GNA11_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 60 | Arg | Cys | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
| 135 | Leu | Gln | Hypocalciurichypercalcemia,familial2(HHC2) | - |
| 181 | Arg | Gln | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
| 211 | Ser | Trp | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
| 341 | Phe | Leu | Hypocalcemia,autosomaldominant2(HYPOC2) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GNA11_HUMAN |
|---|---|---|---|---|
| GO:0016462 | pyrophosphatase activity | 51.2821 | 5 | yes |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 51.2821 | 4 | yes |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 51.2821 | 6 | yes |
| GO:0043168 | anion binding | 51.2821 | 4 | yes |
| GO:0000166 | nucleotide binding | 48.7179 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 48.7179 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 48.7179 | 4 | yes |
| GO:0003924 | GTPase activity | 46.1538 | 7 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 46.1538 | 4 | yes |
| GO:0005525 | GTP binding | 35.8974 | 5 | yes |
| GO:0019001 | guanyl nucleotide binding | 35.8974 | 6 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 35.8974 | 5 | yes |
| GO:0043169 | cation binding | 28.2051 | 4 | yes |
| GO:0046872 | metal ion binding | 28.2051 | 5 | yes |
| GO:0019900 | kinase binding | 25.6410 | 4 | no |
| GO:0019901 | protein kinase binding | 25.6410 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 23.0769 | 4 | yes |
| GO:0030695 | GTPase regulator activity | 20.5128 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GNA11_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 61.5385 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 58.9744 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 48.7179 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 48.7179 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 46.1538 | 4 | no |
| GO:0010646 | regulation of cell communication | 43.5897 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 43.5897 | 4 | no |
| GO:0006996 | organelle organization | 41.0256 | 4 | no |
| GO:0009966 | regulation of signal transduction | 41.0256 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 41.0256 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 41.0256 | 5 | no |
| GO:0008104 | protein localization | 38.4615 | 4 | no |
| GO:0051049 | regulation of transport | 35.8974 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 35.8974 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.8974 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0007010 | cytoskeleton organization | 33.3333 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 33.3333 | 4 | no |
| GO:0031399 | regulation of protein modification process | 33.3333 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 30.7692 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 30.7692 | 4 | yes |
| GO:0022603 | regulation of anatomical structure morphogenesis | 30.7692 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 30.7692 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 30.7692 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 30.7692 | 4 | no |
| GO:0010468 | regulation of gene expression | 30.7692 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 30.7692 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.7692 | 6 | no |
| GO:0022607 | cellular component assembly | 30.7692 | 4 | no |
| GO:0030334 | regulation of cell migration | 30.7692 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 30.7692 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 30.7692 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.7692 | 5 | no |
| GO:2000145 | regulation of cell motility | 30.7692 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.2051 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 28.2051 | 5 | no |
| GO:0033043 | regulation of organelle organization | 28.2051 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 28.2051 | 7 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.2051 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 28.2051 | 6 | no |
| GO:0051094 | positive regulation of developmental process | 28.2051 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.2051 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 28.2051 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 25.6410 | 4 | yes |
| GO:0141124 | intracellular signaling cassette | 25.6410 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 25.6410 | 7 | no |
| GO:0009967 | positive regulation of signal transduction | 25.6410 | 5 | no |
| GO:0097435 | supramolecular fiber organization | 25.6410 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.6410 | 5 | no |
| GO:0032880 | regulation of protein localization | 23.0769 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 23.0769 | 4 | yes |
| GO:0060341 | regulation of cellular localization | 23.0769 | 4 | yes |
| GO:0007264 | small GTPase-mediated signal transduction | 23.0769 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.0769 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.0769 | 4 | no |
| GO:2000026 | regulation of multicellular organismal development | 23.0769 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 23.0769 | 5 | no |
| GO:0071310 | cellular response to organic substance | 23.0769 | 4 | no |
| GO:0071702 | organic substance transport | 23.0769 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.0769 | 4 | no |
| GO:0030030 | cell projection organization | 20.5128 | 4 | no |
| GO:0043066 | negative regulation of apoptotic process | 20.5128 | 6 | no |
| GO:0043069 | negative regulation of programmed cell death | 20.5128 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 20.5128 | 5 | no |
| GO:0060284 | regulation of cell development | 20.5128 | 5 | no |
| GO:0009890 | negative regulation of biosynthetic process | 20.5128 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 20.5128 | 5 | no |
| GO:0030155 | regulation of cell adhesion | 20.5128 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 20.5128 | 7 | no |
| GO:0032970 | regulation of actin filament-based process | 20.5128 | 4 | no |
| GO:0043933 | protein-containing complex organization | 20.5128 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.5128 | 6 | no |
| GO:0060627 | regulation of vesicle-mediated transport | 20.5128 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.5128 | 6 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 20.5128 | 5 | no |
| GO:0010243 | response to organonitrogen compound | 20.5128 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 20.5128 | 4 | no |
| GO:0043549 | regulation of kinase activity | 20.5128 | 5 | no |
| GO:0051338 | regulation of transferase activity | 20.5128 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.5128 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 20.5128 | 5 | no |
| GO:0009894 | regulation of catabolic process | 20.5128 | 4 | no |
| GO:0015031 | protein transport | 20.5128 | 4 | no |
| GO:0051050 | positive regulation of transport | 17.9487 | 4 | yes |
| GO:0009416 | response to light stimulus | 15.3846 | 4 | yes |
| GO:0051046 | regulation of secretion | 15.3846 | 5 | yes |
| GO:0070201 | regulation of establishment of protein localization | 15.3846 | 6 | yes |
| GO:1903530 | regulation of secretion by cell | 15.3846 | 4 | yes |
| GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway | 12.8205 | 4 | yes |
| GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway | 12.8205 | 4 | yes |
| GO:0051223 | regulation of protein transport | 12.8205 | 5 | yes |
| GO:0095500 | acetylcholine receptor signaling pathway | 12.8205 | 4 | yes |
| GO:1903829 | positive regulation of protein localization | 12.8205 | 5 | yes |
| GO:0046883 | regulation of hormone secretion | 10.2564 | 4 | yes |
| GO:0001508 | action potential | 7.6923 | 4 | yes |
| GO:0002791 | regulation of peptide secretion | 7.6923 | 6 | yes |
| GO:0046887 | positive regulation of hormone secretion | 7.6923 | 5 | yes |
| GO:0050708 | regulation of protein secretion | 7.6923 | 5 | yes |
| GO:0050796 | regulation of insulin secretion | 7.6923 | 6 | yes |
| GO:0051047 | positive regulation of secretion | 7.6923 | 5 | yes |
| GO:0051222 | positive regulation of protein transport | 7.6923 | 5 | yes |
| GO:0090087 | regulation of peptide transport | 7.6923 | 5 | yes |
| GO:0090276 | regulation of peptide hormone secretion | 7.6923 | 5 | yes |
| GO:1903532 | positive regulation of secretion by cell | 7.6923 | 5 | yes |
| GO:1904951 | positive regulation of establishment of protein localization | 7.6923 | 6 | yes |
| GO:0002793 | positive regulation of peptide secretion | 5.1282 | 6 | yes |
| GO:0007207 | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway | 5.1282 | 5 | yes |
| GO:0007507 | heart development | 5.1282 | 4 | yes |
| GO:0007603 | phototransduction, visible light | 5.1282 | 4 | yes |
| GO:0009583 | detection of light stimulus | 5.1282 | 4 | yes |
| GO:0009584 | detection of visible light | 5.1282 | 5 | yes |
| GO:0032024 | positive regulation of insulin secretion | 5.1282 | 7 | yes |
| GO:0050714 | positive regulation of protein secretion | 5.1282 | 6 | yes |
| GO:0060158 | phospholipase C-activating dopamine receptor signaling pathway | 5.1282 | 4 | yes |
| GO:0086100 | endothelin receptor signaling pathway | 5.1282 | 4 | yes |
| GO:0090277 | positive regulation of peptide hormone secretion | 5.1282 | 6 | yes |
| GO:0099105 | ion channel modulating, G protein-coupled receptor signaling pathway | 5.1282 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| CD81_HUMAN | [view interactions] | Low throughput | no | no |
| KCNK3_HUMAN | [view interactions] | Low throughput | no | no |
| MTR1A_HUMAN | [view interactions] | Low throughput | no | no |
| RGS3_HUMAN | [view interactions] | Low throughput | no | no |
| EDNRA_HUMAN | [view interactions] | Low throughput | no | yes |
| EDNRB_HUMAN | [view interactions] | Low throughput | no | no |
| RGS13_HUMAN | [view interactions] | Low throughput | no | no |
| PI2R_HUMAN | [view interactions] | Low throughput | no | no |
| NHRF1_HUMAN | [view interactions] | Low throughput | no | no |
| TA2R_HUMAN | [view interactions] | Low throughput | no | no |
| PLCB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBG2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RGS14_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| X3CL1_HUMAN | [view interactions] | Low throughput | no | yes |
| CRFR2_HUMAN | [view interactions] | Low throughput | no | no |
| UCN1_HUMAN | [view interactions] | Low throughput | no | yes |
| ACTB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSCL2_HUMAN | [view interactions] | High throughput | no | yes |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MECOM_HUMAN | [view interactions] | High throughput | no | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| AGAP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RIMS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SYGP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CXCR5_HUMAN | [view interactions] | High throughput | no | yes |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| FXL18_HUMAN | [view interactions] | High throughput | no | no |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| PAPOA_HUMAN | [view interactions] | High throughput | no | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| ATM_HUMAN | [view interactions] | High throughput | no | yes |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| MF13A_HUMAN | [view interactions] | High throughput | no | no |
| DUS9_HUMAN | [view interactions] | High throughput | no | no |
| DUS22_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| TRI25_HUMAN | [view interactions] | High throughput | no | yes |
| RNF6_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| RIC8A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| OTUD3_HUMAN | [view interactions] | High throughput | no | yes |
| WDR36_HUMAN | [view interactions] | High throughput | no | no |
| TEX29_HUMAN | [view interactions] | High throughput | no | no |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| NOL7_HUMAN | [view interactions] | High throughput | no | yes |
| CMIP_HUMAN | [view interactions] | High throughput | no | yes |
| UXS1_HUMAN | [view interactions] | High throughput | no | yes |
| TSN15_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH23_HUMAN | [view interactions] | High throughput | no | no |
| P2RY1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOU_HUMAN | [view interactions] | High throughput | no | no |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RHOQ_HUMAN | [view interactions] | High throughput | no | no |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MOT1_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
| HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LIN7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZO1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MCP_HUMAN | [view interactions] | High throughput | no | no |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| PGLT1_HUMAN | [view interactions] | High throughput | no | no |
| TTL_HUMAN | [view interactions] | High throughput | no | no |
| DPH2_HUMAN | [view interactions] | High throughput | no | no |
| FAIM1_HUMAN | [view interactions] | High throughput | no | yes |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DYLT1_HUMAN | [view interactions] | High throughput | no | no |
| LEG9_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RFA1_HUMAN | [view interactions] | High throughput | no | yes |
| RFA2_HUMAN | [view interactions] | High throughput | no | yes |
| RFA3_HUMAN | [view interactions] | High throughput | no | yes |
| RFA4_HUMAN | [view interactions] | High throughput | no | yes |