Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RHG01_HUMAN

GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RHG01_HUMAN
GO:0043168 anion binding 43.4343 4 no
GO:0000166 nucleotide binding 39.3939 4 no
GO:0017076 purine nucleotide binding 38.3838 5 no
GO:0032555 purine ribonucleotide binding 38.3838 4 no
GO:0035639 purine ribonucleoside triphosphate binding 37.3737 4 no
GO:0016462 pyrophosphatase activity 26.2626 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 26.2626 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 26.2626 6 no
GO:0005525 GTP binding 22.2222 5 no
GO:0019001 guanyl nucleotide binding 22.2222 6 no
GO:0032561 guanyl ribonucleotide binding 22.2222 5 no
GO:0003924 GTPase activity 21.2121 7 no
GO:0045296 cadherin binding 20.2020 4 yes
GO:0003723 RNA binding 20.2020 4 no
GO:0051020 GTPase binding 9.0909 4 yes
GO:0031267 small GTPase binding 7.0707 5 yes
GO:0017124 SH3 domain binding 4.0404 4 yes
GO:0005096 GTPase activator activity 2.0202 4 yes
GO:0030695 GTPase regulator activity 2.0202 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RHG01_HUMAN
GO:0048522 positive regulation of cellular process 59.5960 4 no
GO:0006996 organelle organization 47.4747 4 no
GO:0051128 regulation of cellular component organization 44.4444 4 no
GO:0008104 protein localization 43.4343 4 yes
GO:0010646 regulation of cell communication 41.4141 4 yes
GO:0048523 negative regulation of cellular process 40.4040 4 yes
GO:0031323 regulation of cellular metabolic process 39.3939 4 no
GO:0060255 regulation of macromolecule metabolic process 39.3939 4 no
GO:0051049 regulation of transport 37.3737 4 yes
GO:0060341 regulation of cellular localization 37.3737 4 yes
GO:0009966 regulation of signal transduction 36.3636 4 yes
GO:0071702 organic substance transport 36.3636 4 yes
GO:0071705 nitrogen compound transport 33.3333 4 yes
GO:0048584 positive regulation of response to stimulus 33.3333 4 no
GO:0032880 regulation of protein localization 32.3232 5 no
GO:0080090 regulation of primary metabolic process 32.3232 4 no
GO:0009889 regulation of biosynthetic process 31.3131 4 no
GO:0010647 positive regulation of cell communication 31.3131 5 no
GO:0023056 positive regulation of signaling 31.3131 4 no
GO:0031326 regulation of cellular biosynthetic process 31.3131 5 no
GO:0022607 cellular component assembly 31.3131 4 no
GO:0015031 protein transport 30.3030 4 yes
GO:0009893 positive regulation of metabolic process 30.3030 4 no
GO:0010604 positive regulation of macromolecule metabolic process 30.3030 5 no
GO:0010556 regulation of macromolecule biosynthetic process 30.3030 5 no
GO:0010468 regulation of gene expression 29.2929 6 no
GO:1902531 regulation of intracellular signal transduction 28.2828 5 yes
GO:0033043 regulation of organelle organization 28.2828 5 no
GO:0031325 positive regulation of cellular metabolic process 26.2626 5 no
GO:0051246 regulation of protein metabolic process 26.2626 5 no
GO:0009967 positive regulation of signal transduction 25.2525 5 no
GO:0044087 regulation of cellular component biogenesis 25.2525 4 no
GO:0043067 regulation of programmed cell death 24.2424 4 no
GO:0051130 positive regulation of cellular component organization 23.2323 5 no
GO:0042981 regulation of apoptotic process 23.2323 5 no
GO:0071310 cellular response to organic substance 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0007010 cytoskeleton organization 22.2222 5 no
GO:0009891 positive regulation of biosynthetic process 21.2121 5 no
GO:0030334 regulation of cell migration 21.2121 5 no
GO:0031328 positive regulation of cellular biosynthetic process 21.2121 6 no
GO:2000145 regulation of cell motility 21.2121 4 no
GO:1903829 positive regulation of protein localization 21.2121 5 no
GO:0051247 positive regulation of protein metabolic process 21.2121 6 no
GO:0060627 regulation of vesicle-mediated transport 20.2020 4 yes
GO:0070201 regulation of establishment of protein localization 20.2020 6 no
GO:0051240 positive regulation of multicellular organismal process 20.2020 4 no
GO:1902533 positive regulation of intracellular signal transduction 20.2020 6 no
GO:0043933 protein-containing complex organization 20.2020 4 no
GO:0009892 negative regulation of metabolic process 20.2020 4 no
GO:0031324 negative regulation of cellular metabolic process 20.2020 5 no
GO:0141124 intracellular signaling cassette 18.1818 4 yes
GO:0032386 regulation of intracellular transport 17.1717 5 yes
GO:0007264 small GTPase-mediated signal transduction 15.1515 5 yes
GO:0051051 negative regulation of transport 9.0909 4 yes
GO:0006811 monoatomic ion transport 8.0808 4 yes
GO:0051056 regulation of small GTPase mediated signal transduction 8.0808 6 yes
GO:0006812 monoatomic cation transport 7.0707 5 yes
GO:0030001 metal ion transport 7.0707 6 yes
GO:0007266 Rho protein signal transduction 6.0606 6 yes
GO:0000041 transition metal ion transport 5.0505 7 yes
GO:0006826 iron ion transport 5.0505 8 yes
GO:0033572 transferrin transport 4.0404 5 yes
GO:2001135 regulation of endocytic recycling 3.0303 5 yes
GO:0032387 negative regulation of intracellular transport 2.0202 5 yes
GO:2001136 negative regulation of endocytic recycling 2.0202 6 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
CDC42_HUMAN [view entry] [view interactions] Low throughput yes yes
RHOA_HUMAN [view entry] [view interactions] Low throughput yes yes
BNIP2_HUMAN [view interactions] Low throughput no yes
BNIPL_HUMAN [view interactions] Low throughput no no
RAC1_HUMAN [view entry] [view interactions] Low throughput yes no
NDEL1_HUMAN [view entry] [view interactions] Low throughput yes yes
LIS1_HUMAN [view entry] [view interactions] Low throughput yes yes
RHG01_HUMAN [view entry] [view interactions] Low throughput yes yes
SRC_HUMAN [view entry] [view interactions] Low throughput yes no
P85A_HUMAN [view interactions] Low throughput no yes
TAXB1_HUMAN [view interactions] High throughput no yes
ATG9A_HUMAN [view interactions] High throughput no yes
STING_HUMAN [view interactions] High throughput no yes
ARL15_HUMAN [view interactions] High throughput no yes
STAU1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
RAB25_HUMAN [view interactions] High throughput no no
RAB18_HUMAN [view entry] [view interactions] High throughput yes yes
ESYT1_HUMAN [view entry] [view interactions] High throughput yes yes
ATRAP_HUMAN [view interactions] High throughput no yes
RFA1_HUMAN [view interactions] High throughput no yes
MTR1B_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
FOXR2_HUMAN [view interactions] High throughput no no
RFA3_HUMAN [view interactions] High throughput no yes
FIBB_HUMAN [view entry] [view interactions] High throughput yes no
FSD1_HUMAN [view entry] [view interactions] High throughput yes no
XPO7_HUMAN [view entry] [view interactions] High throughput yes yes
RAN_HUMAN [view entry] [view interactions] High throughput yes no
SRGP1_HUMAN [view interactions] High throughput no no
ARHGJ_HUMAN [view interactions] High throughput no no
MMTA2_HUMAN [view interactions] High throughput no yes
CDK9_HUMAN [view interactions] High throughput no yes
CKAP4_HUMAN [view entry] [view interactions] High throughput yes yes
CNBP_HUMAN [view interactions] High throughput no no
KC1D_HUMAN [view entry] [view interactions] High throughput yes yes
DHE3_HUMAN [view entry] [view interactions] High throughput yes yes
LC7L2_HUMAN [view interactions] High throughput no yes
MAZ_HUMAN [view interactions] High throughput no yes
PHF6_HUMAN [view interactions] High throughput no yes
PSPC1_HUMAN [view interactions] High throughput no yes
TACO1_HUMAN [view interactions] High throughput no yes
ZN207_HUMAN [view interactions] High throughput no yes
DDX42_HUMAN [view interactions] High throughput no yes
SOX2_HUMAN [view interactions] High throughput no yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
PP1A_HUMAN [view entry] [view interactions] High throughput yes yes
TX101_HUMAN [view interactions] High throughput no no
CHK2_HUMAN [view interactions] High throughput no yes
SH3G1_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
STK4_HUMAN [view interactions] High throughput no yes
LCOR_HUMAN [view interactions] High throughput no yes
TMM17_HUMAN [view interactions] High throughput no yes
TECT2_HUMAN [view interactions] High throughput no yes
TM216_HUMAN [view interactions] High throughput no no
CALX_HUMAN [view entry] [view interactions] High throughput yes yes
LAMP1_HUMAN [view entry] [view interactions] High throughput yes yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RASN_HUMAN [view entry] [view interactions] High throughput yes no
RASH_HUMAN [view entry] [view interactions] High throughput yes no
PPM1H_HUMAN [view interactions] High throughput no yes
EGFR_HUMAN [view interactions] High throughput no no
FGFR1_HUMAN [view entry] [view interactions] High throughput yes yes
FGFR4_HUMAN [view interactions] High throughput no no
IGF1R_HUMAN [view entry] [view interactions] High throughput yes yes
INSR_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
FHI1A_HUMAN [view interactions] High throughput no yes
FHI1B_HUMAN [view interactions] High throughput no yes
FHI2A_HUMAN [view interactions] High throughput no yes
SWAP1_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
EED_HUMAN [view interactions] High throughput no yes
FBX25_HUMAN [view interactions] High throughput no no
CDK15_HUMAN [view interactions] High throughput no no
SETX_HUMAN [view interactions] High throughput no yes
TRI25_HUMAN [view interactions] High throughput no yes
TES_HUMAN [view interactions] High throughput no yes
DUS22_HUMAN [view interactions] High throughput no yes
BOLA2_HUMAN [view interactions] High throughput no yes
CAH2_HUMAN [view entry] [view interactions] High throughput yes no
CCNT1_HUMAN [view interactions] High throughput no yes
FIP1_HUMAN [view interactions] High throughput no yes
HMGB1_HUMAN [view interactions] High throughput no yes
LMNA_HUMAN [view entry] [view interactions] High throughput yes yes
LMNB2_HUMAN [view entry] [view interactions] High throughput yes yes
AMRP_HUMAN [view interactions] High throughput no yes
CPSF5_HUMAN [view interactions] High throughput no yes
POTEE_HUMAN [view interactions] High throughput no no
PPIL4_HUMAN [view interactions] High throughput no yes
PRDX2_HUMAN [view entry] [view interactions] High throughput yes yes
PRP4B_HUMAN [view interactions] High throughput no yes
P5CR2_HUMAN [view interactions] High throughput no yes
STML2_HUMAN [view entry] [view interactions] High throughput yes yes
WDR82_HUMAN [view interactions] High throughput no no
2ABB_HUMAN [view interactions] High throughput no yes
STX17_HUMAN [view interactions] High throughput no yes
AATC_HUMAN [view entry] [view interactions] High throughput yes yes
GCH1_HUMAN [view interactions] High throughput no no
SARAF_HUMAN [view interactions] High throughput no no
PINK1_HUMAN [view interactions] High throughput no yes
UPK1A_HUMAN [view interactions] High throughput no no
NTNG1_HUMAN [view interactions] High throughput no no
FNDC5_HUMAN [view interactions] High throughput no no
FA81B_HUMAN [view interactions] High throughput no no
TGFR2_HUMAN [view interactions] High throughput no no
SSUH2_HUMAN [view interactions] High throughput no no
PHF11_HUMAN [view interactions] High throughput no no
NRSN1_HUMAN [view interactions] High throughput no yes
MBNL1_HUMAN [view interactions] High throughput no yes
PRR11_HUMAN [view interactions] High throughput no no
CCR1_HUMAN [view interactions] High throughput no no
RHOJ_HUMAN [view interactions] High throughput no yes
RHOQ_HUMAN [view interactions] High throughput no no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOD_HUMAN [view interactions] High throughput no no
RHOF_HUMAN [view interactions] High throughput no no
RHOH_HUMAN [view interactions] High throughput no yes
RND2_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HSP7C_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
ANLN_HUMAN [view interactions] High throughput no yes
SPRNG_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
AP1B1_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA1_HUMAN [view entry] [view interactions] High throughput yes yes
CCD22_HUMAN [view entry] [view interactions] High throughput yes no
FRIH_HUMAN [view entry] [view interactions] High throughput yes yes
I2BP1_HUMAN [view interactions] High throughput no yes
SYLC_HUMAN [view interactions] High throughput no yes
NMD3_HUMAN [view interactions] High throughput no no
PFKAP_HUMAN [view entry] [view interactions] High throughput yes yes
PUR1_HUMAN [view interactions] High throughput no yes
ELOC_HUMAN [view interactions] High throughput no no
UBA1_HUMAN [view entry] [view interactions] High throughput yes yes
GFPT1_HUMAN [view interactions] High throughput no no
RUVB2_HUMAN [view interactions] High throughput no yes
PAK3_HUMAN [view entry] [view interactions] High throughput yes no
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
MP2K4_HUMAN [view interactions] High throughput no yes
PTN11_HUMAN [view entry] [view interactions] High throughput yes yes
RHG18_HUMAN [view interactions] High throughput no yes
E41L1_HUMAN [view entry] [view interactions] High throughput yes yes
DRG1_HUMAN [view interactions] High throughput no yes
VIGLN_HUMAN [view entry] [view interactions] High throughput yes yes
PLOD2_HUMAN [view interactions] High throughput no yes
HNRDL_HUMAN [view interactions] High throughput no yes
MCES_HUMAN [view interactions] High throughput no yes
HNRPR_HUMAN [view interactions] High throughput no yes
E41L2_HUMAN [view entry] [view interactions] High throughput yes yes
AP1G1_HUMAN [view entry] [view interactions] High throughput yes yes
AIFM1_HUMAN [view entry] [view interactions] High throughput yes no
HEXA_HUMAN [view interactions] High throughput no yes
SYEP_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
MOES_HUMAN [view entry] [view interactions] High throughput yes no
U2AF2_HUMAN [view interactions] High throughput no yes
RADI_HUMAN [view entry] [view interactions] High throughput yes yes
LONM_HUMAN [view entry] [view interactions] High throughput yes yes
SERPH_HUMAN [view interactions] High throughput no no
ACLY_HUMAN [view entry] [view interactions] High throughput yes yes
SYMC_HUMAN [view interactions] High throughput no yes
EF1A1_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
PSME1_HUMAN [view interactions] High throughput no yes
TADBP_HUMAN [view interactions] High throughput no yes
AIMP2_HUMAN [view interactions] High throughput no yes
DNJC3_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
SEPT7_HUMAN [view entry] [view interactions] High throughput yes yes
NIBA2_HUMAN [view interactions] High throughput no no
AP1M1_HUMAN [view entry] [view interactions] High throughput yes yes
GOLP3_HUMAN [view interactions] High throughput no no
RPR1B_HUMAN [view interactions] High throughput no yes
CHMP3_HUMAN [view interactions] High throughput no yes
CADH1_HUMAN [view entry] [view interactions] High throughput yes no
AGR2_HUMAN [view interactions] High throughput no no
DC1L2_HUMAN [view entry] [view interactions] High throughput yes yes
BICD2_HUMAN [view interactions] High throughput no yes
RHBL4_HUMAN [view interactions] High throughput no no
OTULL_HUMAN [view interactions] High throughput no no
SYVN1_HUMAN [view interactions] High throughput no yes
ST7_HUMAN [view interactions] High throughput no yes
FIS1_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH2_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
PTN1_HUMAN [view entry] [view interactions] High throughput yes yes
S2546_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC1_HUMAN [view interactions] High throughput no yes
DJC25_HUMAN [view interactions] High throughput no yes
DNJC5_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
ACBD5_HUMAN [view entry] [view interactions] High throughput yes yes
AKAP1_HUMAN [view entry] [view interactions] High throughput yes yes
ANFY1_HUMAN [view entry] [view interactions] High throughput yes yes
ARF6_HUMAN [view entry] [view interactions] High throughput yes yes
AT2A1_HUMAN [view entry] [view interactions] High throughput yes no
B3GA1_HUMAN [view interactions] High throughput no yes
BAP31_HUMAN [view interactions] High throughput no yes
CAV1_HUMAN [view interactions] High throughput no no
CXAR_HUMAN [view interactions] High throughput no yes
DERL1_HUMAN [view interactions] High throughput no yes
DIRA3_HUMAN [view interactions] High throughput no yes
RCAS1_HUMAN [view interactions] High throughput no yes
ELOV5_HUMAN [view interactions] High throughput no yes
EMD_HUMAN [view interactions] High throughput no yes
ERGI1_HUMAN [view interactions] High throughput no yes
CXA1_HUMAN [view entry] [view interactions] High throughput yes yes
CXD3_HUMAN [view interactions] High throughput no no
DHB11_HUMAN [view interactions] High throughput no yes
3BHS7_HUMAN [view interactions] High throughput no no
LAMP2_HUMAN [view interactions] High throughput no yes
LAMP3_HUMAN [view interactions] High throughput no no
LTOR1_HUMAN [view entry] [view interactions] High throughput yes yes
LMAN1_HUMAN [view entry] [view interactions] High throughput yes yes
LNP_HUMAN [view interactions] High throughput no yes
LRC59_HUMAN [view entry] [view interactions] High throughput yes yes
MARCS_HUMAN [view entry] [view interactions] High throughput yes yes
TMT1A_HUMAN [view interactions] High throughput no no
OCLN_HUMAN [view interactions] High throughput no no
PANX1_HUMAN [view interactions] High throughput no no
PXMP2_HUMAN [view interactions] High throughput no no
RB11A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB2A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB35_HUMAN [view entry] [view interactions] High throughput yes yes
RAB3B_HUMAN [view interactions] High throughput no no
RAB4A_HUMAN [view entry] [view interactions] High throughput yes no
RAB5A_HUMAN [view entry] [view interactions] High throughput yes yes
RAB5C_HUMAN [view entry] [view interactions] High throughput yes yes
RAB9A_HUMAN [view interactions] High throughput no yes
REEP5_HUMAN [view entry] [view interactions] High throughput yes yes
RPN1_HUMAN [view entry] [view interactions] High throughput yes yes
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
SC61B_HUMAN [view interactions] High throughput no yes
SEC62_HUMAN [view interactions] High throughput no yes
SSRA_HUMAN [view entry] [view interactions] High throughput yes yes
STIM1_HUMAN [view interactions] High throughput no yes
STX4_HUMAN [view entry] [view interactions] High throughput yes no
STX6_HUMAN [view interactions] High throughput no yes
STX7_HUMAN [view entry] [view interactions] High throughput yes yes
LAP2A_HUMAN [view interactions] High throughput no yes
ZFPL1_HUMAN [view interactions] High throughput no yes
TFR1_HUMAN [view entry] [view interactions] High throughput yes yes
IFM1_HUMAN [view interactions] High throughput no no
DPP4_HUMAN [view interactions] High throughput no no
BASI_HUMAN [view entry] [view interactions] High throughput yes no
IFM3_HUMAN [view interactions] High throughput no yes
TM11B_HUMAN [view interactions] High throughput no no
ACE2_HUMAN [view interactions] High throughput no no
TMPS4_HUMAN [view interactions] High throughput no yes
CLC4E_HUMAN [view interactions] High throughput no no