PLCB1_HUMAN
Evidence for PS localization
Functions
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors (PubMed). Regulates the function of the endothelial barrier. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PLCB1_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 39.0625 | 4 | no |
| GO:0017076 | purine nucleotide binding | 28.1250 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 28.1250 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 28.1250 | 4 | no |
| GO:0046872 | metal ion binding | 22.6563 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 20.3125 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 20.3125 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 20.3125 | 6 | no |
| GO:0005509 | calcium ion binding | 6.2500 | 5 | yes |
| GO:0030695 | GTPase regulator activity | 6.2500 | 4 | yes |
| GO:0005096 | GTPase activator activity | 4.6875 | 4 | yes |
| GO:0004620 | phospholipase activity | 3.1250 | 5 | yes |
| GO:0016298 | lipase activity | 3.1250 | 4 | yes |
| GO:0035091 | phosphatidylinositol binding | 3.1250 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 3.1250 | 4 | yes |
| GO:0004435 | phosphatidylinositol phospholipase C activity | 2.3438 | 7 | yes |
| GO:0004629 | phospholipase C activity | 2.3438 | 6 | yes |
| GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 2.3438 | 4 | yes |
| GO:0008081 | phosphoric diester hydrolase activity | 2.3438 | 5 | yes |
| GO:1901981 | phosphatidylinositol phosphate binding | 2.3438 | 5 | yes |
| GO:1902936 | phosphatidylinositol bisphosphate binding | 2.3438 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PLCB1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 47.6563 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 43.7500 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.6250 | 4 | yes |
| GO:0080090 | regulation of primary metabolic process | 40.6250 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 39.0625 | 4 | yes |
| GO:0051171 | regulation of nitrogen compound metabolic process | 38.2813 | 4 | yes |
| GO:0010646 | regulation of cell communication | 35.9375 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 34.3750 | 4 | yes |
| GO:0010468 | regulation of gene expression | 30.4688 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 29.6875 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 27.3438 | 5 | yes |
| GO:0009889 | regulation of biosynthetic process | 26.5625 | 4 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 26.5625 | 5 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 26.5625 | 5 | yes |
| GO:0051128 | regulation of cellular component organization | 26.5625 | 4 | yes |
| GO:0022607 | cellular component assembly | 26.5625 | 4 | no |
| GO:0010941 | regulation of cell death | 26.5625 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 25.7813 | 5 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.7813 | 5 | yes |
| GO:0006996 | organelle organization | 25.7813 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 25.7813 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 25.7813 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 24.2188 | 4 | yes |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.2188 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 24.2188 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 24.2188 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 23.4375 | 5 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 22.6563 | 5 | yes |
| GO:0051252 | regulation of RNA metabolic process | 22.6563 | 5 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 21.8750 | 5 | yes |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.8750 | 5 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 21.8750 | 4 | no |
| GO:0071702 | organic substance transport | 21.8750 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 20.3125 | 4 | no |
| GO:0051049 | regulation of transport | 20.3125 | 4 | no |
| GO:0060548 | negative regulation of cell death | 20.3125 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 19.5313 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 19.5313 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 19.5313 | 4 | yes |
| GO:1903506 | regulation of nucleic acid-templated transcription | 18.7500 | 7 | yes |
| GO:2001141 | regulation of RNA biosynthetic process | 18.7500 | 6 | yes |
| GO:0009967 | positive regulation of signal transduction | 17.9688 | 5 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 17.9688 | 6 | yes |
| GO:0033043 | regulation of organelle organization | 17.1875 | 5 | yes |
| GO:0071310 | cellular response to organic substance | 17.1875 | 4 | yes |
| GO:0051130 | positive regulation of cellular component organization | 15.6250 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 14.8438 | 5 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 14.8438 | 6 | yes |
| GO:0051247 | positive regulation of protein metabolic process | 14.8438 | 6 | yes |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 14.0625 | 6 | yes |
| GO:1902533 | positive regulation of intracellular signal transduction | 14.0625 | 6 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 13.2813 | 6 | yes |
| GO:0080134 | regulation of response to stress | 13.2813 | 4 | yes |
| GO:0010628 | positive regulation of gene expression | 12.5000 | 6 | yes |
| GO:0045934 | negative regulation of nucleobase-containing compound metabolic process | 12.5000 | 6 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 11.7188 | 5 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 11.7188 | 6 | yes |
| GO:0010638 | positive regulation of organelle organization | 11.7188 | 6 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 11.7188 | 6 | yes |
| GO:0033993 | response to lipid | 11.7188 | 4 | yes |
| GO:0051253 | negative regulation of RNA metabolic process | 11.7188 | 6 | yes |
| GO:0051726 | regulation of cell cycle | 11.7188 | 4 | yes |
| GO:0010243 | response to organonitrogen compound | 10.9375 | 4 | yes |
| GO:0043408 | regulation of MAPK cascade | 10.9375 | 6 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 10.9375 | 4 | yes |
| GO:0014070 | response to organic cyclic compound | 10.1563 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 10.1563 | 5 | yes |
| GO:0051254 | positive regulation of RNA metabolic process | 10.1563 | 6 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 10.1563 | 4 | yes |
| GO:1901701 | cellular response to oxygen-containing compound | 10.1563 | 4 | yes |
| GO:0030334 | regulation of cell migration | 9.3750 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 9.3750 | 4 | yes |
| GO:0045893 | positive regulation of DNA-templated transcription | 9.3750 | 7 | yes |
| GO:0080135 | regulation of cellular response to stress | 9.3750 | 4 | yes |
| GO:1902679 | negative regulation of RNA biosynthetic process | 9.3750 | 7 | yes |
| GO:1902680 | positive regulation of RNA biosynthetic process | 9.3750 | 7 | yes |
| GO:1903507 | negative regulation of nucleic acid-templated transcription | 9.3750 | 8 | yes |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 9.3750 | 8 | yes |
| GO:2000145 | regulation of cell motility | 9.3750 | 4 | yes |
| GO:0043410 | positive regulation of MAPK cascade | 8.5938 | 7 | yes |
| GO:0045892 | negative regulation of DNA-templated transcription | 8.5938 | 7 | yes |
| GO:0051094 | positive regulation of developmental process | 8.5938 | 4 | yes |
| GO:2000112 | regulation of cellular macromolecule biosynthetic process | 8.5938 | 6 | yes |
| GO:0010564 | regulation of cell cycle process | 7.8125 | 5 | yes |
| GO:0050890 | cognition | 7.8125 | 4 | yes |
| GO:0071396 | cellular response to lipid | 7.8125 | 5 | yes |
| GO:2000026 | regulation of multicellular organismal development | 7.8125 | 4 | yes |
| GO:0006644 | phospholipid metabolic process | 7.8125 | 4 | yes |
| GO:0046486 | glycerolipid metabolic process | 7.0313 | 4 | yes |
| GO:0071407 | cellular response to organic cyclic compound | 7.0313 | 5 | yes |
| GO:0006650 | glycerophospholipid metabolic process | 7.0313 | 5 | yes |
| GO:0045597 | positive regulation of cell differentiation | 6.2500 | 5 | yes |
| GO:0045787 | positive regulation of cell cycle | 6.2500 | 5 | yes |
| GO:0071417 | cellular response to organonitrogen compound | 6.2500 | 4 | yes |
| GO:1901699 | cellular response to nitrogen compound | 6.2500 | 4 | yes |
| GO:0001817 | regulation of cytokine production | 6.2500 | 4 | yes |
| GO:0007346 | regulation of mitotic cell cycle | 6.2500 | 5 | yes |
| GO:0007612 | learning | 6.2500 | 4 | yes |
| GO:0032870 | cellular response to hormone stimulus | 5.4688 | 4 | yes |
| GO:0060284 | regulation of cell development | 5.4688 | 5 | yes |
| GO:0070302 | regulation of stress-activated protein kinase signaling cascade | 5.4688 | 5 | yes |
| GO:1901652 | response to peptide | 5.4688 | 4 | yes |
| GO:1901987 | regulation of cell cycle phase transition | 5.4688 | 6 | yes |
| GO:0002683 | negative regulation of immune system process | 5.4688 | 4 | yes |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 5.4688 | 5 | yes |
| GO:0032872 | regulation of stress-activated MAPK cascade | 4.6875 | 6 | yes |
| GO:0046488 | phosphatidylinositol metabolic process | 4.6875 | 6 | yes |
| GO:0090068 | positive regulation of cell cycle process | 4.6875 | 6 | yes |
| GO:0095500 | acetylcholine receptor signaling pathway | 4.6875 | 4 | yes |
| GO:1901990 | regulation of mitotic cell cycle phase transition | 4.6875 | 6 | yes |
| GO:0001819 | positive regulation of cytokine production | 4.6875 | 5 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 4.6875 | 4 | yes |
| GO:0040013 | negative regulation of locomotion | 3.9063 | 4 | yes |
| GO:0043434 | response to peptide hormone | 3.9063 | 4 | yes |
| GO:0045927 | positive regulation of growth | 3.9063 | 4 | yes |
| GO:0045931 | positive regulation of mitotic cell cycle | 3.9063 | 6 | yes |
| GO:0070304 | positive regulation of stress-activated protein kinase signaling cascade | 3.9063 | 6 | yes |
| GO:1901653 | cellular response to peptide | 3.9063 | 5 | yes |
| GO:1901989 | positive regulation of cell cycle phase transition | 3.9063 | 7 | yes |
| GO:1902806 | regulation of cell cycle G1/S phase transition | 3.9063 | 7 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 3.9063 | 4 | yes |
| GO:0007613 | memory | 3.9063 | 4 | yes |
| GO:0016042 | lipid catabolic process | 3.1250 | 4 | yes |
| GO:0019751 | polyol metabolic process | 3.1250 | 4 | yes |
| GO:0030336 | negative regulation of cell migration | 3.1250 | 6 | yes |
| GO:0032874 | positive regulation of stress-activated MAPK cascade | 3.1250 | 7 | yes |
| GO:0046328 | regulation of JNK cascade | 3.1250 | 7 | yes |
| GO:0046330 | positive regulation of JNK cascade | 3.1250 | 8 | yes |
| GO:1901992 | positive regulation of mitotic cell cycle phase transition | 3.1250 | 7 | yes |
| GO:1902808 | positive regulation of cell cycle G1/S phase transition | 3.1250 | 8 | yes |
| GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 3.1250 | 7 | yes |
| GO:2000146 | negative regulation of cell motility | 3.1250 | 5 | yes |
| GO:0007167 | enzyme-linked receptor protein signaling pathway | 3.1250 | 4 | yes |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | 3.1250 | 5 | yes |
| GO:0009395 | phospholipid catabolic process | 2.3438 | 5 | yes |
| GO:0009743 | response to carbohydrate | 2.3438 | 4 | yes |
| GO:0040019 | positive regulation of embryonic development | 2.3438 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 2.3438 | 4 | yes |
| GO:0045444 | fat cell differentiation | 2.3438 | 4 | yes |
| GO:0045995 | regulation of embryonic development | 2.3438 | 5 | yes |
| GO:0046434 | organophosphate catabolic process | 2.3438 | 4 | yes |
| GO:0046475 | glycerophospholipid catabolic process | 2.3438 | 6 | yes |
| GO:0046503 | glycerolipid catabolic process | 2.3438 | 5 | yes |
| GO:0048015 | phosphatidylinositol-mediated signaling | 2.3438 | 5 | yes |
| GO:0048017 | inositol lipid-mediated signaling | 2.3438 | 4 | yes |
| GO:0048638 | regulation of developmental growth | 2.3438 | 4 | yes |
| GO:0048639 | positive regulation of developmental growth | 2.3438 | 5 | yes |
| GO:0051783 | regulation of nuclear division | 2.3438 | 6 | yes |
| GO:0071375 | cellular response to peptide hormone stimulus | 2.3438 | 5 | yes |
| GO:0071675 | regulation of mononuclear cell migration | 2.3438 | 5 | yes |
| GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | 2.3438 | 8 | yes |
| GO:1904116 | response to vasopressin | 2.3438 | 5 | yes |
| GO:1904117 | cellular response to vasopressin | 2.3438 | 6 | yes |
| GO:0002685 | regulation of leukocyte migration | 2.3438 | 4 | yes |
| GO:0010559 | regulation of glycoprotein biosynthetic process | 1.5625 | 6 | yes |
| GO:0010560 | positive regulation of glycoprotein biosynthetic process | 1.5625 | 7 | yes |
| GO:0019221 | cytokine-mediated signaling pathway | 1.5625 | 4 | yes |
| GO:0030856 | regulation of epithelial cell differentiation | 1.5625 | 5 | yes |
| GO:0031161 | phosphatidylinositol catabolic process | 1.5625 | 7 | yes |
| GO:0032655 | regulation of interleukin-12 production | 1.5625 | 5 | yes |
| GO:0032735 | positive regulation of interleukin-12 production | 1.5625 | 6 | yes |
| GO:0032957 | inositol trisphosphate metabolic process | 1.5625 | 5 | yes |
| GO:0034284 | response to monosaccharide | 1.5625 | 5 | yes |
| GO:0035722 | interleukin-12-mediated signaling pathway | 1.5625 | 5 | yes |
| GO:0035723 | interleukin-15-mediated signaling pathway | 1.5625 | 5 | yes |
| GO:0040020 | regulation of meiotic nuclear division | 1.5625 | 5 | yes |
| GO:0043647 | inositol phosphate metabolic process | 1.5625 | 4 | yes |
| GO:0044772 | mitotic cell cycle phase transition | 1.5625 | 4 | yes |
| GO:0044839 | cell cycle G2/M phase transition | 1.5625 | 4 | yes |
| GO:0045472 | response to ether | 1.5625 | 4 | yes |
| GO:0045601 | regulation of endothelial cell differentiation | 1.5625 | 6 | yes |
| GO:0045661 | regulation of myoblast differentiation | 1.5625 | 5 | yes |
| GO:0045663 | positive regulation of myoblast differentiation | 1.5625 | 6 | yes |
| GO:0045836 | positive regulation of meiotic nuclear division | 1.5625 | 6 | yes |
| GO:0048009 | insulin-like growth factor receptor signaling pathway | 1.5625 | 6 | yes |
| GO:0051445 | regulation of meiotic cell cycle | 1.5625 | 4 | yes |
| GO:0051446 | positive regulation of meiotic cell cycle | 1.5625 | 5 | yes |
| GO:0051785 | positive regulation of nuclear division | 1.5625 | 7 | yes |
| GO:0060046 | regulation of acrosome reaction | 1.5625 | 4 | yes |
| GO:0070498 | interleukin-1-mediated signaling pathway | 1.5625 | 5 | yes |
| GO:0070542 | response to fatty acid | 1.5625 | 4 | yes |
| GO:0071322 | cellular response to carbohydrate stimulus | 1.5625 | 5 | yes |
| GO:0071326 | cellular response to monosaccharide stimulus | 1.5625 | 6 | yes |
| GO:0071362 | cellular response to ether | 1.5625 | 5 | yes |
| GO:0071398 | cellular response to fatty acid | 1.5625 | 5 | yes |
| GO:0071676 | negative regulation of mononuclear cell migration | 1.5625 | 6 | yes |
| GO:0080154 | regulation of fertilization | 1.5625 | 4 | yes |
| GO:0090427 | activation of meiosis | 1.5625 | 7 | yes |
| GO:0099170 | postsynaptic modulation of chemical synaptic transmission | 1.5625 | 6 | yes |
| GO:0099178 | regulation of retrograde trans-synaptic signaling by endocanabinoid | 1.5625 | 5 | yes |
| GO:1901550 | regulation of endothelial cell development | 1.5625 | 6 | yes |
| GO:1902617 | response to fluoride | 1.5625 | 4 | yes |
| GO:1902618 | cellular response to fluoride | 1.5625 | 4 | yes |
| GO:1903018 | regulation of glycoprotein metabolic process | 1.5625 | 5 | yes |
| GO:1903020 | positive regulation of glycoprotein metabolic process | 1.5625 | 6 | yes |
| GO:1903140 | regulation of establishment of endothelial barrier | 1.5625 | 7 | yes |
| GO:1904636 | response to ionomycin | 1.5625 | 5 | yes |
| GO:1904637 | cellular response to ionomycin | 1.5625 | 6 | yes |
| GO:1905630 | response to glyceraldehyde | 1.5625 | 6 | yes |
| GO:1905631 | cellular response to glyceraldehyde | 1.5625 | 7 | yes |
| GO:2000243 | positive regulation of reproductive process | 1.5625 | 4 | yes |
| GO:2000344 | positive regulation of acrosome reaction | 1.5625 | 5 | yes |
| GO:2000437 | regulation of monocyte extravasation | 1.5625 | 6 | yes |
| GO:2000438 | negative regulation of monocyte extravasation | 1.5625 | 7 | yes |
| GO:2000559 | regulation of CD24 production | 1.5625 | 7 | yes |
| GO:2000560 | positive regulation of CD24 production | 1.5625 | 8 | yes |
| GO:0000086 | G2/M transition of mitotic cell cycle | 1.5625 | 5 | yes |
| GO:0002686 | negative regulation of leukocyte migration | 1.5625 | 5 | yes |
| GO:0002691 | regulation of cellular extravasation | 1.5625 | 5 | yes |
| GO:0002692 | negative regulation of cellular extravasation | 1.5625 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in PLCB1_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 2.3438 | 3 | no |
| DOID:1289 | neurodegenerative disease | 1.5625 | 4 | no |
| DOID:0080001 | bone disease | 1.5625 | 4 | no |
| DOID:0080006 | bone development disease | 1.5625 | 5 | no |
| DOID:65 | connective tissue disease | 1.5625 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SYUA_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ARBK1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PARD3_HUMAN | [view interactions] | Low throughput | no | yes |
| PAR6A_HUMAN | [view interactions] | Low throughput | no | yes |
| TRPM7_HUMAN | [view interactions] | Low throughput | no | no |
| NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
| KRIT1_HUMAN | [view interactions] | Low throughput | no | no |
| CDC20_HUMAN | [view interactions] | Low throughput | no | no |
| UBC_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| PLCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DEFI8_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| KCNE3_HUMAN | [view interactions] | High throughput | no | yes |
| PCF11_HUMAN | [view interactions] | High throughput | no | no |
| GCR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CK052_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMPN_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H11_HUMAN | [view interactions] | High throughput | no | no |
| RUFY1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VGFR1_HUMAN | [view interactions] | High throughput | no | no |
| STA5B_HUMAN | [view interactions] | High throughput | no | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| CTBP2_HUMAN | [view interactions] | High throughput | no | no |
| CEP76_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| SPTB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KISSR_HUMAN | [view interactions] | High throughput | no | yes |
| 1433Z_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATPA_HUMAN | [view interactions] | High throughput | no | yes |
| CAH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EF1A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3G_HUMAN | [view interactions] | High throughput | no | yes |
| IF5A1_HUMAN | [view interactions] | High throughput | no | yes |
| IF5A2_HUMAN | [view interactions] | High throughput | no | yes |
| GRP75_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCM7_HUMAN | [view interactions] | High throughput | no | no |
| PCBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HAP28_HUMAN | [view interactions] | High throughput | no | yes |
| RLA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PAIRB_HUMAN | [view interactions] | High throughput | no | yes |
| SMD3_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF2_HUMAN | [view interactions] | High throughput | no | yes |
| SRSF3_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ARF4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DDX3Y_HUMAN | [view interactions] | High throughput | no | yes |
| DHX9_HUMAN | [view interactions] | High throughput | no | yes |
| IF2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2AZ_HUMAN | [view interactions] | High throughput | no | yes |
| H2AV_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H2B2F_HUMAN | [view interactions] | High throughput | no | yes |
| H2B2E_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1K_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1C_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1H_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1D_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1A_HUMAN | [view interactions] | High throughput | no | no |
| H2B1J_HUMAN | [view interactions] | High throughput | no | yes |
| H2B1L_HUMAN | [view interactions] | High throughput | no | yes |
| H2B3B_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB2_HUMAN | [view interactions] | High throughput | no | yes |
| ROAA_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NACAM_HUMAN | [view interactions] | High throughput | no | no |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPID_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RBMX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL15_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL31_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS15A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS17_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS24_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SET_HUMAN | [view interactions] | High throughput | no | yes |
| ADT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADT4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMO3_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| TCP4_HUMAN | [view interactions] | High throughput | no | yes |
| TPM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACL6A_HUMAN | [view interactions] | High throughput | no | yes |
| AHSA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AN32B_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| APEX1_HUMAN | [view interactions] | High throughput | no | yes |
| ATAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5H_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TCPB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TCPH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| CHD5_HUMAN | [view interactions] | High throughput | no | no |
| CNOT1_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF6_HUMAN | [view interactions] | High throughput | no | yes |
| CSK21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSTF3_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC2_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3I_HUMAN | [view interactions] | High throughput | no | yes |
| EIF3M_HUMAN | [view interactions] | High throughput | no | yes |
| IF4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CHTOP_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| G6PI_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HEM3_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB3_HUMAN | [view interactions] | High throughput | no | no |
| ROA3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPC_HUMAN | [view interactions] | High throughput | no | yes |
| HP1B3_HUMAN | [view interactions] | High throughput | no | yes |
| IMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| IMB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| MBD3_HUMAN | [view interactions] | High throughput | no | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NPM3_HUMAN | [view interactions] | High throughput | no | yes |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| OLA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PELP1_HUMAN | [view interactions] | High throughput | no | yes |
| PGAM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX4_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL18A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL27_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL30_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RL9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS20_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPCP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| SMC1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMD1_HUMAN | [view interactions] | High throughput | no | yes |
| SMD2_HUMAN | [view interactions] | High throughput | no | yes |
| SRP68_HUMAN | [view interactions] | High throughput | no | yes |
| LA_HUMAN | [view interactions] | High throughput | no | yes |
| SSRD_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TLN1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| TOM22_HUMAN | [view interactions] | High throughput | no | yes |
| TPIS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPR_HUMAN | [view interactions] | High throughput | no | yes |
| TCTP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SR140_HUMAN | [view interactions] | High throughput | no | yes |
| QCR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| BT2A1_HUMAN | [view interactions] | High throughput | no | yes |
| PE2R3_HUMAN | [view interactions] | High throughput | no | no |
| GAN_HUMAN | [view interactions] | High throughput | no | yes |
| GBG1_HUMAN | [view interactions] | Computational | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DGKQ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| PI51B_HUMAN | [view interactions] | Computational | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DGKZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PI5L1_HUMAN | [view interactions] | Computational | no | no |
| THRB_HUMAN | [view interactions] | Computational | no | no |
| PI42B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCL11_HUMAN | [view interactions] | Computational | no | no |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KGP2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| CASR_HUMAN | [view interactions] | Computational | no | no |
| PAR4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PI42A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB2_HUMAN | [view interactions] | Computational | no | no |
| GNAT3_HUMAN | [view interactions] | Computational | no | no |
| PLCB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KGP1_HUMAN | [view interactions] | Computational | no | yes |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| ITPR2_HUMAN | [view interactions] | Computational | no | yes |
| PI51A_HUMAN | [view interactions] | Computational | no | yes |
| ITPR3_HUMAN | [view interactions] | Computational | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| SDF1_HUMAN | [view interactions] | Computational | no | no |
| CCL4_HUMAN | [view interactions] | Computational | no | no |
| PI51C_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MTG1_HUMAN | [view interactions] | Computational | no | yes |
| ANGT_HUMAN | [view interactions] | Computational | no | no |
| TSNAX_HUMAN | [view interactions] | Computational | no | yes |
| EDNRA_HUMAN | [view interactions] | Computational | no | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GPC6A_HUMAN | [view interactions] | Computational | no | no |
| EDNRB_HUMAN | [view interactions] | Computational | no | no |
| FPR1_HUMAN | [view interactions] | Computational | no | no |
| KPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PI42C_HUMAN | [view interactions] | Computational | no | yes |