Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

GBG7_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Plays a role in the regulation of adenylyl cyclase signaling in certain regions of the brain. Plays a role in the formation or stabilzation of a G protein heterotrimer (G(olf) subunit alpha-beta-gamma-7) that is required for adenylyl cyclase activity in the striatum . [View more on UniProt]

Protein features

Binary interactions with known binding regions

Interacting region for partners were not defined.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in GBG7_HUMAN
GO:0003924 GTPase activity 36.8421 7 no
GO:0016462 pyrophosphatase activity 36.8421 5 no
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 36.8421 4 no
GO:0017111 ribonucleoside triphosphate phosphatase activity 36.8421 6 no
GO:0046872 metal ion binding 31.5789 4 no
GO:0017076 purine nucleotide binding 26.3158 4 no
GO:0032555 purine ribonucleotide binding 26.3158 4 no
GO:0035639 purine ribonucleoside triphosphate binding 26.3158 4 no
GO:0030159 signaling receptor complex adaptor activity 21.0526 4 no
GO:0004930 G protein-coupled receptor activity 21.0526 4 no
GO:0001664 G protein-coupled receptor binding 21.0526 4 no
GO:0005525 GTP binding 21.0526 5 no
GO:0019001 guanyl nucleotide binding 21.0526 5 no
GO:0032561 guanyl ribonucleotide binding 21.0526 5 no

Biological process

Term Name % Distance from top the of the tree Annotated in GBG7_HUMAN
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 42.1053 4 no
GO:0048522 positive regulation of cellular process 42.1053 4 no
GO:0051049 regulation of transport 42.1053 4 no
GO:0009966 regulation of signal transduction 36.8421 4 yes
GO:0010646 regulation of cell communication 36.8421 4 yes
GO:0043269 regulation of ion transport 36.8421 5 no
GO:0043085 positive regulation of catalytic activity 36.8421 4 no
GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 31.5789 5 no
GO:0048523 negative regulation of cellular process 31.5789 4 no
GO:0044057 regulation of system process 26.3158 4 no
GO:0010959 regulation of metal ion transport 26.3158 6 no
GO:0034762 regulation of transmembrane transport 26.3158 4 no
GO:0034765 regulation of ion transmembrane transport 26.3158 5 no
GO:0048584 positive regulation of response to stimulus 26.3158 4 no
GO:0051050 positive regulation of transport 26.3158 4 no
GO:0051924 regulation of calcium ion transport 26.3158 7 no
GO:0051336 regulation of hydrolase activity 26.3158 4 no
GO:1902531 regulation of intracellular signal transduction 26.3158 5 no
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 21.0526 4 no
GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 21.0526 4 no
GO:0095500 acetylcholine receptor signaling pathway 21.0526 4 no
GO:0099537 trans-synaptic signaling 21.0526 4 no
GO:1903169 regulation of calcium ion transmembrane transport 21.0526 7 no
GO:1904062 regulation of cation transmembrane transport 21.0526 6 no
GO:0033993 response to lipid 21.0526 4 no
GO:0009893 positive regulation of metabolic process 21.0526 4 no
GO:0010941 regulation of cell death 21.0526 4 no
GO:0031323 regulation of cellular metabolic process 21.0526 4 no
GO:0031325 positive regulation of cellular metabolic process 21.0526 5 no
GO:0042127 regulation of cell population proliferation 21.0526 4 no
GO:0042981 regulation of apoptotic process 21.0526 6 no
GO:0043066 negative regulation of apoptotic process 21.0526 7 no
GO:0043067 regulation of programmed cell death 21.0526 5 no
GO:0043069 negative regulation of programmed cell death 21.0526 6 no
GO:0060548 negative regulation of cell death 21.0526 5 no
GO:0009967 positive regulation of signal transduction 21.0526 5 no
GO:0010647 positive regulation of cell communication 21.0526 5 no
GO:0023056 positive regulation of signaling 21.0526 4 no
GO:0032880 regulation of protein localization 21.0526 5 no
GO:0043408 regulation of MAPK cascade 21.0526 6 no
GO:0043410 positive regulation of MAPK cascade 21.0526 7 no
GO:0060341 regulation of cellular localization 21.0526 4 no
GO:1902533 positive regulation of intracellular signal transduction 21.0526 6 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 10.5263 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
KCNK2_HUMAN [view interactions] Low throughput no no
GBB1_HUMAN [view entry] [view interactions] Low throughput yes yes
RIC8B_HUMAN [view interactions] Low throughput no yes
NUFP1_HUMAN [view interactions] High throughput no yes
GNAI1_HUMAN [view entry] [view interactions] High throughput yes yes
S2541_HUMAN [view interactions] High throughput no no
GNAI3_HUMAN [view entry] [view interactions] High throughput yes yes
ITM2B_HUMAN [view interactions] High throughput no yes
GORS2_HUMAN [view interactions] High throughput no yes
PPA6_HUMAN [view interactions] High throughput no no
MPP3_HUMAN [view entry] [view interactions] High throughput yes yes
GNB5_HUMAN [view entry] [view interactions] High throughput yes yes
GBB2_HUMAN [view entry] [view interactions] High throughput yes yes
GBB3_HUMAN [view interactions] High throughput no yes
GBB4_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
UIF_HUMAN [view interactions] High throughput no yes
GNAI2_HUMAN [view entry] [view interactions] High throughput yes yes
CD81_HUMAN [view interactions] High throughput no no
GLUC_HUMAN [view interactions] High throughput no no
CENPM_HUMAN [view interactions] High throughput no yes
KCTD2_HUMAN [view interactions] High throughput no no
KCTD5_HUMAN [view interactions] High throughput no no
ADCY3_HUMAN [view interactions] Computational no yes
GNAO_HUMAN [view entry] [view interactions] Computational yes yes
LPAR6_HUMAN [view interactions] Computational no no
LPAR2_HUMAN [view interactions] Computational no yes
GBG13_HUMAN [view interactions] Computational no no
CACB2_HUMAN [view interactions] Computational no yes
SRC_HUMAN [view entry] [view interactions] Computational yes no
LPAR1_HUMAN [view entry] [view interactions] Computational yes no
LPAR4_HUMAN [view interactions] Computational no no
PAR1_HUMAN [view entry] [view interactions] Computational yes yes
GNAL_HUMAN [view interactions] Computational no yes
ACM2_HUMAN [view entry] [view interactions] Computational yes yes
ACM1_HUMAN [view entry] [view interactions] Computational yes yes
CACB3_HUMAN [view entry] [view interactions] Computational yes no
CAC1D_HUMAN [view interactions] Computational no yes
GBG1_HUMAN [view interactions] Computational no no
LPAR3_HUMAN [view interactions] Computational no no
CAC1C_HUMAN [view entry] [view interactions] Computational yes no
CA2D2_HUMAN [view entry] [view interactions] Computational yes yes
LPAR5_HUMAN [view interactions] Computational no yes