EFHD2_HUMAN
Evidence for PS localization
Functions
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EFHD2_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 40.9091 | 4 | no |
| GO:0017076 | purine nucleotide binding | 40.9091 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 38.6364 | 4 | no |
| GO:0043168 | anion binding | 38.6364 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.3636 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 34.0909 | 6 | no |
| GO:0032559 | adenyl ribonucleotide binding | 31.8182 | 5 | no |
| GO:0005524 | ATP binding | 29.5455 | 5 | no |
| GO:0045296 | cadherin binding | 22.7273 | 4 | yes |
| GO:0003779 | actin binding | 22.7273 | 4 | no |
| GO:0003723 | RNA binding | 22.7273 | 4 | no |
| GO:0043169 | cation binding | 20.4545 | 4 | yes |
| GO:0046872 | metal ion binding | 20.4545 | 5 | yes |
| GO:0005509 | calcium ion binding | 6.8182 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EFHD2_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 54.5455 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 52.2727 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 47.7273 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 45.4545 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 45.4545 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.1818 | 4 | no |
| GO:0022607 | cellular component assembly | 38.6364 | 4 | no |
| GO:0008104 | protein localization | 38.6364 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.6364 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 36.3636 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 36.3636 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 36.3636 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 36.3636 | 5 | no |
| GO:0006996 | organelle organization | 36.3636 | 4 | no |
| GO:0010468 | regulation of gene expression | 36.3636 | 6 | no |
| GO:0009893 | positive regulation of metabolic process | 34.0909 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.8182 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.5455 | 5 | no |
| GO:0033043 | regulation of organelle organization | 29.5455 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.5455 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.5455 | 5 | no |
| GO:0009894 | regulation of catabolic process | 29.5455 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.2727 | 5 | no |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | no |
| GO:0032880 | regulation of protein localization | 27.2727 | 5 | no |
| GO:0060341 | regulation of cellular localization | 27.2727 | 4 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0071310 | cellular response to organic substance | 25.0000 | 4 | no |
| GO:0009890 | negative regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 25.0000 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0031399 | regulation of protein modification process | 25.0000 | 6 | no |
| GO:0015031 | protein transport | 25.0000 | 4 | no |
| GO:0071702 | organic substance transport | 25.0000 | 4 | no |
| GO:0071705 | nitrogen compound transport | 25.0000 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 25.0000 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.7273 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 22.7273 | 6 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.7273 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 22.7273 | 5 | no |
| GO:0080134 | regulation of response to stress | 22.7273 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 22.7273 | 5 | no |
| GO:0043933 | protein-containing complex organization | 22.7273 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 22.7273 | 6 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 22.7273 | 4 | no |
| GO:0051726 | regulation of cell cycle | 22.7273 | 4 | no |
| GO:0007010 | cytoskeleton organization | 22.7273 | 5 | no |
| GO:0009966 | regulation of signal transduction | 22.7273 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 22.7273 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 20.4545 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 20.4545 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.4545 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4545 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.4545 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.4545 | 5 | no |
| GO:0010629 | negative regulation of gene expression | 20.4545 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 20.4545 | 5 | no |
| GO:0023056 | positive regulation of signaling | 20.4545 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 20.4545 | 7 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MTAP_HUMAN | [view interactions] | Low throughput | no | no |
| UBP11_HUMAN | [view interactions] | Low throughput | no | yes |
| SETB1_HUMAN | [view interactions] | Low throughput | no | yes |
| RA51D_HUMAN | [view interactions] | Low throughput | no | no |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PK3CA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP26B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMZ2_HUMAN | [view interactions] | High throughput | no | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| SWAP1_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| T2R41_HUMAN | [view interactions] | High throughput | no | no |
| RDH12_HUMAN | [view interactions] | High throughput | no | no |
| OR2K2_HUMAN | [view interactions] | High throughput | no | no |
| OR5F1_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF38_HUMAN | [view interactions] | High throughput | no | yes |
| E2F4_HUMAN | [view interactions] | High throughput | no | no |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| OVOL2_HUMAN | [view interactions] | High throughput | no | no |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP1_HUMAN | [view interactions] | High throughput | no | yes |
| HS71B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HS71A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARPT_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ARC1B_HUMAN | [view interactions] | High throughput | no | no |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCK_HUMAN | [view interactions] | High throughput | no | no |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| FCL_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| PAPS2_HUMAN | [view interactions] | High throughput | no | yes |
| UNG_HUMAN | [view interactions] | High throughput | no | yes |
| DNJB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| LRC40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHD1_HUMAN | [view interactions] | High throughput | no | no |
| STA10_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP1_HUMAN | [view interactions] | High throughput | no | yes |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KBTB4_HUMAN | [view interactions] | High throughput | no | yes |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB25_HUMAN | [view interactions] | High throughput | no | no |
| RAB18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| WWTR1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |