Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCNK2_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Does not display channel activity but reduces the channel activity of isoform 1 and isoform 2 and reduces cell surface expression of isoform 2. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KCNK2_HUMAN
GO:0015459 potassium channel regulator activity 33.3333 5 yes
GO:0099106 ion channel regulator activity 33.3333 4 yes
GO:0005216 monoatomic ion channel activity 22.2222 4 yes
GO:0005244 voltage-gated monoatomic ion channel activity 22.2222 5 yes
GO:0005249 voltage-gated potassium channel activity 22.2222 7 yes
GO:0005261 monoatomic cation channel activity 22.2222 5 yes
GO:0005267 potassium channel activity 22.2222 6 yes
GO:0008200 ion channel inhibitor activity 22.2222 5 yes
GO:0008324 monoatomic cation transmembrane transporter activity 22.2222 4 yes
GO:0015079 potassium ion transmembrane transporter activity 22.2222 6 yes
GO:0015267 channel activity 22.2222 4 yes
GO:0015271 outward rectifier potassium channel activity 22.2222 8 yes
GO:0016248 channel inhibitor activity 22.2222 4 yes
GO:0019870 potassium channel inhibitor activity 22.2222 6 yes
GO:0022832 voltage-gated channel activity 22.2222 6 yes
GO:0022836 gated channel activity 22.2222 5 yes
GO:0022840 leak channel activity 22.2222 6 yes
GO:0022841 potassium ion leak channel activity 22.2222 7 yes
GO:0022842 narrow pore channel activity 22.2222 5 yes
GO:0022843 voltage-gated monoatomic cation channel activity 22.2222 6 yes
GO:0022890 inorganic cation transmembrane transporter activity 22.2222 4 yes
GO:0046873 metal ion transmembrane transporter activity 22.2222 5 yes
GO:0008179 adenylate cyclase binding 22.2222 4 no

Biological process

Term Name % Distance from top the of the tree Annotated in KCNK2_HUMAN
GO:0048522 positive regulation of cellular process 44.4444 4 yes
GO:0048584 positive regulation of response to stimulus 44.4444 4 yes
GO:0080090 regulation of primary metabolic process 33.3333 4 yes
GO:2000026 regulation of multicellular organismal development 33.3333 4 yes
GO:0071310 cellular response to organic substance 33.3333 4 no
GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 33.3333 4 no
GO:0009966 regulation of signal transduction 33.3333 4 no
GO:0010646 regulation of cell communication 33.3333 4 no
GO:0009889 regulation of biosynthetic process 33.3333 4 yes
GO:0010556 regulation of macromolecule biosynthetic process 33.3333 5 yes
GO:0019219 regulation of nucleobase-containing compound metabolic process 33.3333 5 yes
GO:0031323 regulation of cellular metabolic process 33.3333 4 yes
GO:0031326 regulation of cellular biosynthetic process 33.3333 5 yes
GO:0045926 negative regulation of growth 33.3333 4 yes
GO:0048523 negative regulation of cellular process 33.3333 4 yes
GO:0048638 regulation of developmental growth 33.3333 4 yes
GO:0048640 negative regulation of developmental growth 33.3333 5 yes
GO:0051093 negative regulation of developmental process 33.3333 4 yes
GO:0051241 negative regulation of multicellular organismal process 33.3333 4 yes
GO:0060255 regulation of macromolecule metabolic process 33.3333 4 yes
GO:0060420 regulation of heart growth 22.2222 5 yes
GO:0061117 negative regulation of heart growth 22.2222 6 yes
GO:0071453 cellular response to oxygen levels 22.2222 4 yes
GO:0071456 cellular response to hypoxia 22.2222 4 yes
GO:0071805 potassium ion transmembrane transport 22.2222 5 yes
GO:0080134 regulation of response to stress 22.2222 4 yes
GO:0080135 regulation of cellular response to stress 22.2222 4 yes
GO:0098655 monoatomic cation transmembrane transport 22.2222 4 yes
GO:0098662 inorganic cation transmembrane transport 22.2222 4 yes
GO:1900037 regulation of cellular response to hypoxia 22.2222 5 yes
GO:1900039 positive regulation of cellular response to hypoxia 22.2222 5 yes
GO:2000278 regulation of DNA biosynthetic process 22.2222 6 yes
GO:2000279 negative regulation of DNA biosynthetic process 22.2222 7 yes
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 22.2222 5 no
GO:0008277 regulation of G protein-coupled receptor signaling pathway 22.2222 5 no
GO:0009967 positive regulation of signal transduction 22.2222 5 no
GO:0010243 response to organonitrogen compound 22.2222 4 no
GO:0010647 positive regulation of cell communication 22.2222 5 no
GO:0010738 regulation of protein kinase A signaling 22.2222 6 no
GO:0010959 regulation of metal ion transport 22.2222 6 no
GO:0023056 positive regulation of signaling 22.2222 4 no
GO:0031279 regulation of cyclase activity 22.2222 4 no
GO:0034762 regulation of transmembrane transport 22.2222 4 no
GO:0034764 positive regulation of transmembrane transport 22.2222 5 no
GO:0034765 regulation of monoatomic ion transmembrane transport 22.2222 5 no
GO:0034767 positive regulation of monoatomic ion transmembrane transport 22.2222 6 no
GO:0043269 regulation of monoatomic ion transport 22.2222 5 no
GO:0043270 positive regulation of monoatomic ion transport 22.2222 5 no
GO:0045761 regulation of adenylate cyclase activity 22.2222 5 no
GO:0050804 modulation of chemical synaptic transmission 22.2222 5 no
GO:0051049 regulation of transport 22.2222 4 no
GO:0051050 positive regulation of transport 22.2222 4 no
GO:0051339 regulation of lyase activity 22.2222 4 no
GO:0071417 cellular response to organonitrogen compound 22.2222 4 no
GO:0099177 regulation of trans-synaptic signaling 22.2222 4 no
GO:1901699 cellular response to nitrogen compound 22.2222 4 no
GO:1901701 cellular response to oxygen-containing compound 22.2222 4 no
GO:1902531 regulation of intracellular signal transduction 22.2222 5 no
GO:1902533 positive regulation of intracellular signal transduction 22.2222 6 no
GO:0003231 cardiac ventricle development 22.2222 4 yes
GO:0006811 monoatomic ion transport 22.2222 4 yes
GO:0006812 monoatomic cation transport 22.2222 5 yes
GO:0006813 potassium ion transport 22.2222 7 yes
GO:0007613 memory 22.2222 4 yes
GO:0008285 negative regulation of cell population proliferation 22.2222 5 yes
GO:0009890 negative regulation of biosynthetic process 22.2222 5 yes
GO:0009892 negative regulation of metabolic process 22.2222 4 yes
GO:0010558 negative regulation of macromolecule biosynthetic process 22.2222 6 yes
GO:0010605 negative regulation of macromolecule metabolic process 22.2222 5 yes
GO:0030001 metal ion transport 22.2222 6 yes
GO:0030322 stabilization of membrane potential 22.2222 4 yes
GO:0031324 negative regulation of cellular metabolic process 22.2222 5 yes
GO:0031327 negative regulation of cellular biosynthetic process 22.2222 6 yes
GO:0036293 response to decreased oxygen levels 22.2222 4 yes
GO:0036294 cellular response to decreased oxygen levels 22.2222 5 yes
GO:0042127 regulation of cell population proliferation 22.2222 4 yes
GO:0045934 negative regulation of nucleobase-containing compound metabolic process 22.2222 5 yes
GO:0046620 regulation of organ growth 22.2222 4 yes
GO:0046621 negative regulation of organ growth 22.2222 5 yes
GO:0048678 response to axon injury 22.2222 4 yes
GO:0050890 cognition 22.2222 4 yes
GO:0051052 regulation of DNA metabolic process 22.2222 5 yes
GO:0051053 negative regulation of DNA metabolic process 22.2222 6 yes
GO:0055021 regulation of cardiac muscle tissue growth 22.2222 6 yes
GO:0055022 negative regulation of cardiac muscle tissue growth 22.2222 7 yes
GO:0060043 regulation of cardiac muscle cell proliferation 22.2222 5 yes
GO:0060044 negative regulation of cardiac muscle cell proliferation 22.2222 6 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GBG4_HUMAN [view interactions] Low throughput no no
GBG8_HUMAN [view interactions] Low throughput no no
GBG13_HUMAN [view interactions] Low throughput no no
GBG1_HUMAN [view interactions] Low throughput no no
GBG7_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG3_HUMAN [view entry] [view interactions] Low throughput yes no
GBG2_HUMAN [view entry] [view interactions] Low throughput yes yes
GBG12_HUMAN [view entry] [view interactions] Low throughput yes yes
ADRB2_HUMAN [view entry] [view interactions] Low throughput yes no
AKAP5_HUMAN [view entry] [view interactions] Low throughput yes yes
SORT_HUMAN [view interactions] Low throughput no yes
KCNK2_HUMAN [view entry] [view interactions] Low throughput yes no
FAS_HUMAN [view entry] [view interactions] High throughput yes no