OLA1_HUMAN
Evidence for PS localization
Functions
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in OLA1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 40.0000 | 4 | no |
| GO:0017076 | purine nucleotide binding | 22.2222 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.0000 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.0000 | 4 | yes |
| GO:0045296 | cadherin binding | 17.7778 | 4 | yes |
| GO:0046872 | metal ion binding | 17.7778 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 15.5556 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 15.5556 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 15.5556 | 6 | yes |
| GO:0030554 | adenyl nucleotide binding | 13.3333 | 5 | yes |
| GO:0005524 | ATP binding | 11.1111 | 5 | yes |
| GO:0005525 | GTP binding | 11.1111 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 11.1111 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 11.1111 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 11.1111 | 5 | yes |
| GO:0016887 | ATP hydrolysis activity | 6.6667 | 7 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in OLA1_HUMAN |
|---|---|---|---|---|
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 40.0000 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 40.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0006996 | organelle organization | 35.5556 | 4 | no |
| GO:0010468 | regulation of gene expression | 35.5556 | 5 | no |
| GO:0010646 | regulation of cell communication | 35.5556 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 35.5556 | 4 | no |
| GO:0009059 | macromolecule biosynthetic process | 33.3333 | 4 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 31.1111 | 4 | no |
| GO:0009966 | regulation of signal transduction | 31.1111 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 31.1111 | 4 | no |
| GO:0043604 | amide biosynthetic process | 31.1111 | 5 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 31.1111 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 28.8889 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.8889 | 5 | no |
| GO:0006412 | translation | 28.8889 | 4 | no |
| GO:0006518 | peptide metabolic process | 28.8889 | 4 | no |
| GO:0034645 | cellular macromolecule biosynthetic process | 28.8889 | 4 | no |
| GO:0043043 | peptide biosynthetic process | 28.8889 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 26.6667 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 26.6667 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 26.6667 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 26.6667 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0002181 | cytoplasmic translation | 26.6667 | 5 | no |
| GO:0022607 | cellular component assembly | 26.6667 | 4 | no |
| GO:0008104 | protein localization | 26.6667 | 4 | no |
| GO:0010941 | regulation of cell death | 24.4444 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 24.4444 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.4444 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 24.4444 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.4444 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 22.2222 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.2222 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 22.2222 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 22.2222 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 22.2222 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 22.2222 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.0000 | 4 | yes |
| GO:0006163 | purine nucleotide metabolic process | 8.8889 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 8.8889 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 8.8889 | 5 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 8.8889 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 8.8889 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 8.8889 | 4 | yes |
| GO:0072521 | purine-containing compound metabolic process | 8.8889 | 4 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 6.6667 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 6.6667 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 6.6667 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 6.6667 | 7 | yes |
| GO:0046034 | ATP metabolic process | 6.6667 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in OLA1_HUMAN |
|---|---|---|---|---|
| DOID:0050539 | Charcot-Marie-Tooth disease type 2 | 4.4444 | 7 | no |
| DOID:0050700 | cardiomyopathy | 4.4444 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 4.4444 | 5 | no |
| DOID:0080000 | muscular disease | 4.4444 | 3 | no |
| DOID:10595 | Charcot-Marie-Tooth disease | 4.4444 | 6 | no |
| DOID:114 | heart disease | 4.4444 | 3 | no |
| DOID:12930 | dilated cardiomyopathy | 4.4444 | 6 | no |
| DOID:423 | myopathy | 4.4444 | 5 | no |
| DOID:440 | neuromuscular disease | 4.4444 | 5 | no |
| DOID:574 | peripheral nervous system disease | 4.4444 | 3 | no |
| DOID:66 | muscle tissue disease | 4.4444 | 4 | no |
| DOID:870 | neuropathy | 4.4444 | 4 | no |
| DOID:1289 | neurodegenerative disease | 4.4444 | 4 | no |
| DOID:331 | central nervous system disease | 4.4444 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HSP74_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CHIP_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BRCA1_HUMAN | [view interactions] | Low throughput | no | yes |
| TBG1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BARD1_HUMAN | [view interactions] | Low throughput | no | yes |
| RACK1_HUMAN | [view interactions] | Low throughput | no | yes |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARC1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIC_HUMAN | [view interactions] | High throughput | no | yes |
| ASNS_HUMAN | [view interactions] | High throughput | no | yes |
| RUXE_HUMAN | [view interactions] | High throughput | no | no |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDGF_HUMAN | [view interactions] | High throughput | no | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSHB_HUMAN | [view interactions] | High throughput | no | no |
| GDS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUXF_HUMAN | [view interactions] | High throughput | no | no |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| GNL3L_HUMAN | [view interactions] | High throughput | no | yes |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| PYRD_HUMAN | [view interactions] | High throughput | no | yes |
| RL27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THNS2_HUMAN | [view interactions] | High throughput | no | no |
| RL40_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL19_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS27A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL7A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS4X_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NHLC2_HUMAN | [view interactions] | High throughput | no | yes |
| NECD_HUMAN | [view interactions] | High throughput | no | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| FBRL_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| P53_HUMAN | [view interactions] | High throughput | no | no |
| SHOC2_HUMAN | [view interactions] | High throughput | no | yes |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| FINC_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| KPCZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NEK7_HUMAN | [view interactions] | High throughput | no | yes |
| HMGA1_HUMAN | [view interactions] | High throughput | no | yes |
| BCL6_HUMAN | [view interactions] | High throughput | no | no |
| PUF60_HUMAN | [view interactions] | High throughput | no | yes |
| GPC5C_HUMAN | [view interactions] | High throughput | no | no |
| SGK1_HUMAN | [view interactions] | High throughput | no | yes |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| ASCC2_HUMAN | [view interactions] | High throughput | no | yes |
| ANM5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP31_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TIFAB_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| LMTK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LSM8_HUMAN | [view interactions] | High throughput | no | yes |
| SART3_HUMAN | [view interactions] | High throughput | no | yes |
| THOC4_HUMAN | [view interactions] | High throughput | no | no |
| PPIH_HUMAN | [view interactions] | High throughput | no | yes |
| PRPF3_HUMAN | [view interactions] | High throughput | no | yes |
| PRP4_HUMAN | [view interactions] | High throughput | no | yes |
| RL26L_HUMAN | [view interactions] | High throughput | no | yes |
| LSM4_HUMAN | [view interactions] | High throughput | no | yes |
| RAD21_HUMAN | [view interactions] | High throughput | no | yes |
| GRK5_HUMAN | [view interactions] | High throughput | no | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZN346_HUMAN | [view interactions] | High throughput | no | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL7_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| WWP2_HUMAN | [view interactions] | High throughput | no | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| PPP6_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| U5S1_HUMAN | [view interactions] | High throughput | no | yes |
| REQU_HUMAN | [view interactions] | High throughput | no | yes |
| UBE3A_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| CDX2_HUMAN | [view interactions] | High throughput | no | no |
| RU17_HUMAN | [view interactions] | High throughput | no | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MAFB_HUMAN | [view interactions] | High throughput | no | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| DDX58_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| EP300_HUMAN | [view interactions] | High throughput | no | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| FAS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LDLR_HUMAN | [view interactions] | High throughput | no | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRP75_HUMAN | [view entry] [view interactions] | Computational | yes | yes |