ARPC5_HUMAN
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
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No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARPC5_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 42.8571 | 4 | yes |
GO:0000166 | nucleotide binding | 30.3571 | 4 | no |
GO:0017076 | purine nucleotide binding | 30.3571 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
GO:0043168 | anion binding | 28.5714 | 4 | no |
GO:0019900 | kinase binding | 28.5714 | 4 | no |
GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 26.7857 | 4 | no |
GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
GO:0032559 | adenyl ribonucleotide binding | 23.2143 | 5 | no |
GO:0043169 | cation binding | 23.2143 | 4 | no |
GO:0046872 | metal ion binding | 23.2143 | 5 | no |
GO:0005524 | ATP binding | 21.4286 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARPC5_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 58.9286 | 4 | no |
GO:0006996 | organelle organization | 51.7857 | 4 | yes |
GO:0051128 | regulation of cellular component organization | 46.4286 | 4 | yes |
GO:0022607 | cellular component assembly | 46.4286 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | no |
GO:0048523 | negative regulation of cellular process | 46.4286 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.6429 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 41.0714 | 4 | no |
GO:0097435 | supramolecular fiber organization | 39.2857 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 39.2857 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
GO:0010646 | regulation of cell communication | 35.7143 | 4 | no |
GO:0007010 | cytoskeleton organization | 33.9286 | 5 | yes |
GO:0007015 | actin filament organization | 33.9286 | 5 | yes |
GO:0044087 | regulation of cellular component biogenesis | 33.9286 | 4 | yes |
GO:0009966 | regulation of signal transduction | 33.9286 | 4 | no |
GO:0033043 | regulation of organelle organization | 32.1429 | 5 | yes |
GO:0009889 | regulation of biosynthetic process | 30.3571 | 4 | no |
GO:0010468 | regulation of gene expression | 30.3571 | 6 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 30.3571 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 30.3571 | 5 | no |
GO:0051049 | regulation of transport | 30.3571 | 4 | no |
GO:0008104 | protein localization | 28.5714 | 4 | no |
GO:0032970 | regulation of actin filament-based process | 26.7857 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 26.7857 | 6 | yes |
GO:0048584 | positive regulation of response to stimulus | 26.7857 | 4 | no |
GO:0043933 | protein-containing complex organization | 26.7857 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 26.7857 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 26.7857 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 25.0000 | 5 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 25.0000 | 5 | yes |
GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
GO:0110053 | regulation of actin filament organization | 23.2143 | 6 | yes |
GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.2143 | 6 | no |
GO:0071310 | cellular response to organic substance | 23.2143 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 23.2143 | 5 | no |
GO:0051050 | positive regulation of transport | 23.2143 | 4 | no |
GO:0030030 | cell projection organization | 21.4286 | 4 | no |
GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 17.8571 | 5 | yes |
GO:0008064 | regulation of actin polymerization or depolymerization | 16.0714 | 6 | yes |
GO:0030832 | regulation of actin filament length | 16.0714 | 5 | yes |
GO:0032271 | regulation of protein polymerization | 16.0714 | 6 | yes |
GO:0032535 | regulation of cellular component size | 16.0714 | 4 | yes |
GO:0030833 | regulation of actin filament polymerization | 14.2857 | 7 | yes |
GO:0034314 | Arp2/3 complex-mediated actin nucleation | 14.2857 | 7 | yes |
GO:0045010 | actin nucleation | 14.2857 | 6 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
ARPIN_HUMAN | [view interactions] | Low throughput | no | yes |
GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
MAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ACTS_HUMAN | [view interactions] | Low throughput | no | no |
ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FLNB_HUMAN | [view interactions] | High throughput | no | no |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RNH2B_HUMAN | [view interactions] | High throughput | no | yes |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
RASA1_HUMAN | [view interactions] | High throughput | no | yes |
PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TMIG1_HUMAN | [view interactions] | High throughput | no | no |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
HTRA4_HUMAN | [view interactions] | High throughput | no | no |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
ASCC3_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
ZNG1C_HUMAN | [view interactions] | High throughput | no | yes |
HOIL1_HUMAN | [view interactions] | High throughput | no | no |
TROP_HUMAN | [view interactions] | High throughput | no | no |
VP13A_HUMAN | [view interactions] | High throughput | no | yes |
KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MKS1_HUMAN | [view interactions] | High throughput | no | no |
VP13C_HUMAN | [view interactions] | High throughput | no | yes |
DPOA2_HUMAN | [view interactions] | High throughput | no | yes |
RAD21_HUMAN | [view interactions] | High throughput | no | yes |
HUS1_HUMAN | [view interactions] | High throughput | no | yes |
TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
DCPS_HUMAN | [view interactions] | High throughput | no | yes |
IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PPARG_HUMAN | [view interactions] | High throughput | no | yes |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CHUR_HUMAN | [view interactions] | High throughput | no | yes |
PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
T11L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GGACT_HUMAN | [view interactions] | High throughput | no | no |
SIK2_HUMAN | [view interactions] | High throughput | no | yes |
BRD3_HUMAN | [view interactions] | High throughput | no | yes |
PLK4_HUMAN | [view interactions] | High throughput | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK26_HUMAN | [view interactions] | High throughput | no | no |
UBP22_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
BAP1_HUMAN | [view interactions] | High throughput | no | yes |
DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
SPPL3_HUMAN | [view interactions] | High throughput | no | no |
ITA2B_HUMAN | [view interactions] | High throughput | no | no |
ITB2_HUMAN | [view interactions] | High throughput | no | no |
AASD1_HUMAN | [view interactions] | High throughput | no | yes |
AN32B_HUMAN | [view interactions] | High throughput | no | yes |
BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
TRMB_HUMAN | [view interactions] | High throughput | no | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
2AAB_HUMAN | [view interactions] | High throughput | no | yes |
KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ACSF2_HUMAN | [view interactions] | High throughput | no | no |
BICD2_HUMAN | [view interactions] | High throughput | no | yes |
TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
STING_HUMAN | [view interactions] | High throughput | no | yes |