Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KCC2G_HUMAN

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. [View more on UniProt]

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No data found.

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Molecular function

Term Name % Distance from the top of the tree Annotated in KCC2G_HUMAN
GO:0019900 kinase binding 29.8701 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0017076 purine nucleotide binding 24.6753 4 yes
GO:0032555 purine ribonucleotide binding 24.6753 4 yes
GO:0035639 purine ribonucleoside triphosphate binding 24.6753 4 yes
GO:0005524 ATP binding 22.0779 5 yes
GO:0030554 adenyl nucleotide binding 22.0779 5 yes
GO:0032559 adenyl ribonucleotide binding 22.0779 5 yes
GO:0046872 metal ion binding 22.0779 4 no
GO:0045296 cadherin binding 22.0779 4 no
GO:0003779 actin binding 20.7792 4 no
GO:0016301 kinase activity 16.8831 4 yes
GO:0016773 phosphotransferase activity, alcohol group as acceptor 16.8831 4 yes
GO:0042803 protein homodimerization activity 16.8831 4 yes
GO:0004712 protein serine/threonine/tyrosine kinase activity 15.5844 4 yes
GO:0004674 protein serine/threonine kinase activity 11.6883 4 yes
GO:0106310 protein serine kinase activity 11.6883 4 yes
GO:0042578 phosphoric ester hydrolase activity 7.7922 4 yes
GO:0004683 calmodulin-dependent protein kinase activity 6.4935 5 yes
GO:0004722 protein serine/threonine phosphatase activity 6.4935 4 yes
GO:0016791 phosphatase activity 6.4935 5 yes
GO:0004723 calcium-dependent protein serine/threonine phosphatase activity 2.5974 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KCC2G_HUMAN
GO:0048523 negative regulation of cellular process 63.6364 4 no
GO:0010646 regulation of cell communication 61.0390 4 no
GO:0048522 positive regulation of cellular process 59.7403 4 no
GO:0031323 regulation of cellular metabolic process 58.4416 4 no
GO:0051171 regulation of nitrogen compound metabolic process 58.4416 4 no
GO:0060255 regulation of macromolecule metabolic process 58.4416 4 no
GO:0080090 regulation of primary metabolic process 58.4416 4 no
GO:0009966 regulation of signal transduction 51.9481 4 no
GO:0051128 regulation of cellular component organization 50.6494 4 yes
GO:0051246 regulation of protein metabolic process 46.7532 5 no
GO:0010468 regulation of gene expression 42.8571 5 no
GO:0009892 negative regulation of metabolic process 41.5584 4 no
GO:0031399 regulation of protein modification process 40.2597 6 no
GO:0009893 positive regulation of metabolic process 38.9610 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.9610 5 no
GO:0031324 negative regulation of cellular metabolic process 38.9610 5 no
GO:0051172 negative regulation of nitrogen compound metabolic process 38.9610 5 no
GO:0009889 regulation of biosynthetic process 37.6623 4 no
GO:0010556 regulation of macromolecule biosynthetic process 37.6623 5 no
GO:0010604 positive regulation of macromolecule metabolic process 37.6623 5 no
GO:0031326 regulation of cellular biosynthetic process 37.6623 5 no
GO:0051173 positive regulation of nitrogen compound metabolic process 37.6623 5 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 36.3636 5 no
GO:0019220 regulation of phosphate metabolic process 36.3636 6 no
GO:0051174 regulation of phosphorus metabolic process 36.3636 5 no
GO:0051049 regulation of transport 35.0649 4 yes
GO:1902531 regulation of intracellular signal transduction 35.0649 5 no
GO:0022607 cellular component assembly 33.7662 4 no
GO:0031325 positive regulation of cellular metabolic process 33.7662 5 no
GO:0051252 regulation of RNA metabolic process 33.7662 5 no
GO:0006996 organelle organization 33.7662 4 no
GO:0042325 regulation of phosphorylation 33.7662 7 no
GO:0051247 positive regulation of protein metabolic process 32.4675 6 no
GO:0051248 negative regulation of protein metabolic process 32.4675 6 no
GO:0048584 positive regulation of response to stimulus 31.1688 4 no
GO:0010941 regulation of cell death 31.1688 4 no
GO:0036211 protein modification process 29.8701 4 no
GO:0043412 macromolecule modification 29.8701 4 no
GO:0001932 regulation of protein phosphorylation 29.8701 7 no
GO:0008104 protein localization 28.5714 4 yes
GO:0006355 regulation of DNA-templated transcription 28.5714 6 no
GO:0010647 positive regulation of cell communication 28.5714 5 no
GO:0023056 positive regulation of signaling 28.5714 4 no
GO:1903506 regulation of nucleic acid-templated transcription 28.5714 7 no
GO:2001141 regulation of RNA biosynthetic process 28.5714 6 no
GO:0031344 regulation of cell projection organization 27.2727 5 yes
GO:0120035 regulation of plasma membrane bounded cell projection organization 27.2727 6 yes
GO:0030030 cell projection organization 27.2727 4 no
GO:0031401 positive regulation of protein modification process 27.2727 7 no
GO:0043067 regulation of programmed cell death 27.2727 5 no
GO:0050804 modulation of chemical synaptic transmission 25.9740 5 no
GO:0099177 regulation of trans-synaptic signaling 25.9740 4 no
GO:0044087 regulation of cellular component biogenesis 25.9740 4 no
GO:0009967 positive regulation of signal transduction 24.6753 5 no
GO:0043085 positive regulation of catalytic activity 24.6753 4 no
GO:0042981 regulation of apoptotic process 24.6753 6 no
GO:0043269 regulation of ion transport 23.3766 5 yes
GO:0033043 regulation of organelle organization 23.3766 5 no
GO:0044057 regulation of system process 22.0779 4 yes
GO:0051336 regulation of hydrolase activity 22.0779 4 no
GO:0010562 positive regulation of phosphorus metabolic process 22.0779 6 no
GO:0031400 negative regulation of protein modification process 22.0779 7 no
GO:0042327 positive regulation of phosphorylation 22.0779 8 no
GO:0045937 positive regulation of phosphate metabolic process 22.0779 7 no
GO:0051338 regulation of transferase activity 22.0779 4 no
GO:0010648 negative regulation of cell communication 22.0779 5 no
GO:0023057 negative regulation of signaling 22.0779 4 no
GO:0010959 regulation of metal ion transport 20.7792 6 yes
GO:0051130 positive regulation of cellular component organization 20.7792 5 no
GO:0007010 cytoskeleton organization 20.7792 5 no
GO:0010563 negative regulation of phosphorus metabolic process 20.7792 6 no
GO:0043549 regulation of kinase activity 20.7792 5 no
GO:0045936 negative regulation of phosphate metabolic process 20.7792 7 no
GO:0071310 cellular response to organic substance 20.7792 4 no
GO:0001934 positive regulation of protein phosphorylation 20.7792 8 no
GO:0048585 negative regulation of response to stimulus 20.7792 4 no
GO:0010975 regulation of neuron projection development 18.1818 7 yes
GO:0071702 organic substance transport 18.1818 4 yes
GO:0051924 regulation of calcium ion transport 16.8831 7 yes
GO:0071705 nitrogen compound transport 16.8831 4 yes
GO:0015031 protein transport 14.2857 4 yes
GO:0090257 regulation of muscle system process 11.6883 5 yes
GO:0007399 nervous system development 5.1948 4 yes
GO:0043502 regulation of muscle adaptation 5.1948 4 yes
GO:0014733 regulation of skeletal muscle adaptation 3.8961 5 yes
GO:0023061 signal release 3.8961 4 yes
GO:0046903 secretion 3.8961 4 yes
GO:0002790 peptide secretion 2.5974 5 yes
GO:0009306 protein secretion 2.5974 4 yes
GO:0009914 hormone transport 2.5974 4 yes
GO:0015833 peptide transport 2.5974 5 yes
GO:0030072 peptide hormone secretion 2.5974 6 yes
GO:0030073 insulin secretion 2.5974 5 yes
GO:0035592 establishment of protein localization to extracellular region 2.5974 4 yes
GO:0042886 amide transport 2.5974 5 yes
GO:0046879 hormone secretion 2.5974 5 yes
GO:0071692 protein localization to extracellular region 2.5974 5 yes

Disease

Term Name % Distance from top the of the tree Annotated in KCC2G_HUMAN
DOID:114 heart disease 3.8961 3 no
DOID:557 kidney disease 2.5974 3 no
DOID:0080001 bone disease 2.5974 4 no
DOID:0080006 bone development disease 2.5974 5 no
DOID:65 connective tissue disease 2.5974 3 no
DOID:0050700 cardiomyopathy 2.5974 4 no
DOID:0060036 intrinsic cardiomyopathy 2.5974 5 no
DOID:2843 long QT syndrome 2.5974 6 no
DOID:0050686 organ system cancer 2.5974 3 no
DOID:120 female reproductive organ cancer 2.5974 5 no
DOID:193 reproductive organ cancer 2.5974 4 no
Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
STMN1_HUMAN [view interactions] Low throughput no yes
RAD_HUMAN [view interactions] Low throughput no yes
CABP2_HUMAN [view interactions] Low throughput no no
SMAD2_HUMAN [view interactions] Low throughput no yes
SMAD4_HUMAN [view interactions] Low throughput no yes
ZN363_HUMAN [view interactions] Low throughput no yes
NMDZ1_HUMAN [view entry] [view interactions] Low throughput yes yes
SHAN3_HUMAN [view entry] [view interactions] Low throughput yes no
KCC2G_HUMAN [view entry] [view interactions] Low throughput yes yes
LOX5_HUMAN [view interactions] Low throughput no no
NR1H2_HUMAN [view interactions] Low throughput no yes
CALM2_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM3_HUMAN [view entry] [view interactions] Low throughput yes yes
CALM1_HUMAN [view entry] [view interactions] Low throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] Low throughput yes no
BCL10_HUMAN [view interactions] Low throughput no yes
MALT1_HUMAN [view interactions] Low throughput no no
SIVA_HUMAN [view interactions] Low throughput no no
BECN1_HUMAN [view interactions] Low throughput no yes
PTEN_HUMAN [view entry] [view interactions] Low throughput yes yes
NMDE2_HUMAN [view entry] [view interactions] Low throughput yes no
XPF_HUMAN [view interactions] High throughput no yes
TBCD4_HUMAN [view interactions] High throughput no yes
MCM5_HUMAN [view interactions] High throughput no no
T200A_HUMAN [view interactions] High throughput no yes
NPAS1_HUMAN [view interactions] High throughput no no
KLH26_HUMAN [view interactions] High throughput no no
INF2_HUMAN [view entry] [view interactions] High throughput yes yes
UBXN6_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG7_HUMAN [view interactions] High throughput no no
SIR6_HUMAN [view interactions] High throughput no yes
B4GT2_HUMAN [view interactions] High throughput no no
MECP2_HUMAN [view interactions] High throughput no yes
BAIP2_HUMAN [view entry] [view interactions] High throughput yes yes
CARM1_HUMAN [view interactions] High throughput no yes
CAPZB_HUMAN [view entry] [view interactions] High throughput yes yes
SRC8_HUMAN [view entry] [view interactions] High throughput yes yes
1433B_HUMAN [view entry] [view interactions] High throughput yes yes
1433E_HUMAN [view entry] [view interactions] High throughput yes yes
CP4FC_HUMAN [view interactions] High throughput no no
MAPK2_HUMAN [view interactions] High throughput no yes
LCK_HUMAN [view entry] [view interactions] High throughput yes no
PTPRE_HUMAN [view interactions] High throughput no no
ERBB2_HUMAN [view entry] [view interactions] High throughput yes no
PRSS8_HUMAN [view interactions] High throughput no no
GPX1_HUMAN [view entry] [view interactions] High throughput yes yes
SC5A5_HUMAN [view interactions] High throughput no no
KPCD_HUMAN [view entry] [view interactions] High throughput yes yes
M3K8_HUMAN [view interactions] High throughput no yes
SKP2_HUMAN [view interactions] High throughput no yes
NOS2_HUMAN [view interactions] High throughput no yes
LTC4S_HUMAN [view interactions] High throughput no no
ANPRB_HUMAN [view interactions] High throughput no no
TRYB1_HUMAN [view interactions] High throughput no no
FAS_HUMAN [view entry] [view interactions] High throughput yes no
RASK_HUMAN [view entry] [view interactions] High throughput yes no
DDX11_HUMAN [view interactions] High throughput no yes
PDLI5_HUMAN [view entry] [view interactions] High throughput yes no
SBDS_HUMAN [view interactions] High throughput no yes
PEA15_HUMAN [view entry] [view interactions] High throughput yes no
PLCB3_HUMAN [view entry] [view interactions] High throughput yes no
SYN1_HUMAN [view entry] [view interactions] High throughput yes no
TY3H_HUMAN [view interactions] High throughput no no
TIAM2_HUMAN [view interactions] High throughput no yes
DPPA3_HUMAN [view interactions] High throughput no no
NHLC2_HUMAN [view interactions] High throughput no yes
RPA49_HUMAN [view interactions] High throughput no yes
GLUT4_HUMAN [view interactions] High throughput no no
UBP19_HUMAN [view interactions] High throughput no no
HS90B_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2A_HUMAN [view entry] [view interactions] High throughput yes yes
MECOM_HUMAN [view interactions] High throughput no yes
RHG29_HUMAN [view interactions] High throughput no yes
IMP1L_HUMAN [view interactions] High throughput no yes
IMP2L_HUMAN [view interactions] High throughput no yes
CTBP1_HUMAN [view entry] [view interactions] High throughput yes yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
HMGA2_HUMAN [view interactions] High throughput no yes
YES_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
DZIP1_HUMAN [view interactions] High throughput no yes
PHOCN_HUMAN [view interactions] High throughput no yes
PSD13_HUMAN [view interactions] High throughput no yes
PNMA2_HUMAN [view interactions] High throughput no yes
FGOP2_HUMAN [view interactions] High throughput no yes
STRN4_HUMAN [view entry] [view interactions] High throughput yes yes
PAK6_HUMAN [view entry] [view interactions] High throughput yes yes
CK2N2_HUMAN [view interactions] High throughput no yes
CALL4_HUMAN [view interactions] High throughput no no
NEUA_HUMAN [view interactions] High throughput no yes
PELI3_HUMAN [view interactions] High throughput no yes
CK2N1_HUMAN [view entry] [view interactions] High throughput yes yes
STRP1_HUMAN [view interactions] High throughput no yes
PON2_HUMAN [view interactions] High throughput no yes
SLMAP_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR1_HUMAN [view entry] [view interactions] High throughput yes yes
ITPR3_HUMAN [view interactions] High throughput no yes
ITPR2_HUMAN [view interactions] High throughput no yes
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
FKBP5_HUMAN [view interactions] High throughput no yes
STRN3_HUMAN [view interactions] High throughput no yes
TRI26_HUMAN [view interactions] High throughput no yes
1433F_HUMAN [view entry] [view interactions] High throughput yes yes
ADA17_HUMAN [view interactions] High throughput no yes
DYL1_HUMAN [view entry] [view interactions] High throughput yes no
1433G_HUMAN [view entry] [view interactions] High throughput yes yes
ZEP2_HUMAN [view interactions] High throughput no no
2AAA_HUMAN [view entry] [view interactions] High throughput yes no
ITPI2_HUMAN [view interactions] High throughput no yes
PDE4A_HUMAN [view interactions] High throughput no no
ZEP1_HUMAN [view interactions] High throughput no yes
FLNB_HUMAN [view interactions] High throughput no no
STRN_HUMAN [view entry] [view interactions] High throughput yes yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
PSD12_HUMAN [view interactions] High throughput no yes
MELK_HUMAN [view interactions] High throughput no yes
PKN3_HUMAN [view interactions] High throughput no yes
AAKG3_HUMAN [view interactions] High throughput no no
CILK1_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
MCM7_HUMAN [view interactions] High throughput no no
FMR1_HUMAN [view entry] [view interactions] High throughput yes yes
TNIK_HUMAN [view entry] [view interactions] High throughput yes yes
TSC1_HUMAN [view entry] [view interactions] High throughput yes yes
DLGP1_HUMAN [view entry] [view interactions] High throughput yes no
AGAP2_HUMAN [view entry] [view interactions] High throughput yes yes
IFIH1_HUMAN [view interactions] High throughput no yes
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
FXR1_HUMAN [view entry] [view interactions] High throughput yes yes
FXR2_HUMAN [view entry] [view interactions] High throughput yes yes
1433Z_HUMAN [view entry] [view interactions] High throughput yes yes
CUL3_HUMAN [view entry] [view interactions] High throughput yes yes
LRRK2_HUMAN [view interactions] High throughput no yes
PCNA_HUMAN [view interactions] High throughput no no
SMAD3_HUMAN [view interactions] High throughput no yes
FLNA_HUMAN [view entry] [view interactions] High throughput yes no
PSB1_HUMAN [view interactions] High throughput no yes
TNPO3_HUMAN [view interactions] High throughput no yes
NTF2_HUMAN [view interactions] High throughput no yes
UBC9_HUMAN [view interactions] High throughput no yes
CDC37_HUMAN [view interactions] High throughput no yes
TNPO2_HUMAN [view interactions] High throughput no yes
TTC5_HUMAN [view interactions] High throughput no yes
NXF1_HUMAN [view interactions] High throughput no yes
STRBP_HUMAN [view interactions] High throughput no yes
DUS1L_HUMAN [view interactions] High throughput no yes
RM11_HUMAN [view interactions] High throughput no yes
KRA61_HUMAN [view interactions] High throughput no no
ERR3_HUMAN [view interactions] High throughput no yes
KANK2_HUMAN [view entry] [view interactions] High throughput yes yes
KR193_HUMAN [view interactions] High throughput no no
HS90A_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
TIRAP_HUMAN [view interactions] High throughput no no
ECHM_HUMAN [view interactions] High throughput no yes
DACT2_HUMAN [view interactions] High throughput no yes
RHG25_HUMAN [view interactions] High throughput no no
NDUA8_HUMAN [view entry] [view interactions] High throughput yes yes
CAZA2_HUMAN [view entry] [view interactions] High throughput yes yes
DREB_HUMAN [view entry] [view interactions] High throughput yes yes
IGBP1_HUMAN [view interactions] High throughput no yes
TBG1_HUMAN [view entry] [view interactions] High throughput yes yes
IQGA1_HUMAN [view entry] [view interactions] High throughput yes no
SYNPO_HUMAN [view entry] [view interactions] High throughput yes no
ANLN_HUMAN [view interactions] High throughput no yes
THOC2_HUMAN [view interactions] High throughput no yes
CSK_HUMAN [view interactions] High throughput no yes
PLAK_HUMAN [view entry] [view interactions] High throughput yes yes
MYO1C_HUMAN [view entry] [view interactions] High throughput yes yes
UFL1_HUMAN [view interactions] High throughput no yes
CALL3_HUMAN [view interactions] High throughput no yes
RBM42_HUMAN [view interactions] High throughput no yes
ZN488_HUMAN [view interactions] High throughput no no
KALRN_HUMAN [view entry] [view interactions] High throughput yes yes
RNF4_HUMAN [view interactions] High throughput no yes
NEB2_HUMAN [view entry] [view interactions] High throughput yes yes
MYC_HUMAN [view interactions] High throughput no yes
MARE1_HUMAN [view entry] [view interactions] High throughput yes yes
KPCD2_HUMAN [view interactions] High throughput no yes
APEX1_HUMAN [view interactions] High throughput no yes
RGS14_HUMAN [view entry] [view interactions] High throughput yes yes
CTNB1_HUMAN [view entry] [view interactions] High throughput yes yes
GRIA4_HUMAN [view entry] [view interactions] High throughput yes no
PKHA4_HUMAN [view interactions] High throughput no yes
ZCH18_HUMAN [view interactions] High throughput no yes
KIF23_HUMAN [view interactions] High throughput no yes
NINL_HUMAN [view interactions] High throughput no yes
CUL4A_HUMAN [view interactions] High throughput no no
ASXL1_HUMAN [view interactions] High throughput no no
TRI37_HUMAN [view entry] [view interactions] High throughput yes yes
DNAL4_HUMAN [view interactions] High throughput no yes
F163B_HUMAN [view interactions] High throughput no yes
GCR_HUMAN [view entry] [view interactions] High throughput yes yes
MAGA9_HUMAN [view interactions] High throughput no no
PUSL1_HUMAN [view interactions] High throughput no yes
SNPC4_HUMAN [view interactions] High throughput no no
RUSD4_HUMAN [view interactions] High throughput no yes
SHSA6_HUMAN [view entry] [view interactions] High throughput yes no
MAP10_HUMAN [view interactions] High throughput no no
TCPQM_HUMAN [view interactions] High throughput no no
HNRC2_HUMAN [view interactions] High throughput no no