ARPC3_HUMAN
Evidence for PS localization
Functions
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARPC3_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 48.0000 | 4 | yes |
| GO:0045296 | cadherin binding | 25.3333 | 4 | no |
| GO:0019900 | kinase binding | 24.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 24.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 24.0000 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.0000 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 22.6667 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 21.3333 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.3333 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARPC3_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 64.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 62.6667 | 4 | no |
| GO:0006996 | organelle organization | 54.6667 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 53.3333 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.6667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 49.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 48.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 46.6667 | 5 | yes |
| GO:0022607 | cellular component assembly | 45.3333 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 44.0000 | 4 | yes |
| GO:0051493 | regulation of cytoskeleton organization | 44.0000 | 6 | yes |
| GO:0032970 | regulation of actin filament-based process | 40.0000 | 4 | yes |
| GO:0032956 | regulation of actin cytoskeleton organization | 38.6667 | 5 | yes |
| GO:0007010 | cytoskeleton organization | 38.6667 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 37.3333 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.3333 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 36.0000 | 6 | yes |
| GO:1902903 | regulation of supramolecular fiber organization | 36.0000 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.0000 | 5 | no |
| GO:0030030 | cell projection organization | 34.6667 | 4 | no |
| GO:0010646 | regulation of cell communication | 34.6667 | 4 | no |
| GO:0007015 | actin filament organization | 33.3333 | 5 | yes |
| GO:0097435 | supramolecular fiber organization | 33.3333 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 33.3333 | 5 | no |
| GO:0051049 | regulation of transport | 32.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.6667 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.6667 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.6667 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.3333 | 4 | no |
| GO:0008104 | protein localization | 29.3333 | 4 | no |
| GO:0009966 | regulation of signal transduction | 29.3333 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 28.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.0000 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 28.0000 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0032535 | regulation of cellular component size | 24.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 24.0000 | 6 | no |
| GO:0043412 | macromolecule modification | 24.0000 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.0000 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 24.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.0000 | 4 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 22.6667 | 5 | yes |
| GO:0036211 | protein modification process | 22.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.6667 | 5 | no |
| GO:0008064 | regulation of actin polymerization or depolymerization | 21.3333 | 6 | yes |
| GO:0030832 | regulation of actin filament length | 21.3333 | 5 | yes |
| GO:0019220 | regulation of phosphate metabolic process | 21.3333 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 21.3333 | 5 | no |
| GO:0051050 | positive regulation of transport | 21.3333 | 4 | no |
| GO:0010638 | positive regulation of organelle organization | 21.3333 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 21.3333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 21.3333 | 4 | no |
| GO:0030833 | regulation of actin filament polymerization | 18.6667 | 7 | yes |
| GO:0032271 | regulation of protein polymerization | 18.6667 | 6 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 9.3333 | 7 | yes |
| GO:0045010 | actin nucleation | 9.3333 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ARPC3_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 5.3333 | 3 | no |
| DOID:0050700 | cardiomyopathy | 4.0000 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.0000 | 5 | no |
| DOID:2843 | long QT syndrome | 2.6667 | 6 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RS4X_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC5_HUMAN | [view interactions] | Low throughput | no | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| VASP_HUMAN | [view interactions] | High throughput | no | yes |
| UFM1_HUMAN | [view interactions] | High throughput | no | yes |
| PREP_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| LATS1_HUMAN | [view interactions] | High throughput | no | yes |
| PO2F1_HUMAN | [view interactions] | High throughput | no | yes |
| SYBU_HUMAN | [view interactions] | High throughput | no | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| OBSL1_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| DOCK7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DUS6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS8_HUMAN | [view interactions] | High throughput | no | no |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| AAR2_HUMAN | [view interactions] | High throughput | no | no |
| PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANO7_HUMAN | [view interactions] | High throughput | no | no |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUDC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| MNDA_HUMAN | [view interactions] | High throughput | no | no |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BCOR_HUMAN | [view interactions] | High throughput | no | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALR_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| TM10A_HUMAN | [view interactions] | High throughput | no | no |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAP0_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HCD2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTPRF_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STXB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| FURIN_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| CATS_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| MK06_HUMAN | [view interactions] | High throughput | no | yes |
| DCTN3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| ML12B_HUMAN | [view interactions] | High throughput | no | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFA97_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DOCK8_HUMAN | [view interactions] | High throughput | no | yes |
| LRCH2_HUMAN | [view interactions] | High throughput | no | no |
| GALT_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CXCR2_HUMAN | [view interactions] | High throughput | no | no |
| LITD1_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HXA3_HUMAN | [view interactions] | High throughput | no | no |
| GOGA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NRIP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYTC2_HUMAN | [view interactions] | High throughput | no | yes |
| RETR3_HUMAN | [view interactions] | High throughput | no | yes |
| RB8NL_HUMAN | [view interactions] | High throughput | no | no |
| FAM9A_HUMAN | [view interactions] | High throughput | no | no |
| DUS29_HUMAN | [view interactions] | High throughput | no | yes |
| ZN576_HUMAN | [view interactions] | High throughput | no | no |
| CCR10_HUMAN | [view interactions] | High throughput | no | yes |
| BAG6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDN2B_HUMAN | [view interactions] | High throughput | no | no |
| ARAP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANM1_HUMAN | [view interactions] | High throughput | no | yes |
| LEG4_HUMAN | [view interactions] | High throughput | no | no |
| CETP_HUMAN | [view interactions] | High throughput | no | no |
| OTUD5_HUMAN | [view interactions] | High throughput | no | yes |
| THNS2_HUMAN | [view interactions] | High throughput | no | no |
| LKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| PCARE_HUMAN | [view interactions] | High throughput | no | no |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| CE290_HUMAN | [view interactions] | High throughput | no | no |
| CE128_HUMAN | [view interactions] | High throughput | no | yes |
| CE104_HUMAN | [view interactions] | High throughput | no | yes |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| FOS_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| SPN90_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ARP3C_HUMAN | [view interactions] | Computational | no | no |
| NCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ABI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| IGLL5_HUMAN | [view interactions] | Computational | no | no |
| PGFRB_HUMAN | [view interactions] | Computational | no | yes |
| PSB2_HUMAN | [view interactions] | Computational | no | yes |
| NCKP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| WASF3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDGFB_HUMAN | [view interactions] | Computational | no | yes |
| PSB3_HUMAN | [view interactions] | Computational | no | yes |
| HCLS1_HUMAN | [view interactions] | Computational | no | no |
| WASF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GAB1_HUMAN | [view interactions] | Computational | no | yes |
| FCG2A_HUMAN | [view interactions] | Computational | no | no |
| NCK1_HUMAN | [view interactions] | Computational | no | yes |
| FCGR1_HUMAN | [view interactions] | Computational | no | no |
| BRK1_HUMAN | [view interactions] | Computational | no | no |
| PSA7_HUMAN | [view interactions] | Computational | no | yes |
| CD3Z_HUMAN | [view interactions] | Computational | no | no |
| WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |