Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

RIR1_HUMAN

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in RIR1_HUMAN
GO:0017076 purine nucleotide binding 60.7143 4 yes
GO:0032555 purine ribonucleotide binding 60.7143 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 60.7143 4 yes
GO:0005524 ATP binding 50.0000 5 yes
GO:0030554 adenyl nucleotide binding 50.0000 5 yes
GO:0032559 adenyl ribonucleotide binding 50.0000 5 yes
GO:0046872 metal ion binding 39.2857 4 no
GO:0003723 RNA binding 35.7143 4 no
GO:0016301 kinase activity 35.7143 4 no
GO:0019900 kinase binding 21.4286 4 no
GO:0019901 protein kinase binding 21.4286 5 no
GO:0016776 phosphotransferase activity, phosphate group as acceptor 21.4286 4 no
GO:0019205 nucleobase-containing compound kinase activity 21.4286 5 no
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor 7.1429 6 yes
GO:0016728 oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor 7.1429 4 yes
GO:0061731 ribonucleoside-diphosphate reductase activity 7.1429 5 yes
GO:0097718 disordered domain specific binding 7.1429 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in RIR1_HUMAN
GO:0006796 phosphate-containing compound metabolic process 64.2857 4 yes
GO:0044271 cellular nitrogen compound biosynthetic process 53.5714 4 yes
GO:0048522 positive regulation of cellular process 46.4286 4 yes
GO:1901362 organic cyclic compound biosynthetic process 46.4286 4 yes
GO:0018130 heterocycle biosynthetic process 42.8571 4 yes
GO:0019438 aromatic compound biosynthetic process 42.8571 4 yes
GO:0006753 nucleoside phosphate metabolic process 39.2857 4 yes
GO:0009117 nucleotide metabolic process 39.2857 5 yes
GO:0034654 nucleobase-containing compound biosynthetic process 39.2857 4 yes
GO:1901566 organonitrogen compound biosynthetic process 39.2857 4 no
GO:0090407 organophosphate biosynthetic process 35.7143 4 yes
GO:0060255 regulation of macromolecule metabolic process 35.7143 4 no
GO:0031323 regulation of cellular metabolic process 32.1429 4 no
GO:0051171 regulation of nitrogen compound metabolic process 32.1429 4 no
GO:0080090 regulation of primary metabolic process 32.1429 4 no
GO:0048523 negative regulation of cellular process 32.1429 4 no
GO:0009165 nucleotide biosynthetic process 32.1429 6 yes
GO:1901137 carbohydrate derivative biosynthetic process 32.1429 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 32.1429 5 yes
GO:0009893 positive regulation of metabolic process 28.5714 4 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 28.5714 5 no
GO:0010468 regulation of gene expression 28.5714 5 no
GO:0036211 protein modification process 28.5714 4 no
GO:0043412 macromolecule modification 28.5714 4 no
GO:0006163 purine nucleotide metabolic process 28.5714 5 no
GO:0009259 ribonucleotide metabolic process 28.5714 5 no
GO:0019693 ribose phosphate metabolic process 28.5714 4 no
GO:0072521 purine-containing compound metabolic process 28.5714 4 no
GO:0051246 regulation of protein metabolic process 25.0000 5 no
GO:0009966 regulation of signal transduction 25.0000 4 no
GO:0010646 regulation of cell communication 25.0000 4 no
GO:0051128 regulation of cellular component organization 25.0000 4 no
GO:1902531 regulation of intracellular signal transduction 25.0000 5 no
GO:0010941 regulation of cell death 25.0000 4 no
GO:0009132 nucleoside diphosphate metabolic process 25.0000 5 yes
GO:0045595 regulation of cell differentiation 25.0000 4 no
GO:0051094 positive regulation of developmental process 25.0000 4 no
GO:0009141 nucleoside triphosphate metabolic process 25.0000 5 no
GO:0009150 purine ribonucleotide metabolic process 25.0000 6 no
GO:0016310 phosphorylation 25.0000 5 no
GO:0009059 macromolecule biosynthetic process 21.4286 4 no
GO:0009889 regulation of biosynthetic process 21.4286 4 no
GO:0010556 regulation of macromolecule biosynthetic process 21.4286 5 no
GO:0031326 regulation of cellular biosynthetic process 21.4286 5 no
GO:0051247 positive regulation of protein metabolic process 21.4286 6 no
GO:0080134 regulation of response to stress 21.4286 4 no
GO:0080135 regulation of cellular response to stress 21.4286 4 no
GO:0006996 organelle organization 21.4286 4 no
GO:0019220 regulation of phosphate metabolic process 21.4286 6 no
GO:0042981 regulation of apoptotic process 21.4286 6 no
GO:0043067 regulation of programmed cell death 21.4286 5 no
GO:0051174 regulation of phosphorus metabolic process 21.4286 5 no
GO:0009185 ribonucleoside diphosphate metabolic process 21.4286 6 yes
GO:0010564 regulation of cell cycle process 21.4286 5 yes
GO:0045787 positive regulation of cell cycle 21.4286 5 yes
GO:0051726 regulation of cell cycle 21.4286 4 yes
GO:0090068 positive regulation of cell cycle process 21.4286 6 yes
GO:0045597 positive regulation of cell differentiation 21.4286 5 no
GO:0006164 purine nucleotide biosynthetic process 21.4286 6 no
GO:0009142 nucleoside triphosphate biosynthetic process 21.4286 6 no
GO:0009144 purine nucleoside triphosphate metabolic process 21.4286 6 no
GO:0009199 ribonucleoside triphosphate metabolic process 21.4286 6 no
GO:0009205 purine ribonucleoside triphosphate metabolic process 21.4286 7 no
GO:0009260 ribonucleotide biosynthetic process 21.4286 6 no
GO:0046390 ribose phosphate biosynthetic process 21.4286 5 no
GO:0072522 purine-containing compound biosynthetic process 21.4286 5 no
GO:0007346 regulation of mitotic cell cycle 17.8571 5 yes
GO:0022607 cellular component assembly 17.8571 4 yes
GO:0090304 nucleic acid metabolic process 17.8571 4 yes
GO:0006259 DNA metabolic process 14.2857 4 yes
GO:0006281 DNA repair 14.2857 5 yes
GO:0006974 cellular response to DNA damage stimulus 14.2857 4 yes
GO:0009262 deoxyribonucleotide metabolic process 14.2857 4 yes
GO:0009263 deoxyribonucleotide biosynthetic process 14.2857 5 yes
GO:0009265 2-deoxyribonucleotide biosynthetic process 14.2857 6 yes
GO:0009394 2-deoxyribonucleotide metabolic process 14.2857 5 yes
GO:0019692 deoxyribose phosphate metabolic process 14.2857 4 yes
GO:0043933 protein-containing complex organization 14.2857 4 yes
GO:0045931 positive regulation of mitotic cell cycle 14.2857 6 yes
GO:0046385 deoxyribose phosphate biosynthetic process 14.2857 5 yes
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 14.2857 8 yes
GO:1901987 regulation of cell cycle phase transition 14.2857 6 yes
GO:1901989 positive regulation of cell cycle phase transition 14.2857 7 yes
GO:1901990 regulation of mitotic cell cycle phase transition 14.2857 6 yes
GO:1901992 positive regulation of mitotic cell cycle phase transition 14.2857 7 yes
GO:1902806 regulation of cell cycle G1/S phase transition 14.2857 7 yes
GO:1902808 positive regulation of cell cycle G1/S phase transition 14.2857 8 yes
GO:2000045 regulation of G1/S transition of mitotic cell cycle 14.2857 7 yes
GO:0006260 DNA replication 10.7143 5 yes
GO:0006261 DNA-templated DNA replication 10.7143 6 yes
GO:0032042 mitochondrial DNA metabolic process 10.7143 5 yes
GO:0065003 protein-containing complex assembly 10.7143 5 yes
GO:0006264 mitochondrial DNA replication 7.1429 6 yes
GO:0010389 regulation of G2/M transition of mitotic cell cycle 7.1429 7 yes
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 7.1429 8 yes
GO:0051259 protein complex oligomerization 7.1429 6 yes
GO:0051262 protein tetramerization 7.1429 7 yes
GO:0051290 protein heterotetramerization 7.1429 8 yes
GO:0051291 protein heterooligomerization 7.1429 7 yes
GO:0070316 regulation of G0 to G1 transition 7.1429 6 yes
GO:0070318 positive regulation of G0 to G1 transition 7.1429 7 yes
GO:1902749 regulation of cell cycle G2/M phase transition 7.1429 7 yes
GO:1902751 positive regulation of cell cycle G2/M phase transition 7.1429 8 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
RIR2_HUMAN [view interactions] Low throughput no no
RIR1_HUMAN [view entry] [view interactions] Low throughput yes yes
KAT5_HUMAN [view interactions] Low throughput no yes
RIR2B_HUMAN [view interactions] Low throughput no yes
RING2_HUMAN [view interactions] Low throughput no yes
BMI1_HUMAN [view interactions] Low throughput no yes
MDM2_HUMAN [view interactions] Low throughput no yes
OTUB1_HUMAN [view interactions] High throughput no yes
BOREA_HUMAN [view interactions] High throughput no yes
TRI33_HUMAN [view interactions] High throughput no yes
RNH2B_HUMAN [view interactions] High throughput no yes
CARF_HUMAN [view interactions] High throughput no yes
T184A_HUMAN [view interactions] High throughput no no
ARL5B_HUMAN [view interactions] High throughput no yes
GLRX3_HUMAN [view interactions] High throughput no yes
LRRK2_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
HMGA2_HUMAN [view interactions] High throughput no yes
GCH1_HUMAN [view interactions] High throughput no no
NCF1_HUMAN [view interactions] High throughput no no
CRCM_HUMAN [view interactions] High throughput no no
IF6_HUMAN [view interactions] High throughput no yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
ATG5_HUMAN [view interactions] High throughput no no
TRM7_HUMAN [view interactions] High throughput no yes
AAKB1_HUMAN [view interactions] High throughput no yes
HLAB_HUMAN [view interactions] High throughput no yes
IKKE_HUMAN [view interactions] High throughput no yes
HSC20_HUMAN [view interactions] High throughput no yes
ATM_HUMAN [view interactions] High throughput no yes
G3BP1_HUMAN [view interactions] High throughput no yes
ZN655_HUMAN [view interactions] High throughput no yes
RIF1_HUMAN [view interactions] High throughput no yes
MYC_HUMAN [view interactions] High throughput no yes
CSN5_HUMAN [view interactions] High throughput no yes
OFD1_HUMAN [view interactions] High throughput no yes
CE152_HUMAN [view interactions] High throughput no yes
EPHA6_HUMAN [view interactions] High throughput no no
LRIF1_HUMAN [view interactions] High throughput no yes
PP1G_HUMAN [view entry] [view interactions] High throughput yes yes
CDK2_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
PLCB1_HUMAN [view entry] [view interactions] High throughput yes yes
EED_HUMAN [view interactions] High throughput no yes
NTRK1_HUMAN [view interactions] High throughput no yes
UBR5_HUMAN [view interactions] High throughput no no
ABCG1_HUMAN [view interactions] High throughput no yes
RN126_HUMAN [view interactions] High throughput no yes
SENP3_HUMAN [view interactions] High throughput no yes
TRI69_HUMAN [view interactions] High throughput no no
EGLN3_HUMAN [view interactions] High throughput no no
U5S1_HUMAN [view interactions] High throughput no yes
AAR2_HUMAN [view interactions] High throughput no no
PIHD1_HUMAN [view interactions] High throughput no yes
UB2R1_HUMAN [view interactions] High throughput no yes
HEXI1_HUMAN [view interactions] High throughput no yes
UBE3C_HUMAN [view entry] [view interactions] High throughput yes yes
DYR1A_HUMAN [view interactions] High throughput no yes
GSK3B_HUMAN [view entry] [view interactions] High throughput yes yes
PKHA4_HUMAN [view interactions] High throughput no yes
EMC2_HUMAN [view interactions] High throughput no yes
EMC4_HUMAN [view interactions] High throughput no yes
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
PD1L1_HUMAN [view interactions] High throughput no no
FZR1_HUMAN [view interactions] High throughput no no
ANR39_HUMAN [view interactions] High throughput no no
PFD2_HUMAN [view interactions] High throughput no yes
GPR37_HUMAN [view interactions] High throughput no no
EP300_HUMAN [view interactions] High throughput no yes
PARP1_HUMAN [view entry] [view interactions] High throughput yes yes
REV3L_HUMAN [view entry] [view interactions] High throughput yes yes
CI114_HUMAN [view interactions] High throughput no yes
FPPS_HUMAN [view entry] [view interactions] High throughput yes yes
GFI1B_HUMAN [view interactions] High throughput no no
T2EA_HUMAN [view interactions] High throughput no yes
HUS1_HUMAN [view interactions] High throughput no yes
LEO1_HUMAN [view interactions] High throughput no yes
MTBP_HUMAN [view interactions] High throughput no no
RL10_HUMAN [view entry] [view interactions] High throughput yes yes
RL35_HUMAN [view entry] [view interactions] High throughput yes yes
EGFR_HUMAN [view interactions] High throughput no no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
RIT1_HUMAN [view interactions] High throughput no yes
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
SUMO2_HUMAN [view interactions] High throughput no yes
SPHM_HUMAN [view interactions] High throughput no yes
NDUV1_HUMAN [view entry] [view interactions] High throughput yes yes
SUCB1_HUMAN [view entry] [view interactions] High throughput yes yes
DJB11_HUMAN [view interactions] High throughput no yes
EF2_HUMAN [view entry] [view interactions] High throughput yes yes
DNS2A_HUMAN [view interactions] High throughput no yes
TM177_HUMAN [view interactions] High throughput no no
PPIB_HUMAN [view entry] [view interactions] High throughput yes yes
TNPO1_HUMAN [view entry] [view interactions] High throughput yes yes
DNJC7_HUMAN [view interactions] High throughput no yes
NBR1_HUMAN [view interactions] High throughput no yes
CACO2_HUMAN [view interactions] High throughput no yes
SQSTM_HUMAN [view interactions] High throughput no yes
GLRX1_HUMAN [view interactions] Computational no yes
ENTP3_HUMAN [view interactions] Computational no no
MCM9_HUMAN [view interactions] Computational no yes
SMC4_HUMAN [view interactions] Computational no yes
WDHD1_HUMAN [view interactions] Computational no no
PRC1_HUMAN [view interactions] Computational no yes
MCM7_HUMAN [view interactions] Computational no no
RFA1_HUMAN [view interactions] Computational no yes
CDK1_HUMAN [view interactions] Computational no no
PRI1_HUMAN [view interactions] Computational no no
BUB3_HUMAN [view interactions] Computational no yes
MSH2_HUMAN [view interactions] Computational no yes
MCM2_HUMAN [view interactions] Computational no no
CDC45_HUMAN [view interactions] Computational no no
MCM6_HUMAN [view interactions] Computational no yes
CND1_HUMAN [view interactions] Computational no yes
NTPCR_HUMAN [view interactions] Computational no yes
SMC2_HUMAN [view interactions] Computational no yes
KAD4_HUMAN [view interactions] Computational no yes
ENTP2_HUMAN [view interactions] Computational no yes
BUB1_HUMAN [view interactions] Computational no no
RFA3_HUMAN [view interactions] Computational no yes
TOP2A_HUMAN [view interactions] Computational no no
MD2L1_HUMAN [view interactions] Computational no no
RFC3_HUMAN [view interactions] Computational no yes
KGUA_HUMAN [view entry] [view interactions] Computational yes yes
CAF1B_HUMAN [view interactions] Computational no no
DUT_HUMAN [view interactions] Computational no yes
SLBP_HUMAN [view interactions] Computational no yes
KPYR_HUMAN [view entry] [view interactions] Computational yes no
CDC6_HUMAN [view interactions] Computational no yes
INCE_HUMAN [view interactions] Computational no no
CCNA2_HUMAN [view interactions] Computational no no
RFC4_HUMAN [view interactions] Computational no yes
CDCA7_HUMAN [view interactions] Computational no no
CCNB2_HUMAN [view interactions] Computational no yes
PRI2_HUMAN [view interactions] Computational no no
NDK5_HUMAN [view interactions] Computational no yes
SSRP1_HUMAN [view interactions] Computational no yes
TYSY_HUMAN [view interactions] Computational no yes
DPOLA_HUMAN [view interactions] Computational no yes
KPYM_HUMAN [view interactions] Computational no yes
NDKA_HUMAN [view entry] [view interactions] Computational yes yes
DCK_HUMAN [view interactions] Computational no no
THIO_HUMAN [view interactions] Computational no yes
NDC80_HUMAN [view interactions] Computational no no
RU1C_HUMAN [view interactions] Computational no yes
KIF23_HUMAN [view interactions] Computational no yes
MCMBP_HUMAN [view interactions] Computational no yes
CMPK2_HUMAN [view interactions] Computational no yes
DPOE2_HUMAN [view interactions] Computational no no
PCNA_HUMAN [view interactions] Computational no no
DNLI1_HUMAN [view interactions] Computational no yes
RFC5_HUMAN [view interactions] Computational no yes
CDT1_HUMAN [view interactions] Computational no yes
DPOA2_HUMAN [view interactions] Computational no yes
KTHY_HUMAN [view interactions] Computational no yes
CND3_HUMAN [view interactions] Computational no yes
DTL_HUMAN [view interactions] Computational no no
ERCC1_HUMAN [view interactions] Computational no yes
RGAP1_HUMAN [view interactions] Computational no no
KAD8_HUMAN [view interactions] Computational no no
ENTP1_HUMAN [view interactions] Computational no yes
NDK7_HUMAN [view interactions] Computational no yes
KCY_HUMAN [view entry] [view interactions] Computational yes yes
PLK1_HUMAN [view interactions] Computational no yes
KAD3_HUMAN [view entry] [view interactions] Computational yes yes
CCNB1_HUMAN [view interactions] Computational no no
DPOE1_HUMAN [view interactions] Computational no no
NASP_HUMAN [view interactions] Computational no yes
MESH1_HUMAN [view interactions] Computational no yes
NDK3_HUMAN [view entry] [view interactions] Computational yes yes
KAD7_HUMAN [view interactions] Computational no no
MCM4_HUMAN [view interactions] Computational no yes
ESCO2_HUMAN [view interactions] Computational no no
CHK2_HUMAN [view interactions] Computational no yes
NDKM_HUMAN [view interactions] Computational no yes
RFA2_HUMAN [view interactions] Computational no yes
CDC20_HUMAN [view interactions] Computational no no
KIF11_HUMAN [view interactions] Computational no yes
DCTP1_HUMAN [view interactions] Computational no no
KAD5_HUMAN [view entry] [view interactions] Computational yes yes
MCM5_HUMAN [view interactions] Computational no no
TADBP_HUMAN [view interactions] Computational no yes
ENTP8_HUMAN [view interactions] Computational no no
IF4G1_HUMAN [view entry] [view interactions] Computational yes yes
FEN1_HUMAN [view interactions] Computational no yes
MCM3_HUMAN [view interactions] Computational no no