CAH4_HUMAN
Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in CAH4_HUMAN |
---|---|---|---|---|
GO:0005452 | solute:inorganic anion antiporter activity | 33.3333 | 5 | no |
GO:0008509 | anion transmembrane transporter activity | 33.3333 | 4 | no |
GO:0008514 | organic anion transmembrane transporter activity | 33.3333 | 5 | no |
GO:0015103 | inorganic anion transmembrane transporter activity | 33.3333 | 4 | no |
GO:0015106 | bicarbonate transmembrane transporter activity | 33.3333 | 6 | no |
GO:0015291 | secondary active transmembrane transporter activity | 33.3333 | 4 | no |
GO:0015297 | antiporter activity | 33.3333 | 5 | no |
GO:0022853 | active ion transmembrane transporter activity | 33.3333 | 4 | no |
GO:0140323 | solute:anion antiporter activity | 33.3333 | 6 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in CAH4_HUMAN |
---|---|---|---|---|
GO:0031323 | regulation of cellular metabolic process | 83.3333 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 83.3333 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 83.3333 | 4 | no |
GO:0019219 | regulation of nucleobase-containing compound metabolic process | 66.6667 | 5 | no |
GO:0006811 | ion transport | 50.0000 | 4 | yes |
GO:0006820 | anion transport | 50.0000 | 5 | yes |
GO:0015701 | bicarbonate transport | 50.0000 | 6 | yes |
GO:0015711 | organic anion transport | 50.0000 | 5 | yes |
GO:0071702 | organic substance transport | 50.0000 | 4 | yes |
GO:0009894 | regulation of catabolic process | 50.0000 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 50.0000 | 6 | no |
GO:0042325 | regulation of phosphorylation | 50.0000 | 7 | no |
GO:0048522 | positive regulation of cellular process | 50.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
GO:0051174 | regulation of phosphorus metabolic process | 50.0000 | 5 | no |
GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
GO:0009896 | positive regulation of catabolic process | 33.3333 | 5 | no |
GO:0009966 | regulation of signal transduction | 33.3333 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
GO:0009968 | negative regulation of signal transduction | 33.3333 | 5 | no |
GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
GO:0010647 | positive regulation of cell communication | 33.3333 | 5 | no |
GO:0010648 | negative regulation of cell communication | 33.3333 | 5 | no |
GO:0010941 | regulation of cell death | 33.3333 | 4 | no |
GO:0023056 | positive regulation of signaling | 33.3333 | 4 | no |
GO:0023057 | negative regulation of signaling | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
GO:0031329 | regulation of cellular catabolic process | 33.3333 | 5 | no |
GO:0031331 | positive regulation of cellular catabolic process | 33.3333 | 6 | no |
GO:0042981 | regulation of apoptotic process | 33.3333 | 6 | no |
GO:0043066 | negative regulation of apoptotic process | 33.3333 | 7 | no |
GO:0043067 | regulation of programmed cell death | 33.3333 | 5 | no |
GO:0043069 | negative regulation of programmed cell death | 33.3333 | 6 | no |
GO:0048584 | positive regulation of response to stimulus | 33.3333 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 33.3333 | 4 | no |
GO:0060548 | negative regulation of cell death | 33.3333 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
GO:2001233 | regulation of apoptotic signaling pathway | 33.3333 | 5 | no |
GO:2001234 | negative regulation of apoptotic signaling pathway | 33.3333 | 6 | no |
GO:2001236 | regulation of extrinsic apoptotic signaling pathway | 33.3333 | 6 | no |
GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 33.3333 | 7 | no |
GO:0006109 | regulation of carbohydrate metabolic process | 33.3333 | 5 | no |
GO:0006110 | regulation of glycolytic process | 33.3333 | 6 | no |
GO:0006140 | regulation of nucleotide metabolic process | 33.3333 | 5 | no |
GO:0006873 | cellular ion homeostasis | 33.3333 | 4 | no |
GO:0006885 | regulation of pH | 33.3333 | 8 | no |
GO:0030003 | cellular cation homeostasis | 33.3333 | 5 | no |
GO:0030004 | cellular monovalent inorganic cation homeostasis | 33.3333 | 6 | no |
GO:0030641 | regulation of cellular pH | 33.3333 | 7 | no |
GO:0043467 | regulation of generation of precursor metabolites and energy | 33.3333 | 5 | no |
GO:0043470 | regulation of carbohydrate catabolic process | 33.3333 | 5 | no |
GO:0048878 | chemical homeostasis | 33.3333 | 4 | no |
GO:0050801 | ion homeostasis | 33.3333 | 5 | no |
GO:0051453 | regulation of intracellular pH | 33.3333 | 8 | no |
GO:0055067 | monovalent inorganic cation homeostasis | 33.3333 | 7 | no |
GO:0055080 | cation homeostasis | 33.3333 | 6 | no |
GO:0062012 | regulation of small molecule metabolic process | 33.3333 | 4 | no |
GO:0098771 | inorganic ion homeostasis | 33.3333 | 6 | no |
GO:1900542 | regulation of purine nucleotide metabolic process | 33.3333 | 6 | no |
GO:1903578 | regulation of ATP metabolic process | 33.3333 | 7 | no |
GO:0006355 | regulation of DNA-templated transcription | 33.3333 | 6 | no |
GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
GO:0010468 | regulation of gene expression | 33.3333 | 5 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 33.3333 | 5 | no |
GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
GO:1903506 | regulation of nucleic acid-templated transcription | 33.3333 | 7 | no |
GO:2001141 | regulation of RNA biosynthetic process | 33.3333 | 6 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
S4A4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
FL2D_HUMAN | [view interactions] | Low throughput | no | yes |
B3AT_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CD177_HUMAN | [view interactions] | High throughput | no | no |
TX101_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK6_HUMAN | [view interactions] | High throughput | no | yes |
AL1A2_HUMAN | [view interactions] | High throughput | no | yes |
CP24A_HUMAN | [view interactions] | Computational | no | no |