THIK_HUMAN
Evidence for PS localization
Functions
Responsible for the thiolytic cleavage of straight chain 3-oxoacyl-CoAs. Catalyzes the cleavage of short, medium and long straight chain 3-oxoacyl-CoAs, medium chain 3-oxoacyl-CoAs being the best substrates. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in THIK_HUMAN |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | 27.5862 | 4 | no |
| GO:0017076 | purine nucleotide binding | 24.1379 | 5 | no |
| GO:0043168 | anion binding | 24.1379 | 4 | no |
| GO:0003723 | RNA binding | 24.1379 | 4 | no |
| GO:0032555 | purine ribonucleotide binding | 20.6897 | 4 | no |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 13.7931 | 4 | yes |
| GO:0003985 | acetyl-CoA C-acetyltransferase activity | 10.3448 | 7 | yes |
| GO:0003988 | acetyl-CoA C-acyltransferase activity | 10.3448 | 6 | yes |
| GO:0016407 | acetyltransferase activity | 10.3448 | 5 | yes |
| GO:0016408 | C-acyltransferase activity | 10.3448 | 5 | yes |
| GO:0016453 | C-acetyltransferase activity | 10.3448 | 6 | yes |
| GO:0003997 | acyl-CoA oxidase activity | 6.8966 | 5 | yes |
| GO:0008410 | CoA-transferase activity | 6.8966 | 4 | yes |
| GO:0008775 | acetate CoA-transferase activity | 6.8966 | 5 | yes |
| GO:0016401 | palmitoyl-CoA oxidase activity | 6.8966 | 6 | yes |
| GO:0016634 | oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor | 6.8966 | 4 | yes |
| GO:0019107 | myristoyltransferase activity | 6.8966 | 5 | yes |
| GO:0050633 | acetyl-CoA C-myristoyltransferase activity | 6.8966 | 6 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in THIK_HUMAN |
|---|---|---|---|---|
| GO:0006796 | phosphate-containing compound metabolic process | 41.3793 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 37.9310 | 5 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 37.9310 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 37.9310 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 37.9310 | 4 | no |
| GO:0019752 | carboxylic acid metabolic process | 31.0345 | 5 | yes |
| GO:0043436 | oxoacid metabolic process | 31.0345 | 4 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 31.0345 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 31.0345 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 31.0345 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 27.5862 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 27.5862 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 27.5862 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 24.1379 | 6 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 24.1379 | 4 | no |
| GO:0016054 | organic acid catabolic process | 20.6897 | 4 | yes |
| GO:0046395 | carboxylic acid catabolic process | 20.6897 | 5 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 20.6897 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 20.6897 | 4 | no |
| GO:0022607 | cellular component assembly | 20.6897 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 20.6897 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 20.6897 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 20.6897 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 20.6897 | 4 | no |
| GO:0008104 | protein localization | 20.6897 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 20.6897 | 4 | no |
| GO:0009966 | regulation of signal transduction | 20.6897 | 4 | no |
| GO:0010646 | regulation of cell communication | 20.6897 | 4 | no |
| GO:0006996 | organelle organization | 20.6897 | 4 | no |
| GO:0009062 | fatty acid catabolic process | 17.2414 | 5 | yes |
| GO:0016042 | lipid catabolic process | 17.2414 | 4 | yes |
| GO:0019395 | fatty acid oxidation | 17.2414 | 5 | yes |
| GO:0030258 | lipid modification | 17.2414 | 4 | yes |
| GO:0034440 | lipid oxidation | 17.2414 | 5 | yes |
| GO:0044242 | cellular lipid catabolic process | 17.2414 | 4 | yes |
| GO:0072329 | monocarboxylic acid catabolic process | 17.2414 | 6 | yes |
| GO:1901361 | organic cyclic compound catabolic process | 17.2414 | 4 | yes |
| GO:0006631 | fatty acid metabolic process | 17.2414 | 4 | yes |
| GO:0006635 | fatty acid beta-oxidation | 17.2414 | 6 | yes |
| GO:0008202 | steroid metabolic process | 17.2414 | 4 | yes |
| GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase | 10.3448 | 7 | yes |
| GO:0033559 | unsaturated fatty acid metabolic process | 10.3448 | 5 | yes |
| GO:0036109 | alpha-linolenic acid metabolic process | 10.3448 | 4 | yes |
| GO:0000038 | very long-chain fatty acid metabolic process | 10.3448 | 5 | yes |
| GO:0001676 | long-chain fatty acid metabolic process | 10.3448 | 5 | yes |
| GO:0008206 | bile acid metabolic process | 10.3448 | 4 | yes |
| GO:0010124 | phenylacetate catabolic process | 6.8966 | 5 | yes |
| GO:0042178 | xenobiotic catabolic process | 6.8966 | 4 | yes |
| GO:0042537 | benzene-containing compound metabolic process | 6.8966 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| HAT1_HUMAN | [view interactions] | Low throughput | no | yes |
| THIK_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| GLUT4_HUMAN | [view interactions] | High throughput | no | no |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| KHDR2_HUMAN | [view interactions] | High throughput | no | yes |
| PEX7_HUMAN | [view interactions] | High throughput | no | yes |
| MTDC_HUMAN | [view interactions] | High throughput | no | yes |
| CF226_HUMAN | [view interactions] | High throughput | no | yes |
| RM42_HUMAN | [view interactions] | High throughput | no | yes |
| COQ9_HUMAN | [view interactions] | High throughput | no | yes |
| SHAN3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| HTRA2_HUMAN | [view interactions] | High throughput | no | yes |
| IMP1L_HUMAN | [view interactions] | High throughput | no | yes |
| IMP2L_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HMGA2_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA7_HUMAN | [view interactions] | High throughput | no | yes |
| HDAC5_HUMAN | [view interactions] | High throughput | no | yes |
| UD2B7_HUMAN | [view interactions] | High throughput | no | no |
| FEM1A_HUMAN | [view interactions] | High throughput | no | no |
| TFCP2_HUMAN | [view interactions] | High throughput | no | no |
| RAB21_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| BMP2K_HUMAN | [view interactions] | High throughput | no | yes |
| CATA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| IF1AX_HUMAN | [view interactions] | High throughput | no | yes |
| TPPC9_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PEX5_HUMAN | [view interactions] | High throughput | no | yes |
| FACD2_HUMAN | [view interactions] | High throughput | no | no |
| CRYL1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| ESR1_HUMAN | [view interactions] | High throughput | no | no |
| TFPT_HUMAN | [view interactions] | High throughput | no | yes |
| TRM6_HUMAN | [view interactions] | High throughput | no | yes |
| RL35A_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SPXN_HUMAN | [view interactions] | High throughput | no | no |
| ACACB_HUMAN | [view interactions] | High throughput | no | no |
| TIM10_HUMAN | [view interactions] | High throughput | no | yes |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ARG39_HUMAN | [view interactions] | High throughput | no | yes |
| ACOX1_HUMAN | [view interactions] | High throughput | no | yes |
| SORT_HUMAN | [view interactions] | High throughput | no | yes |
| ABI1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HBB_HUMAN | [view interactions] | High throughput | no | no |
| HBA_HUMAN | [view interactions] | High throughput | no | no |
| PP1R7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| WASC3_HUMAN | [view interactions] | High throughput | no | yes |
| BMI1_HUMAN | [view interactions] | High throughput | no | yes |
| ZRAN1_HUMAN | [view interactions] | High throughput | no | yes |
| TRI67_HUMAN | [view interactions] | High throughput | no | no |
| TET5C_HUMAN | [view interactions] | High throughput | no | yes |
| DHB4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SUGP1_HUMAN | [view interactions] | High throughput | no | yes |
| SCP2_HUMAN | [view interactions] | High throughput | no | no |
| NDUA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RM53_HUMAN | [view interactions] | High throughput | no | yes |
| SRPRB_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| RS19_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ZDHC5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PPIB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TPPC5_HUMAN | [view interactions] | High throughput | no | yes |
| SF3B4_HUMAN | [view interactions] | High throughput | no | yes |
| SARNP_HUMAN | [view interactions] | High throughput | no | yes |
| NDUA7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| VDAC3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SBDS_HUMAN | [view interactions] | High throughput | no | yes |
| CDK12_HUMAN | [view interactions] | High throughput | no | yes |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| KAD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ENOA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACSL1_HUMAN | [view interactions] | High throughput | no | no |
| ACOT8_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KCC2G_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| AGR2_HUMAN | [view interactions] | High throughput | no | no |
| TERA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ADAS_HUMAN | [view interactions] | High throughput | no | yes |