Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

SHSA6_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB

Functions

Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in SHSA6_HUMAN
GO:0005216 ion channel activity 21.0526 4 no
GO:0005261 cation channel activity 21.0526 5 no
GO:0008324 cation transmembrane transporter activity 21.0526 4 no
GO:0015267 channel activity 21.0526 4 no
GO:0022836 gated channel activity 21.0526 5 no
GO:0022890 inorganic cation transmembrane transporter activity 21.0526 4 no
GO:0017076 purine nucleotide binding 21.0526 4 no
GO:0030554 adenyl nucleotide binding 21.0526 5 no
GO:0019900 kinase binding 21.0526 4 no
GO:0030165 PDZ domain binding 15.7895 4 yes
GO:0035254 glutamate receptor binding 15.7895 4 yes
GO:0035255 ionotropic glutamate receptor binding 15.7895 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in SHSA6_HUMAN
GO:0048522 positive regulation of cellular process 68.4211 4 no
GO:0048523 negative regulation of cellular process 57.8947 4 yes
GO:0051049 regulation of transport 57.8947 4 yes
GO:0008104 protein localization 57.8947 4 no
GO:0010646 regulation of cell communication 52.6316 4 yes
GO:0043269 regulation of ion transport 47.3684 5 yes
GO:0051128 regulation of cellular component organization 47.3684 4 no
GO:0050804 modulation of chemical synaptic transmission 42.1053 5 yes
GO:0099177 regulation of trans-synaptic signaling 42.1053 4 yes
GO:0060255 regulation of macromolecule metabolic process 42.1053 4 no
GO:0009966 regulation of signal transduction 36.8421 4 yes
GO:0022898 regulation of transmembrane transporter activity 36.8421 4 yes
GO:0032412 regulation of ion transmembrane transporter activity 36.8421 5 yes
GO:0034762 regulation of transmembrane transport 36.8421 4 yes
GO:0034765 regulation of ion transmembrane transport 36.8421 5 yes
GO:0060341 regulation of cellular localization 36.8421 4 yes
GO:1904062 regulation of cation transmembrane transport 36.8421 6 yes
GO:0031344 regulation of cell projection organization 36.8421 5 no
GO:0009893 positive regulation of metabolic process 36.8421 4 no
GO:0031323 regulation of cellular metabolic process 36.8421 4 no
GO:0051171 regulation of nitrogen compound metabolic process 36.8421 4 no
GO:0080090 regulation of primary metabolic process 36.8421 4 no
GO:0044057 regulation of system process 31.5789 4 yes
GO:2001257 regulation of cation channel activity 31.5789 6 yes
GO:0010975 regulation of neuron projection development 31.5789 7 no
GO:0120035 regulation of plasma membrane bounded cell projection organization 31.5789 6 no
GO:0010604 positive regulation of macromolecule metabolic process 31.5789 5 no
GO:0051246 regulation of protein metabolic process 31.5789 5 no
GO:0010648 negative regulation of cell communication 26.3158 5 yes
GO:0023057 negative regulation of signaling 26.3158 4 yes
GO:0032880 regulation of protein localization 26.3158 5 yes
GO:0048168 regulation of neuronal synaptic plasticity 26.3158 4 yes
GO:0099601 regulation of neurotransmitter receptor activity 26.3158 4 yes
GO:0016192 vesicle-mediated transport 26.3158 4 no
GO:0050890 cognition 26.3158 4 no
GO:0043113 receptor clustering 26.3158 5 no
GO:0072657 protein localization to membrane 26.3158 4 no
GO:0015031 protein transport 26.3158 4 no
GO:0071702 organic substance transport 26.3158 4 no
GO:0071705 nitrogen compound transport 26.3158 4 no
GO:0031325 positive regulation of cellular metabolic process 26.3158 5 no
GO:0031399 regulation of protein modification process 26.3158 6 no
GO:0051173 positive regulation of nitrogen compound metabolic process 26.3158 5 no
GO:0051247 positive regulation of protein metabolic process 26.3158 6 no
GO:0009892 negative regulation of metabolic process 26.3158 4 no
GO:0022603 regulation of anatomical structure morphogenesis 26.3158 4 no
GO:0051051 negative regulation of transport 26.3158 4 no
GO:0010647 positive regulation of cell communication 26.3158 5 no
GO:0023056 positive regulation of signaling 26.3158 4 no
GO:0036211 protein modification process 26.3158 4 no
GO:0043412 macromolecule modification 26.3158 4 no
GO:0007268 chemical synaptic transmission 21.0526 6 yes
GO:0098916 anterograde trans-synaptic signaling 21.0526 5 yes
GO:0099537 trans-synaptic signaling 21.0526 4 yes
GO:2000311 regulation of AMPA receptor activity 21.0526 5 yes
GO:0010959 regulation of metal ion transport 21.0526 6 no
GO:0031401 positive regulation of protein modification process 21.0526 7 no
GO:0010605 negative regulation of macromolecule metabolic process 21.0526 5 no
GO:0031324 negative regulation of cellular metabolic process 21.0526 5 no
GO:0006996 organelle organization 21.0526 4 no
GO:0050806 positive regulation of synaptic transmission 21.0526 5 no
GO:0009889 regulation of biosynthetic process 21.0526 4 no
GO:0010468 regulation of gene expression 21.0526 5 no
GO:0010556 regulation of macromolecule biosynthetic process 21.0526 5 no
GO:0010941 regulation of cell death 21.0526 4 no
GO:0031326 regulation of cellular biosynthetic process 21.0526 5 no
GO:0042981 regulation of apoptotic process 21.0526 6 no
GO:0043067 regulation of programmed cell death 21.0526 5 no
GO:0009968 negative regulation of signal transduction 15.7895 5 yes
GO:0031644 regulation of nervous system process 15.7895 5 yes
GO:0048585 negative regulation of response to stimulus 15.7895 4 yes
GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping 15.7895 4 yes
GO:0099628 neurotransmitter receptor diffusion trapping 15.7895 4 yes
GO:0106104 regulation of glutamate receptor clustering 15.7895 8 yes
GO:1903909 regulation of receptor clustering 15.7895 7 yes
GO:1904717 regulation of AMPA glutamate receptor clustering 15.7895 9 yes
GO:1905475 regulation of protein localization to membrane 15.7895 6 yes
GO:0048172 regulation of short-term neuronal synaptic plasticity 10.5263 5 yes
GO:0098962 regulation of postsynaptic neurotransmitter receptor activity 10.5263 5 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
GRIA2_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA1_HUMAN [view entry] [view interactions] Low throughput yes yes
GRIA3_HUMAN [view entry] [view interactions] Low throughput yes yes
DLG4_HUMAN [view entry] [view interactions] Low throughput yes yes
SRCN1_HUMAN [view entry] [view interactions] High throughput yes yes
PKHG4_HUMAN [view interactions] High throughput no no
K1H1_HUMAN [view interactions] High throughput no no
CRTP1_HUMAN [view interactions] High throughput no yes
GOGA2_HUMAN [view entry] [view interactions] High throughput yes yes
HSF2B_HUMAN [view interactions] High throughput no yes
TRIP6_HUMAN [view interactions] High throughput no yes
MS18B_HUMAN [view interactions] High throughput no no
PFD5_HUMAN [view interactions] High throughput no yes
BAG3_HUMAN [view entry] [view interactions] High throughput yes no
FBLI1_HUMAN [view interactions] High throughput no yes
KRA33_HUMAN [view interactions] High throughput no no
CDN1A_HUMAN [view interactions] High throughput no no
SMRD1_HUMAN [view interactions] High throughput no yes
KAT5_HUMAN [view interactions] High throughput no yes
EXOS5_HUMAN [view interactions] High throughput no yes
CIAO1_HUMAN [view interactions] High throughput no yes
TSSK3_HUMAN [view interactions] High throughput no no
KIF9_HUMAN [view interactions] High throughput no yes
TTC19_HUMAN [view interactions] High throughput no yes
ARMC7_HUMAN [view interactions] High throughput no yes
TRPV2_HUMAN [view interactions] High throughput no yes
LMO3_HUMAN [view interactions] High throughput no no
ANS1A_HUMAN [view interactions] High throughput no yes
NEDD4_HUMAN [view entry] [view interactions] High throughput yes yes
TLE5_HUMAN [view interactions] High throughput no no
KIFC3_HUMAN [view interactions] High throughput no no
UBS3A_HUMAN [view interactions] High throughput no no
CTBP2_HUMAN [view interactions] High throughput no no
CCD57_HUMAN [view interactions] High throughput no yes
CARD9_HUMAN [view interactions] High throughput no no
SYGP1_HUMAN [view entry] [view interactions] High throughput yes yes
KLH42_HUMAN [view interactions] High throughput no yes
KLH18_HUMAN [view interactions] High throughput no yes
SELH_HUMAN [view interactions] High throughput no yes
NAGK_HUMAN [view interactions] High throughput no no
KCC2D_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2G_HUMAN [view entry] [view interactions] High throughput yes yes
KCC2B_HUMAN [view entry] [view interactions] High throughput yes yes
PTER_HUMAN [view interactions] High throughput no yes
NOE1_HUMAN [view entry] [view interactions] High throughput yes no
PRRT1_HUMAN [view entry] [view interactions] High throughput yes yes
CCG8_HUMAN [view entry] [view interactions] High throughput yes no
DLG3_HUMAN [view entry] [view interactions] High throughput yes yes
LRRC7_HUMAN [view entry] [view interactions] High throughput yes no
SHSA7_HUMAN [view entry] [view interactions] High throughput yes no