DC1L2_HUMAN
Evidence for PS localization
Functions
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DC1L2_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 29.4118 | 4 | no |
| GO:0046872 | metal ion binding | 23.5294 | 4 | no |
| GO:0019900 | kinase binding | 22.0588 | 4 | no |
| GO:0019901 | protein kinase binding | 22.0588 | 5 | no |
| GO:0017076 | purine nucleotide binding | 20.5882 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.5882 | 4 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.5882 | 4 | yes |
| GO:0045296 | cadherin binding | 20.5882 | 4 | no |
| GO:0005524 | ATP binding | 17.6471 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 17.6471 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 17.6471 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DC1L2_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 54.4118 | 4 | no |
| GO:0006996 | organelle organization | 50.0000 | 4 | yes |
| GO:0022607 | cellular component assembly | 45.5882 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 44.1176 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.6471 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.6471 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.6471 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 41.1765 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 41.1765 | 4 | no |
| GO:0010646 | regulation of cell communication | 35.2941 | 4 | no |
| GO:0009966 | regulation of signal transduction | 33.8235 | 4 | no |
| GO:0033043 | regulation of organelle organization | 33.8235 | 5 | no |
| GO:0007010 | cytoskeleton organization | 32.3529 | 5 | yes |
| GO:0051246 | regulation of protein metabolic process | 32.3529 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 32.3529 | 4 | no |
| GO:0008104 | protein localization | 30.8824 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 29.4118 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 27.9412 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 27.9412 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 27.9412 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 27.9412 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.4706 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.4706 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.4706 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 26.4706 | 5 | no |
| GO:0051049 | regulation of transport | 26.4706 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.4706 | 5 | no |
| GO:0043933 | protein-containing complex organization | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0031399 | regulation of protein modification process | 23.5294 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 23.5294 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.5294 | 6 | no |
| GO:0009889 | regulation of biosynthetic process | 23.5294 | 4 | no |
| GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 23.5294 | 5 | no |
| GO:0010468 | regulation of gene expression | 23.5294 | 5 | no |
| GO:0065003 | protein-containing complex assembly | 22.0588 | 5 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 22.0588 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 22.0588 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 20.5882 | 4 | no |
| GO:0051050 | positive regulation of transport | 20.5882 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 20.5882 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 20.5882 | 4 | no |
| GO:0071310 | cellular response to organic substance | 14.7059 | 4 | yes |
| GO:0070848 | response to growth factor | 10.2941 | 4 | yes |
| GO:0071363 | cellular response to growth factor stimulus | 10.2941 | 5 | yes |
| GO:1990090 | cellular response to nerve growth factor stimulus | 5.8824 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DC1L2_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 4.4118 | 3 | no |
| DOID:2843 | long QT syndrome | 2.9412 | 6 | no |
| DOID:1289 | neurodegenerative disease | 2.9412 | 4 | no |
| DOID:331 | central nervous system disease | 2.9412 | 3 | no |
| DOID:0050700 | cardiomyopathy | 2.9412 | 4 | no |
| DOID:0060036 | intrinsic cardiomyopathy | 2.9412 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DYHC1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DC1I2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TRI58_HUMAN | [view interactions] | Low throughput | no | no |
| BRCA2_HUMAN | [view interactions] | Low throughput | no | no |
| ARFG1_HUMAN | [view interactions] | High throughput | no | no |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EPB41_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MK11_HUMAN | [view interactions] | High throughput | no | yes |
| NBEA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| DC1L1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DLRB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LIS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NEK4_HUMAN | [view interactions] | High throughput | no | yes |
| TAGL_HUMAN | [view interactions] | High throughput | no | no |
| SNW1_HUMAN | [view interactions] | High throughput | no | yes |
| CDC5L_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| DEMA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| DRC5_HUMAN | [view interactions] | High throughput | no | no |
| NIN_HUMAN | [view interactions] | High throughput | no | no |
| NINL_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK2_HUMAN | [view interactions] | High throughput | no | yes |
| LYAG_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CALM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| C2CD2_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| DC1I1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP4_HUMAN | [view interactions] | High throughput | no | no |
| TEDC2_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| TRPV1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DCTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR5_HUMAN | [view interactions] | High throughput | no | no |
| CP2J2_HUMAN | [view interactions] | High throughput | no | no |
| RASEF_HUMAN | [view interactions] | High throughput | no | yes |
| DYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CSTL1_HUMAN | [view interactions] | High throughput | no | no |
| GLMN_HUMAN | [view interactions] | High throughput | no | no |
| NRP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FKBP4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACTZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DCTN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB4B_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT3_HUMAN | [view interactions] | High throughput | no | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRUN2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3K_HUMAN | [view interactions] | High throughput | no | yes |
| RACK1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RSSA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMT1_HUMAN | [view interactions] | High throughput | no | yes |
| RS23_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS26_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RS5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YBOX1_HUMAN | [view interactions] | High throughput | no | yes |
| CLU_HUMAN | [view interactions] | High throughput | no | yes |
| STRN3_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUBP1_HUMAN | [view interactions] | High throughput | no | yes |
| ANKL2_HUMAN | [view interactions] | High throughput | no | yes |
| RHG01_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHAR4_HUMAN | [view interactions] | High throughput | no | yes |
| CASP8_HUMAN | [view interactions] | High throughput | no | yes |
| CEP41_HUMAN | [view interactions] | High throughput | no | yes |
| DC1L2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AKAP2_HUMAN | [view interactions] | High throughput | no | no |
| MAVS_HUMAN | [view interactions] | High throughput | no | yes |
| ANXA2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CALD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYNJ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| HOOK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RPAC1_HUMAN | [view interactions] | High throughput | no | no |
| TUT7_HUMAN | [view interactions] | High throughput | no | yes |
| PJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BICD2_HUMAN | [view interactions] | High throughput | no | yes |
| WDR11_HUMAN | [view interactions] | High throughput | no | yes |
| DBNL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRBS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BT3L4_HUMAN | [view interactions] | High throughput | no | yes |
| CCD43_HUMAN | [view interactions] | High throughput | no | yes |
| ICAL_HUMAN | [view interactions] | High throughput | no | yes |
| EFHD2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CL16A_HUMAN | [view interactions] | High throughput | no | yes |
| ITSN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JUPI2_HUMAN | [view interactions] | High throughput | no | no |
| RS7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SH3G1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RP25L_HUMAN | [view interactions] | High throughput | no | yes |
| CLCC1_HUMAN | [view interactions] | High throughput | no | yes |
| ATG2A_HUMAN | [view interactions] | High throughput | no | yes |
| TRUA_HUMAN | [view interactions] | High throughput | no | yes |
| TANC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ELOB_HUMAN | [view interactions] | High throughput | no | no |
| SCAM1_HUMAN | [view interactions] | High throughput | no | no |
| SEPT6_HUMAN | [view interactions] | High throughput | no | yes |
| CUL4B_HUMAN | [view interactions] | High throughput | no | yes |
| EP15R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPD54_HUMAN | [view interactions] | High throughput | no | yes |
| GCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RBGPR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MCR_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ANDR_HUMAN | [view interactions] | Computational | no | no |
| DCTN6_HUMAN | [view interactions] | Computational | no | no |
| HS90A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RILP_HUMAN | [view interactions] | Computational | no | no |
| CAZA1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB18_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DC2L1_HUMAN | [view interactions] | Computational | no | no |
| HS90B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCTN5_HUMAN | [view interactions] | Computational | no | yes |
| RAB7B_HUMAN | [view interactions] | Computational | no | no |
| DLRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PRGR_HUMAN | [view interactions] | Computational | no | no |
| ARP10_HUMAN | [view interactions] | Computational | no | no |
| RAB7A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RB3GP_HUMAN | [view entry] [view interactions] | Computational | yes | yes |