GBB4_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBB4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 44.4444 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 44.4444 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 44.4444 | 4 | no |
| GO:0003924 | GTPase activity | 37.0370 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 37.0370 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 37.0370 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 37.0370 | 6 | no |
| GO:0005525 | GTP binding | 31.4815 | 5 | no |
| GO:0019001 | guanyl nucleotide binding | 31.4815 | 5 | no |
| GO:0032561 | guanyl ribonucleotide binding | 31.4815 | 5 | no |
| GO:0046872 | metal ion binding | 27.7778 | 4 | no |
| GO:0019900 | kinase binding | 22.2222 | 4 | no |
| GO:0019901 | protein kinase binding | 22.2222 | 5 | no |
| GO:0001664 | G protein-coupled receptor binding | 20.3704 | 4 | no |
| GO:0030159 | signaling receptor complex adaptor activity | 3.7037 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBB4_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 51.8519 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.2963 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 44.4444 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.5926 | 4 | no |
| GO:0010646 | regulation of cell communication | 42.5926 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 40.7407 | 4 | no |
| GO:0051049 | regulation of transport | 35.1852 | 4 | no |
| GO:0006996 | organelle organization | 35.1852 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 35.1852 | 4 | no |
| GO:0033043 | regulation of organelle organization | 35.1852 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 35.1852 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 33.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 33.3333 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.6296 | 5 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 29.6296 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 29.6296 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 27.7778 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 27.7778 | 5 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 25.9259 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 25.9259 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 25.9259 | 6 | no |
| GO:0010941 | regulation of cell death | 25.9259 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.9259 | 5 | no |
| GO:0022607 | cellular component assembly | 24.0741 | 4 | no |
| GO:0023056 | positive regulation of signaling | 24.0741 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 24.0741 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 24.0741 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 24.0741 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.0741 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 24.0741 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 22.2222 | 5 | no |
| GO:0030334 | regulation of cell migration | 22.2222 | 5 | no |
| GO:0032956 | regulation of actin cytoskeleton organization | 22.2222 | 5 | no |
| GO:0042127 | regulation of cell population proliferation | 22.2222 | 4 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
| GO:2000145 | regulation of cell motility | 22.2222 | 4 | no |
| GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
| GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
| GO:0043067 | regulation of programmed cell death | 22.2222 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 22.2222 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 20.3704 | 5 | no |
| GO:0031399 | regulation of protein modification process | 20.3704 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 20.3704 | 7 | no |
| GO:0043269 | regulation of ion transport | 20.3704 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.3704 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 20.3704 | 6 | no |
| GO:0010638 | positive regulation of organelle organization | 20.3704 | 6 | no |
| GO:0060548 | negative regulation of cell death | 20.3704 | 5 | no |
| GO:0061024 | membrane organization | 20.3704 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 20.3704 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 20.3704 | 6 | no |
| GO:0010468 | regulation of gene expression | 20.3704 | 5 | no |
| GO:0007010 | cytoskeleton organization | 20.3704 | 5 | no |
| GO:0021762 | substantia nigra development | 5.5556 | 4 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in GBB4_HUMAN |
|---|---|---|---|---|
| DOID:0050686 | organ system cancer | 3.7037 | 3 | no |
| DOID:120 | female reproductive organ cancer | 3.7037 | 5 | no |
| DOID:193 | reproductive organ cancer | 3.7037 | 4 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GBG13_HUMAN | [view interactions] | Low throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
| SKA3_HUMAN | [view interactions] | High throughput | no | no |
| GBG10_HUMAN | [view interactions] | High throughput | no | no |
| GBG8_HUMAN | [view interactions] | High throughput | no | no |
| GBG1_HUMAN | [view interactions] | High throughput | no | no |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOH_HUMAN | [view interactions] | High throughput | no | yes |
| RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
| RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RHOC_HUMAN | [view interactions] | High throughput | no | no |
| RND2_HUMAN | [view interactions] | High throughput | no | no |
| CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCTD2_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| KCD17_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| GBG11_HUMAN | [view interactions] | High throughput | no | no |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST1_HUMAN | [view interactions] | High throughput | no | no |
| ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
| CATL1_HUMAN | [view interactions] | High throughput | no | yes |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GALK2_HUMAN | [view interactions] | High throughput | no | yes |
| HXB5_HUMAN | [view interactions] | High throughput | no | no |
| CXB7_HUMAN | [view interactions] | High throughput | no | no |
| PACC1_HUMAN | [view interactions] | High throughput | no | no |
| SDC1_HUMAN | [view interactions] | High throughput | no | no |
| FZD10_HUMAN | [view interactions] | High throughput | no | no |
| RSBN1_HUMAN | [view interactions] | High throughput | no | yes |
| KCNJ5_HUMAN | [view interactions] | High throughput | no | yes |
| TFAP4_HUMAN | [view interactions] | High throughput | no | yes |
| GP161_HUMAN | [view interactions] | High throughput | no | yes |
| KCND2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GBG4_HUMAN | [view interactions] | High throughput | no | no |
| SEHL2_HUMAN | [view interactions] | High throughput | no | no |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
| TNFA_HUMAN | [view interactions] | High throughput | no | no |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| CD177_HUMAN | [view interactions] | High throughput | no | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| CASP6_HUMAN | [view interactions] | High throughput | no | no |
| SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
| CDK1_HUMAN | [view interactions] | High throughput | no | no |
| HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| TRI69_HUMAN | [view interactions] | High throughput | no | no |
| HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
| CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NUDC_HUMAN | [view interactions] | High throughput | no | yes |
| FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
| PFD5_HUMAN | [view interactions] | High throughput | no | yes |
| HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H31_HUMAN | [view interactions] | High throughput | no | yes |
| GBGT2_HUMAN | [view interactions] | High throughput | no | no |
| GBG5_HUMAN | [view interactions] | High throughput | no | no |
| GBG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CEP97_HUMAN | [view interactions] | High throughput | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RGS6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PHLP_HUMAN | [view interactions] | High throughput | no | yes |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ERR2_HUMAN | [view interactions] | High throughput | no | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| LIMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LRIQ3_HUMAN | [view interactions] | High throughput | no | no |
| ANR12_HUMAN | [view interactions] | High throughput | no | yes |
| TSN17_HUMAN | [view interactions] | High throughput | no | yes |
| DFFA_HUMAN | [view interactions] | High throughput | no | yes |
| T185A_HUMAN | [view interactions] | High throughput | no | no |
| MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
| NR2E1_HUMAN | [view interactions] | High throughput | no | yes |
| ZNT4_HUMAN | [view interactions] | High throughput | no | no |
| RD3_HUMAN | [view interactions] | High throughput | no | no |
| CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
| MB3L1_HUMAN | [view interactions] | High throughput | no | no |
| CUL4A_HUMAN | [view interactions] | High throughput | no | no |
| OXDA_HUMAN | [view interactions] | High throughput | no | no |
| PKHG5_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CP2S1_HUMAN | [view interactions] | High throughput | no | no |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| NPC1_HUMAN | [view interactions] | High throughput | no | yes |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LPAR4_HUMAN | [view interactions] | Computational | no | no |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNAL_HUMAN | [view interactions] | Computational | no | yes |
| ACM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LPAR6_HUMAN | [view interactions] | Computational | no | no |
| LPAR2_HUMAN | [view interactions] | Computational | no | yes |
| GNAT2_HUMAN | [view interactions] | Computational | no | no |
| PLCB2_HUMAN | [view interactions] | Computational | no | no |
| GNAT3_HUMAN | [view interactions] | Computational | no | no |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| OPSD_HUMAN | [view interactions] | Computational | no | no |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAS1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |
| LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNAO_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA15_HUMAN | [view interactions] | Computational | no | yes |
| GNAT1_HUMAN | [view interactions] | Computational | no | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| LPAR3_HUMAN | [view interactions] | Computational | no | no |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LPAR5_HUMAN | [view interactions] | Computational | no | yes |
| GNA14_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| GNAZ_HUMAN | [view entry] [view interactions] | Computational | yes | yes |