RN138_HUMAN
Evidence for PS localization
Functions
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed, PubMed). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed, PubMed). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed). [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in RN138_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 26.8293 | 4 | yes |
| GO:0043168 | anion binding | 26.8293 | 4 | no |
| GO:0046872 | metal ion binding | 24.3902 | 5 | yes |
| GO:0000166 | nucleotide binding | 24.3902 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.3902 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 24.3902 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 24.3902 | 4 | no |
| GO:0003723 | RNA binding | 21.9512 | 4 | no |
| GO:0019900 | kinase binding | 19.5122 | 4 | yes |
| GO:0019901 | protein kinase binding | 17.0732 | 5 | yes |
| GO:0003677 | DNA binding | 12.1951 | 4 | yes |
| GO:0004842 | ubiquitin-protein transferase activity | 9.7561 | 4 | yes |
| GO:0016755 | aminoacyltransferase activity | 9.7561 | 4 | yes |
| GO:0061630 | ubiquitin protein ligase activity | 4.8780 | 5 | yes |
| GO:0061659 | ubiquitin-like protein ligase activity | 4.8780 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in RN138_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 58.5366 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 48.7805 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 48.7805 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 46.3415 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 43.9024 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 43.9024 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 39.0244 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 39.0244 | 4 | no |
| GO:0010468 | regulation of gene expression | 39.0244 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 39.0244 | 5 | no |
| GO:0010646 | regulation of cell communication | 39.0244 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 39.0244 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 39.0244 | 5 | no |
| GO:0033043 | regulation of organelle organization | 39.0244 | 5 | no |
| GO:0009966 | regulation of signal transduction | 36.5854 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.5854 | 5 | no |
| GO:0022607 | cellular component assembly | 36.5854 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 34.1463 | 5 | no |
| GO:0006996 | organelle organization | 34.1463 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 31.7073 | 4 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.7073 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 29.2683 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 29.2683 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 29.2683 | 5 | no |
| GO:0023056 | positive regulation of signaling | 29.2683 | 4 | no |
| GO:0051049 | regulation of transport | 29.2683 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 29.2683 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 29.2683 | 6 | no |
| GO:1902531 | regulation of intracellular signal transduction | 29.2683 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 29.2683 | 5 | no |
| GO:0009891 | positive regulation of biosynthetic process | 29.2683 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 29.2683 | 6 | no |
| GO:0071310 | cellular response to organic substance | 26.8293 | 4 | yes |
| GO:0009967 | positive regulation of signal transduction | 26.8293 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.8293 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 26.8293 | 4 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.8293 | 4 | no |
| GO:0051493 | regulation of cytoskeleton organization | 26.8293 | 6 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.8293 | 6 | no |
| GO:0036211 | protein modification process | 24.3902 | 4 | yes |
| GO:0043412 | macromolecule modification | 24.3902 | 4 | yes |
| GO:0031399 | regulation of protein modification process | 24.3902 | 6 | no |
| GO:0042981 | regulation of apoptotic process | 24.3902 | 5 | no |
| GO:0043067 | regulation of programmed cell death | 24.3902 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 24.3902 | 6 | no |
| GO:0097435 | supramolecular fiber organization | 24.3902 | 4 | no |
| GO:0006355 | regulation of DNA-templated transcription | 24.3902 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 24.3902 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 24.3902 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 24.3902 | 6 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 24.3902 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 21.9512 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 21.9512 | 5 | no |
| GO:0023057 | negative regulation of signaling | 21.9512 | 4 | no |
| GO:0031401 | positive regulation of protein modification process | 21.9512 | 7 | no |
| GO:0042127 | regulation of cell population proliferation | 21.9512 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.9512 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.9512 | 4 | no |
| GO:0007010 | cytoskeleton organization | 21.9512 | 5 | no |
| GO:0008104 | protein localization | 21.9512 | 4 | no |
| GO:0043933 | protein-containing complex organization | 21.9512 | 4 | no |
| GO:1902903 | regulation of supramolecular fiber organization | 21.9512 | 5 | no |
| GO:0060341 | regulation of cellular localization | 21.9512 | 4 | no |
| GO:0010628 | positive regulation of gene expression | 21.9512 | 7 | no |
| GO:0034097 | response to cytokine | 17.0732 | 4 | yes |
| GO:0090304 | nucleic acid metabolic process | 17.0732 | 4 | yes |
| GO:0032446 | protein modification by small protein conjugation | 14.6341 | 7 | yes |
| GO:0043687 | post-translational protein modification | 14.6341 | 5 | yes |
| GO:0070647 | protein modification by small protein conjugation or removal | 14.6341 | 6 | yes |
| GO:0006974 | DNA damage response | 12.1951 | 4 | yes |
| GO:0016567 | protein ubiquitination | 12.1951 | 8 | yes |
| GO:0071345 | cellular response to cytokine stimulus | 12.1951 | 5 | yes |
| GO:0006259 | DNA metabolic process | 9.7561 | 5 | yes |
| GO:0006281 | DNA repair | 9.7561 | 5 | yes |
| GO:0016055 | Wnt signaling pathway | 7.3171 | 4 | yes |
| GO:0000724 | double-strand break repair via homologous recombination | 4.8780 | 7 | yes |
| GO:0000725 | recombinational repair | 4.8780 | 6 | yes |
| GO:0000729 | DNA double-strand break processing | 4.8780 | 6 | yes |
| GO:0006302 | double-strand break repair | 4.8780 | 6 | yes |
| GO:0006310 | DNA recombination | 4.8780 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| RS3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TPPC9_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| CTIP_HUMAN | [view interactions] | Low throughput | no | no |
| SMRC1_HUMAN | [view interactions] | Low throughput | no | yes |
| UB2E1_HUMAN | [view interactions] | Low throughput | no | yes |
| UBE2N_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| H31_HUMAN | [view interactions] | Low throughput | no | yes |
| P53_HUMAN | [view interactions] | Low throughput | no | no |
| UBE2K_HUMAN | [view interactions] | Low throughput | no | yes |
| RA51D_HUMAN | [view interactions] | Low throughput | no | no |
| CAC1A_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| LEF1_HUMAN | [view interactions] | Low throughput | no | no |
| TF7L2_HUMAN | [view interactions] | Low throughput | no | yes |
| LYAR_HUMAN | [view interactions] | Low throughput | no | no |
| EF1A1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| HDAC1_HUMAN | [view interactions] | Low throughput | no | no |
| RBBP4_HUMAN | [view interactions] | Low throughput | no | yes |
| GNAI2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LAP2A_HUMAN | [view interactions] | High throughput | no | yes |
| ZO3_HUMAN | [view interactions] | High throughput | no | yes |
| ADDA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARPC2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAI14_HUMAN | [view interactions] | High throughput | no | yes |
| MYPT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASM3B_HUMAN | [view interactions] | High throughput | no | no |
| GNAI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CTNB1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LYN_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TMOD3_HUMAN | [view interactions] | High throughput | no | yes |
| LRRF2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433T_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAPZB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| UBC12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| RIGI_HUMAN | [view interactions] | High throughput | no | yes |
| PSB2_HUMAN | [view interactions] | High throughput | no | yes |
| DPOE3_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| PHF8_HUMAN | [view interactions] | High throughput | no | yes |
| EIF1A_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| RBX2_HUMAN | [view interactions] | High throughput | no | yes |
| HSF2B_HUMAN | [view interactions] | High throughput | no | yes |
| CC85A_HUMAN | [view interactions] | High throughput | no | yes |
| CD6_HUMAN | [view interactions] | High throughput | no | no |
| RHG12_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MADD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAXC_HUMAN | [view interactions] | High throughput | no | no |
| M3K20_HUMAN | [view interactions] | High throughput | no | yes |
| MPDZ_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CCNF_HUMAN | [view interactions] | High throughput | no | no |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SERC5_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| GCSP_HUMAN | [view interactions] | High throughput | no | yes |
| MIDN_HUMAN | [view interactions] | High throughput | no | no |
| SMCA4_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1A_HUMAN | [view interactions] | High throughput | no | yes |
| SMCA2_HUMAN | [view interactions] | High throughput | no | yes |
| PLEC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| H4_HUMAN | [view interactions] | High throughput | no | yes |
| ATX2L_HUMAN | [view interactions] | High throughput | no | no |
| ACTC_HUMAN | [view interactions] | High throughput | no | no |
| UBP2L_HUMAN | [view interactions] | High throughput | no | yes |
| ACTG_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| K2C6B_HUMAN | [view interactions] | High throughput | no | no |
| K2C6A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| K2C6C_HUMAN | [view interactions] | High throughput | no | no |
| RENT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CUX1_HUMAN | [view interactions] | High throughput | no | yes |
| ALBU_HUMAN | [view interactions] | High throughput | no | no |
| CHD4_HUMAN | [view interactions] | High throughput | no | yes |
| SRRM2_HUMAN | [view interactions] | High throughput | no | yes |
| PYR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF4G3_HUMAN | [view interactions] | High throughput | no | yes |
| SMRC2_HUMAN | [view interactions] | High throughput | no | yes |
| SNF5_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RYR1_HUMAN | [view interactions] | High throughput | no | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| RIPK4_HUMAN | [view interactions] | High throughput | no | no |
| PR15A_HUMAN | [view interactions] | High throughput | no | yes |
| XPO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCBP4_HUMAN | [view interactions] | High throughput | no | no |
| QKI_HUMAN | [view interactions] | High throughput | no | no |
| TAF9_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D4_HUMAN | [view interactions] | High throughput | no | yes |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| UBE2W_HUMAN | [view interactions] | High throughput | no | yes |
| TRIM8_HUMAN | [view interactions] | High throughput | no | yes |
| LNX2_HUMAN | [view interactions] | High throughput | no | yes |
| TSTD2_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN4_HUMAN | [view interactions] | High throughput | no | no |
| NTAQ1_HUMAN | [view interactions] | High throughput | no | yes |
| ADRB2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FGFR3_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| NMDE3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| GELS_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RASH_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| LMNA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RNF11_HUMAN | [view interactions] | High throughput | no | yes |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| SPRE1_HUMAN | [view interactions] | High throughput | no | yes |
| SYUA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TADBP_HUMAN | [view interactions] | High throughput | no | yes |
| CF206_HUMAN | [view interactions] | High throughput | no | yes |
| CSN5_HUMAN | [view interactions] | High throughput | no | yes |
| CSN6_HUMAN | [view interactions] | High throughput | no | yes |
| SMAD4_HUMAN | [view interactions] | High throughput | no | yes |
| TGFR1_HUMAN | [view interactions] | High throughput | no | no |
| SMUF1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MK14_HUMAN | [view interactions] | High throughput | no | yes |
| TRPV5_HUMAN | [view interactions] | High throughput | no | no |
| 5MP2_HUMAN | [view interactions] | High throughput | no | yes |
| NP1L5_HUMAN | [view interactions] | High throughput | no | yes |
| UBXN7_HUMAN | [view interactions] | High throughput | no | yes |
| NECA1_HUMAN | [view interactions] | High throughput | no | yes |
| DAAF8_HUMAN | [view interactions] | High throughput | no | no |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| JMJD6_HUMAN | [view interactions] | High throughput | no | yes |
| F136A_HUMAN | [view interactions] | High throughput | no | yes |
| CSN8_HUMAN | [view interactions] | High throughput | no | yes |
| FRYL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WDR4_HUMAN | [view interactions] | High throughput | no | no |
| PRIC3_HUMAN | [view interactions] | High throughput | no | yes |
| ARI1_HUMAN | [view interactions] | High throughput | no | yes |
| CPNE2_HUMAN | [view interactions] | High throughput | no | yes |
| GP156_HUMAN | [view interactions] | High throughput | no | no |
| CC120_HUMAN | [view interactions] | High throughput | no | no |
| TNR1A_HUMAN | [view interactions] | High throughput | no | yes |
| AP2M1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIE_HUMAN | [view interactions] | High throughput | no | yes |
| CD59_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MPRIP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NHS_HUMAN | [view interactions] | High throughput | no | yes |