JAK2_HUMAN
Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed). Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. Part of a signaling cascade that is activated by increased cellular retinol and that leads to the activation of STAT5 (STAT5A or STAT5B) (PubMed). In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation (PubMed). Plays a role in cell cycle by phosphorylating CDKN1B (PubMed). Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of Tyr-41 of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin (PubMed). [View more on UniProt]
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Position | Amino acid | Mutation | Disease | Overlap with binding region |
---|---|---|---|---|
607 | Lys | Asn | Leukemia,acutemyelogenous(AML) | - |
617 | Val | Phe | Leukemia,acutemyelogenous(AML) | - |
617 | Val | Phe | Polycythemiavera(PV) | - |
617 | Val | Phe | Thrombocythemia3(THCYT3) | - |
617 | Val | Ile | Thrombocythemia3(THCYT3) | - |
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in JAK2_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 44.0476 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 44.0476 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 44.0476 | 4 | yes |
GO:0005524 | ATP binding | 39.2857 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 39.2857 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 39.2857 | 5 | yes |
GO:0019900 | kinase binding | 33.3333 | 4 | yes |
GO:0019901 | protein kinase binding | 32.1429 | 5 | yes |
GO:0016301 | kinase activity | 30.9524 | 4 | yes |
GO:0016773 | phosphotransferase activity, alcohol group as acceptor | 30.9524 | 4 | yes |
GO:0004712 | protein serine/threonine/tyrosine kinase activity | 30.9524 | 4 | yes |
GO:0003723 | RNA binding | 26.1905 | 4 | no |
GO:0044389 | ubiquitin-like protein ligase binding | 22.6190 | 4 | no |
GO:0046872 | metal ion binding | 21.4286 | 4 | yes |
GO:0031625 | ubiquitin protein ligase binding | 21.4286 | 5 | no |
GO:0004713 | protein tyrosine kinase activity | 19.0476 | 4 | yes |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 13.0952 | 5 | yes |
GO:0070851 | growth factor receptor binding | 10.7143 | 4 | yes |
GO:0001664 | G protein-coupled receptor binding | 9.5238 | 4 | yes |
GO:0005126 | cytokine receptor binding | 8.3333 | 4 | yes |
GO:0042169 | SH2 domain binding | 7.1429 | 4 | yes |
GO:0020037 | heme binding | 3.5714 | 4 | yes |
GO:0035173 | histone kinase activity | 3.5714 | 4 | yes |
GO:0051427 | hormone receptor binding | 3.5714 | 4 | yes |
GO:0051428 | peptide hormone receptor binding | 3.5714 | 5 | yes |
GO:0005131 | growth hormone receptor binding | 2.3810 | 5 | yes |
GO:0005143 | interleukin-12 receptor binding | 2.3810 | 5 | yes |
GO:0031701 | angiotensin receptor binding | 2.3810 | 5 | yes |
GO:0031702 | type 1 angiotensin receptor binding | 2.3810 | 6 | yes |
GO:0033130 | acetylcholine receptor binding | 2.3810 | 4 | yes |
GO:0035400 | histone tyrosine kinase activity | 2.3810 | 5 | yes |
GO:0035401 | histone kinase activity (H3-Y41 specific) | 2.3810 | 6 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in JAK2_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 80.9524 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 77.3810 | 4 | yes |
GO:0080090 | regulation of primary metabolic process | 76.1905 | 4 | yes |
GO:0010646 | regulation of cell communication | 75.0000 | 4 | yes |
GO:0031323 | regulation of cellular metabolic process | 75.0000 | 4 | yes |
GO:0051171 | regulation of nitrogen compound metabolic process | 73.8095 | 4 | yes |
GO:0009966 | regulation of signal transduction | 67.8571 | 4 | yes |
GO:0009893 | positive regulation of metabolic process | 65.4762 | 4 | yes |
GO:0048523 | negative regulation of cellular process | 64.2857 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 60.7143 | 5 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 60.7143 | 5 | yes |
GO:0051246 | regulation of protein metabolic process | 59.5238 | 5 | yes |
GO:0010468 | regulation of gene expression | 59.5238 | 5 | yes |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 58.3333 | 5 | yes |
GO:1902531 | regulation of intracellular signal transduction | 55.9524 | 5 | yes |
GO:0048584 | positive regulation of response to stimulus | 53.5714 | 4 | yes |
GO:0031399 | regulation of protein modification process | 52.3810 | 6 | yes |
GO:0051174 | regulation of phosphorus metabolic process | 52.3810 | 5 | yes |
GO:0019220 | regulation of phosphate metabolic process | 52.3810 | 6 | yes |
GO:0031326 | regulation of cellular biosynthetic process | 51.1905 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 51.1905 | 4 | yes |
GO:0042325 | regulation of phosphorylation | 50.0000 | 7 | yes |
GO:0051247 | positive regulation of protein metabolic process | 50.0000 | 6 | yes |
GO:0010647 | positive regulation of cell communication | 50.0000 | 5 | yes |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 50.0000 | 5 | yes |
GO:0023056 | positive regulation of signaling | 50.0000 | 4 | yes |
GO:0009967 | positive regulation of signal transduction | 47.6190 | 5 | yes |
GO:0045937 | positive regulation of phosphate metabolic process | 46.4286 | 7 | yes |
GO:0010562 | positive regulation of phosphorus metabolic process | 46.4286 | 6 | yes |
GO:0036211 | protein modification process | 45.2381 | 4 | yes |
GO:0042327 | positive regulation of phosphorylation | 45.2381 | 8 | yes |
GO:0043085 | positive regulation of catalytic activity | 45.2381 | 4 | yes |
GO:0043412 | macromolecule modification | 45.2381 | 4 | yes |
GO:0051049 | regulation of transport | 45.2381 | 4 | yes |
GO:0010556 | regulation of macromolecule biosynthetic process | 45.2381 | 5 | yes |
GO:0031401 | positive regulation of protein modification process | 44.0476 | 7 | yes |
GO:0051128 | regulation of cellular component organization | 44.0476 | 4 | no |
GO:0042127 | regulation of cell population proliferation | 44.0476 | 4 | yes |
GO:0009892 | negative regulation of metabolic process | 42.8571 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 42.8571 | 7 | yes |
GO:0010941 | regulation of cell death | 42.8571 | 4 | yes |
GO:0042981 | regulation of apoptotic process | 41.6667 | 6 | yes |
GO:0043067 | regulation of programmed cell death | 41.6667 | 5 | yes |
GO:0006796 | phosphate-containing compound metabolic process | 41.6667 | 4 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 40.4762 | 5 | no |
GO:0071310 | cellular response to organic substance | 40.4762 | 4 | yes |
GO:1902533 | positive regulation of intracellular signal transduction | 40.4762 | 6 | yes |
GO:0051252 | regulation of RNA metabolic process | 39.2857 | 5 | yes |
GO:0001934 | positive regulation of protein phosphorylation | 39.2857 | 8 | yes |
GO:0045595 | regulation of cell differentiation | 36.9048 | 4 | yes |
GO:0031324 | negative regulation of cellular metabolic process | 35.7143 | 5 | no |
GO:0051240 | positive regulation of multicellular organismal process | 35.7143 | 4 | yes |
GO:0008284 | positive regulation of cell population proliferation | 35.7143 | 5 | yes |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 34.5238 | 5 | no |
GO:0043408 | regulation of MAPK cascade | 34.5238 | 6 | yes |
GO:0051338 | regulation of transferase activity | 34.5238 | 4 | yes |
GO:0080134 | regulation of response to stress | 34.5238 | 4 | yes |
GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | yes |
GO:0051336 | regulation of hydrolase activity | 33.3333 | 4 | yes |
GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 6 | yes |
GO:0007167 | enzyme-linked receptor protein signaling pathway | 33.3333 | 4 | yes |
GO:0016310 | phosphorylation | 33.3333 | 5 | yes |
GO:1903506 | regulation of nucleic acid-templated transcription | 33.3333 | 7 | yes |
GO:0043549 | regulation of kinase activity | 32.1429 | 5 | yes |
GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 32.1429 | 6 | yes |
GO:0051347 | positive regulation of transferase activity | 32.1429 | 5 | yes |
GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 32.1429 | 5 | yes |
GO:0010243 | response to organonitrogen compound | 32.1429 | 4 | yes |
GO:0031328 | positive regulation of cellular biosynthetic process | 30.9524 | 6 | yes |
GO:0010648 | negative regulation of cell communication | 30.9524 | 5 | no |
GO:0023057 | negative regulation of signaling | 30.9524 | 4 | no |
GO:0051094 | positive regulation of developmental process | 30.9524 | 4 | yes |
GO:0002684 | positive regulation of immune system process | 30.9524 | 4 | yes |
GO:0006468 | protein phosphorylation | 30.9524 | 5 | yes |
GO:0060548 | negative regulation of cell death | 30.9524 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 30.9524 | 5 | yes |
GO:0022607 | cellular component assembly | 30.9524 | 4 | yes |
GO:0006996 | organelle organization | 29.7619 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 29.7619 | 4 | no |
GO:0033674 | positive regulation of kinase activity | 29.7619 | 6 | yes |
GO:0043066 | negative regulation of apoptotic process | 29.7619 | 7 | yes |
GO:0043069 | negative regulation of programmed cell death | 29.7619 | 6 | yes |
GO:0060341 | regulation of cellular localization | 28.5714 | 4 | yes |
GO:0010628 | positive regulation of gene expression | 28.5714 | 6 | yes |
GO:1901701 | cellular response to oxygen-containing compound | 28.5714 | 4 | yes |
GO:0032101 | regulation of response to external stimulus | 27.3810 | 4 | yes |
GO:0009894 | regulation of catabolic process | 27.3810 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 27.3810 | 4 | no |
GO:0050776 | regulation of immune response | 27.3810 | 4 | no |
GO:0051345 | positive regulation of hydrolase activity | 27.3810 | 5 | yes |
GO:2000145 | regulation of cell motility | 26.1905 | 4 | yes |
GO:0043410 | positive regulation of MAPK cascade | 26.1905 | 7 | yes |
GO:0045859 | regulation of protein kinase activity | 26.1905 | 6 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.1905 | 6 | yes |
GO:0014070 | response to organic cyclic compound | 26.1905 | 4 | yes |
GO:0030155 | regulation of cell adhesion | 26.1905 | 4 | yes |
GO:0009968 | negative regulation of signal transduction | 25.0000 | 5 | no |
GO:0051248 | negative regulation of protein metabolic process | 25.0000 | 6 | no |
GO:0030334 | regulation of cell migration | 25.0000 | 5 | yes |
GO:0051130 | positive regulation of cellular component organization | 23.8095 | 5 | no |
GO:0032880 | regulation of protein localization | 23.8095 | 5 | yes |
GO:2000026 | regulation of multicellular organismal development | 23.8095 | 4 | no |
GO:0043933 | protein-containing complex organization | 23.8095 | 4 | yes |
GO:0045597 | positive regulation of cell differentiation | 23.8095 | 5 | yes |
GO:0050804 | modulation of chemical synaptic transmission | 23.8095 | 5 | yes |
GO:0051050 | positive regulation of transport | 23.8095 | 4 | yes |
GO:0099177 | regulation of trans-synaptic signaling | 23.8095 | 4 | yes |
GO:0018193 | peptidyl-amino acid modification | 23.8095 | 5 | yes |
GO:0030162 | regulation of proteolysis | 23.8095 | 6 | yes |
GO:0044057 | regulation of system process | 22.6190 | 4 | yes |
GO:0045785 | positive regulation of cell adhesion | 22.6190 | 5 | yes |
GO:0045860 | positive regulation of protein kinase activity | 22.6190 | 7 | yes |
GO:0051254 | positive regulation of RNA metabolic process | 22.6190 | 6 | yes |
GO:0031347 | regulation of defense response | 21.4286 | 5 | yes |
GO:0051726 | regulation of cell cycle | 21.4286 | 4 | no |
GO:0008104 | protein localization | 21.4286 | 4 | no |
GO:0070372 | regulation of ERK1 and ERK2 cascade | 21.4286 | 7 | no |
GO:0033993 | response to lipid | 21.4286 | 4 | yes |
GO:0050865 | regulation of cell activation | 21.4286 | 4 | yes |
GO:0022407 | regulation of cell-cell adhesion | 21.4286 | 5 | yes |
GO:0009890 | negative regulation of biosynthetic process | 20.2381 | 5 | no |
GO:0031327 | negative regulation of cellular biosynthetic process | 20.2381 | 6 | no |
GO:0090304 | nucleic acid metabolic process | 20.2381 | 4 | no |
GO:0031329 | regulation of cellular catabolic process | 20.2381 | 5 | no |
GO:0046777 | protein autophosphorylation | 20.2381 | 6 | yes |
GO:0001817 | regulation of cytokine production | 20.2381 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 20.2381 | 5 | yes |
GO:2000147 | positive regulation of cell motility | 19.0476 | 5 | yes |
GO:0040017 | positive regulation of locomotion | 19.0476 | 4 | yes |
GO:0045893 | positive regulation of DNA-templated transcription | 19.0476 | 7 | yes |
GO:0051046 | regulation of secretion | 19.0476 | 5 | yes |
GO:0002694 | regulation of leukocyte activation | 19.0476 | 4 | yes |
GO:0006357 | regulation of transcription by RNA polymerase II | 19.0476 | 7 | yes |
GO:0008285 | negative regulation of cell population proliferation | 19.0476 | 5 | yes |
GO:1902680 | positive regulation of RNA biosynthetic process | 19.0476 | 7 | yes |
GO:1903508 | positive regulation of nucleic acid-templated transcription | 19.0476 | 8 | yes |
GO:0030030 | cell projection organization | 19.0476 | 4 | yes |
GO:0030335 | positive regulation of cell migration | 19.0476 | 6 | yes |
GO:0045862 | positive regulation of proteolysis | 17.8571 | 7 | yes |
GO:0051241 | negative regulation of multicellular organismal process | 17.8571 | 4 | yes |
GO:0051249 | regulation of lymphocyte activation | 17.8571 | 5 | yes |
GO:0071396 | cellular response to lipid | 17.8571 | 5 | yes |
GO:0071407 | cellular response to organic cyclic compound | 17.8571 | 5 | yes |
GO:1903037 | regulation of leukocyte cell-cell adhesion | 17.8571 | 6 | yes |
GO:1903530 | regulation of secretion by cell | 17.8571 | 4 | yes |
GO:0034097 | response to cytokine | 16.6667 | 4 | yes |
GO:0050863 | regulation of T cell activation | 16.6667 | 6 | yes |
GO:0050867 | positive regulation of cell activation | 16.6667 | 5 | yes |
GO:0051251 | positive regulation of lymphocyte activation | 16.6667 | 6 | yes |
GO:0001819 | positive regulation of cytokine production | 16.6667 | 5 | yes |
GO:0002696 | positive regulation of leukocyte activation | 16.6667 | 5 | yes |
GO:1903039 | positive regulation of leukocyte cell-cell adhesion | 16.6667 | 7 | yes |
GO:0022409 | positive regulation of cell-cell adhesion | 16.6667 | 6 | yes |
GO:2001233 | regulation of apoptotic signaling pathway | 15.4762 | 5 | yes |
GO:0032103 | positive regulation of response to external stimulus | 15.4762 | 5 | yes |
GO:0032386 | regulation of intracellular transport | 15.4762 | 5 | yes |
GO:0032870 | cellular response to hormone stimulus | 15.4762 | 4 | yes |
GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | 15.4762 | 8 | yes |
GO:0050870 | positive regulation of T cell activation | 15.4762 | 7 | yes |
GO:0051223 | regulation of protein transport | 15.4762 | 5 | yes |
GO:0006915 | apoptotic process | 15.4762 | 4 | yes |
GO:0070201 | regulation of establishment of protein localization | 15.4762 | 6 | yes |
GO:0050727 | regulation of inflammatory response | 14.2857 | 5 | yes |
GO:0052547 | regulation of peptidase activity | 14.2857 | 5 | yes |
GO:0052548 | regulation of endopeptidase activity | 14.2857 | 6 | yes |
GO:0010942 | positive regulation of cell death | 14.2857 | 5 | yes |
GO:0120036 | plasma membrane bounded cell projection organization | 14.2857 | 5 | yes |
GO:0018108 | peptidyl-tyrosine phosphorylation | 14.2857 | 6 | yes |
GO:0018212 | peptidyl-tyrosine modification | 14.2857 | 6 | yes |
GO:1903829 | positive regulation of protein localization | 14.2857 | 5 | yes |
GO:0035303 | regulation of dephosphorylation | 13.0952 | 7 | yes |
GO:0043065 | positive regulation of apoptotic process | 13.0952 | 7 | yes |
GO:0043068 | positive regulation of programmed cell death | 13.0952 | 6 | yes |
GO:0045944 | positive regulation of transcription by RNA polymerase II | 13.0952 | 8 | yes |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 13.0952 | 9 | yes |
GO:0035304 | regulation of protein dephosphorylation | 11.9048 | 7 | yes |
GO:0051091 | positive regulation of DNA-binding transcription factor activity | 11.9048 | 4 | yes |
GO:0051222 | positive regulation of protein transport | 11.9048 | 5 | yes |
GO:0070663 | regulation of leukocyte proliferation | 11.9048 | 5 | yes |
GO:0071345 | cellular response to cytokine stimulus | 11.9048 | 5 | yes |
GO:0010950 | positive regulation of endopeptidase activity | 11.9048 | 7 | yes |
GO:0010952 | positive regulation of peptidase activity | 11.9048 | 6 | yes |
GO:0019221 | cytokine-mediated signaling pathway | 11.9048 | 4 | yes |
GO:1903522 | regulation of blood circulation | 11.9048 | 5 | yes |
GO:1904951 | positive regulation of establishment of protein localization | 11.9048 | 6 | yes |
GO:0033157 | regulation of intracellular protein transport | 10.7143 | 6 | yes |
GO:0035306 | positive regulation of dephosphorylation | 10.7143 | 8 | yes |
GO:0048545 | response to steroid hormone | 10.7143 | 4 | yes |
GO:0070665 | positive regulation of leukocyte proliferation | 10.7143 | 6 | yes |
GO:1901214 | regulation of neuron death | 10.7143 | 5 | yes |
GO:0031175 | neuron projection development | 10.7143 | 6 | yes |
GO:2000116 | regulation of cysteine-type endopeptidase activity | 9.5238 | 7 | yes |
GO:0032147 | activation of protein kinase activity | 9.5238 | 8 | yes |
GO:0032388 | positive regulation of intracellular transport | 9.5238 | 5 | yes |
GO:0035307 | positive regulation of protein dephosphorylation | 9.5238 | 8 | yes |
GO:0048534 | hematopoietic or lymphoid organ development | 9.5238 | 4 | yes |
GO:0008016 | regulation of heart contraction | 9.5238 | 6 | yes |
GO:0090316 | positive regulation of intracellular protein transport | 9.5238 | 6 | yes |
GO:0031349 | positive regulation of defense response | 8.3333 | 5 | yes |
GO:0032944 | regulation of mononuclear cell proliferation | 8.3333 | 6 | yes |
GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 8.3333 | 8 | yes |
GO:0043523 | regulation of neuron apoptotic process | 8.3333 | 6 | yes |
GO:0043524 | negative regulation of neuron apoptotic process | 8.3333 | 7 | yes |
GO:0043666 | regulation of phosphoprotein phosphatase activity | 8.3333 | 6 | yes |
GO:0045428 | regulation of nitric oxide biosynthetic process | 8.3333 | 6 | yes |
GO:0046822 | regulation of nucleocytoplasmic transport | 8.3333 | 6 | yes |
GO:0050670 | regulation of lymphocyte proliferation | 8.3333 | 6 | yes |
GO:0007162 | negative regulation of cell adhesion | 8.3333 | 5 | yes |
GO:0071383 | cellular response to steroid hormone stimulus | 8.3333 | 5 | yes |
GO:0080164 | regulation of nitric oxide metabolic process | 8.3333 | 5 | yes |
GO:0010810 | regulation of cell-substrate adhesion | 8.3333 | 5 | yes |
GO:0010921 | regulation of phosphatase activity | 8.3333 | 5 | yes |
GO:0097435 | supramolecular fiber organization | 8.3333 | 4 | yes |
GO:1900180 | regulation of protein localization to nucleus | 8.3333 | 6 | yes |
GO:1901215 | negative regulation of neuron death | 8.3333 | 6 | yes |
GO:1901654 | response to ketone | 8.3333 | 4 | yes |
GO:2001056 | positive regulation of cysteine-type endopeptidase activity | 7.1429 | 8 | yes |
GO:0031960 | response to corticosteroid | 7.1429 | 5 | yes |
GO:0032496 | response to lipopolysaccharide | 7.1429 | 4 | yes |
GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 7.1429 | 7 | yes |
GO:0032680 | regulation of tumor necrosis factor production | 7.1429 | 6 | yes |
GO:0051099 | positive regulation of binding | 7.1429 | 4 | yes |
GO:0051101 | regulation of DNA binding | 7.1429 | 4 | yes |
GO:0002237 | response to molecule of bacterial origin | 7.1429 | 4 | yes |
GO:0071219 | cellular response to molecule of bacterial origin | 7.1429 | 4 | yes |
GO:0071222 | cellular response to lipopolysaccharide | 7.1429 | 5 | yes |
GO:0010660 | regulation of muscle cell apoptotic process | 7.1429 | 7 | yes |
GO:0010922 | positive regulation of phosphatase activity | 7.1429 | 6 | yes |
GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | 7.1429 | 6 | yes |
GO:0014068 | positive regulation of phosphatidylinositol 3-kinase signaling | 7.1429 | 7 | yes |
GO:1900182 | positive regulation of protein localization to nucleus | 7.1429 | 6 | yes |
GO:1903555 | regulation of tumor necrosis factor superfamily cytokine production | 7.1429 | 5 | yes |
GO:2001235 | positive regulation of apoptotic signaling pathway | 5.9524 | 6 | yes |
GO:0032651 | regulation of interleukin-1 beta production | 5.9524 | 6 | yes |
GO:0032652 | regulation of interleukin-1 production | 5.9524 | 5 | yes |
GO:0032760 | positive regulation of tumor necrosis factor production | 5.9524 | 7 | yes |
GO:0032946 | positive regulation of mononuclear cell proliferation | 5.9524 | 7 | yes |
GO:0033209 | tumor necrosis factor-mediated signaling pathway | 5.9524 | 5 | yes |
GO:0034110 | regulation of homotypic cell-cell adhesion | 5.9524 | 6 | yes |
GO:0034612 | response to tumor necrosis factor | 5.9524 | 5 | yes |
GO:0042129 | regulation of T cell proliferation | 5.9524 | 7 | yes |
GO:0042509 | regulation of tyrosine phosphorylation of STAT protein | 5.9524 | 9 | yes |
GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein | 5.9524 | 10 | yes |
GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 5.9524 | 9 | yes |
GO:0043388 | positive regulation of DNA binding | 5.9524 | 5 | yes |
GO:0045429 | positive regulation of nitric oxide biosynthetic process | 5.9524 | 7 | yes |
GO:0046824 | positive regulation of nucleocytoplasmic transport | 5.9524 | 6 | yes |
GO:0048660 | regulation of smooth muscle cell proliferation | 5.9524 | 5 | yes |
GO:0048661 | positive regulation of smooth muscle cell proliferation | 5.9524 | 6 | yes |
GO:0050671 | positive regulation of lymphocyte proliferation | 5.9524 | 7 | yes |
GO:0050708 | regulation of protein secretion | 5.9524 | 5 | yes |
GO:0051047 | positive regulation of secretion | 5.9524 | 5 | yes |
GO:0051384 | response to glucocorticoid | 5.9524 | 6 | yes |
GO:0006325 | chromatin organization | 5.9524 | 4 | yes |
GO:0060396 | growth hormone receptor signaling pathway | 5.9524 | 6 | yes |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 5.9524 | 10 | yes |
GO:0007015 | actin filament organization | 5.9524 | 5 | yes |
GO:0010543 | regulation of platelet activation | 5.9524 | 5 | yes |
GO:0010656 | negative regulation of muscle cell apoptotic process | 5.9524 | 8 | yes |
GO:0090330 | regulation of platelet aggregation | 5.9524 | 6 | yes |
GO:1901655 | cellular response to ketone | 5.9524 | 5 | yes |
GO:0022408 | negative regulation of cell-cell adhesion | 5.9524 | 6 | yes |
GO:1903532 | positive regulation of secretion by cell | 5.9524 | 5 | yes |
GO:0030099 | myeloid cell differentiation | 5.9524 | 4 | yes |
GO:1903557 | positive regulation of tumor necrosis factor superfamily cytokine production | 5.9524 | 6 | yes |
GO:1904407 | positive regulation of nitric oxide metabolic process | 5.9524 | 6 | yes |
GO:0032649 | regulation of interferon-gamma production | 4.7619 | 5 | yes |
GO:0032731 | positive regulation of interleukin-1 beta production | 4.7619 | 7 | yes |
GO:0032732 | positive regulation of interleukin-1 production | 4.7619 | 6 | yes |
GO:0042102 | positive regulation of T cell proliferation | 4.7619 | 8 | yes |
GO:0042306 | regulation of protein import into nucleus | 4.7619 | 7 | yes |
GO:0042307 | positive regulation of protein import into nucleus | 4.7619 | 7 | yes |
GO:0046425 | regulation of receptor signaling pathway via JAK-STAT | 4.7619 | 6 | yes |
GO:0046634 | regulation of alpha-beta T cell activation | 4.7619 | 7 | yes |
GO:0046883 | regulation of hormone secretion | 4.7619 | 4 | yes |
GO:0050796 | regulation of insulin secretion | 4.7619 | 6 | yes |
GO:0051100 | negative regulation of binding | 4.7619 | 4 | yes |
GO:0002791 | regulation of peptide secretion | 4.7619 | 6 | yes |
GO:0060397 | growth hormone receptor signaling pathway via JAK-STAT | 4.7619 | 7 | yes |
GO:0060429 | epithelium development | 4.7619 | 4 | yes |
GO:0007259 | receptor signaling pathway via JAK-STAT | 4.7619 | 5 | yes |
GO:0070102 | interleukin-6-mediated signaling pathway | 4.7619 | 5 | yes |
GO:0071548 | response to dexamethasone | 4.7619 | 5 | yes |
GO:0090087 | regulation of peptide transport | 4.7619 | 5 | yes |
GO:0090092 | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 4.7619 | 5 | yes |
GO:0010662 | regulation of striated muscle cell apoptotic process | 4.7619 | 8 | yes |
GO:0090276 | regulation of peptide hormone secretion | 4.7619 | 5 | yes |
GO:0010665 | regulation of cardiac muscle cell apoptotic process | 4.7619 | 9 | yes |
GO:0010811 | positive regulation of cell-substrate adhesion | 4.7619 | 6 | yes |
GO:0097193 | intrinsic apoptotic signaling pathway | 4.7619 | 4 | yes |
GO:0097696 | receptor signaling pathway via STAT | 4.7619 | 4 | yes |
GO:0099527 | postsynapse to nucleus signaling pathway | 4.7619 | 4 | yes |
GO:0120162 | positive regulation of cold-induced thermogenesis | 4.7619 | 4 | yes |
GO:0030097 | hemopoiesis | 4.7619 | 5 | yes |
GO:1904035 | regulation of epithelial cell apoptotic process | 4.7619 | 7 | yes |
GO:1904892 | regulation of receptor signaling pathway via STAT | 4.7619 | 5 | yes |
GO:0032729 | positive regulation of interferon-gamma production | 3.5714 | 6 | yes |
GO:0033194 | response to hydroperoxide | 3.5714 | 4 | yes |
GO:0042116 | macrophage activation | 3.5714 | 4 | yes |
GO:0042976 | activation of Janus kinase activity | 3.5714 | 7 | yes |
GO:0043401 | steroid hormone mediated signaling pathway | 3.5714 | 4 | yes |
GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT | 3.5714 | 7 | yes |
GO:0046635 | positive regulation of alpha-beta T cell activation | 3.5714 | 8 | yes |
GO:0046887 | positive regulation of hormone secretion | 3.5714 | 5 | yes |
GO:0048008 | platelet-derived growth factor receptor signaling pathway | 3.5714 | 6 | yes |
GO:0048678 | response to axon injury | 3.5714 | 4 | yes |
GO:0050714 | positive regulation of protein secretion | 3.5714 | 6 | yes |
GO:0001774 | microglial cell activation | 3.5714 | 4 | yes |
GO:0051769 | regulation of nitric-oxide synthase biosynthetic process | 3.5714 | 6 | yes |
GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process | 3.5714 | 7 | yes |
GO:0060333 | interferon-gamma-mediated signaling pathway | 3.5714 | 5 | yes |
GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | 3.5714 | 5 | yes |
GO:0070671 | response to interleukin-12 | 3.5714 | 5 | yes |
GO:0071384 | cellular response to corticosteroid stimulus | 3.5714 | 6 | yes |
GO:0071385 | cellular response to glucocorticoid stimulus | 3.5714 | 7 | yes |
GO:0071549 | cellular response to dexamethasone stimulus | 3.5714 | 6 | yes |
GO:0090100 | positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 3.5714 | 6 | yes |
GO:0010664 | negative regulation of striated muscle cell apoptotic process | 3.5714 | 9 | yes |
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | 3.5714 | 10 | yes |
GO:0014075 | response to amine | 3.5714 | 5 | yes |
GO:1903523 | negative regulation of blood circulation | 3.5714 | 5 | yes |
GO:0030218 | erythrocyte differentiation | 3.5714 | 5 | yes |
GO:1904037 | positive regulation of epithelial cell apoptotic process | 3.5714 | 8 | yes |
GO:0030518 | intracellular steroid hormone receptor signaling pathway | 3.5714 | 4 | yes |
GO:1904894 | positive regulation of receptor signaling pathway via STAT | 3.5714 | 6 | yes |
GO:2000273 | positive regulation of signaling receptor activity | 2.3810 | 4 | yes |
GO:0031958 | corticosteroid receptor signaling pathway | 2.3810 | 5 | yes |
GO:0031959 | mineralocorticoid receptor signaling pathway | 2.3810 | 6 | yes |
GO:2001267 | regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 2.3810 | 9 | yes |
GO:2001269 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 2.3810 | 10 | yes |
GO:0032024 | positive regulation of insulin secretion | 2.3810 | 7 | yes |
GO:0032814 | regulation of natural killer cell activation | 2.3810 | 6 | yes |
GO:0032816 | positive regulation of natural killer cell activation | 2.3810 | 7 | yes |
GO:0032817 | regulation of natural killer cell proliferation | 2.3810 | 7 | yes |
GO:0032819 | positive regulation of natural killer cell proliferation | 2.3810 | 8 | yes |
GO:0034050 | programmed cell death induced by symbiont | 2.3810 | 4 | yes |
GO:0034112 | positive regulation of homotypic cell-cell adhesion | 2.3810 | 7 | yes |
GO:0035166 | post-embryonic hemopoiesis | 2.3810 | 5 | yes |
GO:0035722 | interleukin-12-mediated signaling pathway | 2.3810 | 5 | yes |
GO:0036015 | response to interleukin-3 | 2.3810 | 5 | yes |
GO:0036016 | cellular response to interleukin-3 | 2.3810 | 6 | yes |
GO:0038065 | collagen-activated signaling pathway | 2.3810 | 4 | yes |
GO:0038157 | granulocyte-macrophage colony-stimulating factor signaling pathway | 2.3810 | 5 | yes |
GO:0043392 | negative regulation of DNA binding | 2.3810 | 5 | yes |
GO:0045346 | regulation of MHC class II biosynthetic process | 2.3810 | 6 | yes |
GO:0045348 | positive regulation of MHC class II biosynthetic process | 2.3810 | 7 | yes |
GO:0045822 | negative regulation of heart contraction | 2.3810 | 6 | yes |
GO:0046640 | regulation of alpha-beta T cell proliferation | 2.3810 | 8 | yes |
GO:0046641 | positive regulation of alpha-beta T cell proliferation | 2.3810 | 9 | yes |
GO:0048569 | post-embryonic animal organ development | 2.3810 | 4 | yes |
GO:0050729 | positive regulation of inflammatory response | 2.3810 | 6 | yes |
GO:0051133 | regulation of NK T cell activation | 2.3810 | 8 | yes |
GO:0051135 | positive regulation of NK T cell activation | 2.3810 | 9 | yes |
GO:0051140 | regulation of NK T cell proliferation | 2.3810 | 9 | yes |
GO:0051142 | positive regulation of NK T cell proliferation | 2.3810 | 10 | yes |
GO:0051258 | protein polymerization | 2.3810 | 6 | yes |
GO:0002793 | positive regulation of peptide secretion | 2.3810 | 6 | yes |
GO:0060390 | regulation of SMAD protein signal transduction | 2.3810 | 5 | yes |
GO:0060391 | positive regulation of SMAD protein signal transduction | 2.3810 | 6 | yes |
GO:0060398 | regulation of growth hormone receptor signaling pathway | 2.3810 | 5 | yes |
GO:0060399 | positive regulation of growth hormone receptor signaling pathway | 2.3810 | 6 | yes |
GO:0061180 | mammary gland epithelium development | 2.3810 | 5 | yes |
GO:0007260 | tyrosine phosphorylation of STAT protein | 2.3810 | 7 | yes |
GO:0061564 | axon development | 2.3810 | 7 | yes |
GO:0007498 | mesoderm development | 2.3810 | 4 | yes |
GO:0008154 | actin polymerization or depolymerization | 2.3810 | 6 | yes |
GO:0070757 | interleukin-35-mediated signaling pathway | 2.3810 | 5 | yes |
GO:0010572 | positive regulation of platelet activation | 2.3810 | 6 | yes |
GO:0090277 | positive regulation of peptide hormone secretion | 2.3810 | 6 | yes |
GO:0097191 | extrinsic apoptotic signaling pathway | 2.3810 | 4 | yes |
GO:0097296 | activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 2.3810 | 11 | yes |
GO:0014842 | regulation of skeletal muscle satellite cell proliferation | 2.3810 | 6 | yes |
GO:0014857 | regulation of skeletal muscle cell proliferation | 2.3810 | 5 | yes |
GO:0014858 | positive regulation of skeletal muscle cell proliferation | 2.3810 | 6 | yes |
GO:1901731 | positive regulation of platelet aggregation | 2.3810 | 7 | yes |
GO:1902724 | positive regulation of skeletal muscle satellite cell proliferation | 2.3810 | 7 | yes |
GO:1902728 | positive regulation of growth factor dependent skeletal muscle satellite cell proliferation | 2.3810 | 8 | yes |
GO:0030041 | actin filament polymerization | 2.3810 | 7 | yes |
GO:1904705 | regulation of vascular associated smooth muscle cell proliferation | 2.3810 | 6 | yes |
GO:0031102 | neuron projection regeneration | 2.3810 | 4 | yes |
GO:1904707 | positive regulation of vascular associated smooth muscle cell proliferation | 2.3810 | 7 | yes |
GO:0031103 | axon regeneration | 2.3810 | 5 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in JAK2_HUMAN |
---|---|---|---|---|
DOID:0050700 | cardiomyopathy | 5.9524 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 5.9524 | 5 | no |
DOID:114 | heart disease | 5.9524 | 3 | no |
DOID:0050686 | organ system cancer | 4.7619 | 3 | yes |
DOID:2843 | long QT syndrome | 3.5714 | 6 | no |
DOID:612 | primary immunodeficiency disease | 3.5714 | 3 | no |
DOID:0070004 | myeloid neoplasm | 2.3810 | 6 | yes |
DOID:1240 | leukemia | 2.3810 | 5 | yes |
DOID:2224 | essential thrombocythemia | 2.3810 | 8 | yes |
DOID:2226 | myeloproliferative neoplasm | 2.3810 | 7 | yes |
DOID:2531 | hematologic cancer | 2.3810 | 4 | yes |
DOID:4960 | bone marrow cancer | 2.3810 | 5 | yes |
DOID:8692 | myeloid leukemia | 2.3810 | 6 | yes |
DOID:8997 | polycythemia vera | 2.3810 | 8 | yes |
DOID:9119 | acute myeloid leukemia | 2.3810 | 7 | yes |
DOID:12930 | dilated cardiomyopathy | 2.3810 | 6 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
STA5A_HUMAN | [view interactions] | Low throughput | no | no |
STA5B_HUMAN | [view interactions] | Low throughput | no | yes |
DNJA3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PPIA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
I12R2_HUMAN | [view interactions] | Low throughput | no | no |
FYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
CXCR4_HUMAN | [view interactions] | Low throughput | no | no |
HSP7C_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TEC_HUMAN | [view interactions] | Low throughput | no | yes |
PTN12_HUMAN | [view interactions] | Low throughput | no | yes |
FAK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GHR_HUMAN | [view interactions] | Low throughput | no | yes |
VAV_HUMAN | [view interactions] | Low throughput | no | no |
SHPS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
FAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TNR1A_HUMAN | [view interactions] | Low throughput | no | yes |
PTN6_HUMAN | [view interactions] | Low throughput | no | no |
KIT_HUMAN | [view interactions] | Low throughput | no | no |
5HT2A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ERBB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ELP2_HUMAN | [view interactions] | Low throughput | no | yes |
2AAB_HUMAN | [view interactions] | Low throughput | no | yes |
INGR1_HUMAN | [view interactions] | Low throughput | no | no |
IRS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CCR5_HUMAN | [view interactions] | Low throughput | no | no |
PRLR_HUMAN | [view interactions] | Low throughput | no | no |
GRB10_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TSHR_HUMAN | [view interactions] | Low throughput | no | no |
STAM2_HUMAN | [view interactions] | Low throughput | no | yes |
IL2RB_HUMAN | [view interactions] | Low throughput | no | no |
CTLA4_HUMAN | [view interactions] | Low throughput | no | no |
FGFR1_HUMAN | [view interactions] | Low throughput | no | yes |
S1PR1_HUMAN | [view interactions] | Low throughput | no | no |
H32_HUMAN | [view interactions] | Low throughput | no | yes |
VHL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
M3K5_HUMAN | [view interactions] | Low throughput | no | yes |
PTAFR_HUMAN | [view interactions] | Low throughput | no | yes |
PKD1_HUMAN | [view interactions] | Low throughput | no | yes |
CAV1_HUMAN | [view interactions] | Low throughput | no | no |
IL4RA_HUMAN | [view interactions] | Low throughput | no | no |
IL2RG_HUMAN | [view interactions] | Low throughput | no | no |
IL3RA_HUMAN | [view interactions] | Low throughput | no | yes |
CALM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
JAK3_HUMAN | [view interactions] | Low throughput | no | no |
HES1_HUMAN | [view interactions] | Low throughput | no | no |
HES5_HUMAN | [view interactions] | Low throughput | no | yes |
DTX3L_HUMAN | [view interactions] | Low throughput | no | yes |
YES_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBS3B_HUMAN | [view interactions] | Low throughput | no | yes |
HDAC6_HUMAN | [view interactions] | Low throughput | no | yes |
CBL_HUMAN | [view interactions] | Low throughput | no | yes |
GOLP3_HUMAN | [view interactions] | Low throughput | no | no |
IGF1R_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PARP9_HUMAN | [view interactions] | Low throughput | no | no |
SIRPG_HUMAN | [view interactions] | Low throughput | no | no |
LNX1_HUMAN | [view interactions] | Low throughput | no | yes |
LDOC1_HUMAN | [view interactions] | Low throughput | no | no |
ATG5_HUMAN | [view interactions] | Low throughput | no | no |
LYN_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
RAF1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
SOCS5_HUMAN | [view interactions] | Low throughput | no | yes |
TUB_HUMAN | [view interactions] | Low throughput | no | yes |
GTF2I_HUMAN | [view interactions] | Low throughput | no | yes |
H31T_HUMAN | [view interactions] | Low throughput | no | yes |
E2AK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
IKBA_HUMAN | [view interactions] | Low throughput | no | yes |
EZH2_HUMAN | [view interactions] | Low throughput | no | no |
TERA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
P85A_HUMAN | [view interactions] | Low throughput | no | yes |
PLCG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SOCS1_HUMAN | [view interactions] | Low throughput | no | yes |
G3BP1_HUMAN | [view interactions] | Low throughput | no | yes |
EPOR_HUMAN | [view interactions] | Low throughput | no | no |
INGR2_HUMAN | [view interactions] | Low throughput | no | yes |
CDN1B_HUMAN | [view interactions] | Low throughput | no | yes |
FCERG_HUMAN | [view interactions] | Low throughput | no | no |
S40A1_HUMAN | [view interactions] | Low throughput | no | no |
LEPR_HUMAN | [view interactions] | Low throughput | no | no |
BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
STAM1_HUMAN | [view interactions] | Low throughput | no | yes |
PTN1_HUMAN | [view interactions] | Low throughput | no | yes |
SH2B1_HUMAN | [view interactions] | Low throughput | no | yes |
SHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SOCS3_HUMAN | [view interactions] | Low throughput | no | yes |
AGTR1_HUMAN | [view interactions] | Low throughput | no | no |
PTN11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SH2B2_HUMAN | [view interactions] | Low throughput | no | no |
ELOC_HUMAN | [view interactions] | Low throughput | no | no |
ELOB_HUMAN | [view interactions] | Low throughput | no | no |
IL3RB_HUMAN | [view interactions] | Low throughput | no | no |
SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ANM5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
INSR_HUMAN | [view interactions] | Low throughput | no | yes |
TPOR_HUMAN | [view interactions] | Low throughput | no | no |
IL23R_HUMAN | [view interactions] | Low throughput | no | yes |
JAK1_HUMAN | [view interactions] | Low throughput | no | yes |
TYK2_HUMAN | [view interactions] | Low throughput | no | no |
IL5RA_HUMAN | [view interactions] | Low throughput | no | no |
UBB_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RS27A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RL40_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CRLF2_HUMAN | [view interactions] | Low throughput | no | no |
STAT3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ROCK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STRA6_HUMAN | [view interactions] | Low throughput | no | no |
IL6RB_HUMAN | [view interactions] | Low throughput | no | no |
PTPRC_HUMAN | [view interactions] | Low throughput | no | no |
JAK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KPCA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
STAT1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
EGFR_HUMAN | [view interactions] | Low throughput | no | no |
PTPRJ_HUMAN | [view interactions] | High throughput | no | yes |
ALK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HS90B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ASB2_HUMAN | [view interactions] | High throughput | no | no |
SKP2_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
RN123_HUMAN | [view interactions] | High throughput | no | yes |
LMO4_HUMAN | [view interactions] | High throughput | no | yes |
SH2B3_HUMAN | [view interactions] | High throughput | no | yes |
AMY1B_HUMAN | [view interactions] | High throughput | no | no |
AMY1A_HUMAN | [view interactions] | High throughput | no | no |
AMY1C_HUMAN | [view interactions] | High throughput | no | no |
BPIA2_HUMAN | [view interactions] | High throughput | no | no |
RHG18_HUMAN | [view interactions] | High throughput | no | yes |
BACH1_HUMAN | [view interactions] | High throughput | no | no |
HMMR_HUMAN | [view interactions] | High throughput | no | yes |
MUC7_HUMAN | [view interactions] | High throughput | no | no |
CYTT_HUMAN | [view interactions] | High throughput | no | no |
IGJ_HUMAN | [view interactions] | High throughput | no | no |
TOPK_HUMAN | [view interactions] | High throughput | no | no |
MUC5B_HUMAN | [view interactions] | High throughput | no | no |
SPRR3_HUMAN | [view interactions] | High throughput | no | no |
ZG16B_HUMAN | [view interactions] | High throughput | no | no |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
FITM2_HUMAN | [view interactions] | High throughput | no | no |
ATG12_HUMAN | [view interactions] | High throughput | no | yes |
NEMO_HUMAN | [view interactions] | High throughput | no | yes |
TBC31_HUMAN | [view interactions] | High throughput | no | yes |
MLP3A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MLP3B_HUMAN | [view interactions] | High throughput | no | yes |
NCK1_HUMAN | [view interactions] | High throughput | no | yes |
PCKGC_HUMAN | [view interactions] | High throughput | no | no |
TRAF6_HUMAN | [view interactions] | High throughput | no | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBIP1_HUMAN | [view interactions] | High throughput | no | no |
GTR1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NP1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EMD_HUMAN | [view interactions] | High throughput | no | yes |
RCN1_HUMAN | [view interactions] | High throughput | no | yes |
IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
DCAF4_HUMAN | [view interactions] | High throughput | no | yes |
CSF1_HUMAN | [view interactions] | High throughput | no | no |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
ASSY_HUMAN | [view interactions] | High throughput | no | yes |
RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARL11_HUMAN | [view interactions] | High throughput | no | no |
HSFY1_HUMAN | [view interactions] | High throughput | no | no |
ERBB3_HUMAN | [view interactions] | High throughput | no | yes |
CDK6_HUMAN | [view interactions] | Computational | no | yes |
MARK3_HUMAN | [view interactions] | Computational | no | yes |
CDN1C_HUMAN | [view interactions] | Computational | no | yes |
LIF_HUMAN | [view interactions] | Computational | no | yes |
PAXI_HUMAN | [view interactions] | Computational | no | yes |
CISH_HUMAN | [view interactions] | Computational | no | yes |
LCK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
B2L11_HUMAN | [view interactions] | Computational | no | yes |
HS71A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HS71B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL3_HUMAN | [view interactions] | Computational | no | no |
AKAP9_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SDF1_HUMAN | [view interactions] | Computational | no | no |
IL6_HUMAN | [view interactions] | Computational | no | no |
VAV2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL1B_HUMAN | [view interactions] | Computational | no | no |
EDN1_HUMAN | [view interactions] | Computational | no | no |
SL9A1_HUMAN | [view interactions] | Computational | no | no |
NOS2_HUMAN | [view interactions] | Computational | no | yes |
RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TRAK1_HUMAN | [view interactions] | Computational | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLCG2_HUMAN | [view interactions] | Computational | no | yes |
IFNG_HUMAN | [view interactions] | Computational | no | no |
AP3B1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
OSMR_HUMAN | [view interactions] | Computational | no | yes |
EPO_HUMAN | [view interactions] | Computational | no | no |
EMAL4_HUMAN | [view interactions] | Computational | no | yes |
ONCM_HUMAN | [view interactions] | Computational | no | no |
PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
I27RA_HUMAN | [view interactions] | Computational | no | no |
KDM7A_HUMAN | [view interactions] | Computational | no | yes |
TIF1A_HUMAN | [view interactions] | Computational | no | yes |
CDK4_HUMAN | [view interactions] | Computational | no | no |
LMNA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CSF3_HUMAN | [view interactions] | Computational | no | no |
KAPCG_HUMAN | [view interactions] | Computational | no | no |
IFNB_HUMAN | [view interactions] | Computational | no | no |
PRL_HUMAN | [view interactions] | Computational | no | no |
LPPRC_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SPHK2_HUMAN | [view interactions] | Computational | no | no |
ESRP1_HUMAN | [view interactions] | Computational | no | yes |
ACHB4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
RASK_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CLCN6_HUMAN | [view interactions] | Computational | no | yes |
IL2_HUMAN | [view interactions] | Computational | no | no |
KCC2B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ZCCHV_HUMAN | [view interactions] | Computational | no | yes |
SHC4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
F131B_HUMAN | [view interactions] | Computational | no | no |
PK3CD_HUMAN | [view interactions] | Computational | no | no |
I13R1_HUMAN | [view interactions] | Computational | no | no |
LIFR_HUMAN | [view interactions] | Computational | no | no |
1433B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
STAT6_HUMAN | [view interactions] | Computational | no | yes |
NRG1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
I12R1_HUMAN | [view interactions] | Computational | no | no |
INLR1_HUMAN | [view interactions] | Computational | no | no |
PTPA_HUMAN | [view interactions] | Computational | no | yes |
IL11_HUMAN | [view interactions] | Computational | no | no |
M3K1_HUMAN | [view interactions] | Computational | no | yes |
CCND2_HUMAN | [view interactions] | Computational | no | yes |
IL5_HUMAN | [view interactions] | Computational | no | no |
NFKB2_HUMAN | [view interactions] | Computational | no | yes |
SOCS4_HUMAN | [view interactions] | Computational | no | yes |
ATRAP_HUMAN | [view interactions] | Computational | no | yes |
P85B_HUMAN | [view interactions] | Computational | no | yes |
SOMA_HUMAN | [view interactions] | Computational | no | no |
PTN2_HUMAN | [view interactions] | Computational | no | yes |
EDNRA_HUMAN | [view interactions] | Computational | no | yes |
RAGE_HUMAN | [view entry] [view interactions] | Computational | yes | no |
PGFRA_HUMAN | [view interactions] | Computational | no | no |
M3K11_HUMAN | [view interactions] | Computational | no | yes |
IL27A_HUMAN | [view interactions] | Computational | no | no |
IL4_HUMAN | [view interactions] | Computational | no | no |
PGFRB_HUMAN | [view interactions] | Computational | no | yes |
MUC16_HUMAN | [view interactions] | Computational | no | no |
IL12B_HUMAN | [view interactions] | Computational | no | yes |
FXR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IRS2_HUMAN | [view interactions] | Computational | no | yes |
KAPCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
IL7RA_HUMAN | [view interactions] | Computational | no | no |
PK3CG_HUMAN | [view interactions] | Computational | no | yes |
ERBB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
F1142_HUMAN | [view interactions] | Computational | no | yes |
MK03_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CSF2R_HUMAN | [view interactions] | Computational | no | no |
CDN1A_HUMAN | [view interactions] | Computational | no | no |
INAR2_HUMAN | [view interactions] | Computational | no | no |
IL17D_HUMAN | [view interactions] | Computational | no | no |
ACHA6_HUMAN | [view entry] [view interactions] | Computational | yes | no |
IL6RA_HUMAN | [view interactions] | Computational | no | no |
RASH_HUMAN | [view entry] [view interactions] | Computational | yes | no |
STAT4_HUMAN | [view interactions] | Computational | no | yes |
ACHA4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
TF65_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
NFKB1_HUMAN | [view interactions] | Computational | no | yes |
FGFR2_HUMAN | [view interactions] | Computational | no | yes |
AGGF1_HUMAN | [view interactions] | Computational | no | no |
IL12A_HUMAN | [view interactions] | Computational | no | no |
SND1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PDGFB_HUMAN | [view interactions] | Computational | no | yes |
IFNA1_HUMAN | [view interactions] | Computational | no | no |
P55G_HUMAN | [view interactions] | Computational | no | yes |
IL2RA_HUMAN | [view interactions] | Computational | no | no |
GAB2_HUMAN | [view interactions] | Computational | no | yes |
SHC3_HUMAN | [view interactions] | Computational | no | yes |
ACHA3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
K1549_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
HBEGF_HUMAN | [view interactions] | Computational | no | no |
FGFR3_HUMAN | [view interactions] | Computational | no | yes |
IL23A_HUMAN | [view interactions] | Computational | no | no |
ATG7_HUMAN | [view interactions] | Computational | no | yes |
CSF3R_HUMAN | [view interactions] | Computational | no | yes |
PAPS1_HUMAN | [view interactions] | Computational | no | yes |
LEP_HUMAN | [view interactions] | Computational | no | no |
IL27B_HUMAN | [view interactions] | Computational | no | no |
STAT2_HUMAN | [view interactions] | Computational | no | yes |
KSR1_HUMAN | [view interactions] | Computational | no | yes |
ACHB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
SOCS6_HUMAN | [view interactions] | Computational | no | yes |
RASN_HUMAN | [view entry] [view interactions] | Computational | yes | no |
1433Z_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CRKL_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GAB1_HUMAN | [view interactions] | Computational | no | yes |
MET_HUMAN | [view interactions] | Computational | no | yes |
PK3CB_HUMAN | [view interactions] | Computational | no | yes |
QKI_HUMAN | [view interactions] | Computational | no | no |
BCAR1_HUMAN | [view interactions] | Computational | no | yes |
SOCS2_HUMAN | [view interactions] | Computational | no | yes |
FABP4_HUMAN | [view interactions] | Computational | no | no |
KCC2D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MPRIP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
VGFR2_HUMAN | [view interactions] | Computational | no | no |
KPCD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SHIP1_HUMAN | [view interactions] | Computational | no | no |
CSF2_HUMAN | [view interactions] | Computational | no | no |
SHC2_HUMAN | [view interactions] | Computational | no | yes |
AHI1_HUMAN | [view interactions] | Computational | no | yes |
UFO_HUMAN | [view interactions] | Computational | no | no |
PI3R6_HUMAN | [view interactions] | Computational | no | yes |
RELB_HUMAN | [view interactions] | Computational | no | yes |
INAR1_HUMAN | [view interactions] | Computational | no | yes |
MK01_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
BTK_HUMAN | [view interactions] | Computational | no | no |
CCND3_HUMAN | [view interactions] | Computational | no | no |
IL7_HUMAN | [view interactions] | Computational | no | no |
CCND1_HUMAN | [view interactions] | Computational | no | yes |