RIR1_HUMAN
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [View more on UniProt]
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in RIR1_HUMAN |
---|---|---|---|---|
GO:0017076 | purine nucleotide binding | 60.7143 | 4 | yes |
GO:0032555 | purine ribonucleotide binding | 60.7143 | 4 | yes |
GO:0035639 | purine ribonucleoside triphosphate binding | 60.7143 | 4 | yes |
GO:0005524 | ATP binding | 50.0000 | 5 | yes |
GO:0030554 | adenyl nucleotide binding | 50.0000 | 5 | yes |
GO:0032559 | adenyl ribonucleotide binding | 50.0000 | 5 | yes |
GO:0046872 | metal ion binding | 39.2857 | 4 | no |
GO:0003723 | RNA binding | 35.7143 | 4 | no |
GO:0016301 | kinase activity | 35.7143 | 4 | no |
GO:0019900 | kinase binding | 21.4286 | 4 | no |
GO:0019901 | protein kinase binding | 21.4286 | 5 | no |
GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 21.4286 | 4 | no |
GO:0019205 | nucleobase-containing compound kinase activity | 21.4286 | 5 | no |
GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | 7.1429 | 6 | yes |
GO:0016728 | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor | 7.1429 | 4 | yes |
GO:0061731 | ribonucleoside-diphosphate reductase activity | 7.1429 | 5 | yes |
GO:0097718 | disordered domain specific binding | 7.1429 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in RIR1_HUMAN |
---|---|---|---|---|
GO:0006796 | phosphate-containing compound metabolic process | 64.2857 | 4 | yes |
GO:0044271 | cellular nitrogen compound biosynthetic process | 53.5714 | 4 | yes |
GO:0048522 | positive regulation of cellular process | 46.4286 | 4 | yes |
GO:1901362 | organic cyclic compound biosynthetic process | 46.4286 | 4 | yes |
GO:0018130 | heterocycle biosynthetic process | 42.8571 | 4 | yes |
GO:0019438 | aromatic compound biosynthetic process | 42.8571 | 4 | yes |
GO:0006753 | nucleoside phosphate metabolic process | 39.2857 | 4 | yes |
GO:0009117 | nucleotide metabolic process | 39.2857 | 5 | yes |
GO:0034654 | nucleobase-containing compound biosynthetic process | 39.2857 | 4 | yes |
GO:1901566 | organonitrogen compound biosynthetic process | 39.2857 | 4 | no |
GO:0090407 | organophosphate biosynthetic process | 35.7143 | 4 | yes |
GO:0060255 | regulation of macromolecule metabolic process | 35.7143 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 32.1429 | 4 | no |
GO:0051171 | regulation of nitrogen compound metabolic process | 32.1429 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 32.1429 | 4 | no |
GO:0048523 | negative regulation of cellular process | 32.1429 | 4 | no |
GO:0009165 | nucleotide biosynthetic process | 32.1429 | 6 | yes |
GO:1901137 | carbohydrate derivative biosynthetic process | 32.1429 | 4 | yes |
GO:1901293 | nucleoside phosphate biosynthetic process | 32.1429 | 5 | yes |
GO:0009893 | positive regulation of metabolic process | 28.5714 | 4 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.5714 | 5 | no |
GO:0031325 | positive regulation of cellular metabolic process | 28.5714 | 5 | no |
GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.5714 | 5 | no |
GO:0010468 | regulation of gene expression | 28.5714 | 5 | no |
GO:0036211 | protein modification process | 28.5714 | 4 | no |
GO:0043412 | macromolecule modification | 28.5714 | 4 | no |
GO:0006163 | purine nucleotide metabolic process | 28.5714 | 5 | no |
GO:0009259 | ribonucleotide metabolic process | 28.5714 | 5 | no |
GO:0019693 | ribose phosphate metabolic process | 28.5714 | 4 | no |
GO:0072521 | purine-containing compound metabolic process | 28.5714 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
GO:0009966 | regulation of signal transduction | 25.0000 | 4 | no |
GO:0010646 | regulation of cell communication | 25.0000 | 4 | no |
GO:0051128 | regulation of cellular component organization | 25.0000 | 4 | no |
GO:1902531 | regulation of intracellular signal transduction | 25.0000 | 5 | no |
GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
GO:0009132 | nucleoside diphosphate metabolic process | 25.0000 | 5 | yes |
GO:0045595 | regulation of cell differentiation | 25.0000 | 4 | no |
GO:0051094 | positive regulation of developmental process | 25.0000 | 4 | no |
GO:0009141 | nucleoside triphosphate metabolic process | 25.0000 | 5 | no |
GO:0009150 | purine ribonucleotide metabolic process | 25.0000 | 6 | no |
GO:0016310 | phosphorylation | 25.0000 | 5 | no |
GO:0009059 | macromolecule biosynthetic process | 21.4286 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 21.4286 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 21.4286 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 21.4286 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 21.4286 | 6 | no |
GO:0080134 | regulation of response to stress | 21.4286 | 4 | no |
GO:0080135 | regulation of cellular response to stress | 21.4286 | 4 | no |
GO:0006996 | organelle organization | 21.4286 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 21.4286 | 6 | no |
GO:0042981 | regulation of apoptotic process | 21.4286 | 6 | no |
GO:0043067 | regulation of programmed cell death | 21.4286 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 21.4286 | 5 | no |
GO:0009185 | ribonucleoside diphosphate metabolic process | 21.4286 | 6 | yes |
GO:0010564 | regulation of cell cycle process | 21.4286 | 5 | yes |
GO:0045787 | positive regulation of cell cycle | 21.4286 | 5 | yes |
GO:0051726 | regulation of cell cycle | 21.4286 | 4 | yes |
GO:0090068 | positive regulation of cell cycle process | 21.4286 | 6 | yes |
GO:0045597 | positive regulation of cell differentiation | 21.4286 | 5 | no |
GO:0006164 | purine nucleotide biosynthetic process | 21.4286 | 6 | no |
GO:0009142 | nucleoside triphosphate biosynthetic process | 21.4286 | 6 | no |
GO:0009144 | purine nucleoside triphosphate metabolic process | 21.4286 | 6 | no |
GO:0009199 | ribonucleoside triphosphate metabolic process | 21.4286 | 6 | no |
GO:0009205 | purine ribonucleoside triphosphate metabolic process | 21.4286 | 7 | no |
GO:0009260 | ribonucleotide biosynthetic process | 21.4286 | 6 | no |
GO:0046390 | ribose phosphate biosynthetic process | 21.4286 | 5 | no |
GO:0072522 | purine-containing compound biosynthetic process | 21.4286 | 5 | no |
GO:0007346 | regulation of mitotic cell cycle | 17.8571 | 5 | yes |
GO:0022607 | cellular component assembly | 17.8571 | 4 | yes |
GO:0090304 | nucleic acid metabolic process | 17.8571 | 4 | yes |
GO:0006259 | DNA metabolic process | 14.2857 | 4 | yes |
GO:0006281 | DNA repair | 14.2857 | 5 | yes |
GO:0006974 | cellular response to DNA damage stimulus | 14.2857 | 4 | yes |
GO:0009262 | deoxyribonucleotide metabolic process | 14.2857 | 4 | yes |
GO:0009263 | deoxyribonucleotide biosynthetic process | 14.2857 | 5 | yes |
GO:0009265 | 2-deoxyribonucleotide biosynthetic process | 14.2857 | 6 | yes |
GO:0009394 | 2-deoxyribonucleotide metabolic process | 14.2857 | 5 | yes |
GO:0019692 | deoxyribose phosphate metabolic process | 14.2857 | 4 | yes |
GO:0043933 | protein-containing complex organization | 14.2857 | 4 | yes |
GO:0045931 | positive regulation of mitotic cell cycle | 14.2857 | 6 | yes |
GO:0046385 | deoxyribose phosphate biosynthetic process | 14.2857 | 5 | yes |
GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle | 14.2857 | 8 | yes |
GO:1901987 | regulation of cell cycle phase transition | 14.2857 | 6 | yes |
GO:1901989 | positive regulation of cell cycle phase transition | 14.2857 | 7 | yes |
GO:1901990 | regulation of mitotic cell cycle phase transition | 14.2857 | 6 | yes |
GO:1901992 | positive regulation of mitotic cell cycle phase transition | 14.2857 | 7 | yes |
GO:1902806 | regulation of cell cycle G1/S phase transition | 14.2857 | 7 | yes |
GO:1902808 | positive regulation of cell cycle G1/S phase transition | 14.2857 | 8 | yes |
GO:2000045 | regulation of G1/S transition of mitotic cell cycle | 14.2857 | 7 | yes |
GO:0006260 | DNA replication | 10.7143 | 5 | yes |
GO:0006261 | DNA-templated DNA replication | 10.7143 | 6 | yes |
GO:0032042 | mitochondrial DNA metabolic process | 10.7143 | 5 | yes |
GO:0065003 | protein-containing complex assembly | 10.7143 | 5 | yes |
GO:0006264 | mitochondrial DNA replication | 7.1429 | 6 | yes |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 7.1429 | 7 | yes |
GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle | 7.1429 | 8 | yes |
GO:0051259 | protein complex oligomerization | 7.1429 | 6 | yes |
GO:0051262 | protein tetramerization | 7.1429 | 7 | yes |
GO:0051290 | protein heterotetramerization | 7.1429 | 8 | yes |
GO:0051291 | protein heterooligomerization | 7.1429 | 7 | yes |
GO:0070316 | regulation of G0 to G1 transition | 7.1429 | 6 | yes |
GO:0070318 | positive regulation of G0 to G1 transition | 7.1429 | 7 | yes |
GO:1902749 | regulation of cell cycle G2/M phase transition | 7.1429 | 7 | yes |
GO:1902751 | positive regulation of cell cycle G2/M phase transition | 7.1429 | 8 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
RIR2_HUMAN | [view interactions] | Low throughput | no | no |
RIR1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
KAT5_HUMAN | [view interactions] | Low throughput | no | yes |
RIR2B_HUMAN | [view interactions] | Low throughput | no | yes |
RING2_HUMAN | [view interactions] | Low throughput | no | yes |
BMI1_HUMAN | [view interactions] | Low throughput | no | yes |
MDM2_HUMAN | [view interactions] | Low throughput | no | yes |
OTUB1_HUMAN | [view interactions] | High throughput | no | yes |
BOREA_HUMAN | [view interactions] | High throughput | no | yes |
TRI33_HUMAN | [view interactions] | High throughput | no | yes |
RNH2B_HUMAN | [view interactions] | High throughput | no | yes |
CARF_HUMAN | [view interactions] | High throughput | no | yes |
T184A_HUMAN | [view interactions] | High throughput | no | no |
ARL5B_HUMAN | [view interactions] | High throughput | no | yes |
GLRX3_HUMAN | [view interactions] | High throughput | no | yes |
LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
GCH1_HUMAN | [view interactions] | High throughput | no | no |
NCF1_HUMAN | [view interactions] | High throughput | no | no |
CRCM_HUMAN | [view interactions] | High throughput | no | no |
IF6_HUMAN | [view interactions] | High throughput | no | yes |
TNIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ATG5_HUMAN | [view interactions] | High throughput | no | no |
TRM7_HUMAN | [view interactions] | High throughput | no | yes |
AAKB1_HUMAN | [view interactions] | High throughput | no | yes |
HLAB_HUMAN | [view interactions] | High throughput | no | yes |
IKKE_HUMAN | [view interactions] | High throughput | no | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
ATM_HUMAN | [view interactions] | High throughput | no | yes |
G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
ZN655_HUMAN | [view interactions] | High throughput | no | yes |
RIF1_HUMAN | [view interactions] | High throughput | no | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
CSN5_HUMAN | [view interactions] | High throughput | no | yes |
OFD1_HUMAN | [view interactions] | High throughput | no | yes |
CE152_HUMAN | [view interactions] | High throughput | no | yes |
EPHA6_HUMAN | [view interactions] | High throughput | no | no |
LRIF1_HUMAN | [view interactions] | High throughput | no | yes |
PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CDK2_HUMAN | [view interactions] | High throughput | no | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
PLCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EED_HUMAN | [view interactions] | High throughput | no | yes |
NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
UBR5_HUMAN | [view interactions] | High throughput | no | no |
ABCG1_HUMAN | [view interactions] | High throughput | no | yes |
RN126_HUMAN | [view interactions] | High throughput | no | yes |
SENP3_HUMAN | [view interactions] | High throughput | no | yes |
TRI69_HUMAN | [view interactions] | High throughput | no | no |
EGLN3_HUMAN | [view interactions] | High throughput | no | no |
U5S1_HUMAN | [view interactions] | High throughput | no | yes |
AAR2_HUMAN | [view interactions] | High throughput | no | no |
PIHD1_HUMAN | [view interactions] | High throughput | no | yes |
UB2R1_HUMAN | [view interactions] | High throughput | no | yes |
HEXI1_HUMAN | [view interactions] | High throughput | no | yes |
UBE3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DYR1A_HUMAN | [view interactions] | High throughput | no | yes |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
EMC2_HUMAN | [view interactions] | High throughput | no | yes |
EMC4_HUMAN | [view interactions] | High throughput | no | yes |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
FZR1_HUMAN | [view interactions] | High throughput | no | no |
ANR39_HUMAN | [view interactions] | High throughput | no | no |
PFD2_HUMAN | [view interactions] | High throughput | no | yes |
GPR37_HUMAN | [view interactions] | High throughput | no | no |
EP300_HUMAN | [view interactions] | High throughput | no | yes |
PARP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
REV3L_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CI114_HUMAN | [view interactions] | High throughput | no | yes |
FPPS_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GFI1B_HUMAN | [view interactions] | High throughput | no | no |
T2EA_HUMAN | [view interactions] | High throughput | no | yes |
HUS1_HUMAN | [view interactions] | High throughput | no | yes |
LEO1_HUMAN | [view interactions] | High throughput | no | yes |
MTBP_HUMAN | [view interactions] | High throughput | no | no |
RL10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RL35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
EGFR_HUMAN | [view interactions] | High throughput | no | no |
RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RIT1_HUMAN | [view interactions] | High throughput | no | yes |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUMO2_HUMAN | [view interactions] | High throughput | no | yes |
SPHM_HUMAN | [view interactions] | High throughput | no | yes |
NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
SUCB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DJB11_HUMAN | [view interactions] | High throughput | no | yes |
EF2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNS2A_HUMAN | [view interactions] | High throughput | no | yes |
TM177_HUMAN | [view interactions] | High throughput | no | no |
PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TNPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DNJC7_HUMAN | [view interactions] | High throughput | no | yes |
NBR1_HUMAN | [view interactions] | High throughput | no | yes |
CACO2_HUMAN | [view interactions] | High throughput | no | yes |
SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
GLRX1_HUMAN | [view interactions] | Computational | no | yes |
ENTP3_HUMAN | [view interactions] | Computational | no | no |
MCM9_HUMAN | [view interactions] | Computational | no | yes |
SMC4_HUMAN | [view interactions] | Computational | no | yes |
WDHD1_HUMAN | [view interactions] | Computational | no | no |
PRC1_HUMAN | [view interactions] | Computational | no | yes |
MCM7_HUMAN | [view interactions] | Computational | no | no |
RFA1_HUMAN | [view interactions] | Computational | no | yes |
CDK1_HUMAN | [view interactions] | Computational | no | no |
PRI1_HUMAN | [view interactions] | Computational | no | no |
BUB3_HUMAN | [view interactions] | Computational | no | yes |
MSH2_HUMAN | [view interactions] | Computational | no | yes |
MCM2_HUMAN | [view interactions] | Computational | no | no |
CDC45_HUMAN | [view interactions] | Computational | no | no |
MCM6_HUMAN | [view interactions] | Computational | no | yes |
CND1_HUMAN | [view interactions] | Computational | no | yes |
NTPCR_HUMAN | [view interactions] | Computational | no | yes |
SMC2_HUMAN | [view interactions] | Computational | no | yes |
KAD4_HUMAN | [view interactions] | Computational | no | yes |
ENTP2_HUMAN | [view interactions] | Computational | no | yes |
BUB1_HUMAN | [view interactions] | Computational | no | no |
RFA3_HUMAN | [view interactions] | Computational | no | yes |
TOP2A_HUMAN | [view interactions] | Computational | no | no |
MD2L1_HUMAN | [view interactions] | Computational | no | no |
RFC3_HUMAN | [view interactions] | Computational | no | yes |
KGUA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CAF1B_HUMAN | [view interactions] | Computational | no | no |
DUT_HUMAN | [view interactions] | Computational | no | yes |
SLBP_HUMAN | [view interactions] | Computational | no | yes |
KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
CDC6_HUMAN | [view interactions] | Computational | no | yes |
INCE_HUMAN | [view interactions] | Computational | no | no |
CCNA2_HUMAN | [view interactions] | Computational | no | no |
RFC4_HUMAN | [view interactions] | Computational | no | yes |
CDCA7_HUMAN | [view interactions] | Computational | no | no |
CCNB2_HUMAN | [view interactions] | Computational | no | yes |
PRI2_HUMAN | [view interactions] | Computational | no | no |
NDK5_HUMAN | [view interactions] | Computational | no | yes |
SSRP1_HUMAN | [view interactions] | Computational | no | yes |
TYSY_HUMAN | [view interactions] | Computational | no | yes |
DPOLA_HUMAN | [view interactions] | Computational | no | yes |
KPYM_HUMAN | [view interactions] | Computational | no | yes |
NDKA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
DCK_HUMAN | [view interactions] | Computational | no | no |
THIO_HUMAN | [view interactions] | Computational | no | yes |
NDC80_HUMAN | [view interactions] | Computational | no | no |
RU1C_HUMAN | [view interactions] | Computational | no | yes |
KIF23_HUMAN | [view interactions] | Computational | no | yes |
MCMBP_HUMAN | [view interactions] | Computational | no | yes |
CMPK2_HUMAN | [view interactions] | Computational | no | yes |
DPOE2_HUMAN | [view interactions] | Computational | no | no |
PCNA_HUMAN | [view interactions] | Computational | no | no |
DNLI1_HUMAN | [view interactions] | Computational | no | yes |
RFC5_HUMAN | [view interactions] | Computational | no | yes |
CDT1_HUMAN | [view interactions] | Computational | no | yes |
DPOA2_HUMAN | [view interactions] | Computational | no | yes |
KTHY_HUMAN | [view interactions] | Computational | no | yes |
CND3_HUMAN | [view interactions] | Computational | no | yes |
DTL_HUMAN | [view interactions] | Computational | no | no |
ERCC1_HUMAN | [view interactions] | Computational | no | yes |
RGAP1_HUMAN | [view interactions] | Computational | no | no |
KAD8_HUMAN | [view interactions] | Computational | no | no |
ENTP1_HUMAN | [view interactions] | Computational | no | yes |
NDK7_HUMAN | [view interactions] | Computational | no | yes |
KCY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
PLK1_HUMAN | [view interactions] | Computational | no | yes |
KAD3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
CCNB1_HUMAN | [view interactions] | Computational | no | no |
DPOE1_HUMAN | [view interactions] | Computational | no | no |
NASP_HUMAN | [view interactions] | Computational | no | yes |
MESH1_HUMAN | [view interactions] | Computational | no | yes |
NDK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
KAD7_HUMAN | [view interactions] | Computational | no | no |
MCM4_HUMAN | [view interactions] | Computational | no | yes |
ESCO2_HUMAN | [view interactions] | Computational | no | no |
CHK2_HUMAN | [view interactions] | Computational | no | yes |
NDKM_HUMAN | [view interactions] | Computational | no | yes |
RFA2_HUMAN | [view interactions] | Computational | no | yes |
CDC20_HUMAN | [view interactions] | Computational | no | no |
KIF11_HUMAN | [view interactions] | Computational | no | yes |
DCTP1_HUMAN | [view interactions] | Computational | no | no |
KAD5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
MCM5_HUMAN | [view interactions] | Computational | no | no |
TADBP_HUMAN | [view interactions] | Computational | no | yes |
ENTP8_HUMAN | [view interactions] | Computational | no | no |
IF4G1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
FEN1_HUMAN | [view interactions] | Computational | no | yes |
MCM3_HUMAN | [view interactions] | Computational | no | no |