Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

CAH4_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in CAH4_HUMAN
GO:0043169 cation binding 28.5714 4 yes
GO:0005452 solute:inorganic anion antiporter activity 28.5714 5 no
GO:0008509 monoatomic anion transmembrane transporter activity 28.5714 4 no
GO:0015103 inorganic anion transmembrane transporter activity 28.5714 4 no
GO:0015106 bicarbonate transmembrane transporter activity 28.5714 4 no
GO:0015291 secondary active transmembrane transporter activity 28.5714 4 no
GO:0015297 antiporter activity 28.5714 5 no
GO:0022853 active monoatomic ion transmembrane transporter activity 28.5714 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in CAH4_HUMAN
GO:0031323 regulation of cellular metabolic process 71.4286 4 no
GO:0015711 organic anion transport 57.1429 5 yes
GO:0071702 organic substance transport 57.1429 4 yes
GO:0019220 regulation of phosphate metabolic process 57.1429 6 no
GO:0048523 negative regulation of cellular process 57.1429 4 no
GO:0051174 regulation of phosphorus metabolic process 57.1429 5 no
GO:0080090 regulation of primary metabolic process 57.1429 4 no
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0009967 positive regulation of signal transduction 42.8571 5 no
GO:0009968 negative regulation of signal transduction 42.8571 5 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0010647 positive regulation of cell communication 42.8571 5 no
GO:0010648 negative regulation of cell communication 42.8571 5 no
GO:0023056 positive regulation of signaling 42.8571 4 no
GO:0023057 negative regulation of signaling 42.8571 4 no
GO:0042981 regulation of apoptotic process 42.8571 5 no
GO:0043067 regulation of programmed cell death 42.8571 4 no
GO:0048584 positive regulation of response to stimulus 42.8571 4 no
GO:0048585 negative regulation of response to stimulus 42.8571 4 no
GO:1902531 regulation of intracellular signal transduction 42.8571 5 no
GO:2001233 regulation of apoptotic signaling pathway 42.8571 5 no
GO:2001236 regulation of extrinsic apoptotic signaling pathway 42.8571 6 no
GO:0015701 bicarbonate transport 42.8571 6 yes
GO:0009894 regulation of catabolic process 42.8571 4 no
GO:0009966 regulation of signal transduction 42.8571 4 no
GO:0010721 negative regulation of cell development 28.5714 6 no
GO:0030155 regulation of cell adhesion 28.5714 4 no
GO:0043066 negative regulation of apoptotic process 28.5714 6 no
GO:0043069 negative regulation of programmed cell death 28.5714 5 no
GO:0043408 regulation of MAPK cascade 28.5714 6 no
GO:0045595 regulation of cell differentiation 28.5714 4 no
GO:0045596 negative regulation of cell differentiation 28.5714 5 no
GO:0048732 gland development 28.5714 4 no
GO:0051093 negative regulation of developmental process 28.5714 4 no
GO:0051241 negative regulation of multicellular organismal process 28.5714 4 no
GO:0060284 regulation of cell development 28.5714 5 no
GO:0097191 extrinsic apoptotic signaling pathway 28.5714 4 no
GO:1902105 regulation of leukocyte differentiation 28.5714 5 no
GO:1902106 negative regulation of leukocyte differentiation 28.5714 6 no
GO:1903706 regulation of hemopoiesis 28.5714 4 no
GO:1903707 negative regulation of hemopoiesis 28.5714 5 no
GO:2000026 regulation of multicellular organismal development 28.5714 4 no
GO:2001234 negative regulation of apoptotic signaling pathway 28.5714 6 no
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway 28.5714 7 no
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand 28.5714 7 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0006915 apoptotic process 28.5714 4 no
GO:0006996 organelle organization 28.5714 4 no
GO:0007010 cytoskeleton organization 28.5714 5 no
GO:0007612 learning 28.5714 4 no
GO:0031399 regulation of protein modification process 28.5714 6 no
GO:0042325 regulation of phosphorylation 28.5714 7 no
GO:0043065 positive regulation of apoptotic process 28.5714 6 no
GO:0043068 positive regulation of programmed cell death 28.5714 5 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0045859 regulation of protein kinase activity 28.5714 6 no
GO:0050890 cognition 28.5714 4 no
GO:0051049 regulation of transport 28.5714 4 no
GO:0051128 regulation of cellular component organization 28.5714 4 no
GO:0051246 regulation of protein metabolic process 28.5714 5 no
GO:0051336 regulation of hydrolase activity 28.5714 4 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0060255 regulation of macromolecule metabolic process 28.5714 4 no
GO:0071900 regulation of protein serine/threonine kinase activity 28.5714 7 no
GO:0098597 observational learning 28.5714 5 no
GO:0006109 regulation of carbohydrate metabolic process 28.5714 5 no
GO:0006110 regulation of glycolytic process 28.5714 6 no
GO:0006140 regulation of nucleotide metabolic process 28.5714 5 no
GO:0006811 monoatomic ion transport 28.5714 4 no
GO:0006873 intracellular monoatomic ion homeostasis 28.5714 4 no
GO:0008104 protein localization 28.5714 4 no
GO:0009892 negative regulation of metabolic process 28.5714 4 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 28.5714 5 no
GO:0030003 intracellular monoatomic cation homeostasis 28.5714 5 no
GO:0030811 regulation of nucleotide catabolic process 28.5714 5 no
GO:0031324 negative regulation of cellular metabolic process 28.5714 5 no
GO:0033121 regulation of purine nucleotide catabolic process 28.5714 6 no
GO:0043467 regulation of generation of precursor metabolites and energy 28.5714 5 no
GO:0043470 regulation of carbohydrate catabolic process 28.5714 5 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0055080 monoatomic cation homeostasis 28.5714 4 no
GO:0062012 regulation of small molecule metabolic process 28.5714 4 no
GO:1900542 regulation of purine nucleotide metabolic process 28.5714 6 no
GO:1903578 regulation of ATP metabolic process 28.5714 7 no
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0009896 positive regulation of catabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031329 regulation of cellular catabolic process 28.5714 5 no
GO:0031331 positive regulation of cellular catabolic process 28.5714 6 no
GO:0002683 negative regulation of immune system process 28.5714 4 no
GO:0007162 negative regulation of cell adhesion 28.5714 5 no

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
S4A4_HUMAN [view entry] [view interactions] Low throughput yes no
FL2D_HUMAN [view interactions] Low throughput no yes
B3AT_HUMAN [view entry] [view interactions] Low throughput yes no
HD_HUMAN [view entry] [view interactions] High throughput yes yes
CD177_HUMAN [view interactions] High throughput no no
TX101_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
PIHD1_HUMAN [view interactions] High throughput no yes
OXDA_HUMAN [view interactions] High throughput no no
CDK18_HUMAN [view entry] [view interactions] High throughput yes yes
CDK6_HUMAN [view interactions] High throughput no yes
AL1A2_HUMAN [view interactions] High throughput no yes
NF1_HUMAN [view entry] [view interactions] High throughput yes no
SPPL3_HUMAN [view interactions] High throughput no no