ZWINT_HUMAN
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ZWINT_HUMAN |
---|---|---|---|---|
GO:0003723 | RNA binding | 20.5128 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ZWINT_HUMAN |
---|---|---|---|---|
GO:0006996 | organelle organization | 46.1538 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 46.1538 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 38.4615 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 38.4615 | 4 | no |
GO:0010468 | regulation of gene expression | 35.8974 | 5 | no |
GO:0008104 | protein localization | 35.8974 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 35.8974 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 35.8974 | 4 | no |
GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | yes |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0051128 | regulation of cellular component organization | 30.7692 | 4 | yes |
GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
GO:0071702 | organic substance transport | 30.7692 | 4 | no |
GO:0071705 | nitrogen compound transport | 30.7692 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 30.7692 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.7692 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 30.7692 | 5 | no |
GO:0016192 | vesicle-mediated transport | 28.2051 | 4 | no |
GO:0015031 | protein transport | 28.2051 | 4 | no |
GO:0009966 | regulation of signal transduction | 28.2051 | 4 | no |
GO:0033043 | regulation of organelle organization | 25.6410 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 25.6410 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 25.6410 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 25.6410 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.6410 | 5 | no |
GO:0006355 | regulation of DNA-templated transcription | 25.6410 | 6 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 25.6410 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 25.6410 | 6 | no |
GO:0043933 | protein-containing complex organization | 23.0769 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 23.0769 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 23.0769 | 5 | no |
GO:0051726 | regulation of cell cycle | 20.5128 | 4 | yes |
GO:0036211 | protein modification process | 20.5128 | 4 | no |
GO:0043412 | macromolecule modification | 20.5128 | 4 | no |
GO:0051049 | regulation of transport | 20.5128 | 4 | no |
GO:0061024 | membrane organization | 20.5128 | 4 | no |
GO:0007010 | cytoskeleton organization | 20.5128 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 20.5128 | 5 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.5128 | 5 | no |
GO:0051129 | negative regulation of cellular component organization | 17.9487 | 5 | yes |
GO:0010564 | regulation of cell cycle process | 15.3846 | 5 | yes |
GO:0010639 | negative regulation of organelle organization | 15.3846 | 6 | yes |
GO:0007346 | regulation of mitotic cell cycle | 12.8205 | 5 | yes |
GO:1901987 | regulation of cell cycle phase transition | 12.8205 | 6 | yes |
GO:0033044 | regulation of chromosome organization | 10.2564 | 6 | yes |
GO:0051983 | regulation of chromosome segregation | 10.2564 | 4 | yes |
GO:1901990 | regulation of mitotic cell cycle phase transition | 10.2564 | 6 | yes |
GO:0007088 | regulation of mitotic nuclear division | 7.6923 | 6 | yes |
GO:0010965 | regulation of mitotic sister chromatid separation | 7.6923 | 6 | yes |
GO:0033045 | regulation of sister chromatid segregation | 7.6923 | 5 | yes |
GO:0051783 | regulation of nuclear division | 7.6923 | 6 | yes |
GO:1905818 | regulation of chromosome separation | 7.6923 | 5 | yes |
GO:2001251 | negative regulation of chromosome organization | 7.6923 | 7 | yes |
GO:0000070 | mitotic sister chromatid segregation | 5.1282 | 4 | yes |
GO:0000075 | cell cycle checkpoint signaling | 5.1282 | 4 | yes |
GO:0000819 | sister chromatid segregation | 5.1282 | 4 | yes |
GO:0007093 | mitotic cell cycle checkpoint signaling | 5.1282 | 4 | yes |
GO:0007094 | mitotic spindle assembly checkpoint signaling | 5.1282 | 6 | yes |
GO:0010948 | negative regulation of cell cycle process | 5.1282 | 6 | yes |
GO:0030071 | regulation of mitotic metaphase/anaphase transition | 5.1282 | 7 | yes |
GO:0031577 | spindle checkpoint signaling | 5.1282 | 5 | yes |
GO:0033046 | negative regulation of sister chromatid segregation | 5.1282 | 6 | yes |
GO:0033047 | regulation of mitotic sister chromatid segregation | 5.1282 | 6 | yes |
GO:0033048 | negative regulation of mitotic sister chromatid segregation | 5.1282 | 7 | yes |
GO:0045786 | negative regulation of cell cycle | 5.1282 | 5 | yes |
GO:0045839 | negative regulation of mitotic nuclear division | 5.1282 | 7 | yes |
GO:0045841 | negative regulation of mitotic metaphase/anaphase transition | 5.1282 | 8 | yes |
GO:0045930 | negative regulation of mitotic cell cycle | 5.1282 | 6 | yes |
GO:0051276 | chromosome organization | 5.1282 | 5 | yes |
GO:0051784 | negative regulation of nuclear division | 5.1282 | 7 | yes |
GO:0051985 | negative regulation of chromosome segregation | 5.1282 | 5 | yes |
GO:0071173 | spindle assembly checkpoint signaling | 5.1282 | 6 | yes |
GO:0071174 | mitotic spindle checkpoint signaling | 5.1282 | 5 | yes |
GO:1901988 | negative regulation of cell cycle phase transition | 5.1282 | 7 | yes |
GO:1901991 | negative regulation of mitotic cell cycle phase transition | 5.1282 | 7 | yes |
GO:1902099 | regulation of metaphase/anaphase transition of cell cycle | 5.1282 | 6 | yes |
GO:1902100 | negative regulation of metaphase/anaphase transition of cell cycle | 5.1282 | 7 | yes |
GO:1905819 | negative regulation of chromosome separation | 5.1282 | 6 | yes |
GO:2000816 | negative regulation of mitotic sister chromatid separation | 5.1282 | 7 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
NDC80_HUMAN | [view interactions] | Low throughput | no | no |
BECN1_HUMAN | [view interactions] | Low throughput | no | yes |
ZW10_HUMAN | [view interactions] | Low throughput | no | yes |
MIS12_HUMAN | [view interactions] | Low throughput | no | yes |
NSL1_HUMAN | [view interactions] | Low throughput | no | no |
KNL1_HUMAN | [view interactions] | Low throughput | no | no |
MD2L1_HUMAN | [view interactions] | Low throughput | no | no |
BUB1B_HUMAN | [view interactions] | Low throughput | no | no |
CLUS_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
TRI17_HUMAN | [view interactions] | Low throughput | no | yes |
P53_HUMAN | [view interactions] | Low throughput | no | no |
SNP25_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
CDC20_HUMAN | [view interactions] | Low throughput | no | no |
MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
PHAX_HUMAN | [view interactions] | High throughput | no | yes |
SPC25_HUMAN | [view interactions] | High throughput | no | no |
SPC24_HUMAN | [view interactions] | High throughput | no | no |
DSN1_HUMAN | [view interactions] | High throughput | no | yes |
PLBL2_HUMAN | [view interactions] | High throughput | no | yes |
RAIN_HUMAN | [view interactions] | High throughput | no | no |
ZSWM6_HUMAN | [view interactions] | High throughput | no | no |
EI2BG_HUMAN | [view interactions] | High throughput | no | yes |
BI2L1_HUMAN | [view interactions] | High throughput | no | yes |
RHG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
IPO4_HUMAN | [view interactions] | High throughput | no | no |
MED24_HUMAN | [view interactions] | High throughput | no | no |
CC174_HUMAN | [view interactions] | High throughput | no | yes |
PMF1_HUMAN | [view interactions] | High throughput | no | no |
ASTE1_HUMAN | [view interactions] | High throughput | no | no |
RIN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
M3K20_HUMAN | [view interactions] | High throughput | no | yes |
TYW3_HUMAN | [view interactions] | High throughput | no | yes |
SQOR_HUMAN | [view interactions] | High throughput | no | yes |
IPYR2_HUMAN | [view interactions] | High throughput | no | yes |
AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BUB1_HUMAN | [view interactions] | High throughput | no | no |
TPC_HUMAN | [view interactions] | High throughput | no | no |
RABL6_HUMAN | [view interactions] | High throughput | no | yes |
HTF4_HUMAN | [view interactions] | High throughput | no | yes |
TAF12_HUMAN | [view interactions] | High throughput | no | yes |
T126A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CO1A2_HUMAN | [view interactions] | High throughput | no | yes |
ARPC5_HUMAN | [view interactions] | High throughput | no | yes |
RBM25_HUMAN | [view interactions] | High throughput | no | yes |
NUF2_HUMAN | [view interactions] | High throughput | no | no |
SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
F167A_HUMAN | [view interactions] | High throughput | no | yes |
TNR3_HUMAN | [view interactions] | High throughput | no | yes |
STX11_HUMAN | [view interactions] | High throughput | no | yes |
STX19_HUMAN | [view interactions] | High throughput | no | yes |
STX18_HUMAN | [view interactions] | High throughput | no | yes |
RRBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LYRM4_HUMAN | [view interactions] | High throughput | no | yes |
MLF1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYCE3_HUMAN | [view interactions] | High throughput | no | no |
NEUR2_HUMAN | [view interactions] | High throughput | no | no |
TSP2_HUMAN | [view interactions] | High throughput | no | yes |
CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PCOC2_HUMAN | [view interactions] | High throughput | no | no |
SPAT7_HUMAN | [view interactions] | High throughput | no | no |
MAFB_HUMAN | [view interactions] | High throughput | no | yes |
TS101_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSGN1_HUMAN | [view interactions] | High throughput | no | no |
K2C75_HUMAN | [view interactions] | High throughput | no | no |
NUP54_HUMAN | [view interactions] | High throughput | no | yes |
F90A1_HUMAN | [view interactions] | High throughput | no | no |
SPF27_HUMAN | [view interactions] | High throughput | no | yes |
KLF11_HUMAN | [view interactions] | High throughput | no | no |
NUP58_HUMAN | [view interactions] | High throughput | no | yes |
CETN3_HUMAN | [view interactions] | High throughput | no | yes |
ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CENPC_HUMAN | [view interactions] | High throughput | no | no |
RCN1_HUMAN | [view interactions] | High throughput | no | yes |
TRIM5_HUMAN | [view interactions] | High throughput | no | yes |
LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
HNRPF_HUMAN | [view interactions] | High throughput | no | yes |
DDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SNP29_HUMAN | [view interactions] | High throughput | no | yes |
CCN1_HUMAN | [view interactions] | High throughput | no | yes |
CNBP_HUMAN | [view interactions] | High throughput | no | no |
DDX17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSF1_HUMAN | [view interactions] | High throughput | no | yes |
EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TPM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
THA11_HUMAN | [view interactions] | High throughput | no | yes |
GANAB_HUMAN | [view interactions] | High throughput | no | yes |
HSF2_HUMAN | [view interactions] | High throughput | no | no |
GLU2B_HUMAN | [view interactions] | High throughput | no | yes |
KIFC3_HUMAN | [view interactions] | High throughput | no | no |
OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TACC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EDEM3_HUMAN | [view interactions] | High throughput | no | yes |
DNLI4_HUMAN | [view interactions] | High throughput | no | yes |
BFSP1_HUMAN | [view interactions] | High throughput | no | no |
CCHCR_HUMAN | [view interactions] | High throughput | no | no |
N62CL_HUMAN | [view interactions] | High throughput | no | no |
NUP62_HUMAN | [view interactions] | High throughput | no | yes |
SMTN_HUMAN | [view interactions] | High throughput | no | no |
TTBK2_HUMAN | [view interactions] | High throughput | no | yes |
GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SMG5_HUMAN | [view interactions] | High throughput | no | no |
UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NEDD1_HUMAN | [view interactions] | High throughput | no | yes |
MTMR6_HUMAN | [view interactions] | High throughput | no | no |
NFS1_HUMAN | [view interactions] | High throughput | no | yes |
FBX28_HUMAN | [view interactions] | High throughput | no | yes |
ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SSRG_HUMAN | [view interactions] | High throughput | no | yes |
STX3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
IFT88_HUMAN | [view interactions] | High throughput | no | no |
SCMH1_HUMAN | [view interactions] | High throughput | no | no |
DGCR8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZSWM5_HUMAN | [view interactions] | High throughput | no | no |
E41L5_HUMAN | [view interactions] | High throughput | no | no |
TJAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LENG8_HUMAN | [view interactions] | High throughput | no | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EXOC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
CDC37_HUMAN | [view interactions] | High throughput | no | yes |
AGRIN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
APEX1_HUMAN | [view interactions] | High throughput | no | yes |
KCC2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PURG_HUMAN | [view interactions] | High throughput | no | yes |
YBEY_HUMAN | [view interactions] | High throughput | no | yes |
RM47_HUMAN | [view interactions] | High throughput | no | yes |
TRMB_HUMAN | [view interactions] | High throughput | no | yes |
CCD96_HUMAN | [view interactions] | High throughput | no | no |
KRT83_HUMAN | [view interactions] | High throughput | no | no |
S100P_HUMAN | [view interactions] | High throughput | no | no |
DUS16_HUMAN | [view interactions] | High throughput | no | yes |
ING1_HUMAN | [view interactions] | High throughput | no | yes |
TRI34_HUMAN | [view interactions] | High throughput | no | no |
KRT37_HUMAN | [view interactions] | High throughput | no | no |
KRT38_HUMAN | [view interactions] | High throughput | no | no |
S10A2_HUMAN | [view interactions] | High throughput | no | no |
NPAS1_HUMAN | [view interactions] | High throughput | no | no |
TPST2_HUMAN | [view interactions] | High throughput | no | yes |
AMY1B_HUMAN | [view interactions] | High throughput | no | no |
AMY1A_HUMAN | [view interactions] | High throughput | no | no |
AMY1C_HUMAN | [view interactions] | High throughput | no | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
HSP74_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ARP10_HUMAN | [view interactions] | High throughput | no | no |
APC13_HUMAN | [view interactions] | High throughput | no | no |
BUB3_HUMAN | [view interactions] | High throughput | no | yes |
CENPK_HUMAN | [view interactions] | High throughput | no | no |
CENPM_HUMAN | [view interactions] | High throughput | no | yes |
CENPW_HUMAN | [view interactions] | High throughput | no | no |
CEP63_HUMAN | [view interactions] | High throughput | no | yes |
DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
LIAS_HUMAN | [view interactions] | High throughput | no | yes |
GWL_HUMAN | [view interactions] | High throughput | no | yes |
MAP2_HUMAN | [view interactions] | High throughput | no | yes |
SKA3_HUMAN | [view interactions] | High throughput | no | no |
SPDLY_HUMAN | [view interactions] | High throughput | no | yes |
TAF2_HUMAN | [view interactions] | High throughput | no | no |
TIPIN_HUMAN | [view interactions] | High throughput | no | no |
A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OTUD4_HUMAN | [view interactions] | High throughput | no | yes |
CENPE_HUMAN | [view interactions] | High throughput | no | no |
CLAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PK3C3_HUMAN | [view interactions] | High throughput | no | yes |
PI3R4_HUMAN | [view interactions] | High throughput | no | yes |
CCD14_HUMAN | [view interactions] | High throughput | no | yes |
BORC6_HUMAN | [view interactions] | High throughput | no | yes |
NFM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MCM2_HUMAN | [view interactions] | Computational | no | no |
CDC45_HUMAN | [view interactions] | Computational | no | no |
TTK_HUMAN | [view interactions] | Computational | no | yes |
NEK2_HUMAN | [view interactions] | Computational | no | no |
RIR2_HUMAN | [view interactions] | Computational | no | no |
RGAP1_HUMAN | [view interactions] | Computational | no | no |
DTL_HUMAN | [view interactions] | Computational | no | no |
CND3_HUMAN | [view interactions] | Computational | no | yes |
ZWILC_HUMAN | [view interactions] | Computational | no | no |
HMMR_HUMAN | [view interactions] | Computational | no | yes |
BOREA_HUMAN | [view interactions] | Computational | no | yes |
CDKN3_HUMAN | [view interactions] | Computational | no | no |
UBE2C_HUMAN | [view interactions] | Computational | no | yes |
MS18B_HUMAN | [view interactions] | Computational | no | no |
TYSY_HUMAN | [view interactions] | Computational | no | yes |
KI67_HUMAN | [view interactions] | Computational | no | no |
KNTC1_HUMAN | [view interactions] | Computational | no | no |
PRC1_HUMAN | [view interactions] | Computational | no | yes |
TPX2_HUMAN | [view interactions] | Computational | no | yes |
CDK1_HUMAN | [view interactions] | Computational | no | no |
KIF23_HUMAN | [view interactions] | Computational | no | yes |
MCM10_HUMAN | [view interactions] | Computational | no | no |
FANCI_HUMAN | [view interactions] | Computational | no | yes |
PAF15_HUMAN | [view interactions] | Computational | no | no |
KI20A_HUMAN | [view interactions] | Computational | no | yes |
AURKB_HUMAN | [view interactions] | Computational | no | yes |
CENPF_HUMAN | [view interactions] | Computational | no | no |
PCH2_HUMAN | [view interactions] | Computational | no | no |
KIF11_HUMAN | [view interactions] | Computational | no | yes |
CCNA2_HUMAN | [view interactions] | Computational | no | no |
CEP55_HUMAN | [view interactions] | Computational | no | yes |
CCNB2_HUMAN | [view interactions] | Computational | no | yes |
AURKA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
R51A1_HUMAN | [view interactions] | Computational | no | no |
RFC4_HUMAN | [view interactions] | Computational | no | yes |
CDCA5_HUMAN | [view interactions] | Computational | no | yes |
NUSAP_HUMAN | [view interactions] | Computational | no | no |
FOXM1_HUMAN | [view interactions] | Computational | no | yes |
CCNB1_HUMAN | [view interactions] | Computational | no | no |
KIF2C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CENPU_HUMAN | [view interactions] | Computational | no | no |
TOPK_HUMAN | [view interactions] | Computational | no | no |
SPAG5_HUMAN | [view interactions] | Computational | no | yes |
TOP2A_HUMAN | [view interactions] | Computational | no | no |
DLGP5_HUMAN | [view interactions] | Computational | no | no |
KIF15_HUMAN | [view interactions] | Computational | no | no |
KIF4A_HUMAN | [view interactions] | Computational | no | yes |
MELK_HUMAN | [view interactions] | Computational | no | yes |
CENPA_HUMAN | [view interactions] | Computational | no | no |
HJURP_HUMAN | [view interactions] | Computational | no | yes |
PSF2_HUMAN | [view interactions] | Computational | no | no |
PTTG1_HUMAN | [view interactions] | Computational | no | no |
ASPM_HUMAN | [view interactions] | Computational | no | no |