GBG12_HUMAN
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. [View more on UniProt]
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Interacting region for partners were not defined.
No data found.
No data found.
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Molecular function
Term | Name | % | Distance from the top of the tree | Annotated in GBG12_HUMAN |
---|---|---|---|---|
GO:0000166 | nucleotide binding | 38.2353 | 4 | no |
GO:0017076 | purine nucleotide binding | 38.2353 | 5 | no |
GO:0032555 | purine ribonucleotide binding | 35.2941 | 4 | no |
GO:0035639 | purine ribonucleoside triphosphate binding | 35.2941 | 4 | no |
GO:0043168 | anion binding | 35.2941 | 4 | no |
GO:0016462 | pyrophosphatase activity | 32.3529 | 5 | no |
GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 32.3529 | 4 | no |
GO:0017111 | ribonucleoside triphosphate phosphatase activity | 32.3529 | 6 | no |
GO:0030554 | adenyl nucleotide binding | 26.4706 | 6 | no |
GO:0003924 | GTPase activity | 26.4706 | 7 | no |
GO:0005524 | ATP binding | 23.5294 | 5 | no |
GO:0032559 | adenyl ribonucleotide binding | 23.5294 | 5 | no |
Biological process
Term | Name | % | Distance from top the of the tree | Annotated in GBG12_HUMAN |
---|---|---|---|---|
GO:0048522 | positive regulation of cellular process | 52.9412 | 4 | no |
GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
GO:0048523 | negative regulation of cellular process | 47.0588 | 4 | no |
GO:0060255 | regulation of macromolecule metabolic process | 44.1176 | 4 | no |
GO:0080090 | regulation of primary metabolic process | 44.1176 | 4 | no |
GO:0010646 | regulation of cell communication | 41.1765 | 4 | no |
GO:0009966 | regulation of signal transduction | 38.2353 | 4 | no |
GO:0051049 | regulation of transport | 35.2941 | 4 | no |
GO:0051246 | regulation of protein metabolic process | 35.2941 | 5 | no |
GO:0051128 | regulation of cellular component organization | 32.3529 | 4 | no |
GO:0009889 | regulation of biosynthetic process | 29.4118 | 4 | no |
GO:0010556 | regulation of macromolecule biosynthetic process | 29.4118 | 5 | no |
GO:0031326 | regulation of cellular biosynthetic process | 29.4118 | 5 | no |
GO:1902531 | regulation of intracellular signal transduction | 29.4118 | 5 | no |
GO:0008104 | protein localization | 29.4118 | 4 | no |
GO:0010468 | regulation of gene expression | 26.4706 | 6 | no |
GO:0071310 | cellular response to organic substance | 26.4706 | 4 | no |
GO:0009892 | negative regulation of metabolic process | 23.5294 | 4 | no |
GO:0032880 | regulation of protein localization | 23.5294 | 5 | no |
GO:0060341 | regulation of cellular localization | 23.5294 | 4 | no |
GO:0010647 | positive regulation of cell communication | 23.5294 | 5 | no |
GO:0023056 | positive regulation of signaling | 23.5294 | 4 | no |
GO:0048584 | positive regulation of response to stimulus | 23.5294 | 4 | no |
GO:0044087 | regulation of cellular component biogenesis | 23.5294 | 4 | no |
GO:0051240 | positive regulation of multicellular organismal process | 23.5294 | 4 | no |
GO:0006996 | organelle organization | 20.5882 | 4 | no |
GO:0010243 | response to organonitrogen compound | 20.5882 | 4 | no |
GO:0010605 | negative regulation of macromolecule metabolic process | 20.5882 | 5 | no |
GO:0031324 | negative regulation of cellular metabolic process | 20.5882 | 5 | no |
GO:0051050 | positive regulation of transport | 20.5882 | 4 | no |
GO:0051094 | positive regulation of developmental process | 20.5882 | 4 | no |
GO:0009967 | positive regulation of signal transduction | 20.5882 | 5 | no |
GO:0014070 | response to organic cyclic compound | 20.5882 | 4 | no |
GO:0072657 | protein localization to membrane | 20.5882 | 4 | no |
GO:0019220 | regulation of phosphate metabolic process | 20.5882 | 6 | no |
GO:0031399 | regulation of protein modification process | 20.5882 | 6 | no |
GO:0051130 | positive regulation of cellular component organization | 20.5882 | 5 | no |
GO:0051174 | regulation of phosphorus metabolic process | 20.5882 | 5 | no |
Disease
No data found.
Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
---|---|---|---|---|
GBB3_HUMAN | [view interactions] | Low throughput | no | yes |
KCNK2_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
ZBT18_HUMAN | [view interactions] | High throughput | no | yes |
STAM2_HUMAN | [view interactions] | High throughput | no | yes |
CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MED23_HUMAN | [view interactions] | High throughput | no | no |
MED20_HUMAN | [view interactions] | High throughput | no | no |
CDN1A_HUMAN | [view interactions] | High throughput | no | no |
CFTR_HUMAN | [view interactions] | High throughput | no | no |
BCKD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GSK3B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
TWF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
PIM3_HUMAN | [view interactions] | High throughput | no | no |
HASP_HUMAN | [view interactions] | High throughput | no | yes |
CDKL2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KC1G1_HUMAN | [view interactions] | High throughput | no | no |
KLF16_HUMAN | [view interactions] | High throughput | no | yes |
EPHA1_HUMAN | [view interactions] | High throughput | no | yes |
EPHA2_HUMAN | [view interactions] | High throughput | no | no |
INSRR_HUMAN | [view interactions] | High throughput | no | no |
IF4A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
HSC20_HUMAN | [view interactions] | High throughput | no | yes |
CD81_HUMAN | [view interactions] | High throughput | no | no |
BMI1_HUMAN | [view interactions] | High throughput | no | yes |
RIPK3_HUMAN | [view interactions] | High throughput | no | no |
CBX1_HUMAN | [view interactions] | High throughput | no | yes |
POC1B_HUMAN | [view interactions] | High throughput | no | no |
SCC4_HUMAN | [view interactions] | High throughput | no | no |
TRI69_HUMAN | [view interactions] | High throughput | no | no |
Z518A_HUMAN | [view interactions] | High throughput | no | no |
ACTS_HUMAN | [view interactions] | High throughput | no | no |
FHI2A_HUMAN | [view interactions] | High throughput | no | yes |
HDAC7_HUMAN | [view interactions] | High throughput | no | no |
GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
PAN2_HUMAN | [view interactions] | High throughput | no | no |
ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MEF2A_HUMAN | [view interactions] | High throughput | no | yes |
TBP_HUMAN | [view interactions] | High throughput | no | yes |
WDTC1_HUMAN | [view interactions] | High throughput | no | yes |
RAD18_HUMAN | [view interactions] | High throughput | no | yes |
HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
COPE_HUMAN | [view interactions] | High throughput | no | yes |
DX39B_HUMAN | [view interactions] | High throughput | no | no |
ESR2_HUMAN | [view interactions] | High throughput | no | no |
GLP1R_HUMAN | [view interactions] | High throughput | no | no |
VIR_HUMAN | [view interactions] | High throughput | no | yes |
ACTC_HUMAN | [view interactions] | High throughput | no | no |
UBP14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CLUA1_HUMAN | [view interactions] | High throughput | no | yes |
RGS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
YAP1_HUMAN | [view interactions] | High throughput | no | yes |
TFCP2_HUMAN | [view interactions] | High throughput | no | no |
ANLN_HUMAN | [view interactions] | High throughput | no | yes |
CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
ECT2_HUMAN | [view interactions] | High throughput | no | no |
KIF14_HUMAN | [view interactions] | High throughput | no | no |
KI20A_HUMAN | [view interactions] | High throughput | no | yes |
KIF23_HUMAN | [view interactions] | High throughput | no | yes |
PRC1_HUMAN | [view interactions] | High throughput | no | yes |
NUPR1_HUMAN | [view interactions] | High throughput | no | no |
CFAD_HUMAN | [view interactions] | High throughput | no | no |
FNDC5_HUMAN | [view interactions] | High throughput | no | no |
APR_HUMAN | [view interactions] | High throughput | no | yes |
PD1L1_HUMAN | [view interactions] | High throughput | no | no |
LACC1_HUMAN | [view interactions] | High throughput | no | yes |
GNAQ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
F264_HUMAN | [view interactions] | High throughput | no | no |
BANP_HUMAN | [view interactions] | High throughput | no | yes |
GNA13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MSPD2_HUMAN | [view interactions] | High throughput | no | yes |
PHLP_HUMAN | [view interactions] | High throughput | no | yes |
BTF3_HUMAN | [view interactions] | High throughput | no | yes |
SEPT9_HUMAN | [view interactions] | High throughput | no | no |
TMPS2_HUMAN | [view interactions] | High throughput | no | no |
TOP3B_HUMAN | [view interactions] | High throughput | no | no |
IFM1_HUMAN | [view interactions] | High throughput | no | no |
BASI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
IFM3_HUMAN | [view interactions] | High throughput | no | yes |
CLC4D_HUMAN | [view interactions] | High throughput | no | no |
CLC4E_HUMAN | [view interactions] | High throughput | no | no |
CCNF_HUMAN | [view interactions] | High throughput | no | no |
RHOB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KCTD2_HUMAN | [view interactions] | High throughput | no | no |
PLK4_HUMAN | [view interactions] | High throughput | no | yes |
TRI31_HUMAN | [view interactions] | High throughput | no | no |
MYCN_HUMAN | [view interactions] | High throughput | no | no |
MYC_HUMAN | [view interactions] | High throughput | no | yes |
RNF38_HUMAN | [view interactions] | High throughput | no | yes |
HDAC6_HUMAN | [view interactions] | High throughput | no | yes |
DOT1L_HUMAN | [view interactions] | High throughput | no | yes |
MEN1_HUMAN | [view interactions] | High throughput | no | yes |
HSP7C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
UBE2O_HUMAN | [view interactions] | High throughput | no | yes |
CBL_HUMAN | [view interactions] | High throughput | no | yes |
MIDN_HUMAN | [view interactions] | High throughput | no | no |
RICTR_HUMAN | [view interactions] | High throughput | no | yes |
TNIP1_HUMAN | [view interactions] | High throughput | no | yes |
GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
MET_HUMAN | [view interactions] | High throughput | no | yes |
FLOT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
FLOT2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
RAP1A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
KPYM_HUMAN | [view interactions] | High throughput | no | yes |
S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
CYB5_HUMAN | [view interactions] | High throughput | no | no |
NIPS2_HUMAN | [view interactions] | High throughput | no | yes |
GBG2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
CAN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
GBG11_HUMAN | [view interactions] | High throughput | no | no |
KCRS_HUMAN | [view interactions] | High throughput | no | no |
GNB5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
KGP1_HUMAN | [view interactions] | High throughput | no | yes |
MUC18_HUMAN | [view interactions] | High throughput | no | yes |
SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
FHL2_HUMAN | [view interactions] | High throughput | no | yes |
DUX4_HUMAN | [view interactions] | High throughput | no | no |
BLK_HUMAN | [view interactions] | High throughput | no | no |
MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
BMR1A_HUMAN | [view interactions] | High throughput | no | no |
KCTD5_HUMAN | [view interactions] | High throughput | no | no |
FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
2ABD_HUMAN | [view interactions] | High throughput | no | yes |
GBB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |