CAH2_HUMAN
Evidence for PS localization
Functions
Essential for bone resorption and osteoclast differentiation . Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CAH2_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 27.5862 | 4 | yes |
| GO:0003779 | actin binding | 24.1379 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.1379 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 24.1379 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.1379 | 4 | no |
| GO:0003723 | RNA binding | 20.6897 | 4 | no |
| GO:0045296 | cadherin binding | 20.6897 | 4 | no |
| GO:0008270 | zinc ion binding | 10.3448 | 6 | yes |
| GO:0046914 | transition metal ion binding | 10.3448 | 5 | yes |
| GO:0004064 | arylesterase activity | 6.8966 | 5 | yes |
| GO:0004089 | carbonate dehydratase activity | 6.8966 | 5 | yes |
| GO:0016836 | hydro-lyase activity | 6.8966 | 4 | yes |
| GO:0052689 | carboxylic ester hydrolase activity | 6.8966 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CAH2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 72.4138 | 4 | yes |
| GO:0010646 | regulation of cell communication | 62.0690 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.6207 | 4 | no |
| GO:0009966 | regulation of signal transduction | 51.7241 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 51.7241 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 48.2759 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.3793 | 4 | no |
| GO:0022607 | cellular component assembly | 41.3793 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.3793 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 37.9310 | 5 | no |
| GO:0071310 | cellular response to organic substance | 37.9310 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 34.4828 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 34.4828 | 4 | no |
| GO:0060341 | regulation of cellular localization | 34.4828 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 34.4828 | 4 | no |
| GO:0008104 | protein localization | 34.4828 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 34.4828 | 4 | no |
| GO:0051049 | regulation of transport | 34.4828 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 31.0345 | 4 | no |
| GO:0009894 | regulation of catabolic process | 31.0345 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 31.0345 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 31.0345 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 31.0345 | 5 | no |
| GO:0032880 | regulation of protein localization | 31.0345 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 31.0345 | 7 | no |
| GO:0051128 | regulation of cellular component organization | 31.0345 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 31.0345 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 31.0345 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 31.0345 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 31.0345 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 31.0345 | 4 | no |
| GO:0071417 | cellular response to organonitrogen compound | 31.0345 | 4 | no |
| GO:1901699 | cellular response to nitrogen compound | 31.0345 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 31.0345 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 31.0345 | 4 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 31.0345 | 5 | yes |
| GO:0071702 | organic substance transport | 31.0345 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 31.0345 | 4 | yes |
| GO:0006996 | organelle organization | 27.5862 | 4 | no |
| GO:0010468 | regulation of gene expression | 27.5862 | 5 | no |
| GO:0010941 | regulation of cell death | 27.5862 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.5862 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 27.5862 | 5 | no |
| GO:0023057 | negative regulation of signaling | 27.5862 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 27.5862 | 5 | no |
| GO:0030030 | cell projection organization | 24.1379 | 4 | no |
| GO:0031329 | regulation of cellular catabolic process | 24.1379 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 24.1379 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 24.1379 | 6 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 24.1379 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 24.1379 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 24.1379 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 24.1379 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.1379 | 5 | no |
| GO:0048878 | chemical homeostasis | 24.1379 | 4 | yes |
| GO:0010563 | negative regulation of phosphorus metabolic process | 20.6897 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.6897 | 5 | no |
| GO:0010638 | positive regulation of organelle organization | 20.6897 | 6 | no |
| GO:0010942 | positive regulation of cell death | 20.6897 | 5 | no |
| GO:0033043 | regulation of organelle organization | 20.6897 | 5 | no |
| GO:0034329 | cell junction assembly | 20.6897 | 5 | no |
| GO:0034330 | cell junction organization | 20.6897 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.6897 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 20.6897 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 20.6897 | 4 | no |
| GO:0045936 | negative regulation of phosphate metabolic process | 20.6897 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 20.6897 | 4 | no |
| GO:0051338 | regulation of transferase activity | 20.6897 | 4 | no |
| GO:0090304 | nucleic acid metabolic process | 20.6897 | 4 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 20.6897 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 20.6897 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.6897 | 4 | no |
| GO:0043269 | regulation of ion transport | 20.6897 | 5 | yes |
| GO:0050801 | ion homeostasis | 20.6897 | 5 | yes |
| GO:0055080 | cation homeostasis | 20.6897 | 6 | yes |
| GO:0098771 | inorganic ion homeostasis | 20.6897 | 6 | yes |
| GO:0006873 | cellular ion homeostasis | 17.2414 | 4 | yes |
| GO:0030003 | cellular cation homeostasis | 17.2414 | 5 | yes |
| GO:0030004 | cellular monovalent inorganic cation homeostasis | 17.2414 | 6 | yes |
| GO:0055067 | monovalent inorganic cation homeostasis | 17.2414 | 7 | yes |
| GO:0006885 | regulation of pH | 13.7931 | 8 | yes |
| GO:0030641 | regulation of cellular pH | 13.7931 | 7 | yes |
| GO:0051050 | positive regulation of transport | 13.7931 | 4 | yes |
| GO:0051453 | regulation of intracellular pH | 13.7931 | 8 | yes |
| GO:0002009 | morphogenesis of an epithelium | 10.3448 | 4 | yes |
| GO:0034762 | regulation of transmembrane transport | 10.3448 | 4 | yes |
| GO:0090087 | regulation of peptide transport | 10.3448 | 5 | yes |
| GO:2001150 | positive regulation of dipeptide transmembrane transport | 6.8966 | 6 | yes |
| GO:2001225 | regulation of chloride transport | 6.8966 | 7 | yes |
| GO:0015669 | gas transport | 6.8966 | 4 | yes |
| GO:0015670 | carbon dioxide transport | 6.8966 | 5 | yes |
| GO:0019755 | one-carbon compound transport | 6.8966 | 5 | yes |
| GO:0032228 | regulation of synaptic transmission, GABAergic | 6.8966 | 6 | yes |
| GO:0032230 | positive regulation of synaptic transmission, GABAergic | 6.8966 | 6 | yes |
| GO:0032847 | regulation of cellular pH reduction | 6.8966 | 4 | yes |
| GO:0032849 | positive regulation of cellular pH reduction | 6.8966 | 5 | yes |
| GO:0034764 | positive regulation of transmembrane transport | 6.8966 | 5 | yes |
| GO:0038166 | angiotensin-activated signaling pathway | 6.8966 | 4 | yes |
| GO:0044070 | regulation of anion transport | 6.8966 | 6 | yes |
| GO:0046903 | secretion | 6.8966 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 6.8966 | 5 | yes |
| GO:0051452 | intracellular pH reduction | 6.8966 | 9 | yes |
| GO:0090088 | regulation of oligopeptide transport | 6.8966 | 6 | yes |
| GO:0090089 | regulation of dipeptide transport | 6.8966 | 7 | yes |
| GO:2000878 | positive regulation of oligopeptide transport | 6.8966 | 5 | yes |
| GO:2000880 | positive regulation of dipeptide transport | 6.8966 | 6 | yes |
| GO:2001148 | regulation of dipeptide transmembrane transport | 6.8966 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CAH2_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.8966 | 4 | no |
| DOID:331 | central nervous system disease | 6.8966 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| SL9A1_HUMAN | [view interactions] | Low throughput | no | no |
| S4A8_HUMAN | [view interactions] | Low throughput | no | no |
| B3AT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NONO_HUMAN | [view interactions] | Low throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CAH2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBP42_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| VAV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| NEK8_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| DISP3_HUMAN | [view interactions] | High throughput | no | no |
| ANKZ1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| CUL1_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| KDM4C_HUMAN | [view interactions] | High throughput | no | no |
| CAH9_HUMAN | [view interactions] | High throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HUWE1_HUMAN | [view interactions] | High throughput | no | yes |
| FUS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPTOR_HUMAN | [view interactions] | High throughput | no | yes |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| NEB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BIRC3_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DEP1B_HUMAN | [view interactions] | High throughput | no | yes |
| VAV3_HUMAN | [view interactions] | High throughput | no | yes |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCRU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1E_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PI42A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRC8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARH8_HUMAN | [view interactions] | High throughput | no | no |
| RNF5_HUMAN | [view interactions] | High throughput | no | yes |
| RNF26_HUMAN | [view interactions] | High throughput | no | yes |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BAG1_HUMAN | [view interactions] | High throughput | no | yes |
| ITA2B_HUMAN | [view interactions] | High throughput | no | no |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| S4A4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EWS_HUMAN | [view interactions] | High throughput | no | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| S26A6_HUMAN | [view interactions] | Computational | no | yes |
| CP24A_HUMAN | [view interactions] | Computational | no | no |
| CADH1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| AFAD_HUMAN | [view interactions] | Computational | no | yes |
| RAP1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| RAP1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTND1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CTNB1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |