ARPC4_HUMAN
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in ARPC4_HUMAN |
---|---|---|---|---|
GO:0003779 | actin binding | 48.5714 | 4 | yes |
GO:0017076 | purine nucleotide binding | 24.2857 | 4 | no |
GO:0032555 | purine ribonucleotide binding | 24.2857 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 24.2857 | 4 | no |
GO:0045296 | cadherin binding | 24.2857 | 4 | no |
GO:0019900 | kinase binding | 22.8571 | 4 | no |
GO:0019901 | protein kinase binding | 22.8571 | 5 | no |
GO:0005524 | ATP binding | 21.4286 | 5 | no |
GO:0030554 | adenyl nucleotide binding | 21.4286 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 21.4286 | 5 | no |
GO:0003723 | RNA binding | 21.4286 | 4 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in ARPC4_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 67.1429 | 4 | no |
GO:0051128 | regulation of cellular component organization | 61.4286 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 55.7143 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 54.2857 | 4 | no |
GO:0048523 | negative regulation of cellular process | 54.2857 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 52.8571 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 51.4286 | 4 | no |
GO:0006996 | organelle organization | 50.0000 | 4 | no |
GO:0033043 | regulation of organelle organization | 42.8571 | 5 | yes |
GO:0010646 | regulation of cell communication | 42.8571 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 41.4286 | 4 | yes |
GO:0051493 | regulation of cytoskeleton organization | 41.4286 | 6 | yes |
GO:0009893 | positive regulation of metabolic process | 41.4286 | 4 | no |
GO:0022607 | cellular component assembly | 40.0000 | 4 | yes |
GO:0010604 | positive regulation of macromolecule metabolic process | 38.5714 | 5 | no |
GO:0051246 | regulation of protein metabolic process | 38.5714 | 5 | no |
GO:0032970 | regulation of actin filament-based process | 37.1429 | 4 | yes |
GO:1902903 | regulation of supramolecular fiber organization | 37.1429 | 5 | yes |
GO:0009966 | regulation of signal transduction | 37.1429 | 4 | no |
GO:0010468 | regulation of gene expression | 37.1429 | 5 | no |
GO:0051130 | positive regulation of cellular component organization | 37.1429 | 5 | no |
GO:0007010 | cytoskeleton organization | 37.1429 | 5 | no |
GO:0032956 | regulation of actin cytoskeleton organization | 35.7143 | 5 | yes |
GO:0097435 | supramolecular fiber organization | 35.7143 | 4 | yes |
GO:0031325 | positive regulation of cellular metabolic process | 35.7143 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.7143 | 5 | no |
GO:0110053 | regulation of actin filament organization | 34.2857 | 6 | yes |
GO:0007015 | actin filament organization | 32.8571 | 5 | yes |
GO:0030030 | cell projection organization | 31.4286 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 28.5714 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 28.5714 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 28.5714 | 5 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.1429 | 5 | no |
GO:0120036 | plasma membrane bounded cell projection organization | 27.1429 | 5 | no |
GO:0051049 | regulation of transport | 27.1429 | 4 | no |
GO:0043254 | regulation of protein-containing complex assembly | 25.7143 | 5 | yes |
GO:0009892 | negative regulation of metabolic process | 25.7143 | 4 | no |
GO:0031324 | negative regulation of cellular metabolic process | 25.7143 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 25.7143 | 6 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.7143 | 5 | no |
GO:0031344 | regulation of cell projection organization | 25.7143 | 5 | no |
GO:0032271 | regulation of protein polymerization | 24.2857 | 6 | yes |
GO:0010605 | negative regulation of macromolecule metabolic process | 24.2857 | 5 | no |
GO:0019220 | regulation of phosphate metabolic process | 24.2857 | 6 | no |
GO:0031399 | regulation of protein modification process | 24.2857 | 6 | no |
GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.2857 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 24.2857 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 24.2857 | 5 | no |
GO:0120035 | regulation of plasma membrane bounded cell projection organization | 24.2857 | 6 | no |
GO:0010638 | positive regulation of organelle organization | 24.2857 | 6 | no |
GO:0008064 | regulation of actin polymerization or depolymerization | 22.8571 | 6 | yes |
GO:0030832 | regulation of actin filament length | 22.8571 | 5 | yes |
GO:0032535 | regulation of cellular component size | 22.8571 | 4 | yes |
GO:0036211 | protein modification process | 22.8571 | 4 | no |
GO:0042325 | regulation of phosphorylation | 22.8571 | 7 | no |
GO:0043412 | macromolecule modification | 22.8571 | 4 | no |
GO:0045595 | regulation of cell differentiation | 22.8571 | 4 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 22.8571 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 22.8571 | 6 | no |
GO:0031346 | positive regulation of cell projection organization | 22.8571 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 22.8571 | 4 | no |
GO:0044089 | positive regulation of cellular component biogenesis | 22.8571 | 5 | no |
GO:0008104 | protein localization | 22.8571 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 22.8571 | 4 | no |
GO:0030833 | regulation of actin filament polymerization | 21.4286 | 7 | yes |
GO:0006355 | regulation of DNA-templated transcription | 21.4286 | 6 | no |
GO:0051495 | positive regulation of cytoskeleton organization | 21.4286 | 7 | no |
GO:1902905 | positive regulation of supramolecular fiber organization | 21.4286 | 6 | no |
GO:0010647 | positive regulation of cell communication | 21.4286 | 5 | no |
GO:0023056 | positive regulation of signaling | 21.4286 | 4 | no |
GO:0043933 | protein-containing complex organization | 20.0000 | 4 | yes |
GO:0065003 | protein-containing complex assembly | 17.1429 | 5 | yes |
GO:0008154 | actin polymerization or depolymerization | 11.4286 | 6 | yes |
GO:0034314 | Arp2/3 complex-mediated actin nucleation | 10.0000 | 7 | yes |
GO:0045010 | actin nucleation | 10.0000 | 6 | yes |
GO:0051258 | protein polymerization | 10.0000 | 6 | yes |
GO:0030041 | actin filament polymerization | 7.1429 | 7 | yes |
Disease
Term | Name | % | Distance from top the of the tree | Annotated in ARPC4_HUMAN |
---|---|---|---|---|
DOID:114 | heart disease | 5.7143 | 3 | no |
DOID:0050700 | cardiomyopathy | 4.2857 | 4 | no |
DOID:0060036 | intrinsic cardiomyopathy | 4.2857 | 5 | no |
DOID:2843 | long QT syndrome | 2.8571 | 6 | no |
DOID:0050851 | glomerulosclerosis | 2.8571 | 6 | no |
DOID:10952 | nephritis | 2.8571 | 4 | no |
DOID:1312 | focal segmental glomerulosclerosis | 2.8571 | 7 | no |
DOID:2921 | glomerulonephritis | 2.8571 | 5 | no |
DOID:557 | kidney disease | 2.8571 | 3 | no |
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC5_HUMAN | [view interactions] | Low throughput | no | yes |
ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
WASP_HUMAN | [view interactions] | Low throughput | no | yes |
SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
UB2Q2_HUMAN | [view interactions] | Low throughput | no | no |
ACTS_HUMAN | [view interactions] | Low throughput | no | no |
ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
PRD16_HUMAN | [view interactions] | High throughput | no | no |
MECOM_HUMAN | [view interactions] | High throughput | no | yes |
SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
RASA1_HUMAN | [view interactions] | High throughput | no | yes |
DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VCAM1_HUMAN | [view interactions] | High throughput | no | no |
FINC_HUMAN | [view interactions] | High throughput | no | yes |
ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
VMP1_HUMAN | [view interactions] | High throughput | no | yes |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
EIF1B_HUMAN | [view interactions] | High throughput | no | no |
ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
JUN_HUMAN | [view interactions] | High throughput | no | yes |
CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HERC2_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
MT21A_HUMAN | [view interactions] | High throughput | no | yes |
NELFD_HUMAN | [view interactions] | High throughput | no | yes |
GOLI_HUMAN | [view interactions] | High throughput | no | yes |
IDLC_HUMAN | [view interactions] | High throughput | no | no |
TBA3C_HUMAN | [view interactions] | High throughput | no | no |
TBA3D_HUMAN | [view interactions] | High throughput | no | no |
CHUR_HUMAN | [view interactions] | High throughput | no | yes |
BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ITA4_HUMAN | [view interactions] | High throughput | no | no |
STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MOV10_HUMAN | [view interactions] | High throughput | no | no |
NXF1_HUMAN | [view interactions] | High throughput | no | yes |
RING2_HUMAN | [view interactions] | High throughput | no | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
UNK_HUMAN | [view interactions] | High throughput | no | yes |
MCM2_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
TRI25_HUMAN | [view interactions] | High throughput | no | yes |
LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
SENP2_HUMAN | [view interactions] | High throughput | no | yes |
AGR2_HUMAN | [view interactions] | High throughput | no | no |
RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CDK9_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
BIRC3_HUMAN | [view interactions] | High throughput | no | no |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOX2_HUMAN | [view interactions] | High throughput | no | yes |
TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
DUX4_HUMAN | [view interactions] | High throughput | no | no |
CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
RBM39_HUMAN | [view interactions] | High throughput | no | yes |
F16P1_HUMAN | [view interactions] | High throughput | no | no |
TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SOSD1_HUMAN | [view interactions] | High throughput | no | no |
ZN547_HUMAN | [view interactions] | High throughput | no | no |
NUFP2_HUMAN | [view interactions] | High throughput | no | no |
INSL3_HUMAN | [view interactions] | High throughput | no | no |
TTLL3_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
SIK2_HUMAN | [view interactions] | High throughput | no | yes |
RHBT2_HUMAN | [view interactions] | High throughput | no | no |
ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
STK26_HUMAN | [view interactions] | High throughput | no | no |
ATG7_HUMAN | [view interactions] | High throughput | no | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
CLK1_HUMAN | [view interactions] | High throughput | no | yes |
BAG1_HUMAN | [view interactions] | High throughput | no | yes |
CALU_HUMAN | [view interactions] | High throughput | no | yes |
FKB10_HUMAN | [view interactions] | High throughput | no | yes |
LPP_HUMAN | [view interactions] | High throughput | no | yes |
TRMB_HUMAN | [view interactions] | High throughput | no | yes |
PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA3_HUMAN | [view interactions] | High throughput | no | yes |
RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
SUMO1_HUMAN | [view interactions] | High throughput | no | yes |
TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
TTL12_HUMAN | [view interactions] | High throughput | no | yes |
FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RFA1_HUMAN | [view interactions] | High throughput | no | yes |
SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
PFD3_HUMAN | [view interactions] | High throughput | no | yes |
ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TFR1_HUMAN | [view interactions] | High throughput | no | yes |
CLC4D_HUMAN | [view interactions] | High throughput | no | no |
ACE2_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYO19_HUMAN | [view interactions] | High throughput | no | yes |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CALL3_HUMAN | [view interactions] | High throughput | no | yes |
TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CARF_HUMAN | [view interactions] | High throughput | no | yes |
IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HCLS1_HUMAN | [view interactions] | Computational | no | no |
WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CDC42_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CD3Z_HUMAN | [view interactions] | Computational | no | no |
PDGFB_HUMAN | [view interactions] | Computational | no | yes |
NCKP1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FCGR1_HUMAN | [view interactions] | Computational | no | no |
BRK1_HUMAN | [view interactions] | Computational | no | no |
PSA7_HUMAN | [view interactions] | Computational | no | yes |
IGLL5_HUMAN | [view interactions] | Computational | no | no |
PGFRB_HUMAN | [view interactions] | Computational | no | yes |
FCG2A_HUMAN | [view interactions] | Computational | no | no |
NCK1_HUMAN | [view interactions] | Computational | no | yes |
ACTG_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
SPN90_HUMAN | [view entry] [view interactions] | Computational | yes | no |
ABI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
GAB1_HUMAN | [view interactions] | Computational | no | yes |
NCK2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
ARP3C_HUMAN | [view interactions] | Computational | no | no |
WASF2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |