EFHD2_HUMAN
Evidence for PS localization
Functions
May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in EFHD2_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 34.4828 | 4 | no |
| GO:0005524 | ATP binding | 24.1379 | 5 | no |
| GO:0017076 | purine nucleotide binding | 24.1379 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 24.1379 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.1379 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.1379 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.1379 | 4 | no |
| GO:0045296 | cadherin binding | 20.6897 | 4 | yes |
| GO:0046872 | metal ion binding | 20.6897 | 4 | yes |
| GO:0003723 | RNA binding | 20.6897 | 4 | no |
| GO:0005509 | calcium ion binding | 6.8966 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in EFHD2_HUMAN |
|---|---|---|---|---|
| GO:0051128 | regulation of cellular component organization | 48.2759 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 48.2759 | 4 | no |
| GO:0022607 | cellular component assembly | 44.8276 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.8276 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.3793 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 41.3793 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 41.3793 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 41.3793 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 37.9310 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 37.9310 | 5 | no |
| GO:0006996 | organelle organization | 37.9310 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 34.4828 | 5 | no |
| GO:0033043 | regulation of organelle organization | 34.4828 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.4828 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.0345 | 5 | no |
| GO:0032880 | regulation of protein localization | 31.0345 | 5 | no |
| GO:0060341 | regulation of cellular localization | 31.0345 | 4 | no |
| GO:0008104 | protein localization | 31.0345 | 4 | no |
| GO:0051049 | regulation of transport | 31.0345 | 4 | no |
| GO:0051050 | positive regulation of transport | 31.0345 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 31.0345 | 4 | no |
| GO:0009894 | regulation of catabolic process | 27.5862 | 4 | no |
| GO:0030030 | cell projection organization | 27.5862 | 4 | no |
| GO:0036211 | protein modification process | 27.5862 | 4 | no |
| GO:0043412 | macromolecule modification | 27.5862 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 27.5862 | 6 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 27.5862 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 27.5862 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.1379 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 24.1379 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.1379 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.1379 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.1379 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 24.1379 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 24.1379 | 5 | no |
| GO:0051223 | regulation of protein transport | 24.1379 | 5 | no |
| GO:0070201 | regulation of establishment of protein localization | 24.1379 | 6 | no |
| GO:0007010 | cytoskeleton organization | 24.1379 | 5 | no |
| GO:0071702 | organic substance transport | 24.1379 | 4 | no |
| GO:0031344 | regulation of cell projection organization | 20.6897 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.6897 | 6 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 20.6897 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.6897 | 4 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 20.6897 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 20.6897 | 6 | no |
| GO:0043254 | regulation of protein-containing complex assembly | 20.6897 | 5 | no |
| GO:0051726 | regulation of cell cycle | 20.6897 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.6897 | 4 | no |
| GO:0080134 | regulation of response to stress | 20.6897 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.6897 | 5 | no |
| GO:0007015 | actin filament organization | 20.6897 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 20.6897 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 20.6897 | 5 | no |
| GO:0051222 | positive regulation of protein transport | 20.6897 | 5 | no |
| GO:1903829 | positive regulation of protein localization | 20.6897 | 5 | no |
| GO:1904951 | positive regulation of establishment of protein localization | 20.6897 | 6 | no |
| GO:0015031 | protein transport | 20.6897 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 20.6897 | 5 | no |
| GO:0071705 | nitrogen compound transport | 20.6897 | 4 | no |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in EFHD2_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.8966 | 4 | no |
| DOID:331 | central nervous system disease | 6.8966 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RA51D_HUMAN | [view interactions] | Low throughput | no | no |
| MTAP_HUMAN | [view interactions] | Low throughput | no | no |
| UBP11_HUMAN | [view interactions] | Low throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPCD1_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KITH_HUMAN | [view interactions] | High throughput | no | yes |
| AMZ2_HUMAN | [view interactions] | High throughput | no | yes |
| VP26A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| VP26B_HUMAN | [view interactions] | High throughput | no | yes |
| UBS3A_HUMAN | [view interactions] | High throughput | no | no |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CBL_HUMAN | [view interactions] | High throughput | no | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| AAPK1_HUMAN | [view interactions] | High throughput | no | no |
| AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
| HOME1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYCB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EGLN_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| A16L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SSH1_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| 1433E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| GSX1_HUMAN | [view interactions] | High throughput | no | no |
| FCG2A_HUMAN | [view interactions] | High throughput | no | no |
| T2R41_HUMAN | [view interactions] | High throughput | no | no |
| RDH12_HUMAN | [view interactions] | High throughput | no | no |
| OR2K2_HUMAN | [view interactions] | High throughput | no | no |
| OR5F1_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| SNR27_HUMAN | [view interactions] | High throughput | no | yes |
| TYSY_HUMAN | [view interactions] | High throughput | no | yes |
| DTX3_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| FBXW7_HUMAN | [view interactions] | High throughput | no | yes |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHM4A_HUMAN | [view interactions] | High throughput | no | no |
| COASY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCK_HUMAN | [view interactions] | High throughput | no | no |
| ENOG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
| GUAA_HUMAN | [view interactions] | High throughput | no | no |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RCN1_HUMAN | [view interactions] | High throughput | no | yes |
| FCL_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| TMOD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBF1_HUMAN | [view interactions] | High throughput | no | yes |
| DCA15_HUMAN | [view interactions] | High throughput | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| RHDF2_HUMAN | [view interactions] | High throughput | no | yes |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |