GBG7_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum . [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBG7_HUMAN |
|---|---|---|---|---|
| GO:0003924 | GTPase activity | 54.5455 | 7 | no |
| GO:0016462 | pyrophosphatase activity | 54.5455 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 54.5455 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 54.5455 | 6 | no |
| GO:0030159 | signaling receptor complex adaptor activity | 36.3636 | 4 | no |
| GO:0019001 | guanyl nucleotide binding | 27.2727 | 6 | no |
| GO:0032555 | purine ribonucleotide binding | 27.2727 | 4 | no |
| GO:0032561 | guanyl ribonucleotide binding | 27.2727 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.2727 | 4 | no |
| GO:0043168 | anion binding | 27.2727 | 4 | no |
| GO:0043169 | cation binding | 27.2727 | 4 | no |
| GO:0046872 | metal ion binding | 27.2727 | 5 | no |
| GO:0000166 | nucleotide binding | 27.2727 | 4 | no |
| GO:0001664 | G protein-coupled receptor binding | 27.2727 | 4 | no |
| GO:0005525 | GTP binding | 27.2727 | 5 | no |
| GO:0017076 | purine nucleotide binding | 27.2727 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBG7_HUMAN |
|---|---|---|---|---|
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 36.3636 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 36.3636 | 4 | no |
| GO:0009966 | regulation of signal transduction | 27.2727 | 4 | yes |
| GO:0010646 | regulation of cell communication | 27.2727 | 4 | yes |
| GO:0010959 | regulation of metal ion transport | 27.2727 | 6 | no |
| GO:0043269 | regulation of monoatomic ion transport | 27.2727 | 5 | no |
| GO:0051049 | regulation of transport | 27.2727 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.2727 | 4 | no |
| GO:0007193 | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | 27.2727 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 27.2727 | 4 | no |
| GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 18.1818 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| GBB1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RIC8B_HUMAN | [view interactions] | Low throughput | no | yes |
| KCNK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| S2541_HUMAN | [view interactions] | High throughput | no | no |
| GNAI3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| PPA6_HUMAN | [view interactions] | High throughput | no | no |
| MPP3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB3_HUMAN | [view interactions] | High throughput | no | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UIF_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| GLUC_HUMAN | [view interactions] | High throughput | no | no |
| CENPM_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD2_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| NUFP1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |