ARPC5_HUMAN
Evidence for PS localization
Functions
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARPC5_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 42.8571 | 4 | yes |
| GO:0000166 | nucleotide binding | 30.3571 | 4 | no |
| GO:0017076 | purine nucleotide binding | 30.3571 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 28.5714 | 4 | no |
| GO:0043168 | anion binding | 28.5714 | 4 | no |
| GO:0019900 | kinase binding | 28.5714 | 4 | no |
| GO:0019901 | protein kinase binding | 28.5714 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 26.7857 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 23.2143 | 5 | no |
| GO:0043169 | cation binding | 23.2143 | 4 | no |
| GO:0046872 | metal ion binding | 23.2143 | 5 | no |
| GO:0005524 | ATP binding | 21.4286 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARPC5_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.9286 | 4 | no |
| GO:0006996 | organelle organization | 51.7857 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 46.4286 | 4 | yes |
| GO:0022607 | cellular component assembly | 46.4286 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.4286 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.4286 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.6429 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.0714 | 4 | no |
| GO:0097435 | supramolecular fiber organization | 39.2857 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 39.2857 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 37.5000 | 5 | no |
| GO:0010646 | regulation of cell communication | 35.7143 | 4 | no |
| GO:0007010 | cytoskeleton organization | 33.9286 | 5 | yes |
| GO:0007015 | actin filament organization | 33.9286 | 5 | yes |
| GO:0044087 | regulation of cellular component biogenesis | 33.9286 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 33.9286 | 4 | no |
| GO:0033043 | regulation of organelle organization | 32.1429 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 30.3571 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.3571 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.3571 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.3571 | 5 | no |
| GO:0051049 | regulation of transport | 30.3571 | 4 | no |
| GO:0008104 | protein localization | 28.5714 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 26.7857 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 26.7857 | 6 | yes |
| GO:0048584 | positive regulation of response to stimulus | 26.7857 | 4 | no |
| GO:0043933 | protein-containing complex organization | 26.7857 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.7857 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.7857 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 25.0000 | 5 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 25.0000 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 25.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 23.2143 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.2143 | 6 | no |
| GO:0071310 | cellular response to organic substance | 23.2143 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 23.2143 | 5 | no |
| GO:0051050 | positive regulation of transport | 23.2143 | 4 | no |
| GO:0030030 | cell projection organization | 21.4286 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 21.4286 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 21.4286 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 17.8571 | 5 | yes |
| GO:0008064 | regulation of actin polymerization or depolymerization | 16.0714 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 16.0714 | 5 | yes |
| GO:0032271 | regulation of protein polymerization | 16.0714 | 6 | yes |
| GO:0032535 | regulation of cellular component size | 16.0714 | 4 | yes |
| GO:0030833 | regulation of actin filament polymerization | 14.2857 | 7 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 14.2857 | 7 | yes |
| GO:0045010 | actin nucleation | 14.2857 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARPIN_HUMAN | [view interactions] | Low throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MAPK2_HUMAN | [view interactions] | Low throughput | no | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ARRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3H_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| ZWINT_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH11_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RNH2B_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| PDPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMIG1_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ASCC3_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNG1C_HUMAN | [view interactions] | High throughput | no | yes |
| HOIL1_HUMAN | [view interactions] | High throughput | no | no |
| TROP_HUMAN | [view interactions] | High throughput | no | no |
| VP13A_HUMAN | [view interactions] | High throughput | no | yes |
| KPCD2_HUMAN | [view interactions] | High throughput | no | yes |
| UBB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MKS1_HUMAN | [view interactions] | High throughput | no | no |
| VP13C_HUMAN | [view interactions] | High throughput | no | yes |
| DPOA2_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| HUS1_HUMAN | [view interactions] | High throughput | no | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| DCPS_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPARG_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| BCAR1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| ARP5L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| PAPD1_HUMAN | [view interactions] | High throughput | no | yes |
| T11L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GGACT_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| BRD3_HUMAN | [view interactions] | High throughput | no | yes |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| SPPL3_HUMAN | [view interactions] | High throughput | no | no |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| ITB2_HUMAN | [view interactions] | High throughput | no | no |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
| TRMB_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| CALR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2AAB_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSF2_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| STING_HUMAN | [view interactions] | High throughput | no | yes |