Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBB4_HUMAN

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]

Interacting region for partners were not defined.

Download full PS network for entry.

No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in GBB4_HUMAN
GO:0000166 nucleotide binding 46.6667 4 no
GO:0017076 purine nucleotide binding 42.2222 5 no
GO:0032555 purine ribonucleotide binding 42.2222 4 no
GO:0035639 purine ribonucleoside triphosphate binding 42.2222 4 no
GO:0043168 anion binding 42.2222 4 no
GO:0003924 GTPase activity 35.5556 7 no
GO:0016462 pyrophosphatase activity 35.5556 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 35.5556 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 35.5556 6 no
GO:0043169 cation binding 31.1111 4 no
GO:0005525 GTP binding 28.8889 5 no
GO:0019001 guanyl nucleotide binding 28.8889 6 no
GO:0032561 guanyl ribonucleotide binding 28.8889 5 no
GO:0046872 metal ion binding 24.4444 5 no
GO:0019900 kinase binding 22.2222 4 no
GO:0030159 signaling receptor complex adaptor activity 4.4444 4 yes

Biological process

Term Name % Distance from top the of the tree Annotated in GBB4_HUMAN
GO:0048522 positive regulation of cellular process 57.7778 4 no
GO:0010646 regulation of cell communication 51.1111 4 no
GO:0051128 regulation of cellular component organization 48.8889 4 no
GO:0009966 regulation of signal transduction 46.6667 4 no
GO:0048523 negative regulation of cellular process 46.6667 4 no
GO:0031323 regulation of cellular metabolic process 40.0000 4 no
GO:0009893 positive regulation of metabolic process 37.7778 4 no
GO:0006996 organelle organization 35.5556 4 no
GO:0060255 regulation of macromolecule metabolic process 35.5556 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0080090 regulation of primary metabolic process 33.3333 4 no
GO:0031325 positive regulation of cellular metabolic process 31.1111 5 no
GO:0033043 regulation of organelle organization 31.1111 5 no
GO:1902531 regulation of intracellular signal transduction 31.1111 5 no
GO:0010604 positive regulation of macromolecule metabolic process 28.8889 5 no
GO:0022607 cellular component assembly 28.8889 4 no
GO:0048584 positive regulation of response to stimulus 28.8889 4 no
GO:0051246 regulation of protein metabolic process 28.8889 5 no
GO:0010647 positive regulation of cell communication 26.6667 5 no
GO:0023056 positive regulation of signaling 26.6667 4 no
GO:0044087 regulation of cellular component biogenesis 26.6667 4 no
GO:0051130 positive regulation of cellular component organization 26.6667 5 no
GO:0141124 intracellular signaling cassette 26.6667 4 no
GO:0009967 positive regulation of signal transduction 24.4444 5 no
GO:0030334 regulation of cell migration 24.4444 5 no
GO:2000145 regulation of cell motility 24.4444 4 no
GO:0043085 positive regulation of catalytic activity 24.4444 4 no
GO:0001932 regulation of protein phosphorylation 22.2222 7 no
GO:0019220 regulation of phosphate metabolic process 22.2222 6 no
GO:0022603 regulation of anatomical structure morphogenesis 22.2222 4 no
GO:0031399 regulation of protein modification process 22.2222 6 no
GO:0042325 regulation of phosphorylation 22.2222 7 no
GO:0051174 regulation of phosphorus metabolic process 22.2222 5 no
GO:0051247 positive regulation of protein metabolic process 22.2222 6 no
GO:0051493 regulation of cytoskeleton organization 22.2222 6 no
GO:0061024 membrane organization 22.2222 4 no
GO:0032880 regulation of protein localization 22.2222 5 no
GO:0060341 regulation of cellular localization 22.2222 4 no
GO:0008104 protein localization 22.2222 4 no
GO:0009968 negative regulation of signal transduction 22.2222 5 no
GO:0010648 negative regulation of cell communication 22.2222 5 no
GO:0023057 negative regulation of signaling 22.2222 4 no
GO:0048585 negative regulation of response to stimulus 22.2222 4 no
GO:0042981 regulation of apoptotic process 22.2222 5 no
GO:0043067 regulation of programmed cell death 22.2222 4 no
GO:0021762 substantia nigra development 6.6667 4 yes

Disease

No data found.

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GNAI1_HUMAN [view entry] [view interactions] Low throughput yes yes
GNAI3_HUMAN [view entry] [view interactions] Low throughput yes yes
RPB1_HUMAN [view interactions] Low throughput no no
GNAI2_HUMAN [view entry] [view interactions] Low throughput yes yes
SQSTM_HUMAN [view interactions] Low throughput no yes
GBG13_HUMAN [view interactions] Low throughput no no
DLG4_HUMAN [view entry] [view interactions] High throughput yes yes
MYH10_HUMAN [view entry] [view interactions] High throughput yes yes
GALK2_HUMAN [view interactions] High throughput no yes
HXB5_HUMAN [view interactions] High throughput no no
CXB7_HUMAN [view interactions] High throughput no no
PACC1_HUMAN [view interactions] High throughput no no
SDC1_HUMAN [view interactions] High throughput no no
FZD10_HUMAN [view interactions] High throughput no no
RSBN1_HUMAN [view interactions] High throughput no yes
KCNJ5_HUMAN [view interactions] High throughput no yes
TFAP4_HUMAN [view interactions] High throughput no yes
GP161_HUMAN [view interactions] High throughput no yes
KCND2_HUMAN [view entry] [view interactions] High throughput yes yes
GBG4_HUMAN [view interactions] High throughput no no
GBG3_HUMAN [view entry] [view interactions] High throughput yes no
SEHL2_HUMAN [view interactions] High throughput no no
DUS4_HUMAN [view entry] [view interactions] High throughput yes no
ZDHC5_HUMAN [view entry] [view interactions] High throughput yes yes
TP4A2_HUMAN [view interactions] High throughput no yes
NPC1_HUMAN [view interactions] High throughput no yes
TNFA_HUMAN [view interactions] High throughput no no
XPO1_HUMAN [view entry] [view interactions] High throughput yes yes
ESR1_HUMAN [view interactions] High throughput no no
KLF16_HUMAN [view interactions] High throughput no yes
INSR_HUMAN [view interactions] High throughput no yes
CD177_HUMAN [view interactions] High throughput no no
ITM2B_HUMAN [view interactions] High throughput no yes
BMI1_HUMAN [view interactions] High throughput no yes
CAC1C_HUMAN [view entry] [view interactions] High throughput yes no
CASP6_HUMAN [view interactions] High throughput no no
SHLB1_HUMAN [view interactions] High throughput no yes
RIPK3_HUMAN [view interactions] High throughput no no
MTR1A_HUMAN [view interactions] High throughput no no
MTR1B_HUMAN [view interactions] High throughput no yes
CDK1_HUMAN [view interactions] High throughput no no
HAUS4_HUMAN [view interactions] High throughput no yes
SCC4_HUMAN [view interactions] High throughput no no
TRI69_HUMAN [view interactions] High throughput no no
HAUS1_HUMAN [view interactions] High throughput no yes
CDK18_HUMAN [view entry] [view interactions] High throughput yes yes
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
NUDC_HUMAN [view interactions] High throughput no yes
FKBPL_HUMAN [view interactions] High throughput no yes
PFD5_HUMAN [view interactions] High throughput no yes
HXK1_HUMAN [view entry] [view interactions] High throughput yes yes
H31_HUMAN [view interactions] High throughput no yes
GBGT2_HUMAN [view interactions] High throughput no no
GBG5_HUMAN [view interactions] High throughput no no
GBG7_HUMAN [view entry] [view interactions] High throughput yes yes
CEP97_HUMAN [view interactions] High throughput no yes
GBG2_HUMAN [view entry] [view interactions] High throughput yes yes
RGS6_HUMAN [view entry] [view interactions] High throughput yes no
PHLP_HUMAN [view interactions] High throughput no yes
FBX6_HUMAN [view interactions] High throughput no yes
PAN2_HUMAN [view interactions] High throughput no no
ADRB2_HUMAN [view entry] [view interactions] High throughput yes no
ERR2_HUMAN [view interactions] High throughput no no
ABCE1_HUMAN [view interactions] High throughput no yes
LIMC1_HUMAN [view entry] [view interactions] High throughput yes no
LRIQ3_HUMAN [view interactions] High throughput no no
ANR12_HUMAN [view interactions] High throughput no yes
TSN17_HUMAN [view interactions] High throughput no yes
DFFA_HUMAN [view interactions] High throughput no yes
T185A_HUMAN [view interactions] High throughput no no
MEIS2_HUMAN [view interactions] High throughput no yes
NR2E1_HUMAN [view interactions] High throughput no yes
ZNT4_HUMAN [view interactions] High throughput no no
RD3_HUMAN [view interactions] High throughput no no
CCNL2_HUMAN [view interactions] High throughput no yes
MB3L1_HUMAN [view interactions] High throughput no no
CUL4A_HUMAN [view interactions] High throughput no no
OXDA_HUMAN [view interactions] High throughput no no
PKHG5_HUMAN [view interactions] High throughput no yes
NTRK3_HUMAN [view entry] [view interactions] High throughput yes yes
CP2S1_HUMAN [view interactions] High throughput no no
ARI1_HUMAN [view interactions] High throughput no yes
UBP14_HUMAN [view entry] [view interactions] High throughput yes yes
UBQL2_HUMAN [view interactions] High throughput no yes
YAP1_HUMAN [view interactions] High throughput no yes
TFCP2_HUMAN [view interactions] High throughput no no
FACD2_HUMAN [view interactions] High throughput no no
CTRO_HUMAN [view entry] [view interactions] High throughput yes yes
ANLN_HUMAN [view interactions] High throughput no yes
CHM4B_HUMAN [view entry] [view interactions] High throughput yes yes
ECT2_HUMAN [view interactions] High throughput no no
KIF14_HUMAN [view interactions] High throughput no no
KI20A_HUMAN [view interactions] High throughput no yes
PRC1_HUMAN [view interactions] High throughput no yes
NMRL1_HUMAN [view interactions] High throughput no yes
SKA3_HUMAN [view interactions] High throughput no no
GBG10_HUMAN [view interactions] High throughput no no
GBG8_HUMAN [view interactions] High throughput no no
GBG1_HUMAN [view interactions] High throughput no no
GNA13_HUMAN [view entry] [view interactions] High throughput yes yes
RHOH_HUMAN [view interactions] High throughput no yes
RHOA_HUMAN [view entry] [view interactions] High throughput yes yes
RHOJ_HUMAN [view interactions] High throughput no yes
RAC1_HUMAN [view entry] [view interactions] High throughput yes no
RAC2_HUMAN [view entry] [view interactions] High throughput yes yes
RAC3_HUMAN [view entry] [view interactions] High throughput yes no
RHOG_HUMAN [view entry] [view interactions] High throughput yes no
RHOB_HUMAN [view entry] [view interactions] High throughput yes no
RHOC_HUMAN [view interactions] High throughput no no
RND2_HUMAN [view interactions] High throughput no no
CDC42_HUMAN [view entry] [view interactions] High throughput yes yes
KCTD2_HUMAN [view interactions] High throughput no no
KCTD5_HUMAN [view interactions] High throughput no no
KCD17_HUMAN [view interactions] High throughput no yes
GBB1_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
HDAC6_HUMAN [view interactions] High throughput no yes
DOT1L_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
PRRT2_HUMAN [view entry] [view interactions] High throughput yes no
CFAH_HUMAN [view interactions] High throughput no no
CSK_HUMAN [view interactions] High throughput no yes
GBG11_HUMAN [view interactions] High throughput no no
GBG12_HUMAN [view entry] [view interactions] High throughput yes yes
PTEN_HUMAN [view entry] [view interactions] High throughput yes yes
GNA11_HUMAN [view entry] [view interactions] High throughput yes yes
GNAQ_HUMAN [view entry] [view interactions] High throughput yes yes
NB5R3_HUMAN [view interactions] High throughput no yes
VDAC3_HUMAN [view entry] [view interactions] High throughput yes yes
MGST1_HUMAN [view interactions] High throughput no no
ADT1_HUMAN [view entry] [view interactions] High throughput yes yes
VDAC1_HUMAN [view entry] [view interactions] High throughput yes yes
TOM5_HUMAN [view interactions] High throughput no yes
VDAC2_HUMAN [view entry] [view interactions] High throughput yes yes
MTCH1_HUMAN [view entry] [view interactions] High throughput yes yes
OCAD1_HUMAN [view interactions] High throughput no yes
CATL1_HUMAN [view interactions] High throughput no yes
T106B_HUMAN [view interactions] High throughput no yes
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no