Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RIR1_HUMAN

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RIR1_HUMAN
GO:0000166 nucleotide binding 47.9167 4 yes
GO:0017076 purine nucleotide binding 45.8333 5 yes
GO:0043168 anion binding 45.8333 4 yes
GO:0003723 RNA binding 43.7500 4 no
GO:0032555 purine ribonucleotide binding 41.6667 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 41.6667 4 yes
GO:0030554 adenyl nucleotide binding 33.3333 6 yes
GO:0005524 ATP binding 29.1667 5 yes
GO:0032559 adenyl ribonucleotide binding 29.1667 5 yes
GO:0043169 cation binding 25.0000 4 no
GO:0046872 metal ion binding 25.0000 5 no
GO:0019900 kinase binding 20.8333 4 no
GO:0019901 protein kinase binding 20.8333 5 no
GO:0031625 ubiquitin protein ligase binding 20.8333 5 no
GO:0044389 ubiquitin-like protein ligase binding 20.8333 4 no
GO:0016462 pyrophosphatase activity 20.8333 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 20.8333 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 20.8333 6 no
GO:0097718 disordered domain specific binding 10.4167 4 yes
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor 4.1667 6 yes
GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 4.1667 4 yes
GO:0061731 ribonucleoside-diphosphate reductase activity 4.1667 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RIR1_HUMAN
GO:0048522 positive regulation of cellular process 54.1667 4 yes
GO:0060255 regulation of macromolecule metabolic process 50.0000 4 no
GO:0031323 regulation of cellular metabolic process 47.9167 4 no
GO:0080090 regulation of primary metabolic process 47.9167 4 no
GO:0022607 cellular component assembly 43.7500 4 yes
GO:0048523 negative regulation of cellular process 43.7500 4 no
GO:0009889 regulation of biosynthetic process 41.6667 4 no
GO:0010556 regulation of macromolecule biosynthetic process 41.6667 5 no
GO:0031326 regulation of cellular biosynthetic process 41.6667 5 no
GO:0009966 regulation of signal transduction 39.5833 4 no
GO:0010646 regulation of cell communication 39.5833 4 no
GO:0051128 regulation of cellular component organization 39.5833 4 no
GO:0051246 regulation of protein metabolic process 37.5000 5 no
GO:0010468 regulation of gene expression 37.5000 6 no
GO:0042981 regulation of apoptotic process 37.5000 5 no
GO:0043067 regulation of programmed cell death 37.5000 4 no
GO:0009893 positive regulation of metabolic process 35.4167 4 no
GO:0010604 positive regulation of macromolecule metabolic process 35.4167 5 no
GO:0006796 phosphate-containing compound metabolic process 33.3333 4 yes
GO:0008104 protein localization 33.3333 4 no
GO:0033043 regulation of organelle organization 33.3333 5 no
GO:0009967 positive regulation of signal transduction 31.2500 5 no
GO:0010647 positive regulation of cell communication 31.2500 5 no
GO:0023056 positive regulation of signaling 31.2500 4 no
GO:0031325 positive regulation of cellular metabolic process 31.2500 5 no
GO:0048584 positive regulation of response to stimulus 31.2500 4 no
GO:1902531 regulation of intracellular signal transduction 31.2500 5 no
GO:0009892 negative regulation of metabolic process 31.2500 4 no
GO:0010605 negative regulation of macromolecule metabolic process 31.2500 5 no
GO:0031324 negative regulation of cellular metabolic process 31.2500 5 no
GO:0060341 regulation of cellular localization 31.2500 4 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 31.2500 5 no
GO:0043933 protein-containing complex organization 29.1667 4 yes
GO:0006996 organelle organization 29.1667 4 no
GO:0051247 positive regulation of protein metabolic process 29.1667 6 no
GO:0009890 negative regulation of biosynthetic process 29.1667 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 29.1667 6 no
GO:0031327 negative regulation of cellular biosynthetic process 29.1667 6 no
GO:0032880 regulation of protein localization 29.1667 5 no
GO:0043066 negative regulation of apoptotic process 29.1667 6 no
GO:0043069 negative regulation of programmed cell death 29.1667 5 no
GO:0009059 macromolecule biosynthetic process 27.0833 4 yes
GO:0036211 protein modification process 27.0833 4 no
GO:0043412 macromolecule modification 27.0833 4 no
GO:0009891 positive regulation of biosynthetic process 27.0833 5 no
GO:0009894 regulation of catabolic process 27.0833 4 no
GO:0010557 positive regulation of macromolecule biosynthetic process 27.0833 6 no
GO:0031328 positive regulation of cellular biosynthetic process 27.0833 6 no
GO:0051094 positive regulation of developmental process 27.0833 4 no
GO:0051726 regulation of cell cycle 25.0000 4 yes
GO:0065003 protein-containing complex assembly 25.0000 5 yes
GO:0051130 positive regulation of cellular component organization 25.0000 5 no
GO:0071310 cellular response to organic substance 25.0000 4 no
GO:0006355 regulation of DNA-templated transcription 25.0000 7 no
GO:0051252 regulation of RNA metabolic process 25.0000 5 no
GO:2001141 regulation of RNA biosynthetic process 25.0000 6 no
GO:0051240 positive regulation of multicellular organismal process 25.0000 4 no
GO:0010564 regulation of cell cycle process 22.9167 5 yes
GO:0090304 nucleic acid metabolic process 22.9167 4 yes
GO:1901362 organic cyclic compound biosynthetic process 22.9167 4 yes
GO:0010638 positive regulation of organelle organization 22.9167 6 no
GO:0048585 negative regulation of response to stimulus 22.9167 4 no
GO:0051049 regulation of transport 22.9167 4 no
GO:2001233 regulation of apoptotic signaling pathway 22.9167 5 no
GO:0031399 regulation of protein modification process 20.8333 6 no
GO:1902533 positive regulation of intracellular signal transduction 20.8333 6 no
GO:0009968 negative regulation of signal transduction 20.8333 5 no
GO:0010628 positive regulation of gene expression 20.8333 7 no
GO:0010648 negative regulation of cell communication 20.8333 5 no
GO:0023057 negative regulation of signaling 20.8333 4 no
GO:0044087 regulation of cellular component biogenesis 20.8333 4 no
GO:0045595 regulation of cell differentiation 20.8333 4 no
GO:0051129 negative regulation of cellular component organization 20.8333 5 no
GO:0051493 regulation of cytoskeleton organization 20.8333 6 no
GO:0070201 regulation of establishment of protein localization 20.8333 6 no
GO:0080134 regulation of response to stress 20.8333 4 no
GO:1903829 positive regulation of protein localization 20.8333 5 no
GO:0042127 regulation of cell population proliferation 20.8333 4 no
GO:0006753 nucleoside phosphate metabolic process 18.7500 4 yes
GO:0009117 nucleotide metabolic process 18.7500 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 18.7500 4 yes
GO:0045787 positive regulation of cell cycle 14.5833 5 yes
GO:0090068 positive regulation of cell cycle process 14.5833 6 yes
GO:0007346 regulation of mitotic cell cycle 12.5000 5 yes
GO:0090407 organophosphate biosynthetic process 12.5000 4 yes
GO:0141187 nucleic acid biosynthetic process 12.5000 5 yes
GO:0006974 DNA damage response 10.4167 4 yes
GO:0009165 nucleotide biosynthetic process 10.4167 6 yes
GO:0010212 response to ionizing radiation 10.4167 4 yes
GO:0045931 positive regulation of mitotic cell cycle 10.4167 6 yes
GO:1901137 carbohydrate derivative biosynthetic process 10.4167 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 10.4167 5 yes
GO:1901987 regulation of cell cycle phase transition 10.4167 6 yes
GO:1901989 positive regulation of cell cycle phase transition 10.4167 7 yes
GO:1901990 regulation of mitotic cell cycle phase transition 10.4167 6 yes
GO:1901992 positive regulation of mitotic cell cycle phase transition 10.4167 7 yes
GO:0006259 DNA metabolic process 8.3333 5 yes
GO:0006281 DNA repair 8.3333 5 yes
GO:0009112 nucleobase metabolic process 8.3333 4 yes
GO:0051259 protein complex oligomerization 8.3333 6 yes
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 8.3333 8 yes
GO:1902806 regulation of cell cycle G1/S phase transition 8.3333 7 yes
GO:1902808 positive regulation of cell cycle G1/S phase transition 8.3333 8 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 8.3333 7 yes
GO:0000731 DNA synthesis involved in DNA repair 6.2500 6 yes
GO:0006206 pyrimidine nucleobase metabolic process 6.2500 5 yes
GO:0006260 DNA replication 6.2500 6 yes
GO:0006261 DNA-templated DNA replication 6.2500 7 yes
GO:0008406 gonad development 6.2500 4 yes
GO:0008584 male gonad development 6.2500 5 yes
GO:0009132 nucleoside diphosphate metabolic process 6.2500 5 yes
GO:0009185 ribonucleoside diphosphate metabolic process 6.2500 6 yes
GO:0032042 mitochondrial DNA metabolic process 6.2500 6 yes
GO:0051262 protein tetramerization 6.2500 7 yes
GO:0051290 protein heterotetramerization 6.2500 8 yes
GO:0051291 protein heterooligomerization 6.2500 7 yes
GO:0071897 DNA biosynthetic process 6.2500 5 yes
GO:0072527 pyrimidine-containing compound metabolic process 6.2500 4 yes
GO:0006264 mitochondrial DNA replication 4.1667 7 yes
GO:0009262 deoxyribonucleotide metabolic process 4.1667 4 yes
GO:0009263 deoxyribonucleotide biosynthetic process 4.1667 5 yes
GO:0009265 2-deoxyribonucleotide biosynthetic process 4.1667 6 yes
GO:0009394 2-deoxyribonucleotide metabolic process 4.1667 5 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 4.1667 7 yes
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 4.1667 8 yes
GO:0019692 deoxyribose phosphate metabolic process 4.1667 4 yes
GO:0021846 cell proliferation in forebrain 4.1667 4 yes
GO:0046385 deoxyribose phosphate biosynthetic process 4.1667 5 yes
GO:0070316 regulation of G0 to G1 transition 4.1667 6 yes
GO:0070318 positive regulation of G0 to G1 transition 4.1667 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 4.1667 7 yes
GO:1902751 positive regulation of cell cycle G2/M phase transition 4.1667 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RIR2_HUMAN [view interactions] Low throughput no no
RIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
KAT5_HUMAN [view interactions] Low throughput no yes
RIR2B_HUMAN [view interactions] Low throughput no yes
RING2_HUMAN [view interactions] Low throughput no yes
BMI1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view entry] [view interactions] Low throughput yes yes
OTUB1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
TRI33_HUMAN [view interactions] High throughput no yes
RNH2B_HUMAN [view interactions] High throughput no yes
CARF_HUMAN [view interactions] High throughput no yes
T184A_HUMAN [view interactions] High throughput no no
GLRX3_HUMAN [view interactions] High throughput no yes
ARL5B_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
RASH_HUMAN [view entry] [view interactions] High throughput yes no
HMGA2_HUMAN [view interactions] High throughput no yes
GCH1_HUMAN [view interactions] High throughput no no
NCF1_HUMAN [view interactions] High throughput no no
CRCM_HUMAN [view interactions] High throughput no no
IF6_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view entry] [view interactions] High throughput yes no
TRM7_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
ATM_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
ZN655_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
EPHA6_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
LRIF1_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
ABCG1_HUMAN [view interactions] High throughput no yes
RN126_HUMAN [view interactions] High throughput no yes
SENP3_HUMAN [view interactions] High throughput no yes
TRI69_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
PD1L1_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
ANR39_HUMAN [view interactions] High throughput no no
PFD2_HUMAN [view interactions] High throughput no yes
GPR37_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
HS71B_HUMAN [view entry] [view interactions] High throughput yes yes
HS71A_HUMAN [view entry] [view interactions] High throughput yes yes
TRI67_HUMAN [view interactions] High throughput no no
STIP1_HUMAN [view entry] [view interactions] High throughput yes yes
RHG24_HUMAN [view interactions] High throughput no yes
OTUL_HUMAN [view interactions] High throughput no yes
UBE2H_HUMAN [view interactions] High throughput no yes
REV3L_HUMAN [view entry] [view interactions] High throughput yes yes
CI114_HUMAN [view interactions] High throughput no yes
FPPS_HUMAN [view entry] [view interactions] High throughput yes yes
GFI1B_HUMAN [view interactions] High throughput no no
T2EA_HUMAN [view interactions] High throughput no yes
HUS1_HUMAN [view interactions] High throughput no yes
LEO1_HUMAN [view interactions] High throughput no yes
MTBP_HUMAN [view interactions] High throughput no no
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view entry] [view interactions] High throughput yes yes
SPHM_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
DJB11_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
DNS2A_HUMAN [view interactions] High throughput no yes
TM177_HUMAN [view interactions] High throughput no no
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
SHOT1_HUMAN [view interactions] High throughput no no
DNM1L_HUMAN [view entry] [view interactions] High throughput yes yes
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
EIF3H_HUMAN [view interactions] High throughput no yes
DHX15_HUMAN [view interactions] High throughput no yes
DIAP1_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
H12_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PUR6_HUMAN [view entry] [view interactions] High throughput yes yes
SAHH_HUMAN [view entry] [view interactions] High throughput yes yes
KCY_HUMAN [view entry] [view interactions] High throughput yes yes
PDIA3_HUMAN [view entry] [view interactions] High throughput yes yes
CTNA1_HUMAN [view entry] [view interactions] High throughput yes yes
HEM6_HUMAN [view interactions] High throughput no no
GRP75_HUMAN [view entry] [view interactions] High throughput yes yes
TCPQ_HUMAN [view entry] [view interactions] High throughput yes yes
XPO2_HUMAN [view entry] [view interactions] High throughput yes no
RAB14_HUMAN [view entry] [view interactions] High throughput yes yes
CLH1_HUMAN [view entry] [view interactions] High throughput yes yes
CAP1_HUMAN [view entry] [view interactions] High throughput yes yes
PAK2_HUMAN [view entry] [view interactions] High throughput yes no
CBX3_HUMAN [view interactions] High throughput no yes
SF3B2_HUMAN [view interactions] High throughput no yes
CUL4B_HUMAN [view interactions] High throughput no yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
GEMI5_HUMAN [view interactions] High throughput no yes
DNJC7_HUMAN [view interactions] High throughput no yes
SYFB_HUMAN [view entry] [view interactions] High throughput yes yes
LCMT1_HUMAN [view interactions] High throughput no yes
AGO2_HUMAN [view entry] [view interactions] High throughput yes yes
NBR1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
CCNF_HUMAN [view interactions] High throughput no no
MLP3B_HUMAN [view interactions] High throughput no yes
TGON2_HUMAN [view entry] [view interactions] High throughput yes yes
RFA1_HUMAN [view interactions] High throughput no yes
RFA2_HUMAN [view interactions] High throughput no yes
RFA3_HUMAN [view interactions] High throughput no yes