GBG12_HUMAN
Evidence for PS localization
Functions
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
No data found.
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in GBG12_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 34.6939 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 34.6939 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 34.6939 | 4 | no |
| GO:0005524 | ATP binding | 24.4898 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 24.4898 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 24.4898 | 5 | no |
| GO:0016462 | pyrophosphatase activity | 22.4490 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 22.4490 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 22.4490 | 6 | no |
| GO:0003924 | GTPase activity | 20.4082 | 7 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in GBG12_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 53.0612 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 46.9388 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 46.9388 | 4 | no |
| GO:0010646 | regulation of cell communication | 44.8980 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 42.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | no |
| GO:0009966 | regulation of signal transduction | 42.8571 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.8163 | 4 | no |
| GO:0051049 | regulation of transport | 36.7347 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 34.6939 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 32.6531 | 5 | no |
| GO:0051128 | regulation of cellular component organization | 30.6122 | 4 | no |
| GO:0006996 | organelle organization | 28.5714 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0007188 | adenylate cyclase-modulating G protein-coupled receptor signaling pathway | 26.5306 | 4 | no |
| GO:0010468 | regulation of gene expression | 26.5306 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 26.5306 | 5 | no |
| GO:0023056 | positive regulation of signaling | 26.5306 | 4 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.5306 | 4 | no |
| GO:0033043 | regulation of organelle organization | 24.4898 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 24.4898 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 24.4898 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 24.4898 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 24.4898 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 24.4898 | 5 | no |
| GO:0043269 | regulation of ion transport | 24.4898 | 5 | no |
| GO:0051050 | positive regulation of transport | 24.4898 | 4 | no |
| GO:0036211 | protein modification process | 24.4898 | 4 | no |
| GO:0043412 | macromolecule modification | 24.4898 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 24.4898 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 24.4898 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 22.4490 | 6 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 22.4490 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 22.4490 | 5 | no |
| GO:0071310 | cellular response to organic substance | 22.4490 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 22.4490 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 22.4490 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 22.4490 | 5 | no |
| GO:0043408 | regulation of MAPK cascade | 22.4490 | 6 | no |
| GO:0031399 | regulation of protein modification process | 20.4082 | 6 | no |
| GO:0032970 | regulation of actin filament-based process | 20.4082 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.4082 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 20.4082 | 6 | no |
| GO:0008104 | protein localization | 20.4082 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.4082 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 20.4082 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 20.4082 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 20.4082 | 6 | no |
| GO:0034762 | regulation of transmembrane transport | 20.4082 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 20.4082 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 20.4082 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.4082 | 5 | no |
| GO:0010941 | regulation of cell death | 20.4082 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 20.4082 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 20.4082 | 5 | no |
| GO:0051336 | regulation of hydrolase activity | 20.4082 | 4 | no |
| GO:0032880 | regulation of protein localization | 20.4082 | 5 | no |
| GO:0060341 | regulation of cellular localization | 20.4082 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| KCNK2_HUMAN | [view interactions] | Low throughput | no | no |
| GBB3_HUMAN | [view interactions] | Low throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MEF2A_HUMAN | [view interactions] | High throughput | no | yes |
| TBP_HUMAN | [view interactions] | High throughput | no | yes |
| WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| COPE_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| GLP1R_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
| RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YAP1_HUMAN | [view interactions] | High throughput | no | yes |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| PRC1_HUMAN | [view interactions] | High throughput | no | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| APR_HUMAN | [view interactions] | High throughput | no | yes |
| PD1L1_HUMAN | [view interactions] | High throughput | no | no |
| LACC1_HUMAN | [view interactions] | High throughput | no | yes |
| GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| F264_HUMAN | [view interactions] | High throughput | no | no |
| BANP_HUMAN | [view interactions] | High throughput | no | yes |
| GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
| PHLP_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| TMPS2_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| CLC4D_HUMAN | [view interactions] | High throughput | no | no |
| CLC4E_HUMAN | [view interactions] | High throughput | no | no |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KCTD2_HUMAN | [view interactions] | High throughput | no | no |
| PLK4_HUMAN | [view interactions] | High throughput | no | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CYB5_HUMAN | [view interactions] | High throughput | no | no |
| NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
| GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBG11_HUMAN | [view interactions] | High throughput | no | no |
| KCRS_HUMAN | [view interactions] | High throughput | no | no |
| GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KGP1_HUMAN | [view interactions] | High throughput | no | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FHL2_HUMAN | [view interactions] | High throughput | no | yes |
| DUX4_HUMAN | [view interactions] | High throughput | no | no |
| BLK_HUMAN | [view interactions] | High throughput | no | no |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| KCTD5_HUMAN | [view interactions] | High throughput | no | no |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| 2ABD_HUMAN | [view interactions] | High throughput | no | yes |
| GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
| STAM2_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MED23_HUMAN | [view interactions] | High throughput | no | no |
| MED20_HUMAN | [view interactions] | High throughput | no | no |
| CDN1A_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KC1G1_HUMAN | [view interactions] | High throughput | no | no |
| KLF16_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA2_HUMAN | [view interactions] | High throughput | no | no |
| INSRR_HUMAN | [view interactions] | High throughput | no | no |
| IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| CD81_HUMAN | [view interactions] | High throughput | no | no |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK3_HUMAN | [view interactions] | High throughput | no | no |
| CBX1_HUMAN | [view interactions] | High throughput | no | yes |
| POC1B_HUMAN | [view interactions] | High throughput | no | no |
| SCC4_HUMAN | [view interactions] | High throughput | no | no |
| TRI69_HUMAN | [view interactions] | High throughput | no | no |
| Z518A_HUMAN | [view interactions] | High throughput | no | no |
| ACTS_HUMAN | [view interactions] | High throughput | no | no |
| FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC7_HUMAN | [view interactions] | High throughput | no | no |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| LPAR2_HUMAN | [view interactions] | Computational | no | yes |
| LPAR6_HUMAN | [view interactions] | Computational | no | no |
| PAR4_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| FGD1_HUMAN | [view interactions] | Computational | no | no |
| PAK4_HUMAN | [view interactions] | Computational | no | yes |
| GNAI3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ACM4_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| FGD3_HUMAN | [view interactions] | Computational | no | yes |
| RASA2_HUMAN | [view interactions] | Computational | no | yes |
| PAR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| LPAR4_HUMAN | [view interactions] | Computational | no | no |
| LPAR1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| SRC_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| ACM2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| GBG13_HUMAN | [view interactions] | Computational | no | no |
| PAK6_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CACB2_HUMAN | [view interactions] | Computational | no | yes |
| BKRB2_HUMAN | [view interactions] | Computational | no | yes |
| ACM3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PAK2_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PAK3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| BKRB1_HUMAN | [view interactions] | Computational | no | yes |
| CACB3_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| GNA12_HUMAN | [view interactions] | Computational | no | no |
| ACM1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CA2D2_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1C_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| LPAR3_HUMAN | [view interactions] | Computational | no | no |
| LPAR5_HUMAN | [view interactions] | Computational | no | yes |
| PAK5_HUMAN | [view interactions] | Computational | no | yes |
| ACM5_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| CAC1D_HUMAN | [view interactions] | Computational | no | yes |
| PAK1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |