ADPPT_HUMAN
Evidence for PS localization
Functions
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4-phosphopantetheine moiety from coenzyme A, regardless of whether the CoA is presented in the free thiol form or as an acetyl thioester, to a serine residue of a broad range of acceptors including the acyl carrier domain of FASN. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in ADPPT_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 43.7500 | 4 | yes |
| GO:0005524 | ATP binding | 25.0000 | 5 | no |
| GO:0017076 | purine nucleotide binding | 25.0000 | 4 | no |
| GO:0030554 | adenyl nucleotide binding | 25.0000 | 5 | no |
| GO:0032555 | purine ribonucleotide binding | 25.0000 | 4 | no |
| GO:0032559 | adenyl ribonucleotide binding | 25.0000 | 5 | no |
| GO:0035639 | purine ribonucleoside triphosphate binding | 25.0000 | 4 | no |
| GO:0005509 | calcium ion binding | 25.0000 | 5 | no |
| GO:0000287 | magnesium ion binding | 12.5000 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in ADPPT_HUMAN |
|---|---|---|---|---|
| GO:0071310 | cellular response to organic substance | 43.7500 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 43.7500 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 43.7500 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 37.5000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 37.5000 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 37.5000 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 37.5000 | 4 | no |
| GO:0022607 | cellular component assembly | 37.5000 | 4 | no |
| GO:0043933 | protein-containing complex organization | 37.5000 | 4 | no |
| GO:0051049 | regulation of transport | 37.5000 | 4 | no |
| GO:0065003 | protein-containing complex assembly | 37.5000 | 5 | no |
| GO:0010468 | regulation of gene expression | 31.2500 | 5 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 31.2500 | 4 | no |
| GO:0051050 | positive regulation of transport | 31.2500 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 31.2500 | 4 | no |
| GO:0036211 | protein modification process | 25.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 25.0000 | 4 | yes |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 25.0000 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 25.0000 | 5 | no |
| GO:0006996 | organelle organization | 25.0000 | 4 | no |
| GO:0008104 | protein localization | 25.0000 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 25.0000 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 25.0000 | 5 | no |
| GO:0016192 | vesicle-mediated transport | 25.0000 | 4 | no |
| GO:0030030 | cell projection organization | 25.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 25.0000 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 25.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 25.0000 | 5 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 25.0000 | 5 | no |
| GO:0043269 | regulation of ion transport | 25.0000 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 25.0000 | 4 | no |
| GO:0051129 | negative regulation of cellular component organization | 25.0000 | 5 | no |
| GO:0032386 | regulation of intracellular transport | 25.0000 | 5 | no |
| GO:0032388 | positive regulation of intracellular transport | 25.0000 | 5 | no |
| GO:0048878 | chemical homeostasis | 25.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 25.0000 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 18.7500 | 5 | yes |
| GO:0032787 | monocarboxylic acid metabolic process | 18.7500 | 6 | yes |
| GO:0043436 | oxoacid metabolic process | 18.7500 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 18.7500 | 4 | yes |
| GO:0016053 | organic acid biosynthetic process | 12.5000 | 4 | yes |
| GO:0043603 | cellular amide metabolic process | 12.5000 | 4 | yes |
| GO:0046394 | carboxylic acid biosynthetic process | 12.5000 | 5 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in ADPPT_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 12.5000 | 4 | no |
| DOID:331 | central nervous system disease | 12.5000 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FAS_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| SLX4_HUMAN | [view interactions] | High throughput | no | yes |
| UBP22_HUMAN | [view interactions] | High throughput | no | yes |
| BABA1_HUMAN | [view interactions] | High throughput | no | yes |
| ULK2_HUMAN | [view interactions] | High throughput | no | yes |
| ANGL4_HUMAN | [view interactions] | High throughput | no | no |
| PPR3C_HUMAN | [view interactions] | High throughput | no | yes |
| POTEI_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| DLDH_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| KAPCA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRIO_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EIF1B_HUMAN | [view interactions] | High throughput | no | no |
| HLAB_HUMAN | [view interactions] | High throughput | no | yes |
| JUN_HUMAN | [view interactions] | High throughput | no | yes |
| HSC20_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| G3BP1_HUMAN | [view interactions] | High throughput | no | yes |
| SIAH1_HUMAN | [view interactions] | High throughput | no | yes |
| TRAF2_HUMAN | [view interactions] | High throughput | no | yes |
| EFHC2_HUMAN | [view interactions] | High throughput | no | no |
| CRX_HUMAN | [view interactions] | High throughput | no | no |
| MDFI_HUMAN | [view interactions] | High throughput | no | no |
| STIL_HUMAN | [view interactions] | High throughput | no | no |
| FBX6_HUMAN | [view interactions] | High throughput | no | yes |
| PAXI1_HUMAN | [view interactions] | High throughput | no | no |
| MOV10_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| NTRK1_HUMAN | [view interactions] | High throughput | no | yes |
| MTMRE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGLN3_HUMAN | [view interactions] | High throughput | no | no |
| WWOX_HUMAN | [view interactions] | High throughput | no | yes |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| NR2C2_HUMAN | [view interactions] | High throughput | no | yes |
| PHP14_HUMAN | [view interactions] | High throughput | no | yes |
| NMRL1_HUMAN | [view interactions] | High throughput | no | yes |
| MARH3_HUMAN | [view interactions] | High throughput | no | no |
| TRI13_HUMAN | [view interactions] | High throughput | no | no |
| PRKN_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TULP3_HUMAN | [view interactions] | High throughput | no | yes |
| ANR39_HUMAN | [view interactions] | High throughput | no | no |
| SEN15_HUMAN | [view interactions] | High throughput | no | yes |
| T184A_HUMAN | [view interactions] | High throughput | no | no |
| E41L5_HUMAN | [view interactions] | High throughput | no | no |
| T183A_HUMAN | [view interactions] | High throughput | no | no |
| GT2D1_HUMAN | [view interactions] | High throughput | no | yes |
| CAZA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGTA_HUMAN | [view interactions] | High throughput | no | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| EHD1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| EHD4_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HNRH1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOL3_HUMAN | [view interactions] | High throughput | no | yes |
| PLCG1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NIPA_HUMAN | [view interactions] | High throughput | no | yes |
| PURA2_HUMAN | [view interactions] | High throughput | no | yes |
| DAZP1_HUMAN | [view interactions] | High throughput | no | yes |
| ROA1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| M10L1_HUMAN | [view interactions] | High throughput | no | no |
| RAE1L_HUMAN | [view interactions] | High throughput | no | no |
| UB2D2_HUMAN | [view interactions] | High throughput | no | yes |
| UMPS_HUMAN | [view interactions] | High throughput | no | no |
| TPPC4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ANR17_HUMAN | [view interactions] | High throughput | no | yes |
| DMWD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| FTO_HUMAN | [view interactions] | High throughput | no | yes |
| PDD2L_HUMAN | [view interactions] | High throughput | no | yes |
| DDX24_HUMAN | [view interactions] | High throughput | no | yes |
| SMAP_HUMAN | [view interactions] | High throughput | no | yes |
| NAA40_HUMAN | [view interactions] | High throughput | no | no |
| COASY_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| T126B_HUMAN | [view interactions] | Computational | no | yes |
| ACSF4_HUMAN | [view interactions] | Computational | no | yes |
| ACPM_HUMAN | [view interactions] | Computational | no | yes |