ARPC4_HUMAN
Evidence for PS localization
Functions
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 158 | Arg | Cys | Developmentaldelay,languageimpairment,andocularabnormalities(DEVLO) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ARPC4_HUMAN |
|---|---|---|---|---|
| GO:0003779 | actin binding | 47.2222 | 4 | yes |
| GO:0043168 | anion binding | 29.1667 | 4 | no |
| GO:0000166 | nucleotide binding | 27.7778 | 4 | no |
| GO:0017076 | purine nucleotide binding | 27.7778 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 26.3889 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 26.3889 | 4 | no |
| GO:0043169 | cation binding | 26.3889 | 4 | no |
| GO:0046872 | metal ion binding | 26.3889 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0003723 | RNA binding | 25.0000 | 4 | no |
| GO:0005524 | ATP binding | 23.6111 | 5 | no |
| GO:0045296 | cadherin binding | 23.6111 | 4 | no |
| GO:0019900 | kinase binding | 23.6111 | 4 | no |
| GO:0019901 | protein kinase binding | 20.8333 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ARPC4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.8889 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 61.1111 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 61.1111 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 59.7222 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 58.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.9444 | 4 | no |
| GO:0010646 | regulation of cell communication | 45.8333 | 4 | no |
| GO:0006996 | organelle organization | 44.4444 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 44.4444 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 44.4444 | 4 | no |
| GO:0010468 | regulation of gene expression | 44.4444 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 44.4444 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 44.4444 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 41.6667 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 41.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.6667 | 5 | no |
| GO:0009966 | regulation of signal transduction | 40.2778 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.8889 | 5 | no |
| GO:0022607 | cellular component assembly | 36.1111 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 36.1111 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 33.3333 | 4 | yes |
| GO:0033043 | regulation of organelle organization | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 30.5556 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 30.5556 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 30.5556 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 29.1667 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 29.1667 | 6 | no |
| GO:0051493 | regulation of cytoskeleton organization | 29.1667 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.1667 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.1667 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 29.1667 | 5 | no |
| GO:0051049 | regulation of transport | 29.1667 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.1667 | 6 | no |
| GO:0007010 | cytoskeleton organization | 29.1667 | 5 | no |
| GO:0008104 | protein localization | 29.1667 | 4 | no |
| GO:0007015 | actin filament organization | 27.7778 | 5 | yes |
| GO:0043254 | regulation of protein-containing complex assembly | 27.7778 | 5 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 27.7778 | 5 | no |
| GO:0043933 | protein-containing complex organization | 26.3889 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 26.3889 | 6 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.3889 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 25.0000 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 25.0000 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 23.6111 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 23.6111 | 6 | no |
| GO:0044089 | positive regulation of cellular component biogenesis | 23.6111 | 5 | no |
| GO:0032970 | regulation of actin filament-based process | 23.6111 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 23.6111 | 7 | no |
| GO:0010647 | positive regulation of cell communication | 23.6111 | 5 | no |
| GO:0023056 | positive regulation of signaling | 23.6111 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 22.2222 | 6 | no |
| GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.2222 | 5 | no |
| GO:0110053 | regulation of actin filament organization | 22.2222 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 20.8333 | 8 | no |
| GO:0030030 | cell projection organization | 20.8333 | 4 | no |
| GO:0071310 | cellular response to organic substance | 20.8333 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | no |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | no |
| GO:0036211 | protein modification process | 20.8333 | 4 | no |
| GO:0043412 | macromolecule modification | 20.8333 | 4 | no |
| GO:0060341 | regulation of cellular localization | 20.8333 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 18.0556 | 5 | yes |
| GO:0034314 | Arp2/3 complex-mediated actin nucleation | 11.1111 | 7 | yes |
| GO:0045010 | actin nucleation | 11.1111 | 6 | yes |
| GO:0051258 | protein polymerization | 8.3333 | 6 | yes |
| GO:0008154 | actin polymerization or depolymerization | 6.9444 | 6 | yes |
| GO:0030041 | actin filament polymerization | 4.1667 | 7 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| ACTS_HUMAN | [view interactions] | Low throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARC1B_HUMAN | [view interactions] | Low throughput | no | no |
| ARC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC5_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARP5L_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASP_HUMAN | [view interactions] | Low throughput | no | yes |
| SRC8_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| WASL_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| UB2Q2_HUMAN | [view interactions] | Low throughput | no | no |
| RIT1_HUMAN | [view interactions] | High throughput | no | yes |
| CLK1_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| CALU_HUMAN | [view interactions] | High throughput | no | yes |
| FKB10_HUMAN | [view interactions] | High throughput | no | yes |
| LPP_HUMAN | [view interactions] | High throughput | no | yes |
| TRMB_HUMAN | [view interactions] | High throughput | no | yes |
| PDIA6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RPR1B_HUMAN | [view interactions] | High throughput | no | yes |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPRKB_HUMAN | [view interactions] | High throughput | no | yes |
| TTL12_HUMAN | [view interactions] | High throughput | no | yes |
| FUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| GRPE1_HUMAN | [view interactions] | High throughput | no | yes |
| NIF3L_HUMAN | [view interactions] | High throughput | no | yes |
| PP2AA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAPCB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TM1L1_HUMAN | [view interactions] | High throughput | no | yes |
| PFD3_HUMAN | [view interactions] | High throughput | no | yes |
| ZPR1_HUMAN | [view interactions] | High throughput | no | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| TNR6_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| FOXO1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHOCN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| MY18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO19_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALL3_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CARF_HUMAN | [view interactions] | High throughput | no | yes |
| IQGA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRD16_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| RASA1_HUMAN | [view interactions] | High throughput | no | yes |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| VCAM1_HUMAN | [view interactions] | High throughput | no | no |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SCRB2_HUMAN | [view interactions] | High throughput | no | yes |
| VMP1_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DAPK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| ARP3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| CYFP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HERC2_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| HCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| PNMA5_HUMAN | [view interactions] | High throughput | no | yes |
| MT21A_HUMAN | [view interactions] | High throughput | no | yes |
| NELFD_HUMAN | [view interactions] | High throughput | no | yes |
| GOLI_HUMAN | [view interactions] | High throughput | no | yes |
| IDLC_HUMAN | [view interactions] | High throughput | no | no |
| CHUR_HUMAN | [view interactions] | High throughput | no | yes |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| BCL7C_HUMAN | [view interactions] | High throughput | no | yes |
| STAT1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| PROF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITA4_HUMAN | [view interactions] | High throughput | no | no |
| STAU1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| RING2_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| UNK_HUMAN | [view interactions] | High throughput | no | yes |
| MCM2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| SENP2_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| MYC_HUMAN | [view interactions] | High throughput | no | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| TIF1B_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| CHM4C_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| SC6A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RBM39_HUMAN | [view interactions] | High throughput | no | yes |
| F16P1_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOSD1_HUMAN | [view interactions] | High throughput | no | no |
| ZN547_HUMAN | [view interactions] | High throughput | no | no |
| NUFP2_HUMAN | [view interactions] | High throughput | no | no |
| INSL3_HUMAN | [view interactions] | High throughput | no | no |
| TTLL3_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBT2_HUMAN | [view interactions] | High throughput | no | no |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ACTN4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STK26_HUMAN | [view interactions] | High throughput | no | no |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| ASXL2_HUMAN | [view interactions] | High throughput | no | no |
| ASXL3_HUMAN | [view interactions] | High throughput | no | no |
| UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
| EZH2_HUMAN | [view interactions] | High throughput | no | no |
| B3GN2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2H_HUMAN | [view interactions] | High throughput | no | yes |
| TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |