DUS4_HUMAN
Evidence for PS localization
Functions
Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in DUS4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 29.1667 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 29.1667 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 27.0833 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 27.0833 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 27.0833 | 4 | no |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0003723 | RNA binding | 22.9167 | 4 | no |
| GO:0004722 | protein serine/threonine phosphatase activity | 4.1667 | 4 | yes |
| GO:0004725 | protein tyrosine phosphatase activity | 4.1667 | 4 | yes |
| GO:0008138 | protein tyrosine/serine/threonine phosphatase activity | 4.1667 | 4 | yes |
| GO:0008330 | protein tyrosine/threonine phosphatase activity | 4.1667 | 4 | yes |
| GO:0016791 | phosphatase activity | 4.1667 | 5 | yes |
| GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity | 4.1667 | 5 | yes |
| GO:0033549 | MAP kinase phosphatase activity | 4.1667 | 4 | yes |
| GO:0042578 | phosphoric ester hydrolase activity | 4.1667 | 4 | yes |
| GO:1990439 | MAP kinase serine/threonine phosphatase activity | 4.1667 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in DUS4_HUMAN |
|---|---|---|---|---|
| GO:0060255 | regulation of macromolecule metabolic process | 58.3333 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 56.2500 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 56.2500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 54.1667 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 45.8333 | 4 | no |
| GO:0010468 | regulation of gene expression | 43.7500 | 5 | no |
| GO:0048523 | negative regulation of cellular process | 39.5833 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 39.5833 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.5833 | 5 | no |
| GO:0009889 | regulation of biosynthetic process | 37.5000 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 37.5000 | 5 | no |
| GO:0010646 | regulation of cell communication | 35.4167 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 35.4167 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 35.4167 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 35.4167 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 35.4167 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 33.3333 | 5 | no |
| GO:0009966 | regulation of signal transduction | 31.2500 | 4 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 29.1667 | 5 | no |
| GO:0048584 | positive regulation of response to stimulus | 29.1667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 29.1667 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.0833 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 27.0833 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 27.0833 | 6 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 27.0833 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 27.0833 | 6 | no |
| GO:0008104 | protein localization | 27.0833 | 4 | no |
| GO:0071310 | cellular response to organic substance | 27.0833 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 25.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 25.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 25.0000 | 4 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 25.0000 | 6 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 25.0000 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 25.0000 | 6 | no |
| GO:0010941 | regulation of cell death | 25.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 22.9167 | 4 | yes |
| GO:0043085 | positive regulation of catalytic activity | 22.9167 | 4 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 22.9167 | 6 | no |
| GO:0031399 | regulation of protein modification process | 22.9167 | 6 | no |
| GO:2000145 | regulation of cell motility | 22.9167 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 22.9167 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 22.9167 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 22.9167 | 5 | no |
| GO:0009968 | negative regulation of signal transduction | 20.8333 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 20.8333 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 20.8333 | 4 | yes |
| GO:1902531 | regulation of intracellular signal transduction | 20.8333 | 5 | yes |
| GO:0009967 | positive regulation of signal transduction | 20.8333 | 5 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 20.8333 | 7 | no |
| GO:0051049 | regulation of transport | 20.8333 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 20.8333 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 20.8333 | 8 | no |
| GO:0006996 | organelle organization | 20.8333 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 20.8333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 20.8333 | 5 | no |
| GO:0019220 | regulation of phosphate metabolic process | 20.8333 | 6 | no |
| GO:0030334 | regulation of cell migration | 20.8333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 20.8333 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 20.8333 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 20.8333 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 20.8333 | 5 | no |
| GO:0071702 | organic substance transport | 20.8333 | 4 | no |
| GO:0071705 | nitrogen compound transport | 20.8333 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 16.6667 | 6 | yes |
| GO:0070372 | regulation of ERK1 and ERK2 cascade | 12.5000 | 7 | yes |
| GO:1902532 | negative regulation of intracellular signal transduction | 12.5000 | 6 | yes |
| GO:0043409 | negative regulation of MAPK cascade | 8.3333 | 7 | yes |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 6.2500 | 8 | yes |
| GO:0001706 | endoderm formation | 4.1667 | 4 | yes |
| GO:0016311 | dephosphorylation | 4.1667 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in DUS4_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 6.2500 | 4 | no |
| DOID:331 | central nervous system disease | 6.2500 | 3 | no |
| DOID:0111198 | autosomal dominant distal hereditary motor neuronopathy | 4.1667 | 7 | no |
| DOID:0111206 | distal hereditary motor neuronopathy type 2 | 4.1667 | 8 | no |
| DOID:12377 | spinal muscular atrophy | 4.1667 | 6 | no |
| DOID:231 | motor neuron disease | 4.1667 | 5 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK08_HUMAN | [view interactions] | Low throughput | no | yes |
| MK14_HUMAN | [view interactions] | Low throughput | no | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| DUS4_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| ATX1_HUMAN | [view interactions] | Low throughput | no | yes |
| DPYL1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYO1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSD11_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSDE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSMD3_HUMAN | [view interactions] | High throughput | no | yes |
| MYO1B_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AMY1B_HUMAN | [view interactions] | High throughput | no | no |
| AMY1A_HUMAN | [view interactions] | High throughput | no | no |
| AMY1C_HUMAN | [view interactions] | High throughput | no | no |
| AMYP_HUMAN | [view interactions] | High throughput | no | no |
| AMY2B_HUMAN | [view interactions] | High throughput | no | no |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IMDH2_HUMAN | [view interactions] | High throughput | no | yes |
| CD59_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PLAK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DESP_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EPCAM_HUMAN | [view interactions] | High throughput | no | no |
| PRS6A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYVC_HUMAN | [view interactions] | High throughput | no | yes |
| ITPI2_HUMAN | [view interactions] | High throughput | no | yes |
| CTNA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS7_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD7_HUMAN | [view interactions] | High throughput | no | yes |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS8_HUMAN | [view interactions] | High throughput | no | yes |
| PRS10_HUMAN | [view interactions] | High throughput | no | yes |
| GBB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GBB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRSF6_HUMAN | [view interactions] | High throughput | no | yes |
| DSG2_HUMAN | [view interactions] | High throughput | no | no |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SF3A1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRM1_HUMAN | [view interactions] | High throughput | no | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MISP_HUMAN | [view interactions] | High throughput | no | no |
| HS105_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PKP2_HUMAN | [view interactions] | High throughput | no | yes |
| LYAR_HUMAN | [view interactions] | High throughput | no | no |
| SYLC_HUMAN | [view interactions] | High throughput | no | yes |
| GBG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3BP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PTN12_HUMAN | [view interactions] | High throughput | no | yes |
| FETUA_HUMAN | [view interactions] | High throughput | no | no |
| HSPB1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| BIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRS6B_HUMAN | [view interactions] | High throughput | no | yes |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| CCAR2_HUMAN | [view interactions] | High throughput | no | yes |
| GID8_HUMAN | [view interactions] | High throughput | no | yes |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TECR_HUMAN | [view interactions] | High throughput | no | yes |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF3C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NMDZ1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRAF1_HUMAN | [view interactions] | High throughput | no | no |
| LZTS2_HUMAN | [view interactions] | High throughput | no | no |
| GORS2_HUMAN | [view interactions] | High throughput | no | yes |
| ZN426_HUMAN | [view interactions] | High throughput | no | yes |
| ZN655_HUMAN | [view interactions] | High throughput | no | yes |
| AP4AT_HUMAN | [view interactions] | High throughput | no | no |
| LYSM1_HUMAN | [view interactions] | High throughput | no | no |
| MK09_HUMAN | [view interactions] | High throughput | no | yes |
| PKHF2_HUMAN | [view interactions] | High throughput | no | yes |
| LYSM2_HUMAN | [view interactions] | High throughput | no | yes |
| NOXA1_HUMAN | [view interactions] | High throughput | no | yes |
| NMDE2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| DC2I2_HUMAN | [view interactions] | High throughput | no | yes |
| COA7_HUMAN | [view interactions] | High throughput | no | yes |
| ABHEB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VPS29_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AP3S1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| NXN_HUMAN | [view interactions] | High throughput | no | no |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SDHA_HUMAN | [view interactions] | High throughput | no | yes |
| ACTY_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MP2K6_HUMAN | [view interactions] | High throughput | no | yes |
| DUS12_HUMAN | [view interactions] | High throughput | no | no |
| NUP50_HUMAN | [view interactions] | High throughput | no | yes |
| TNPO3_HUMAN | [view interactions] | High throughput | no | yes |
| UB2L3_HUMAN | [view interactions] | High throughput | no | yes |
| 8ODP_HUMAN | [view interactions] | High throughput | no | yes |
| NUD10_HUMAN | [view interactions] | High throughput | no | yes |
| RN187_HUMAN | [view interactions] | High throughput | no | yes |
| BACH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AMRA1_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPEE_HUMAN | [view interactions] | High throughput | no | yes |
| MTCH2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| QKI_HUMAN | [view interactions] | High throughput | no | no |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PSA1_HUMAN | [view interactions] | High throughput | no | yes |
| PSA2_HUMAN | [view interactions] | High throughput | no | yes |
| PSA3_HUMAN | [view interactions] | High throughput | no | no |
| PSB4_HUMAN | [view interactions] | High throughput | no | yes |
| PSB5_HUMAN | [view interactions] | High throughput | no | yes |
| PSMD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBP11_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EFMT3_HUMAN | [view interactions] | High throughput | no | no |
| HSPB8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DUS6_HUMAN | [view interactions] | Computational | no | yes |
| DUS1_HUMAN | [view interactions] | Computational | no | no |
| DUS2_HUMAN | [view interactions] | Computational | no | no |
| DUS8_HUMAN | [view interactions] | Computational | no | no |
| DUS9_HUMAN | [view interactions] | Computational | no | no |
| MK07_HUMAN | [view interactions] | Computational | no | yes |