Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

S4A4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

May have a higher activity than isoform 1. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

ELM instance Name Type Start End Partner
ELMI004273 TRG_DiLeu_BaEn_2 TRG 1052 1058 -
ELMI004273 TRG_DiLeu_BaEn_2 TRG 1052 1058 -

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in S4A4_HUMAN
GO:0043169 cation binding 42.8571 4 no
GO:0046872 metal ion binding 42.8571 5 no
GO:0046914 transition metal ion binding 28.5714 6 no
GO:0008324 monoatomic cation transmembrane transporter activity 23.8095 4 yes
GO:0022890 inorganic cation transmembrane transporter activity 23.8095 4 yes
GO:0046873 metal ion transmembrane transporter activity 23.8095 5 yes
GO:0022853 active monoatomic ion transmembrane transporter activity 19.0476 4 yes
GO:0008509 monoatomic anion transmembrane transporter activity 14.2857 4 yes
GO:0015081 sodium ion transmembrane transporter activity 14.2857 6 yes
GO:0015103 inorganic anion transmembrane transporter activity 14.2857 4 yes
GO:0015291 secondary active transmembrane transporter activity 14.2857 4 yes
GO:0015293 symporter activity 14.2857 5 yes
GO:0015294 solute:monoatomic cation symporter activity 14.2857 5 yes
GO:0015370 solute:sodium symporter activity 14.2857 6 yes
GO:0005452 solute:inorganic anion antiporter activity 9.5238 5 yes
GO:0008510 sodium:bicarbonate symporter activity 9.5238 6 yes
GO:0015106 bicarbonate transmembrane transporter activity 9.5238 4 yes
GO:0015297 antiporter activity 9.5238 5 yes
GO:0140410 monoatomic cation:bicarbonate symporter activity 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in S4A4_HUMAN
GO:0048522 positive regulation of cellular process 66.6667 4 yes
GO:0010646 regulation of cell communication 66.6667 4 no
GO:0050804 modulation of chemical synaptic transmission 57.1429 5 no
GO:0099177 regulation of trans-synaptic signaling 57.1429 4 no
GO:0051049 regulation of transport 52.3810 4 no
GO:0048523 negative regulation of cellular process 52.3810 4 no
GO:0051128 regulation of cellular component organization 47.6190 4 no
GO:0009893 positive regulation of metabolic process 42.8571 4 yes
GO:0031323 regulation of cellular metabolic process 42.8571 4 yes
GO:0031325 positive regulation of cellular metabolic process 42.8571 5 yes
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0019220 regulation of phosphate metabolic process 38.0952 6 yes
GO:0051174 regulation of phosphorus metabolic process 38.0952 5 yes
GO:0071702 organic substance transport 38.0952 4 yes
GO:0080090 regulation of primary metabolic process 38.0952 4 yes
GO:0023056 positive regulation of signaling 38.0952 4 no
GO:0050890 cognition 38.0952 4 no
GO:0010647 positive regulation of cell communication 33.3333 5 no
GO:1902531 regulation of intracellular signal transduction 33.3333 5 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 no
GO:0006996 organelle organization 33.3333 4 no
GO:0008104 protein localization 33.3333 4 no
GO:0006873 intracellular monoatomic ion homeostasis 28.5714 4 yes
GO:0010562 positive regulation of phosphorus metabolic process 28.5714 6 yes
GO:0030003 intracellular monoatomic cation homeostasis 28.5714 5 yes
GO:0045937 positive regulation of phosphate metabolic process 28.5714 7 yes
GO:0055080 monoatomic cation homeostasis 28.5714 4 yes
GO:0034762 regulation of transmembrane transport 28.5714 4 no
GO:0042981 regulation of apoptotic process 28.5714 5 no
GO:0043067 regulation of programmed cell death 28.5714 4 no
GO:0043933 protein-containing complex organization 28.5714 4 no
GO:0007612 learning 28.5714 4 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0030030 cell projection organization 28.5714 4 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0051129 negative regulation of cellular component organization 28.5714 5 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0120036 plasma membrane bounded cell projection organization 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0051130 positive regulation of cellular component organization 23.8095 5 no
GO:0006811 monoatomic ion transport 23.8095 4 yes
GO:0006812 monoatomic cation transport 23.8095 5 yes
GO:0009894 regulation of catabolic process 23.8095 4 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.8095 5 yes
GO:0030001 metal ion transport 23.8095 6 yes
GO:0031329 regulation of cellular catabolic process 23.8095 5 yes
GO:0098655 monoatomic cation transmembrane transport 23.8095 4 yes
GO:0098662 inorganic cation transmembrane transport 23.8095 4 yes
GO:0043269 regulation of monoatomic ion transport 23.8095 5 no
GO:0051050 positive regulation of transport 23.8095 4 no
GO:0009967 positive regulation of signal transduction 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0036211 protein modification process 23.8095 4 no
GO:0043412 macromolecule modification 23.8095 4 no
GO:0048584 positive regulation of response to stimulus 23.8095 4 no
GO:0048585 negative regulation of response to stimulus 23.8095 4 no
GO:0010038 response to metal ion 23.8095 4 no
GO:0043085 positive regulation of catalytic activity 23.8095 4 no
GO:0044057 regulation of system process 23.8095 4 no
GO:0141124 intracellular signaling cassette 23.8095 4 no
GO:0031344 regulation of cell projection organization 23.8095 5 no
GO:0031399 regulation of protein modification process 23.8095 6 no
GO:0042325 regulation of phosphorylation 23.8095 7 no
GO:0051247 positive regulation of protein metabolic process 23.8095 6 no
GO:0065003 protein-containing complex assembly 23.8095 5 no
GO:0060627 regulation of vesicle-mediated transport 23.8095 4 no
GO:0022603 regulation of anatomical structure morphogenesis 23.8095 4 no
GO:0031175 neuron projection development 23.8095 6 no
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 no
GO:0051094 positive regulation of developmental process 23.8095 4 no
GO:0006109 regulation of carbohydrate metabolic process 19.0476 5 yes
GO:0015711 organic anion transport 19.0476 5 yes
GO:0062012 regulation of small molecule metabolic process 19.0476 4 yes
GO:0003018 vascular process in circulatory system 14.2857 4 yes
GO:0006110 regulation of glycolytic process 14.2857 6 yes
GO:0006140 regulation of nucleotide metabolic process 14.2857 5 yes
GO:0006814 sodium ion transport 14.2857 7 yes
GO:0009896 positive regulation of catabolic process 14.2857 5 yes
GO:0010232 vascular transport 14.2857 4 yes
GO:0015701 bicarbonate transport 14.2857 6 yes
GO:0030811 regulation of nucleotide catabolic process 14.2857 5 yes
GO:0031331 positive regulation of cellular catabolic process 14.2857 6 yes
GO:0033121 regulation of purine nucleotide catabolic process 14.2857 6 yes
GO:0035725 sodium ion transmembrane transport 14.2857 5 yes
GO:0043467 regulation of generation of precursor metabolites and energy 14.2857 5 yes
GO:0043470 regulation of carbohydrate catabolic process 14.2857 5 yes
GO:0045913 positive regulation of carbohydrate metabolic process 14.2857 5 yes
GO:0045935 positive regulation of nucleobase-containing compound metabolic process 14.2857 5 yes
GO:0062013 positive regulation of small molecule metabolic process 14.2857 5 yes
GO:0150104 transport across blood-brain barrier 14.2857 5 yes
GO:1900542 regulation of purine nucleotide metabolic process 14.2857 6 yes
GO:1903578 regulation of ATP metabolic process 14.2857 7 yes
GO:0030813 positive regulation of nucleotide catabolic process 9.5238 6 yes
GO:0033123 positive regulation of purine nucleotide catabolic process 9.5238 7 yes
GO:0036376 sodium ion export across plasma membrane 9.5238 4 yes
GO:0045821 positive regulation of glycolytic process 9.5238 6 yes
GO:0045981 positive regulation of nucleotide metabolic process 9.5238 6 yes
GO:1900544 positive regulation of purine nucleotide metabolic process 9.5238 7 yes
GO:1903580 positive regulation of ATP metabolic process 9.5238 8 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S4A4_HUMAN [view entry] [view interactions] Low throughput yes no
CAH4_HUMAN [view entry] [view interactions] Low throughput yes yes
SCRIB_HUMAN [view entry] [view interactions] High throughput yes no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] High throughput yes no
AT2A2_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
MTR1A_HUMAN [view interactions] High throughput no no
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
PEX5R_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
SRBP2_HUMAN [view interactions] High throughput no yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
OXDA_HUMAN [view interactions] High throughput no no
LNX2_HUMAN [view interactions] High throughput no yes
K1C17_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
AAPK1_HUMAN [view interactions] High throughput no no
AAPK2_HUMAN [view interactions] High throughput no yes
CAH2_HUMAN [view entry] [view interactions] High throughput yes no
KAPCA_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
CNTP2_HUMAN [view entry] [view interactions] High throughput yes yes
LRC4C_HUMAN [view entry] [view interactions] High throughput yes yes
SC6A1_HUMAN [view entry] [view interactions] High throughput yes no
UBP15_HUMAN [view entry] [view interactions] High throughput yes yes
SSR3_HUMAN [view interactions] High throughput no yes