ZWINT_HUMAN
Evidence for PS localization
Functions
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ZWINT_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 21.4286 | 4 | no |
| GO:0043168 | anion binding | 21.4286 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ZWINT_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 52.3810 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.6190 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 45.2381 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 45.2381 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 45.2381 | 5 | no |
| GO:0048522 | positive regulation of cellular process | 45.2381 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.8571 | 6 | no |
| GO:0010646 | regulation of cell communication | 38.0952 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 38.0952 | 4 | yes |
| GO:0008104 | protein localization | 38.0952 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 38.0952 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 35.7143 | 4 | yes |
| GO:0022607 | cellular component assembly | 35.7143 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.7143 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 35.7143 | 5 | no |
| GO:0009966 | regulation of signal transduction | 33.3333 | 4 | yes |
| GO:0071702 | organic substance transport | 30.9524 | 4 | no |
| GO:0071705 | nitrogen compound transport | 30.9524 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.5714 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
| GO:0015031 | protein transport | 28.5714 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
| GO:0009892 | negative regulation of metabolic process | 26.1905 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.1905 | 4 | no |
| GO:0061024 | membrane organization | 26.1905 | 4 | no |
| GO:0023056 | positive regulation of signaling | 26.1905 | 4 | no |
| GO:0051726 | regulation of cell cycle | 23.8095 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 23.8095 | 5 | no |
| GO:0036211 | protein modification process | 23.8095 | 4 | no |
| GO:0043412 | macromolecule modification | 23.8095 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.8095 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 23.8095 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0033043 | regulation of organelle organization | 21.4286 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 21.4286 | 5 | no |
| GO:0009894 | regulation of catabolic process | 21.4286 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 21.4286 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 21.4286 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 21.4286 | 6 | no |
| GO:0042127 | regulation of cell population proliferation | 21.4286 | 4 | no |
| GO:0051049 | regulation of transport | 21.4286 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 21.4286 | 4 | no |
| GO:0010564 | regulation of cell cycle process | 19.0476 | 5 | yes |
| GO:0051129 | negative regulation of cellular component organization | 19.0476 | 5 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 14.2857 | 5 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 14.2857 | 6 | yes |
| GO:0010639 | negative regulation of organelle organization | 11.9048 | 6 | yes |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 11.9048 | 6 | yes |
| GO:0010948 | negative regulation of cell cycle process | 9.5238 | 6 | yes |
| GO:0033044 | regulation of chromosome organization | 9.5238 | 6 | yes |
| GO:0045786 | negative regulation of cell cycle | 9.5238 | 5 | yes |
| GO:0045930 | negative regulation of mitotic cell cycle | 9.5238 | 6 | yes |
| GO:1901988 | negative regulation of cell cycle phase transition | 9.5238 | 7 | yes |
| GO:1901991 | negative regulation of mitotic cell cycle phase transition | 9.5238 | 7 | yes |
| GO:0000075 | cell cycle checkpoint signaling | 7.1429 | 4 | yes |
| GO:0007093 | mitotic cell cycle checkpoint signaling | 7.1429 | 4 | yes |
| GO:0033045 | regulation of sister chromatid segregation | 7.1429 | 7 | yes |
| GO:0051983 | regulation of chromosome segregation | 7.1429 | 6 | yes |
| GO:2001251 | negative regulation of chromosome organization | 7.1429 | 7 | yes |
| GO:0000070 | mitotic sister chromatid segregation | 4.7619 | 4 | yes |
| GO:0000819 | sister chromatid segregation | 4.7619 | 5 | yes |
| GO:0007088 | regulation of mitotic nuclear division | 4.7619 | 6 | yes |
| GO:0007094 | mitotic spindle assembly checkpoint signaling | 4.7619 | 6 | yes |
| GO:0010965 | regulation of mitotic sister chromatid separation | 4.7619 | 8 | yes |
| GO:0030071 | regulation of mitotic metaphase/anaphase transition | 4.7619 | 7 | yes |
| GO:0031577 | spindle checkpoint signaling | 4.7619 | 5 | yes |
| GO:0031619 | homologous chromosome orientation in meiotic metaphase I | 4.7619 | 4 | yes |
| GO:0033046 | negative regulation of sister chromatid segregation | 4.7619 | 8 | yes |
| GO:0033047 | regulation of mitotic sister chromatid segregation | 4.7619 | 8 | yes |
| GO:0033048 | negative regulation of mitotic sister chromatid segregation | 4.7619 | 9 | yes |
| GO:0040020 | regulation of meiotic nuclear division | 4.7619 | 5 | yes |
| GO:0045839 | negative regulation of mitotic nuclear division | 4.7619 | 7 | yes |
| GO:0045841 | negative regulation of mitotic metaphase/anaphase transition | 4.7619 | 8 | yes |
| GO:0051276 | chromosome organization | 4.7619 | 5 | yes |
| GO:0051445 | regulation of meiotic cell cycle | 4.7619 | 4 | yes |
| GO:0051783 | regulation of nuclear division | 4.7619 | 6 | yes |
| GO:0051784 | negative regulation of nuclear division | 4.7619 | 7 | yes |
| GO:0051985 | negative regulation of chromosome segregation | 4.7619 | 7 | yes |
| GO:0060631 | regulation of meiosis I | 4.7619 | 6 | yes |
| GO:0071173 | spindle assembly checkpoint signaling | 4.7619 | 6 | yes |
| GO:0071174 | mitotic spindle checkpoint signaling | 4.7619 | 5 | yes |
| GO:0090231 | regulation of spindle checkpoint | 4.7619 | 7 | yes |
| GO:0098813 | nuclear chromosome segregation | 4.7619 | 4 | yes |
| GO:1901976 | regulation of cell cycle checkpoint | 4.7619 | 6 | yes |
| GO:1901993 | regulation of meiotic cell cycle phase transition | 4.7619 | 4 | yes |
| GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 4.7619 | 7 | yes |
| GO:1902100 | negative regulation of metaphase/anaphase transition of cell cycle | 4.7619 | 8 | yes |
| GO:1902102 | regulation of metaphase/anaphase transition of meiotic cell cycle | 4.7619 | 5 | yes |
| GO:1905132 | regulation of meiotic chromosome separation | 4.7619 | 4 | yes |
| GO:1905325 | regulation of meiosis I spindle assembly checkpoint | 4.7619 | 6 | yes |
| GO:1905818 | regulation of chromosome separation | 4.7619 | 7 | yes |
| GO:1905819 | negative regulation of chromosome separation | 4.7619 | 8 | yes |
| GO:2000816 | negative regulation of mitotic sister chromatid separation | 4.7619 | 9 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NDC80_HUMAN | [view interactions] | Low throughput | no | no |
| BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ZW10_HUMAN | [view interactions] | Low throughput | no | yes |
| MIS12_HUMAN | [view interactions] | Low throughput | no | yes |
| NSL1_HUMAN | [view interactions] | Low throughput | no | no |
| KNL1_HUMAN | [view interactions] | Low throughput | no | no |
| MD2L1_HUMAN | [view interactions] | Low throughput | no | no |
| BUB1B_HUMAN | [view interactions] | Low throughput | no | no |
| CLUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI17_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CDC20_HUMAN | [view interactions] | Low throughput | no | no |
| MDM2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3C3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI3R4_HUMAN | [view interactions] | High throughput | no | yes |
| CCD14_HUMAN | [view interactions] | High throughput | no | yes |
| BORC6_HUMAN | [view interactions] | High throughput | no | yes |
| NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |
| KCNQ2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| EYA4_HUMAN | [view interactions] | High throughput | no | yes |
| PHAX_HUMAN | [view interactions] | High throughput | no | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| NUF2_HUMAN | [view interactions] | High throughput | no | no |
| RBM25_HUMAN | [view interactions] | High throughput | no | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CO1A2_HUMAN | [view interactions] | High throughput | no | yes |
| T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAF12_HUMAN | [view interactions] | High throughput | no | yes |
| HTF4_HUMAN | [view interactions] | High throughput | no | yes |
| RABL6_HUMAN | [view interactions] | High throughput | no | yes |
| TPC_HUMAN | [view interactions] | High throughput | no | no |
| BUB1_HUMAN | [view interactions] | High throughput | no | no |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
| SQOR_HUMAN | [view interactions] | High throughput | no | yes |
| DSN1_HUMAN | [view interactions] | High throughput | no | yes |
| TYW3_HUMAN | [view interactions] | High throughput | no | yes |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASTE1_HUMAN | [view interactions] | High throughput | no | no |
| PMF1_HUMAN | [view interactions] | High throughput | no | no |
| CC174_HUMAN | [view interactions] | High throughput | no | yes |
| MED24_HUMAN | [view interactions] | High throughput | no | no |
| IPO4_HUMAN | [view interactions] | High throughput | no | no |
| RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
| EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
| SPC24_HUMAN | [view interactions] | High throughput | no | no |
| ZSWM6_HUMAN | [view interactions] | High throughput | no | no |
| SPC25_HUMAN | [view interactions] | High throughput | no | no |
| RAIN_HUMAN | [view interactions] | High throughput | no | no |
| PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
| F167A_HUMAN | [view interactions] | High throughput | no | yes |
| TNR3_HUMAN | [view interactions] | High throughput | no | yes |
| STX11_HUMAN | [view interactions] | High throughput | no | yes |
| STX19_HUMAN | [view interactions] | High throughput | no | yes |
| LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
| RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX18_HUMAN | [view interactions] | High throughput | no | yes |
| MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYCE3_HUMAN | [view interactions] | High throughput | no | no |
| NEUR2_HUMAN | [view interactions] | High throughput | no | no |
| TSP2_HUMAN | [view interactions] | High throughput | no | yes |
| PCOC2_HUMAN | [view interactions] | High throughput | no | no |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPAT7_HUMAN | [view interactions] | High throughput | no | no |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSGN1_HUMAN | [view interactions] | High throughput | no | no |
| K2C75_HUMAN | [view interactions] | High throughput | no | no |
| NUP54_HUMAN | [view interactions] | High throughput | no | yes |
| F90A1_HUMAN | [view interactions] | High throughput | no | no |
| SPF27_HUMAN | [view interactions] | High throughput | no | yes |
| KLF11_HUMAN | [view interactions] | High throughput | no | no |
| NUP58_HUMAN | [view interactions] | High throughput | no | yes |
| CETN3_HUMAN | [view interactions] | High throughput | no | yes |
| DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNBP_HUMAN | [view interactions] | High throughput | no | no |
| CCN1_HUMAN | [view interactions] | High throughput | no | yes |
| SNP29_HUMAN | [view interactions] | High throughput | no | yes |
| DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPC_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
| TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIFC3_HUMAN | [view interactions] | High throughput | no | no |
| GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2_HUMAN | [view interactions] | High throughput | no | no |
| GANAB_HUMAN | [view interactions] | High throughput | no | yes |
| THA11_HUMAN | [view interactions] | High throughput | no | yes |
| TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSF1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
| BFSP1_HUMAN | [view interactions] | High throughput | no | no |
| CCHCR_HUMAN | [view interactions] | High throughput | no | no |
| N62CL_HUMAN | [view interactions] | High throughput | no | no |
| NUP62_HUMAN | [view interactions] | High throughput | no | yes |
| SMTN_HUMAN | [view interactions] | High throughput | no | no |
| TTBK2_HUMAN | [view interactions] | High throughput | no | yes |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SMG5_HUMAN | [view interactions] | High throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMR6_HUMAN | [view interactions] | High throughput | no | no |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| FBX28_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSRG_HUMAN | [view interactions] | High throughput | no | yes |
| STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| IFT88_HUMAN | [view interactions] | High throughput | no | no |
| SCMH1_HUMAN | [view interactions] | High throughput | no | no |
| DGCR8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZSWM5_HUMAN | [view interactions] | High throughput | no | no |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| TJAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LENG8_HUMAN | [view interactions] | High throughput | no | yes |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| CDC37_HUMAN | [view interactions] | High throughput | no | yes |
| AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PURG_HUMAN | [view interactions] | High throughput | no | yes |
| YBEY_HUMAN | [view interactions] | High throughput | no | yes |
| RM47_HUMAN | [view interactions] | High throughput | no | yes |
| TRMB_HUMAN | [view interactions] | High throughput | no | yes |
| CCD96_HUMAN | [view interactions] | High throughput | no | no |
| KRT83_HUMAN | [view interactions] | High throughput | no | no |
| S100P_HUMAN | [view interactions] | High throughput | no | no |
| DUS16_HUMAN | [view interactions] | High throughput | no | yes |
| ING1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI34_HUMAN | [view interactions] | High throughput | no | no |
| KRT37_HUMAN | [view interactions] | High throughput | no | no |
| KRT38_HUMAN | [view interactions] | High throughput | no | no |
| S10A2_HUMAN | [view interactions] | High throughput | no | no |
| NPAS1_HUMAN | [view interactions] | High throughput | no | no |
| TPST2_HUMAN | [view interactions] | High throughput | no | yes |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY1A_HUMAN | [view interactions] | High throughput | no | no |
| AMY1C_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ARP10_HUMAN | [view interactions] | High throughput | no | no |
| APC13_HUMAN | [view interactions] | High throughput | no | no |
| BUB3_HUMAN | [view interactions] | High throughput | no | yes |
| CENPK_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| CENPW_HUMAN | [view interactions] | High throughput | no | no |
| CEP63_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEO1_HUMAN | [view interactions] | High throughput | no | yes |
| LIAS_HUMAN | [view interactions] | High throughput | no | yes |
| GWL_HUMAN | [view interactions] | High throughput | no | yes |
| MAP2_HUMAN | [view interactions] | High throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
| TAF2_HUMAN | [view interactions] | High throughput | no | no |
| TIPIN_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OTUD4_HUMAN | [view interactions] | High throughput | no | yes |