth muscle cell proliferation 5.7692 6 yes
GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation 5.7692 7 yes
GO:1904894 positive regulation of receptor signaling pathway via STAT 5.7692 6 yes
GO:0030218 erythrocyte differentiation 5.7692 5 yes
GO:0030518 intracellular steroid hormone receptor signaling pathway 5.7692 5 yes
GO:2001235 positive regulation of apoptotic signaling pathway 5.7692 6 yes
GO:0032649 regulation of type II interferon production 5.7692 5 yes
GO:0032731 positive regulation of interleukin-1 beta production 5.7692 7 yes
GO:0032732 positive regulation of interleukin-1 production 5.7692 6 yes
GO:0038043 interleukin-5-mediated signaling pathway 5.7692 5 yes
GO:0042306 regulation of protein import into nucleus 5.7692 7 yes
GO:0042307 positive regulation of protein import into nucleus 5.7692 7 yes
GO:0042976 activation of Janus kinase activity 5.7692 7 yes
GO:0043401 steroid hormone mediated signaling pathway 5.7692 4 yes
GO:0043524 negative regulation of neuron apoptotic process 5.7692 7 yes
GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT 5.7692 7 yes
GO:0048678 response to axon injury 5.7692 4 yes
GO:0050714 positive regulation of protein secretion 5.7692 6 yes
GO:0051101 regulation of DNA binding 5.7692 4 yes
GO:0051384 response to glucocorticoid 5.7692 6 yes
GO:0051769 regulation of nitric-oxide synthase biosynthetic process 5.7692 6 yes
GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process 5.7692 7 yes
GO:0002793 positive regulation of peptide secretion 3.8462 6 yes
GO:0060398 regulation of growth hormone receptor signaling pathway 3.8462 5 yes
GO:0060399 positive regulation of growth hormone receptor signaling pathway 3.8462 6 yes
GO:0061180 mammary gland epithelium development 3.8462 5 yes
GO:0061564 axon development 3.8462 7 yes
GO:0070757 interleukin-35-mediated signaling pathway 3.8462 5 yes
GO:0007260 tyrosine phosphorylation of STAT protein 3.8462 7 yes
GO:0008154 actin polymerization or depolymerization 3.8462 6 yes
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress 3.8462 5 yes
GO:0090277 positive regulation of peptide hormone secretion 3.8462 6 yes
GO:0097193 intrinsic apoptotic signaling pathway 3.8462 4 yes
GO:0010572 positive regulation of platelet activation 3.8462 6 yes
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3.8462 11 yes
GO:0014075 response to amine 3.8462 5 yes
GO:0014842 regulation of skeletal muscle satellite cell proliferation 3.8462 6 yes
GO:0014857 regulation of skeletal muscle cell proliferation 3.8462 5 yes
GO:1901731 positive regulation of platelet aggregation 3.8462 7 yes
GO:0014858 positive regulation of skeletal muscle cell proliferation 3.8462 6 yes
GO:1902724 positive regulation of skeletal muscle satellite cell proliferation 3.8462 7 yes
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation 3.8462 8 yes
GO:0030041 actin filament polymerization 3.8462 7 yes
GO:1905539 regulation of postsynapse to nucleus signaling pathway 3.8462 5 yes
GO:0031102 neuron projection regeneration 3.8462 4 yes
GO:2000273 positive regulation of signaling receptor activity 3.8462 4 yes
GO:0031103 axon regeneration 3.8462 5 yes
GO:2000316 regulation of T-helper 17 type immune response 3.8462 7 yes
GO:2000318 positive regulation of T-helper 17 type immune response 3.8462 8 yes
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3.8462 9 yes
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway 3.8462 10 yes
GO:0031958 intracellular corticosteroid receptor signaling pathway 3.8462 6 yes
GO:0031959 intracellular mineralocorticoid receptor signaling pathway 3.8462 7 yes
GO:0032024 positive regulation of insulin secretion 3.8462 7 yes
GO:0032660 regulation of interleukin-17 production 3.8462 5 yes
GO:0032729 positive regulation of type II interferon production 3.8462 6 yes
GO:0032740 positive regulation of interleukin-17 production 3.8462 6 yes
GO:0032814 regulation of natural killer cell activation 3.8462 6 yes
GO:0032816 positive regulation of natural killer cell activation 3.8462 7 yes
GO:0032817 regulation of natural killer cell proliferation 3.8462 7 yes
GO:0032819 positive regulation of natural killer cell proliferation 3.8462 8 yes
GO:0033194 response to hydroperoxide 3.8462 4 yes
GO:0034050 symbiont-induced defense-related programmed cell death 3.8462 4 yes
GO:0034112 positive regulation of homotypic cell-cell adhesion 3.8462 7 yes
GO:0034612 response to tumor necrosis factor 3.8462 5 yes
GO:0035166 post-embryonic hemopoiesis 3.8462 5 yes
GO:0035722 interleukin-12-mediated signaling pathway 3.8462 5 yes
GO:0036015 response to interleukin-3 3.8462 5 yes
GO:0036016 cellular response to interleukin-3 3.8462 6 yes
GO:0038065 collagen-activated signaling pathway 3.8462 4 yes
GO:0038156 interleukin-3-mediated signaling pathway 3.8462 5 yes
GO:0038157 granulocyte-macrophage colony-stimulating factor signaling pathway 3.8462 5 yes
GO:0042116 macrophage activation 3.8462 4 yes
GO:0043392 negative regulation of DNA binding 3.8462 5 yes
GO:0045346 regulation of MHC class II biosynthetic process 3.8462 6 yes
GO:0045348 positive regulation of MHC class II biosynthetic process 3.8462 7 yes
GO:0046634 regulation of alpha-beta T cell activation 3.8462 7 yes
GO:0046635 positive regulation of alpha-beta T cell activation 3.8462 8 yes
GO:0046640 regulation of alpha-beta T cell proliferation 3.8462 8 yes
GO:0046641 positive regulation of alpha-beta T cell proliferation 3.8462 9 yes
GO:0051100 negative regulation of binding 3.8462 4 yes
GO:0051133 regulation of NK T cell activation 3.8462 8 yes
GO:0051135 positive regulation of NK T cell activation 3.8462 9 yes
GO:0051140 regulation of NK T cell proliferation 3.8462 9 yes
GO:0051142 positive regulation of NK T cell proliferation 3.8462 10 yes
GO:0051258 protein polymerization 3.8462 6 yes
GO:0001774 microglial cell activation 3.8462 4 yes
GO:0060390 regulation of SMAD protein signal transduction 3.8462 6 yes
GO:0060391 positive regulation of SMAD protein signal transduction 3.8462 7 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
H32_HUMAN [view interactions] Low throughput no yes
VHL_HUMAN [view entry] [view interactions] Low throughput yes yes
M3K5_HUMAN [view interactions] Low throughput no yes
PTAFR_HUMAN [view interactions] Low throughput no yes
PKD1_HUMAN [view interactions] Low throughput no yes
CAV1_HUMAN [view interactions] Low throughput no no
IL4RA_HUMAN [view interactions] Low throughput no no
IL2RG_HUMAN [view interactions] Low throughput no no
IL3RA_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
JAK3_HUMAN [view interactions] Low throughput no no
HES1_HUMAN [view interactions] Low throughput no no
HES5_HUMAN [view interactions] Low throughput no yes
DTX3L_HUMAN [view interactions] Low throughput no yes
YES_HUMAN [view entry] [view interactions] Low throughput yes yes
UBS3B_HUMAN [view interactions] Low throughput no yes
HDAC6_HUMAN [view interactions] Low throughput no yes
CBL_HUMAN [view interactions] Low throughput no yes
GOLP3_HUMAN [view interactions] Low throughput no no
IGF1R_HUMAN [view entry] [view interactions] Low throughput yes yes
PARP9_HUMAN [view interactions] Low throughput no no
LNX1_HUMAN [view entry] [view interactions] Low throughput yes yes
LDOC1_HUMAN [view interactions] Low throughput no no
SH2B3_HUMAN [view interactions] Low throughput no yes
OPTN_HUMAN [view interactions] Low throughput no yes
JOS1_HUMAN [view interactions] Low throughput no no
ATG5_HUMAN [view entry] [view interactions] Low throughput yes no
LYN_HUMAN [view entry] [view interactions] Low throughput yes no
RAF1_HUMAN [view entry] [view interactions] Low throughput yes no
SOCS5_HUMAN [view interactions] Low throughput no yes
TUB_HUMAN [view interactions] Low throughput no yes
GTF2I_HUMAN [view interactions] Low throughput no yes
H31T_HUMAN [view interactions] Low throughput no yes
E2AK2_HUMAN [view entry] [view interactions] Low throughput yes yes
IKBA_HUMAN [view interactions] Low throughput no yes
EZH2_HUMAN [view interactions] Low throughput no no
TERA_HUMAN [view entry] [view interactions] Low throughput yes yes
CISH_HUMAN [view interactions] Low throughput no yes
GRB2_HUMAN [view entry] [view interactions] Low throughput yes yes
P85A_HUMAN [view interactions] Low throughput no yes
PLCG1_HUMAN [view entry] [view interactions] Low throughput yes yes
SOCS1_HUMAN [view interactions] Low throughput no yes
G3BP1_HUMAN [view interactions] Low throughput no yes
EPOR_HUMAN [view interactions] Low throughput no no
INGR2_HUMAN [view interactions] Low throughput no yes
CDN1B_HUMAN [view interactions] Low throughput no yes
FCERG_HUMAN [view interactions] Low throughput no no
S40A1_HUMAN [view interactions] Low throughput no no
LEPR_HUMAN [view interactions] Low throughput no no
BRCA1_HUMAN [view interactions] Low throughput no yes
STAM1_HUMAN [view interactions] Low throughput no yes
PTN1_HUMAN [view entry] [view interactions] Low throughput yes yes
SH2B1_HUMAN [view interactions] Low throughput no yes
SHC1_HUMAN [view entry] [view interactions] Low throughput yes yes
SOCS3_HUMAN [view interactions] Low throughput no yes
AGTR1_HUMAN [view interactions] Low throughput no no
PTN11_HUMAN [view entry] [view interactions] Low throughput yes yes
SH2B2_HUMAN [view interactions] Low throughput no yes
ELOB_HUMAN [view interactions] Low throughput no no
ELOC_HUMAN [view interactions] Low throughput no no
IL3RB_HUMAN [view interactions] Low throughput no no
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
ANM5_HUMAN [view entry] [view interactions] Low throughput yes yes
INSR_HUMAN [view interactions] Low throughput no yes
TPOR_HUMAN [view interactions] Low throughput no no
IL23R_HUMAN [view interactions] Low throughput no yes
JAK1_HUMAN [view interactions] Low throughput no yes
TYK2_HUMAN [view interactions] Low throughput no no
IL5RA_HUMAN [view interactions] Low throughput no no
UBB_HUMAN [view entry] [view interactions] Low throughput yes yes
UBC_HUMAN [view entry] [view interactions] Low throughput yes yes
RS27A_HUMAN [view entry] [view interactions] Low throughput yes yes
RL40_HUMAN [view entry] [view interactions] Low throughput yes yes
CRLF2_HUMAN [view interactions] Low throughput no no
STAT3_HUMAN [view entry] [view interactions] Low throughput yes yes
ROCK2_HUMAN [view entry] [view interactions] Low throughput yes yes
STRA6_HUMAN [view interactions] Low throughput no no
IL6RB_HUMAN [view interactions] Low throughput no no
PTPRC_HUMAN [view interactions] Low throughput no no
JAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
KPCA_HUMAN [view entry] [view interactions] Low throughput yes yes
STAT1_HUMAN [view entry] [view interactions] Low throughput yes no
EGFR_HUMAN [view interactions] Low throughput no no
STA5A_HUMAN [view interactions] Low throughput no no
STA5B_HUMAN [view interactions] Low throughput no yes
DNJA3_HUMAN [view entry] [view interactions] Low throughput yes yes
PPIA_HUMAN [view entry] [view interactions] Low throughput yes yes
I12R2_HUMAN [view interactions] Low throughput no no
FYN_HUMAN [view entry] [view interactions] Low throughput yes no
CXCR4_HUMAN [view interactions] Low throughput no no
HSP7C_HUMAN [view entry] [view interactions] Low throughput yes yes
TEC_HUMAN [view interactions] Low throughput no yes
PTN12_HUMAN [view interactions] Low throughput no yes
FAK1_HUMAN [view entry] [view interactions] Low throughput yes yes
GHR_HUMAN [view interactions] Low throughput no yes
VAV_HUMAN [view interactions] Low throughput no no
SHPS1_HUMAN [view entry] [view interactions] Low throughput yes yes
FAK2_HUMAN [view entry] [view interactions] Low throughput yes yes
TNR1A_HUMAN [view interactions] Low throughput no yes
PTN6_HUMAN [view interactions] Low throughput no no
KIT_HUMAN [view interactions] Low throughput no no
5HT2A_HUMAN [view entry] [view interactions] Low throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] Low throughput yes no
ELP2_HUMAN [view interactions] Low throughput no yes
2AAB_HUMAN [view interactions] Low throughput no yes
INGR1_HUMAN [view interactions] Low throughput no no
IRS1_HUMAN [view entry] [view interactions] Low throughput yes yes
CCR5_HUMAN [view interactions] Low throughput no no
PRLR_HUMAN [view interactions] Low throughput no no
GRB10_HUMAN [view entry] [view interactions] Low throughput yes yes
TSHR_HUMAN [view interactions] Low throughput no no
STAM2_HUMAN [view interactions] Low throughput no yes
IL2RB_HUMAN [view interactions] Low throughput no no
CTLA4_HUMAN [view interactions] Low throughput no no
FGFR1_HUMAN [view entry] [view interactions] Low throughput yes yes
S1PR1_HUMAN [view interactions] Low throughput no no
HNRPL_HUMAN [view interactions] High throughput no yes
RN123_HUMAN [view interactions] High throughput no yes
LMO4_HUMAN [view interactions] High throughput no yes
AMY1B_HUMAN [view interactions] High throughput no no
AMY1A_HUMAN [view interactions] High throughput no no
AMY1C_HUMAN [view interactions] High throughput no no
BPIA2_HUMAN [view interactions] High throughput no no
RHG18_HUMAN [view interactions] High throughput no yes
BACH1_HUMAN [view interactions] High throughput no no
HMMR_HUMAN [view interactions] High throughput no yes
MUC7_HUMAN [view interactions] High throughput no no
CYTT_HUMAN [view interactions] High throughput no no
IGJ_HUMAN [view interactions] High throughput no no
TOPK_HUMAN [view interactions] High throughput no no
MUC5B_HUMAN [view interactions] High throughput no no
SPRR3_HUMAN [view interactions] High throughput no no
PAUF_HUMAN [view interactions] High throughput no no
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
RASF2_HUMAN [view interactions] High throughput no yes
CLSPN_HUMAN [view interactions] High throughput no no
TOP3B_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
FITM2_HUMAN [view interactions] High throughput no no
ATG12_HUMAN [view interactions] High throughput no yes
NEMO_HUMAN [view interactions] High throughput no yes
TBC31_HUMAN [view interactions] High throughput no yes
NCK1_HUMAN [view interactions] High throughput no yes
PCKGC_HUMAN [view interactions] High throughput no no
TRAF6_HUMAN [view entry] [view interactions] High throughput yes yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
IMB1_HUMAN [view entry] [view interactions] High throughput yes yes
RCN1_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
NP1L1_HUMAN [view entry] [view interactions] High throughput yes yes
GTR1_HUMAN [view entry] [view interactions] High throughput yes no
UBIP1_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
CUL4B_HUMAN [view interactions] High throughput no yes
DCAF4_HUMAN [view interactions] High throughput no yes
CSF1_HUMAN [view interactions] High throughput no no
KPYM_HUMAN [view interactions] High throughput no yes
ASSY_HUMAN [view interactions] High throughput no yes
RBMX_HUMAN [view entry] [view interactions] High throughput yes yes
ARL11_HUMAN [view interactions] High throughput no no
HSFY1_HUMAN [view interactions] High throughput no no
ERBB3_HUMAN [view interactions] High throughput no yes
PTPRJ_HUMAN [view interactions] High throughput no yes
ALK_HUMAN [view entry] [view interactions] High throughput yes yes
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
ASB2_HUMAN [view interactions] High throughput no no
SKP2_HUMAN [view interactions] High throughput no yes