GBB4_HUMAN
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]
Interacting region for partners were not defined.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GBB4_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 46.6667 | 4 | no |
GO:0017076 | purine nucleotide binding | 42.2222 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 42.2222 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 42.2222 | 4 | no |
GO:0043168 | anion binding | 42.2222 | 4 | no |
GO:0003924 | GTPase activity | 35.5556 | 7 | no |
GO:0016462 | pyrophosphatase activity | 35.5556 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 35.5556 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 35.5556 | 6 | no |
GO:0043169 | cation binding | 31.1111 | 4 | no |
GO:0005525 | GTP binding | 28.8889 | 5 | no |
GO:0019001 | guanyl nucleotide binding | 28.8889 | 6 | no |
GO:0032561 | guanyl ribonucleotide binding | 28.8889 | 5 | no |
GO:0046872 | metal ion binding | 24.4444 | 5 | no |
GO:0019900 | kinase binding | 22.2222 | 4 | no |
GO:0030159 | signaling receptor complex adaptor activity | 4.4444 | 4 | yes |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GBB4_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 57.7778 | 4 | no |
GO:0010646 | regulation of cell communication | 51.1111 | 4 | no |
GO:0051128 | regulation of cellular component organization | 48.8889 | 4 | no |
GO:0009966 | regulation of signal transduction | 46.6667 | 4 | no |
GO:0048523 | negative regulation of cellular process | 46.6667 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
GO:0009893 | positive regulation of metabolic process | 37.7778 | 4 | no |
GO:0006996 | organelle organization | 35.5556 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 35.5556 | 4 | no |
GO:0051049 | regulation of transport | 33.3333 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 33.3333 | 4 | no |
GO:0031325 | positive regulation of cellular metabolic process | 31.1111 | 5 | no |
GO:0033043 | regulation of organelle organization | 31.1111 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 31.1111 | 5 | no |
GO:0010604 | positive regulation of macromolecule metabolic process | 28.8889 | 5 | no |
GO:0022607 | cellular component assembly | 28.8889 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 28.8889 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 28.8889 | 5 | no |
GO:0010647 | positive regulation of cell communication | 26.6667 | 5 | no |
GO:0023056 | positive regulation of signaling | 26.6667 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 26.6667 | 4 | no |
GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
GO:0141124 | intracellular signaling cassette | 26.6667 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 24.4444 | 5 | no |
GO:0030334 | regulation of cell migration | 24.4444 | 5 | no |
GO:2000145 | regulation of cell motility | 24.4444 | 4 | no |
GO:0043085 | positive regulation of catalytic activity | 24.4444 | 4 | no |
GO:0001932 | regulation of protein phosphorylation | 22.2222 | 7 | no |
GO:0019220 | regulation of phosphate metabolic process | 22.2222 | 6 | no |
GO:0022603 | regulation of anatomical structure morphogenesis | 22.2222 | 4 | no |
GO:0031399 | regulation of protein modification process | 22.2222 | 6 | no |
GO:0042325 | regulation of phosphorylation | 22.2222 | 7 | no |
GO:0051174 | regulation of phosphorus metabolic process | 22.2222 | 5 | no |
GO:0051247 | positive regulation of protein metabolic process | 22.2222 | 6 | no |
GO:0051493 | regulation of cytoskeleton organization | 22.2222 | 6 | no |
GO:0061024 | membrane organization | 22.2222 | 4 | no |
GO:0032880 | regulation of protein localization | 22.2222 | 5 | no |
GO:0060341 | regulation of cellular localization | 22.2222 | 4 | no |
GO:0008104 | protein localization | 22.2222 | 4 | no |
GO:0009968 | negative regulation of signal transduction | 22.2222 | 5 | no |
GO:0010648 | negative regulation of cell communication | 22.2222 | 5 | no |
GO:0023057 | negative regulation of signaling | 22.2222 | 4 | no |
GO:0048585 | negative regulation of response to stimulus | 22.2222 | 4 | no |
GO:0042981 | regulation of apoptotic process | 22.2222 | 5 | no |
GO:0043067 | regulation of programmed cell death | 22.2222 | 4 | no |
GO:0021762 | substantia nigra development | 6.6667 | 4 | yes |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GNAI1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
GNAI3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
RPB1_HUMAN | [view interactions] | Low throughput | no | no |
GNAI2_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
SQSTM_HUMAN | [view interactions] | Low throughput | no | yes |
GBG13_HUMAN | [view interactions] | Low throughput | no | no |
DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GALK2_HUMAN | [view interactions] | High throughput | no | yes |
HXB5_HUMAN | [view interactions] | High throughput | no | no |
CXB7_HUMAN | [view interactions] | High throughput | no | no |
PACC1_HUMAN | [view interactions] | High throughput | no | no |
SDC1_HUMAN | [view interactions] | High throughput | no | no |
FZD10_HUMAN | [view interactions] | High throughput | no | no |
RSBN1_HUMAN | [view interactions] | High throughput | no | yes |
KCNJ5_HUMAN | [view interactions] | High throughput | no | yes |
TFAP4_HUMAN | [view interactions] | High throughput | no | yes |
GP161_HUMAN | [view interactions] | High throughput | no | yes |
KCND2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG4_HUMAN | [view interactions] | High throughput | no | no |
GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
SEHL2_HUMAN | [view interactions] | High throughput | no | no |
DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TP4A2_HUMAN | [view interactions] | High throughput | no | yes |
NPC1_HUMAN | [view interactions] | High throughput | no | yes |
TNFA_HUMAN | [view interactions] | High throughput | no | no |
XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ESR1_HUMAN | [view interactions] | High throughput | no | no |
KLF16_HUMAN | [view interactions] | High throughput | no | yes |
INSR_HUMAN | [view interactions] | High throughput | no | yes |
CD177_HUMAN | [view interactions] | High throughput | no | no |
ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
CAC1C_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CASP6_HUMAN | [view interactions] | High throughput | no | no |
SHLB1_HUMAN | [view interactions] | High throughput | no | yes |
RIPK3_HUMAN | [view interactions] | High throughput | no | no |
MTR1A_HUMAN | [view interactions] | High throughput | no | no |
MTR1B_HUMAN | [view interactions] | High throughput | no | yes |
CDK1_HUMAN | [view interactions] | High throughput | no | no |
HAUS4_HUMAN | [view interactions] | High throughput | no | yes |
SCC4_HUMAN | [view interactions] | High throughput | no | no |
TRI69_HUMAN | [view interactions] | High throughput | no | no |
HAUS1_HUMAN | [view interactions] | High throughput | no | yes |
CDK18_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ERBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
NUDC_HUMAN | [view interactions] | High throughput | no | yes |
FKBPL_HUMAN | [view interactions] | High throughput | no | yes |
PFD5_HUMAN | [view interactions] | High throughput | no | yes |
HXK1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
H31_HUMAN | [view interactions] | High throughput | no | yes |
GBGT2_HUMAN | [view interactions] | High throughput | no | no |
GBG5_HUMAN | [view interactions] | High throughput | no | no |
GBG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CEP97_HUMAN | [view interactions] | High throughput | no | yes |
GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RGS6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PHLP_HUMAN | [view interactions] | High throughput | no | yes |
FBX6_HUMAN | [view interactions] | High throughput | no | yes |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ERR2_HUMAN | [view interactions] | High throughput | no | no |
ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
LIMC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
LRIQ3_HUMAN | [view interactions] | High throughput | no | no |
ANR12_HUMAN | [view interactions] | High throughput | no | yes |
TSN17_HUMAN | [view interactions] | High throughput | no | yes |
DFFA_HUMAN | [view interactions] | High throughput | no | yes |
T185A_HUMAN | [view interactions] | High throughput | no | no |
MEIS2_HUMAN | [view interactions] | High throughput | no | yes |
NR2E1_HUMAN | [view interactions] | High throughput | no | yes |
ZNT4_HUMAN | [view interactions] | High throughput | no | no |
RD3_HUMAN | [view interactions] | High throughput | no | no |
CCNL2_HUMAN | [view interactions] | High throughput | no | yes |
MB3L1_HUMAN | [view interactions] | High throughput | no | no |
CUL4A_HUMAN | [view interactions] | High throughput | no | no |
OXDA_HUMAN | [view interactions] | High throughput | no | no |
PKHG5_HUMAN | [view interactions] | High throughput | no | yes |
NTRK3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CP2S1_HUMAN | [view interactions] | High throughput | no | no |
ARI1_HUMAN | [view interactions] | High throughput | no | yes |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBQL2_HUMAN | [view interactions] | High throughput | no | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
FACD2_HUMAN | [view interactions] | High throughput | no | no |
CTRO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
SKA3_HUMAN | [view interactions] | High throughput | no | no |
GBG10_HUMAN | [view interactions] | High throughput | no | no |
GBG8_HUMAN | [view interactions] | High throughput | no | no |
GBG1_HUMAN | [view interactions] | High throughput | no | no |
GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOH_HUMAN | [view interactions] | High throughput | no | yes |
RHOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RHOJ_HUMAN | [view interactions] | High throughput | no | yes |
RAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOG_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
RHOC_HUMAN | [view interactions] | High throughput | no | no |
RND2_HUMAN | [view interactions] | High throughput | no | no |
CDC42_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KCTD2_HUMAN | [view interactions] | High throughput | no | no |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
KCD17_HUMAN | [view interactions] | High throughput | no | yes |
GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
TRI67_HUMAN | [view interactions] | High throughput | no | no |
PRRT2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CFAH_HUMAN | [view interactions] | High throughput | no | no |
CSK_HUMAN | [view interactions] | High throughput | no | yes |
GBG11_HUMAN | [view interactions] | High throughput | no | no |
GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PTEN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNA11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MGST1_HUMAN | [view interactions] | High throughput | no | no |
ADT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
VDAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TOM5_HUMAN | [view interactions] | High throughput | no | yes |
VDAC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MTCH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
OCAD1_HUMAN | [view interactions] | High throughput | no | yes |
CATL1_HUMAN | [view interactions] | High throughput | no | yes |
T106B_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |