RHG01_HUMAN
Evidence for PS localization
Functions
GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RHG01_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 38.9610 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 38.9610 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 37.6623 | 4 | no |
| GO:0005525 | GTP binding | 25.9740 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 25.9740 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 25.9740 | 5 | no |
| GO:0003924 | GTPase activity | 24.6753 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 24.6753 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 24.6753 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 24.6753 | 6 | no |
| GO:0045296 | cadherin binding | 18.1818 | 4 | yes |
| GO:0051020 | GTPase binding | 11.6883 | 4 | yes |
| GO:0031267 | small GTPase binding | 7.7922 | 5 | yes |
| GO:0017124 | SH3 domain binding | 3.8961 | 4 | yes |
| GO:0005096 | GTPase activator activity | 2.5974 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 2.5974 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RHG01_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 55.8442 | 4 | no |
| GO:0008104 | protein localization | 42.8571 | 4 | yes |
| GO:0010646 | regulation of cell communication | 41.5584 | 4 | yes |
| GO:0006996 | organelle organization | 40.2597 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 40.2597 | 4 | no |
| GO:0051049 | regulation of transport | 38.9610 | 4 | yes |
| GO:0071702 | organic substance transport | 37.6623 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 35.0649 | 4 | yes |
| GO:0071705 | nitrogen compound transport | 35.0649 | 4 | yes |
| GO:0015031 | protein transport | 33.7662 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 33.7662 | 4 | yes |
| GO:0048584 | positive regulation of response to stimulus | 32.4675 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 32.4675 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 31.1688 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 29.8701 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 29.8701 | 5 | yes |
| GO:0060341 | regulation of cellular localization | 28.5714 | 4 | yes |
| GO:0022607 | cellular component assembly | 28.5714 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 28.5714 | 4 | no |
| GO:0007010 | cytoskeleton organization | 27.2727 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 27.2727 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 27.2727 | 5 | no |
| GO:0033043 | regulation of organelle organization | 27.2727 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 27.2727 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 24.6753 | 5 | no |
| GO:0010468 | regulation of gene expression | 24.6753 | 5 | no |
| GO:0030030 | cell projection organization | 24.6753 | 4 | no |
| GO:0071310 | cellular response to organic substance | 24.6753 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.3766 | 4 | no |
| GO:0032880 | regulation of protein localization | 23.3766 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 23.3766 | 5 | no |
| GO:0010941 | regulation of cell death | 22.0779 | 4 | no |
| GO:0051050 | positive regulation of transport | 22.0779 | 4 | no |
| GO:0030334 | regulation of cell migration | 22.0779 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 22.0779 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 22.0779 | 4 | no |
| GO:2000145 | regulation of cell motility | 22.0779 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 20.7792 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 20.7792 | 5 | no |
| GO:0051094 | positive regulation of developmental process | 20.7792 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.7792 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.7792 | 6 | no |
| GO:0045595 | regulation of cell differentiation | 20.7792 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 20.7792 | 5 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 19.4805 | 4 | yes |
| GO:0007264 | small GTPase mediated signal transduction | 18.1818 | 4 | yes |
| GO:0032386 | regulation of intracellular transport | 18.1818 | 5 | yes |
| GO:0007265 | Ras protein signal transduction | 16.8831 | 5 | yes |
| GO:0016197 | endosomal transport | 10.3896 | 4 | yes |
| GO:0051056 | regulation of small GTPase mediated signal transduction | 10.3896 | 6 | yes |
| GO:0006811 | ion transport | 9.0909 | 4 | yes |
| GO:0051051 | negative regulation of transport | 9.0909 | 4 | yes |
| GO:0006812 | cation transport | 7.7922 | 5 | yes |
| GO:0007266 | Rho protein signal transduction | 7.7922 | 6 | yes |
| GO:0030001 | metal ion transport | 7.7922 | 6 | yes |
| GO:0000041 | transition metal ion transport | 3.8961 | 7 | yes |
| GO:0006826 | iron ion transport | 3.8961 | 8 | yes |
| GO:0032387 | negative regulation of intracellular transport | 2.5974 | 5 | yes |
| GO:0033572 | transferrin transport | 2.5974 | 5 | yes |
| GO:2001135 | regulation of endocytic recycling | 2.5974 | 5 | yes |
| GO:2001136 | negative regulation of endocytic recycling | 2.5974 | 6 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in RHG01_HUMAN |
|---|---|---|---|---|
| DOID:331 | central nervous system disease | 3.8961 | 3 | no |
| DOID:1289 | neurodegenerative disease | 2.5974 | 4 | no |
| DOID:0060038 | specific developmental disorder | 2.5974 | 3 | no |
| DOID:1059 | intellectual disability | 2.5974 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CDC42_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHOA_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| BNIP2_HUMAN | [view interactions] | Low throughput | no | yes |
| BNIPL_HUMAN | [view interactions] | Low throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| NDEL1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| LIS1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RHG01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SRC_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| P85A_HUMAN | [view interactions] | Low throughput | no | yes |
| ATRAP_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| FOXR2_HUMAN | [view interactions] | High throughput | no | no |
| FIBB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FSD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| XPO7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SRGP1_HUMAN | [view interactions] | High throughput | no | no |
| PSPC1_HUMAN | [view interactions] | High throughput | no | yes |
| MAZ_HUMAN | [view interactions] | High throughput | no | yes |
| ARHGJ_HUMAN | [view interactions] | High throughput | no | no |
| DDX42_HUMAN | [view interactions] | High throughput | no | yes |
| ZN207_HUMAN | [view interactions] | High throughput | no | yes |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| PHF6_HUMAN | [view interactions] | High throughput | no | yes |
| LC7L2_HUMAN | [view interactions] | High throughput | no | yes |
| DHE3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KC1D_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CNBP_HUMAN | [view interactions] | High throughput | no | no |
| CKAP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDK9_HUMAN | [view interactions] | High throughput | no | yes |
| MMTA2_HUMAN | [view interactions] | High throughput | no | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| CHK2_HUMAN | [view interactions] | High throughput | no | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| STK4_HUMAN | [view interactions] | High throughput | no | yes |
| TMM17_HUMAN | [view interactions] | High throughput | no | yes |
| TECT2_HUMAN | [view interactions] | High throughput | no | yes |
| TM216_HUMAN | [view interactions] | High throughput | no | no |
| CALX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAMP1_HUMAN | [view interactions] | High throughput | no | yes |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PPM1H_HUMAN | [view interactions] | High throughput | no | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| FGFR4_HUMAN | [view interactions] | High throughput | no | no |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FHI1A_HUMAN | [view interactions] | High throughput | no | yes |
| FHI1B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| EED_HUMAN | [view interactions] | High throughput | no | yes |
| FBX25_HUMAN | [view interactions] | High throughput | no | no |
| CDK15_HUMAN | [view interactions] | High throughput | no | no |
| SETX_HUMAN | [view interactions] | High throughput | no | yes |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| TES_HUMAN | [view interactions] | High throughput | no | yes |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| BOLA2_HUMAN | [view interactions] | High throughput | no | yes |
| CAH2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCNT1_HUMAN | [view interactions] | High throughput | no | yes |
| FIP1_HUMAN | [view interactions] | High throughput | no | yes |
| HMGB1_HUMAN | [view interactions] | High throughput | no | yes |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMNB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMRP_HUMAN | [view interactions] | High throughput | no | yes |
| CPSF5_HUMAN | [view interactions] | High throughput | no | yes |
| POTEE_HUMAN | [view interactions] | High throughput | no | no |
| PPIL4_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRP4B_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| STML2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR82_HUMAN | [view interactions] | High throughput | no | no |
| 2ABB_HUMAN | [view interactions] | High throughput | no | yes |
| STX17_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GCH1_HUMAN | [view interactions] | High throughput | no | no |
| SARAF_HUMAN | [view interactions] | High throughput | no | no |
| PINK1_HUMAN | [view interactions] | High throughput | no | yes |
| UPK1A_HUMAN | [view interactions] | High throughput | no | no |
| NTNG1_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| FA81B_HUMAN | [view interactions] | High throughput | no | no |
| TGFR2_HUMAN | [view interactions] | High throughput | no | no |
| SSUH2_HUMAN | [view interactions] | High throughput | no | no |
| PHF11_HUMAN | [view interactions] | High throughput | no | no |
| NRSN1_HUMAN | [view interactions] | High throughput | no | yes |
| MBNL1_HUMAN | [view interactions] | High throughput | no | yes |
| PRR11_HUMAN | [view interactions] | High throughput | no | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOD_HUMAN | [view interactions] | High throughput | no | no |
| RHOF_HUMAN | [view interactions] | High throughput | no | no |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| SPRNG_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP1B1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAZA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCD22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FRIH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| I2BP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| NMD3_HUMAN | [view interactions] | High throughput | no | no |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PUR1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOC_HUMAN | [view interactions] | High throughput | no | no |
| UBA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GFPT1_HUMAN | [view interactions] | High throughput | no | no |
| RUVB2_HUMAN | [view interactions] | High throughput | no | yes |
| PAK3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITPR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MP2K4_HUMAN | [view interactions] | High throughput | no | yes |
| PTN11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHG18_HUMAN | [view interactions] | High throughput | no | yes |
| E41L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DRG1_HUMAN | [view interactions] | High throughput | no | yes |
| VIGLN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CADH1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| RHBL4_HUMAN | [view interactions] | High throughput | no | no |
| OTULL_HUMAN | [view interactions] | High throughput | no | no |
| SYVN1_HUMAN | [view interactions] | High throughput | no | yes |
| ST7_HUMAN | [view interactions] | High throughput | no | yes |
| FIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| PTN1_HUMAN | [view interactions] | High throughput | no | yes |
| S2546_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJC1_HUMAN | [view interactions] | High throughput | no | yes |
| DJC25_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC5_HUMAN | [view interactions] | High throughput | no | yes |
| DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
| ACBD5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AKAP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANFY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARF6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AT2A1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| B3GA1_HUMAN | [view interactions] | High throughput | no | yes |
| BAP31_HUMAN | [view interactions] | High throughput | no | yes |
| CAV1_HUMAN | [view interactions] | High throughput | no | no |
| CXAR_HUMAN | [view interactions] | High throughput | no | yes |
| DERL1_HUMAN | [view interactions] | High throughput | no | yes |
| DIRA3_HUMAN | [view interactions] | High throughput | no | yes |
| RCAS1_HUMAN | [view interactions] | High throughput | no | yes |
| ELOV5_HUMAN | [view interactions] | High throughput | no | yes |
| EMD_HUMAN | [view interactions] | High throughput | no | yes |
| ERGI1_HUMAN | [view interactions] | High throughput | no | yes |
| CXA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXD3_HUMAN | [view interactions] | High throughput | no | no |
| DHB11_HUMAN | [view interactions] | High throughput | no | yes |
| 3BHS7_HUMAN | [view interactions] | High throughput | no | no |
| LAMP2_HUMAN | [view interactions] | High throughput | no | yes |
| LAMP3_HUMAN | [view interactions] | High throughput | no | no |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LMAN1_HUMAN | [view interactions] | High throughput | no | yes |
| LNP_HUMAN | [view interactions] | High throughput | no | yes |
| LRC59_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARCS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET7A_HUMAN | [view interactions] | High throughput | no | no |
| OCLN_HUMAN | [view interactions] | High throughput | no | no |
| PANX1_HUMAN | [view interactions] | High throughput | no | no |
| PXMP2_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB2A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB3B_HUMAN | [view interactions] | High throughput | no | no |
| RAB4A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAB5A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB5C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB9A_HUMAN | [view interactions] | High throughput | no | yes |
| REEP5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SC61B_HUMAN | [view interactions] | High throughput | no | yes |
| SEC62_HUMAN | [view interactions] | High throughput | no | yes |
| SSRA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STIM1_HUMAN | [view interactions] | High throughput | no | yes |
| STX4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| STX7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ZFPL1_HUMAN | [view interactions] | High throughput | no | yes |
| TFR1_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| DPP4_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| ACE2_HUMAN | [view interactions] | High throughput | no | no |
| TMPS4_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| TAXB1_HUMAN | [view interactions] | High throughput | no | yes |
| CLCB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERD23_HUMAN | [view interactions] | Computational | no | yes |
| COPA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RASA1_HUMAN | [view interactions] | Computational | no | yes |
| ARF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ERD21_HUMAN | [view interactions] | Computational | no | yes |
| CLCA_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ERD22_HUMAN | [view interactions] | Computational | no | yes |