TPPC9_HUMAN
Evidence for PS localization
Functions
Functions as an activator of NF-kappa-B through increased phosphorylation of the IKK complex. May function in neuronal cells differentiation. May play a role in vesicular transport from endoplasmic reticulum to Golgi. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TPPC9_HUMAN |
|---|---|---|---|---|
| GO:0043169 | cation binding | 28.5714 | 4 | no |
| GO:0046872 | metal ion binding | 28.5714 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TPPC9_HUMAN |
|---|---|---|---|---|
| GO:0006996 | organelle organization | 52.3810 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 47.6190 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 47.6190 | 4 | no |
| GO:0010646 | regulation of cell communication | 47.6190 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 42.8571 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 42.8571 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.8571 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 42.8571 | 4 | no |
| GO:0022607 | cellular component assembly | 42.8571 | 4 | no |
| GO:0051049 | regulation of transport | 42.8571 | 4 | no |
| GO:0030030 | cell projection organization | 38.0952 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 38.0952 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 38.0952 | 5 | no |
| GO:0008104 | protein localization | 38.0952 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 38.0952 | 4 | no |
| GO:0009966 | regulation of signal transduction | 38.0952 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:1902531 | regulation of intracellular signal transduction | 33.3333 | 5 | no |
| GO:0009892 | negative regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 33.3333 | 5 | no |
| GO:0010468 | regulation of gene expression | 33.3333 | 6 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 33.3333 | 5 | no |
| GO:0009893 | positive regulation of metabolic process | 33.3333 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 33.3333 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 33.3333 | 5 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 28.5714 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 28.5714 | 5 | no |
| GO:0040017 | positive regulation of locomotion | 28.5714 | 4 | no |
| GO:0043408 | regulation of MAPK cascade | 28.5714 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.5714 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 28.5714 | 4 | no |
| GO:0071310 | cellular response to organic substance | 28.5714 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 28.5714 | 6 | no |
| GO:0051246 | regulation of protein metabolic process | 28.5714 | 5 | no |
| GO:0006355 | regulation of DNA-templated transcription | 28.5714 | 7 | no |
| GO:0009890 | negative regulation of biosynthetic process | 28.5714 | 5 | no |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 28.5714 | 6 | no |
| GO:0010629 | negative regulation of gene expression | 28.5714 | 7 | no |
| GO:0031175 | neuron projection development | 28.5714 | 6 | no |
| GO:0031327 | negative regulation of cellular biosynthetic process | 28.5714 | 6 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.5714 | 5 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 28.5714 | 6 | no |
| GO:0044087 | regulation of cellular component biogenesis | 28.5714 | 4 | no |
| GO:0009891 | positive regulation of biosynthetic process | 28.5714 | 5 | no |
| GO:0009967 | positive regulation of signal transduction | 28.5714 | 5 | no |
| GO:0010647 | positive regulation of cell communication | 28.5714 | 5 | no |
| GO:0023056 | positive regulation of signaling | 28.5714 | 4 | no |
| GO:0030334 | regulation of cell migration | 23.8095 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 23.8095 | 6 | no |
| GO:0032101 | regulation of response to external stimulus | 23.8095 | 4 | no |
| GO:0043410 | positive regulation of MAPK cascade | 23.8095 | 7 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 23.8095 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 23.8095 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 23.8095 | 4 | no |
| GO:1902533 | positive regulation of intracellular signal transduction | 23.8095 | 6 | no |
| GO:2000145 | regulation of cell motility | 23.8095 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 23.8095 | 5 | no |
| GO:0007010 | cytoskeleton organization | 23.8095 | 5 | no |
| GO:0098657 | import into cell | 23.8095 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 23.8095 | 4 | no |
| GO:0045664 | regulation of neuron differentiation | 23.8095 | 5 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 23.8095 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 23.8095 | 4 | no |
| GO:0022603 | regulation of anatomical structure morphogenesis | 23.8095 | 4 | no |
| GO:0060341 | regulation of cellular localization | 23.8095 | 4 | no |
| GO:0006886 | intracellular protein transport | 23.8095 | 4 | no |
| GO:0015031 | protein transport | 23.8095 | 4 | no |
| GO:0071702 | organic substance transport | 23.8095 | 4 | no |
| GO:0071705 | nitrogen compound transport | 23.8095 | 4 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 23.8095 | 6 | no |
| GO:0016050 | vesicle organization | 23.8095 | 5 | yes |
| GO:0010243 | response to organonitrogen compound | 23.8095 | 4 | no |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 14.2857 | 4 | yes |
| GO:0006901 | vesicle coating | 14.2857 | 6 | yes |
| GO:0099022 | vesicle tethering | 14.2857 | 4 | yes |
| GO:0030182 | neuron differentiation | 9.5238 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| TPC2B_HUMAN | [view interactions] | Low throughput | no | no |
| TPC2A_HUMAN | [view interactions] | Low throughput | no | yes |
| TPPC8_HUMAN | [view interactions] | Low throughput | no | yes |
| RAB3I_HUMAN | [view interactions] | Low throughput | no | no |
| TPPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| IKKB_HUMAN | [view interactions] | Low throughput | no | yes |
| RN138_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| AMOL2_HUMAN | [view interactions] | High throughput | no | no |
| 1433F_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| MICA1_HUMAN | [view interactions] | High throughput | no | yes |
| CASQ2_HUMAN | [view interactions] | High throughput | no | no |
| PTMS_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC4_HUMAN | [view interactions] | High throughput | no | yes |
| MET_HUMAN | [view interactions] | High throughput | no | yes |
| NOTC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EZRI_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RB11A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFAC3_HUMAN | [view interactions] | High throughput | no | no |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IGF1R_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| INSR_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| 1433G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPC10_HUMAN | [view interactions] | High throughput | no | no |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| TM102_HUMAN | [view interactions] | High throughput | no | no |
| R3GEF_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| TPPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC3L_HUMAN | [view interactions] | High throughput | no | no |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| CMA1D_HUMAN | [view interactions] | High throughput | no | no |
| ST1A2_HUMAN | [view interactions] | High throughput | no | no |
| CNN2_HUMAN | [view interactions] | High throughput | no | no |
| RUFY4_HUMAN | [view interactions] | High throughput | no | no |
| CABS1_HUMAN | [view interactions] | High throughput | no | no |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CRYAB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| KANK4_HUMAN | [view interactions] | High throughput | no | no |
| STMN4_HUMAN | [view interactions] | High throughput | no | no |
| GATA2_HUMAN | [view interactions] | High throughput | no | yes |
| BGAL_HUMAN | [view interactions] | High throughput | no | yes |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| RAB30_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD1_HUMAN | [view interactions] | High throughput | no | yes |
| KCTD3_HUMAN | [view interactions] | High throughput | no | yes |
| LG3BP_HUMAN | [view interactions] | High throughput | no | no |
| TBC14_HUMAN | [view interactions] | High throughput | no | yes |
| TAFA3_HUMAN | [view interactions] | High throughput | no | no |
| CRAC1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRPL_HUMAN | [view interactions] | High throughput | no | yes |
| TISD_HUMAN | [view interactions] | High throughput | no | no |
| VIR_HUMAN | [view interactions] | High throughput | no | yes |
| RC3H2_HUMAN | [view interactions] | High throughput | no | yes |
| DPYL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| HXB6_HUMAN | [view interactions] | High throughput | no | no |
| COPT1_HUMAN | [view interactions] | High throughput | no | no |
| M1IP1_HUMAN | [view interactions] | High throughput | no | yes |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| MTL5_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| GLHA_HUMAN | [view interactions] | High throughput | no | no |
| RAB43_HUMAN | [view interactions] | High throughput | no | yes |
| NACC2_HUMAN | [view interactions] | High throughput | no | yes |
| BHA15_HUMAN | [view interactions] | High throughput | no | no |
| KLK5_HUMAN | [view interactions] | High throughput | no | no |
| TOP3B_HUMAN | [view interactions] | High throughput | no | no |
| TPC13_HUMAN | [view interactions] | High throughput | no | yes |
| MA2A1_HUMAN | [view interactions] | High throughput | no | no |
| ZNT5_HUMAN | [view interactions] | High throughput | no | yes |
| TFE2_HUMAN | [view interactions] | High throughput | no | no |
| MA1A1_HUMAN | [view interactions] | High throughput | no | yes |
| SC24B_HUMAN | [view interactions] | High throughput | no | yes |
| BAZ1A_HUMAN | [view interactions] | High throughput | no | no |
| ACATN_HUMAN | [view interactions] | High throughput | no | yes |
| MPRI_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAST2_HUMAN | [view interactions] | High throughput | no | no |
| TFG_HUMAN | [view interactions] | High throughput | no | yes |
| VPS35_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HTAI2_HUMAN | [view interactions] | High throughput | no | yes |
| LTOR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| STX6_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| ATG9A_HUMAN | [view interactions] | High throughput | no | yes |