TPPC4_HUMAN
Evidence for PS localization
Functions
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed). May play a role in dendrite postsynaptic membrane trafficking . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in TPPC4_HUMAN |
|---|---|---|---|---|
| GO:0017076 | purine nucleotide binding | 36.8421 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 36.8421 | 4 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 36.8421 | 4 | no |
| GO:0046872 | metal ion binding | 26.3158 | 4 | no |
| GO:0016462 | pyrophosphatase activity | 21.0526 | 5 | no |
| GO:0016818 | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 21.0526 | 4 | no |
| GO:0017111 | ribonucleoside triphosphate phosphatase activity | 21.0526 | 6 | no |
| GO:0005524 | ATP binding | 21.0526 | 5 | no |
| GO:0030554 | adenyl nucleotide binding | 21.0526 | 5 | no |
| GO:0032559 | adenyl ribonucleotide binding | 21.0526 | 5 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in TPPC4_HUMAN |
|---|---|---|---|---|
| GO:0016192 | vesicle-mediated transport | 63.1579 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 57.8947 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 52.6316 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 52.6316 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 52.6316 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 52.6316 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 47.3684 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 42.1053 | 4 | no |
| GO:0006996 | organelle organization | 42.1053 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 42.1053 | 4 | no |
| GO:0010468 | regulation of gene expression | 42.1053 | 5 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 42.1053 | 5 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 42.1053 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 42.1053 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 42.1053 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 36.8421 | 5 | no |
| GO:0033043 | regulation of organelle organization | 36.8421 | 5 | no |
| GO:0008104 | protein localization | 36.8421 | 4 | no |
| GO:0022607 | cellular component assembly | 36.8421 | 4 | no |
| GO:0045595 | regulation of cell differentiation | 36.8421 | 4 | no |
| GO:0031399 | regulation of protein modification process | 31.5789 | 6 | no |
| GO:0048193 | Golgi vesicle transport | 31.5789 | 5 | yes |
| GO:0006897 | endocytosis | 31.5789 | 5 | no |
| GO:0015031 | protein transport | 31.5789 | 4 | no |
| GO:0051247 | positive regulation of protein metabolic process | 31.5789 | 6 | no |
| GO:0071702 | organic substance transport | 31.5789 | 4 | no |
| GO:0071705 | nitrogen compound transport | 31.5789 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.5789 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 31.5789 | 5 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5789 | 5 | no |
| GO:0045935 | positive regulation of nucleobase-containing compound metabolic process | 26.3158 | 6 | no |
| GO:0048584 | positive regulation of response to stimulus | 26.3158 | 4 | no |
| GO:0051094 | positive regulation of developmental process | 26.3158 | 4 | no |
| GO:0051252 | regulation of RNA metabolic process | 26.3158 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 26.3158 | 6 | no |
| GO:1901699 | cellular response to nitrogen compound | 26.3158 | 4 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.3158 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.3158 | 6 | no |
| GO:0009966 | regulation of signal transduction | 26.3158 | 4 | no |
| GO:0010646 | regulation of cell communication | 26.3158 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.3158 | 6 | no |
| GO:0043085 | positive regulation of catalytic activity | 26.3158 | 4 | no |
| GO:0043412 | macromolecule modification | 26.3158 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 26.3158 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.3158 | 5 | no |
| GO:0060341 | regulation of cellular localization | 26.3158 | 4 | no |
| GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport | 26.3158 | 4 | yes |
| GO:0030030 | cell projection organization | 26.3158 | 4 | yes |
| GO:0120036 | plasma membrane bounded cell projection organization | 26.3158 | 5 | yes |
| GO:0010628 | positive regulation of gene expression | 26.3158 | 6 | no |
| GO:0006355 | regulation of DNA-templated transcription | 26.3158 | 6 | no |
| GO:0009891 | positive regulation of biosynthetic process | 26.3158 | 5 | no |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 26.3158 | 6 | no |
| GO:0031328 | positive regulation of cellular biosynthetic process | 26.3158 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 26.3158 | 5 | no |
| GO:0044087 | regulation of cellular component biogenesis | 26.3158 | 4 | no |
| GO:0045597 | positive regulation of cell differentiation | 26.3158 | 5 | no |
| GO:0045893 | positive regulation of DNA-templated transcription | 21.0526 | 7 | no |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | 21.0526 | 8 | no |
| GO:0050890 | cognition | 21.0526 | 4 | no |
| GO:0051052 | regulation of DNA metabolic process | 21.0526 | 5 | no |
| GO:0051054 | positive regulation of DNA metabolic process | 21.0526 | 6 | no |
| GO:0051254 | positive regulation of RNA metabolic process | 21.0526 | 6 | no |
| GO:0071310 | cellular response to organic substance | 21.0526 | 4 | no |
| GO:0071407 | cellular response to organic cyclic compound | 21.0526 | 5 | no |
| GO:0071417 | cellular response to organonitrogen compound | 21.0526 | 4 | no |
| GO:0080134 | regulation of response to stress | 21.0526 | 4 | no |
| GO:0080135 | regulation of cellular response to stress | 21.0526 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.0526 | 4 | no |
| GO:1902680 | positive regulation of RNA biosynthetic process | 21.0526 | 7 | no |
| GO:1903508 | positive regulation of nucleic acid-templated transcription | 21.0526 | 8 | no |
| GO:0001932 | regulation of protein phosphorylation | 21.0526 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 21.0526 | 8 | no |
| GO:0010038 | response to metal ion | 21.0526 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 21.0526 | 6 | no |
| GO:0010639 | negative regulation of organelle organization | 21.0526 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 21.0526 | 5 | no |
| GO:0023056 | positive regulation of signaling | 21.0526 | 4 | no |
| GO:0030334 | regulation of cell migration | 21.0526 | 5 | no |
| GO:0030335 | positive regulation of cell migration | 21.0526 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 21.0526 | 7 | no |
| GO:0036211 | protein modification process | 21.0526 | 4 | no |
| GO:0040017 | positive regulation of locomotion | 21.0526 | 4 | no |
| GO:0042127 | regulation of cell population proliferation | 21.0526 | 4 | no |
| GO:0042325 | regulation of phosphorylation | 21.0526 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 21.0526 | 8 | no |
| GO:0045596 | negative regulation of cell differentiation | 21.0526 | 5 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 21.0526 | 7 | no |
| GO:0051049 | regulation of transport | 21.0526 | 4 | no |
| GO:0051093 | negative regulation of developmental process | 21.0526 | 4 | no |
| GO:0071241 | cellular response to inorganic substance | 21.0526 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 21.0526 | 5 | no |
| GO:2000145 | regulation of cell motility | 21.0526 | 4 | no |
| GO:2000147 | positive regulation of cell motility | 21.0526 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 21.0526 | 4 | no |
| GO:0006357 | regulation of transcription by RNA polymerase II | 21.0526 | 7 | no |
| GO:0010243 | response to organonitrogen compound | 21.0526 | 4 | no |
| GO:0014070 | response to organic cyclic compound | 21.0526 | 4 | no |
| GO:0034097 | response to cytokine | 21.0526 | 4 | no |
| GO:0031175 | neuron projection development | 15.7895 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| MK03_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| MK01_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| RAB3I_HUMAN | [view interactions] | Low throughput | no | no |
| TPPC5_HUMAN | [view interactions] | Low throughput | no | yes |
| TPPC1_HUMAN | [view interactions] | Low throughput | no | yes |
| TPC6A_HUMAN | [view interactions] | Low throughput | no | yes |
| TPPC3_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TPPC4_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| CENPE_HUMAN | [view interactions] | High throughput | no | no |
| STMN4_HUMAN | [view interactions] | High throughput | no | no |
| BGAL_HUMAN | [view interactions] | High throughput | no | yes |
| ASTRB_HUMAN | [view interactions] | High throughput | no | yes |
| GATA2_HUMAN | [view interactions] | High throughput | no | yes |
| AASD1_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| HUNK_HUMAN | [view interactions] | High throughput | no | yes |
| GAB2_HUMAN | [view interactions] | High throughput | no | yes |
| OTUB2_HUMAN | [view interactions] | High throughput | no | no |
| KCNQ3_HUMAN | [view interactions] | High throughput | no | no |
| RAB43_HUMAN | [view interactions] | High throughput | no | yes |
| APBA1_HUMAN | [view interactions] | High throughput | no | no |
| MTL5_HUMAN | [view interactions] | High throughput | no | no |
| SNUT1_HUMAN | [view interactions] | High throughput | no | yes |
| CMBL_HUMAN | [view interactions] | High throughput | no | no |
| ISCA1_HUMAN | [view interactions] | High throughput | no | yes |
| MTND_HUMAN | [view interactions] | High throughput | no | yes |
| HXB6_HUMAN | [view interactions] | High throughput | no | no |
| PTGR3_HUMAN | [view interactions] | High throughput | no | yes |
| ARHG7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUFY4_HUMAN | [view interactions] | High throughput | no | no |
| ARP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARL3_HUMAN | [view interactions] | High throughput | no | yes |
| AR6P6_HUMAN | [view interactions] | High throughput | no | yes |
| ARL8A_HUMAN | [view interactions] | High throughput | no | no |
| ARL8B_HUMAN | [view interactions] | High throughput | no | yes |
| RASK_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RRAS2_HUMAN | [view interactions] | High throughput | no | yes |
| 1433B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATRX_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATG7_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADPPT_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PHP14_HUMAN | [view interactions] | High throughput | no | yes |
| PNPH_HUMAN | [view interactions] | High throughput | no | no |
| ILEU_HUMAN | [view interactions] | High throughput | no | no |
| UGDH_HUMAN | [view interactions] | High throughput | no | no |
| TPC6B_HUMAN | [view interactions] | High throughput | no | yes |
| IFM1_HUMAN | [view interactions] | High throughput | no | no |
| IFM3_HUMAN | [view interactions] | High throughput | no | yes |
| EPS15_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIS12_HUMAN | [view interactions] | High throughput | no | yes |
| C102B_HUMAN | [view interactions] | High throughput | no | yes |
| TBC14_HUMAN | [view interactions] | High throughput | no | yes |
| B2L14_HUMAN | [view interactions] | High throughput | no | yes |
| CABS1_HUMAN | [view interactions] | High throughput | no | no |
| KANK4_HUMAN | [view interactions] | High throughput | no | no |
| TPC12_HUMAN | [view interactions] | High throughput | no | yes |
| INTU_HUMAN | [view interactions] | High throughput | no | yes |
| CNN2_HUMAN | [view interactions] | High throughput | no | no |
| RAB30_HUMAN | [view interactions] | High throughput | no | yes |
| BTBD1_HUMAN | [view interactions] | High throughput | no | yes |
| TFP11_HUMAN | [view interactions] | High throughput | no | no |
| PRS23_HUMAN | [view interactions] | High throughput | no | no |
| TGON2_HUMAN | [view interactions] | High throughput | no | yes |
| EPHA5_HUMAN | [view interactions] | High throughput | no | no |
| FGFR1_HUMAN | [view interactions] | High throughput | no | yes |
| LMTK1_HUMAN | [view interactions] | High throughput | no | yes |
| TPC10_HUMAN | [view interactions] | High throughput | no | no |
| M21D2_HUMAN | [view interactions] | High throughput | no | yes |
| TM102_HUMAN | [view interactions] | High throughput | no | no |
| R3GEF_HUMAN | [view interactions] | High throughput | no | yes |
| PDLI7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC2L_HUMAN | [view interactions] | High throughput | no | yes |
| TPPC9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TPC2A_HUMAN | [view interactions] | High throughput | no | yes |
| TPC3L_HUMAN | [view interactions] | High throughput | no | no |
| TPPC8_HUMAN | [view interactions] | High throughput | no | yes |
| TPC11_HUMAN | [view interactions] | High throughput | no | no |
| RAE2_HUMAN | [view interactions] | Computational | no | yes |
| GDIB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAB1B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| TPC13_HUMAN | [view interactions] | Computational | no | yes |
| TPC2B_HUMAN | [view interactions] | Computational | no | no |
| SDC2_HUMAN | [view interactions] | Computational | no | yes |
| SDC1_HUMAN | [view interactions] | Computational | no | no |
| GDIA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| RAE1_HUMAN | [view interactions] | Computational | no | yes |
| RAB1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |