CD59_HUMAN
Evidence for PS localization
Functions
The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
| Position | Amino acid | Mutation | Disease | Overlap with binding region |
|---|---|---|---|---|
| 89 | Cys | Tyr | Hemolyticanemia,CD59-mediated,withorwithoutpolyneuropathy(HACD59) | - |
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in CD59_HUMAN |
|---|---|---|---|---|
| GO:0003723 | RNA binding | 32.0000 | 4 | no |
| GO:0019900 | kinase binding | 28.0000 | 4 | no |
| GO:0003779 | actin binding | 28.0000 | 4 | no |
| GO:0019901 | protein kinase binding | 24.0000 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in CD59_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 52.0000 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 52.0000 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 48.0000 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 48.0000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 44.0000 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 44.0000 | 4 | no |
| GO:0033043 | regulation of organelle organization | 44.0000 | 5 | no |
| GO:0006996 | organelle organization | 44.0000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 36.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 32.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 32.0000 | 5 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 32.0000 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 32.0000 | 6 | no |
| GO:0007010 | cytoskeleton organization | 32.0000 | 5 | no |
| GO:0010646 | regulation of cell communication | 32.0000 | 4 | no |
| GO:0016192 | vesicle-mediated transport | 28.0000 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 28.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 28.0000 | 4 | no |
| GO:0008104 | protein localization | 24.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 24.0000 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 24.0000 | 5 | no |
| GO:0051129 | negative regulation of cellular component organization | 24.0000 | 5 | no |
| GO:0022604 | regulation of cell morphogenesis | 24.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 24.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 24.0000 | 4 | no |
| GO:0032970 | regulation of actin filament-based process | 24.0000 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 24.0000 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 24.0000 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 24.0000 | 4 | no |
| GO:0048585 | negative regulation of response to stimulus | 20.0000 | 4 | yes |
| GO:0001969 | regulation of activation of membrane attack complex | 8.0000 | 6 | yes |
| GO:0001971 | negative regulation of activation of membrane attack complex | 8.0000 | 7 | yes |
| GO:0002683 | negative regulation of immune system process | 8.0000 | 4 | yes |
| GO:0002697 | regulation of immune effector process | 8.0000 | 4 | yes |
| GO:0002698 | negative regulation of immune effector process | 8.0000 | 5 | yes |
| GO:0002920 | regulation of humoral immune response | 8.0000 | 5 | yes |
| GO:0002921 | negative regulation of humoral immune response | 8.0000 | 6 | yes |
| GO:0007599 | hemostasis | 8.0000 | 4 | yes |
| GO:0030449 | regulation of complement activation | 8.0000 | 5 | yes |
| GO:0031341 | regulation of cell killing | 8.0000 | 4 | yes |
| GO:0045916 | negative regulation of complement activation | 8.0000 | 6 | yes |
| GO:0050776 | regulation of immune response | 8.0000 | 4 | yes |
| GO:0050777 | negative regulation of immune response | 8.0000 | 5 | yes |
| GO:1903659 | regulation of complement-dependent cytotoxicity | 8.0000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in CD59_HUMAN |
|---|---|---|---|---|
| DOID:114 | heart disease | 8.0000 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TMED2_HUMAN | [view interactions] | Low throughput | no | yes |
| EGFR_HUMAN | [view interactions] | Low throughput | no | no |
| CAV1_HUMAN | [view interactions] | Low throughput | no | no |
| NCTR1_HUMAN | [view interactions] | Low throughput | no | no |
| NCTR3_HUMAN | [view interactions] | Low throughput | no | no |
| CO9_HUMAN | [view interactions] | Low throughput | no | no |
| CO8A_HUMAN | [view interactions] | Low throughput | no | no |
| CD8A_HUMAN | [view interactions] | Low throughput | no | no |
| CD59_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| PP1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RENR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| UBE2A_HUMAN | [view interactions] | High throughput | no | no |
| MYH10_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FLNB_HUMAN | [view interactions] | High throughput | no | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| TPM1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| COR1C_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DREB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYNPO_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MARE1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MYH9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GOT1B_HUMAN | [view interactions] | High throughput | no | yes |
| GALK2_HUMAN | [view interactions] | High throughput | no | yes |
| CD27_HUMAN | [view interactions] | High throughput | no | no |
| TM11B_HUMAN | [view interactions] | High throughput | no | no |
| IBP1_HUMAN | [view interactions] | High throughput | no | no |
| DUS4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CTBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| GRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOST_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PIM3_HUMAN | [view interactions] | High throughput | no | no |
| TBCK_HUMAN | [view interactions] | High throughput | no | yes |
| HASP_HUMAN | [view interactions] | High throughput | no | yes |
| KC1G1_HUMAN | [view interactions] | High throughput | no | no |
| TX101_HUMAN | [view interactions] | High throughput | no | no |
| F209A_HUMAN | [view interactions] | High throughput | no | no |
| CCR2_HUMAN | [view interactions] | High throughput | no | yes |
| ACM4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| PAN2_HUMAN | [view interactions] | High throughput | no | no |
| ABCE1_HUMAN | [view interactions] | High throughput | no | yes |
| TINAL_HUMAN | [view interactions] | High throughput | no | no |
| RAD18_HUMAN | [view interactions] | High throughput | no | yes |
| BMR1A_HUMAN | [view interactions] | High throughput | no | no |
| DX39B_HUMAN | [view interactions] | High throughput | no | no |
| RN138_HUMAN | [view interactions] | High throughput | no | no |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MED9_HUMAN | [view interactions] | High throughput | no | no |
| RNF6_HUMAN | [view interactions] | High throughput | no | no |
| RNF4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR2_HUMAN | [view interactions] | High throughput | no | no |
| PP1G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SOX2_HUMAN | [view interactions] | High throughput | no | yes |
| SQSTM_HUMAN | [view interactions] | High throughput | no | yes |
| ANLN_HUMAN | [view interactions] | High throughput | no | yes |
| CHM4B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECT2_HUMAN | [view interactions] | High throughput | no | no |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| KI20A_HUMAN | [view interactions] | High throughput | no | yes |
| KIF23_HUMAN | [view interactions] | High throughput | no | yes |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NUPR1_HUMAN | [view interactions] | High throughput | no | no |
| TRI37_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDCD2_HUMAN | [view interactions] | High throughput | no | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| ISK1_HUMAN | [view interactions] | High throughput | no | no |
| MSS4_HUMAN | [view interactions] | High throughput | no | yes |
| TP4A1_HUMAN | [view interactions] | High throughput | no | no |
| PRPH2_HUMAN | [view interactions] | High throughput | no | no |
| DHRS3_HUMAN | [view interactions] | High throughput | no | yes |
| PARVG_HUMAN | [view interactions] | High throughput | no | yes |
| ITA5_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CCR1_HUMAN | [view interactions] | High throughput | no | no |
| ATPG_HUMAN | [view interactions] | High throughput | no | yes |
| BTF3_HUMAN | [view interactions] | High throughput | no | yes |
| SEPT9_HUMAN | [view interactions] | High throughput | no | no |
| SIK2_HUMAN | [view interactions] | High throughput | no | yes |
| S13A1_HUMAN | [view interactions] | High throughput | no | no |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PEBP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TOM5_HUMAN | [view interactions] | High throughput | no | yes |
| PIGA_HUMAN | [view interactions] | Computational | no | yes |
| SCFD1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| MCP_HUMAN | [view interactions] | Computational | no | no |
| STX17_HUMAN | [view interactions] | Computational | no | yes |
| CD2_HUMAN | [view interactions] | Computational | no | no |