GNA11_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 60 | Arg | Cys | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
| 135 | Leu | Gln | Hypocalciurichypercalcemia,familial2(HHC2) | - |
| 181 | Arg | Gln | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
| 211 | Ser | Trp | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
| 341 | Phe | Leu | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNA11_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 43.8596 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 43.8596 | 4 | yes |
| GO:0016462 | pyrophosphatase activity | 42.1053 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 42.1053 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 42.1053 | 6 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 42.1053 | 4 | yes |
| GO:0003924 | GTPase activity | 40.3509 | 7 | yes |
| GO:0005525 | GTP binding | 31.5789 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 31.5789 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 31.5789 | 5 | yes |
| GO:0046872 | metal ion binding | 26.3158 | 4 | yes |
| GO:0019900 | kinase binding | 26.3158 | 4 | no |
| GO:0019901 | protein kinase binding | 26.3158 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 22.8070 | 4 | yes |
| GO:0004930 | G protein-coupled receptor activity | 21.0526 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNA11_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 63.1579 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 57.8947 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.8772 | 4 | no |
| GO:0009966 | regulation of signal transduction | 49.1228 | 4 | no |
| GO:0010646 | regulation of cell communication | 49.1228 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 49.1228 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 49.1228 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 45.6140 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 43.8596 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 40.3509 | 4 | no |
| GO:0051049 | regulation of transport | 40.3509 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 40.3509 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 38.5965 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 36.8421 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 36.8421 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 36.8421 | 5 | no |
| GO:0006996 | organelle organization | 36.8421 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.0877 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 35.0877 | 5 | no |
| GO:0023056 | positive regulation of signaling | 35.0877 | 4 | no |
| GO:0031399 | regulation of protein modification process | 35.0877 | 6 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.0877 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 33.3333 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 33.3333 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 33.3333 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 31.5789 | 4 | yes |
| GO:0042325 | regulation of phosphorylation | 31.5789 | 7 | no |
| GO:0051094 | positive regulation of developmental process | 31.5789 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.5789 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 31.5789 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 29.8246 | 4 | no |
| GO:0010941 | regulation of cell death | 29.8246 | 4 | no |
| GO:0043269 | regulation of ion transport | 29.8246 | 5 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 29.8246 | 6 | no |
| GO:0007010 | cytoskeleton organization | 29.8246 | 5 | no |
| GO:0045595 | regulation of cell differentiation | 28.0702 | 4 | yes |
| GO:0001932 | regulation of protein phosphorylation | 28.0702 | 7 | no |
| GO:0010468 | regulation of gene expression | 28.0702 | 5 | no |
| GO:0042981 | regulation of apoptotic process | 28.0702 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.0702 | 5 | no |
| GO:0071310 | cellular response to organic substance | 28.0702 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 28.0702 | 4 | no |
| GO:0008104 | protein localization | 26.3158 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 26.3158 | 6 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.3158 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 26.3158 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 26.3158 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 26.3158 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 26.3158 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 26.3158 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.5614 | 5 | no |
| GO:0031401 | positive regulation of protein modification process | 24.5614 | 7 | no |
| GO:0033043 | regulation of organelle organization | 24.5614 | 5 | no |
| GO:0042327 | positive regulation of phosphorylation | 24.5614 | 8 | no |
| GO:0048585 | negative regulation of response to stimulus | 24.5614 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 24.5614 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 24.5614 | 4 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 24.5614 | 4 | no |
| GO:0030334 | regulation of cell migration | 24.5614 | 5 | no |
| GO:2000145 | regulation of cell motility | 24.5614 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 22.8070 | 4 | no |
| GO:0010648 | negative regulation of cell communication | 22.8070 | 5 | no |
| GO:0023057 | negative regulation of signaling | 22.8070 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 22.8070 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 22.8070 | 6 | no |
| GO:0051050 | positive regulation of transport | 22.8070 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.8070 | 5 | no |
| GO:0022607 | cellular component assembly | 22.8070 | 4 | no |
| GO:0043549 | regulation of kinase activity | 22.8070 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 22.8070 | 4 | no |
| GO:0051338 | regulation of transferase activity | 22.8070 | 4 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.0526 | 8 | no |
| GO:0016192 | vesicle-mediated transport | 21.0526 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 21.0526 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 21.0526 | 6 | no |
| GO:0043410 | positive regulation of MAPK cascade | 21.0526 | 7 | no |
| GO:0045597 | positive regulation of cell differentiation | 21.0526 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 21.0526 | 5 | no |
| GO:0060548 | negative regulation of cell death | 21.0526 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 21.0526 | 4 | no |
| GO:0044057 | regulation of system process | 21.0526 | 4 | no |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 17.5439 | 4 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 14.0351 | 4 | yes |
| GO:0095500 | acetylcholine receptor signaling pathway | 14.0351 | 4 | yes |
| GO:0009416 | response to light stimulus | 10.5263 | 4 | yes |
| GO:0001508 | action potential | 5.2632 | 4 | yes |
| GO:0007507 | heart development | 3.5088 | 4 | yes |
| GO:0007603 | phototransduction, visible light | 3.5088 | 4 | yes |
| GO:0009583 | detection of light stimulus | 3.5088 | 4 | yes |
| GO:0009584 | detection of visible light | 3.5088 | 5 | yes |
| GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway | 3.5088 | 4 | yes |
| GO:0086100 | endothelin receptor signaling pathway | 3.5088 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD81_HUMAN | [view interactions] | Low throughput | no | no |
| KCNK3_HUMAN | [view interactions] | Low throughput | no | no |
| MTR1A_HUMAN | [view interactions] | Low throughput | no | no |
| RGS3_HUMAN | [view interactions] | Low throughput | no | no |
| EDNRA_HUMAN | [view interactions] | Low throughput | no | yes |
| EDNRB_HUMAN | [view interactions] | Low throughput | no | no |
| RGS13_HUMAN | [view interactions] | Low throughput | no | no |
| PI2R_HUMAN | [view interactions] | Low throughput | no | no |
| NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
| TA2R_HUMAN | [view interactions] | Low throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| X3CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXCR5_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| FXL18_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPOA_HUMAN | [view interactions] | High throughput | no | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| MF13A_HUMAN | [view interactions] | High throughput | no | no |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF6_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | yes |
| TEX29_HUMAN | [view interactions] | High throughput | no | no |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| NOL7_HUMAN | [view interactions] | High throughput | no | yes |
| CMIP_HUMAN | [view interactions] | High throughput | no | yes |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| P2RY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBB3_HUMAN | [view interactions] | Computational | no | yes |
| CCKAR_HUMAN | [view interactions] | Computational | no | no |
| ARRB2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LPAR2_HUMAN | [view interactions] | Computational | no | yes |
| ANGT_HUMAN | [view interactions] | Computational | no | no |
| ARHGP_HUMAN | [view interactions] | Computational | no | yes |
| AGTR1_HUMAN | [view interactions] | Computational | no | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CCR5_HUMAN | [view interactions] | Computational | no | no |
| PLCG1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADA1A_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PLCB4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BKRB2_HUMAN | [view interactions] | Computational | no | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB2_HUMAN | [view interactions] | Computational | no | no |
| PK3CA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PLCB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FFAR1_HUMAN | [view interactions] | Computational | no | no |
| EDN1_HUMAN | [view interactions] | Computational | no | no |
| CLTR2_HUMAN | [view interactions] | Computational | no | no |
| PLCG2_HUMAN | [view interactions] | Computational | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GHSR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| V1AR_HUMAN | [view interactions] | Computational | no | no |
| ARF6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| GRM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 5HT2B_HUMAN | [view interactions] | Computational | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MK14_HUMAN | [view interactions] | Computational | no | yes |
| PTH1R_HUMAN | [view interactions] | Computational | no | no |
| CASR_HUMAN | [view interactions] | Computational | no | no |
| PAR4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| 5HT2C_HUMAN | [view interactions] | Computational | no | no |
| ADA2C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ADA1D_HUMAN | [view interactions] | Computational | no | no |
| 5HT2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADA1B_HUMAN | [view interactions] | Computational | no | no |
| RGS19_HUMAN | [view interactions] | Computational | no | yes |
| AGTR2_HUMAN | [view interactions] | Computational | no | no |
| RGSL_HUMAN | [view interactions] | Computational | no | no |
| GRM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ADA2B_HUMAN | [view interactions] | Computational | no | no |
| V1BR_HUMAN | [view interactions] | Computational | no | no |
| TRPC6_HUMAN | [view interactions] | Computational | no | no |
| P85A_HUMAN | [view interactions] | Computational | no | yes |
| GNAZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| BKRB1_HUMAN | [view interactions] | Computational | no | yes |
| MK08_HUMAN | [view interactions] | Computational | no | yes |
| ACM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| KISSR_HUMAN | [view interactions] | Computational | no | yes |
| ARRC_HUMAN | [view interactions] | Computational | no | no |
| LPAR3_HUMAN | [view interactions] | Computational | no | no |
| CXCR4_HUMAN | [view interactions] | Computational | no | no |
| S1PR3_HUMAN | [view interactions] | Computational | no | no |
| GNRHR_HUMAN | [view interactions] | Computational | no | no |