NOE1_HUMAN
Evidence for PS localization
Functions
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse . May play an important role in regulating the production of neural crest cells by the neural tube . May be required for normal responses to olfactory stimuli . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NOE1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 70.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 60.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 60.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 60.0000 | 4 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
| GO:0031323 | regulation of cellular metabolic process | 50.0000 | 4 | yes |
| GO:0031324 | negative regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:0031325 | positive regulation of cellular metabolic process | 50.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 50.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 50.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 50.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 50.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 50.0000 | 4 | no |
| GO:0009889 | regulation of biosynthetic process | 40.0000 | 4 | yes |
| GO:0009890 | negative regulation of biosynthetic process | 40.0000 | 5 | yes |
| GO:0009891 | positive regulation of biosynthetic process | 40.0000 | 5 | yes |
| GO:0010468 | regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010556 | regulation of macromolecule biosynthetic process | 40.0000 | 5 | yes |
| GO:0010557 | positive regulation of macromolecule biosynthetic process | 40.0000 | 6 | yes |
| GO:0010558 | negative regulation of macromolecule biosynthetic process | 40.0000 | 6 | yes |
| GO:0010628 | positive regulation of gene expression | 40.0000 | 7 | yes |
| GO:0010629 | negative regulation of gene expression | 40.0000 | 7 | yes |
| GO:0031326 | regulation of cellular biosynthetic process | 40.0000 | 5 | yes |
| GO:0031327 | negative regulation of cellular biosynthetic process | 40.0000 | 6 | yes |
| GO:0031328 | positive regulation of cellular biosynthetic process | 40.0000 | 6 | yes |
| GO:0045597 | positive regulation of cell differentiation | 40.0000 | 5 | yes |
| GO:0048638 | regulation of developmental growth | 40.0000 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 40.0000 | 4 | yes |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0001558 | regulation of cell growth | 30.0000 | 4 | yes |
| GO:0007399 | nervous system development | 30.0000 | 4 | yes |
| GO:0030516 | regulation of axon extension | 30.0000 | 5 | yes |
| GO:0061387 | regulation of extent of cell growth | 30.0000 | 5 | yes |
| GO:0007215 | glutamate receptor signaling pathway | 30.0000 | 4 | no |
| GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 30.0000 | 8 | no |
| GO:0006996 | organelle organization | 30.0000 | 4 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0031344 | regulation of cell projection organization | 30.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 30.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 30.0000 | 7 | no |
| GO:0050807 | regulation of synapse organization | 30.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 30.0000 | 6 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 30.0000 | 5 | no |
| GO:0009966 | regulation of signal transduction | 30.0000 | 4 | no |
| GO:0010647 | positive regulation of cell communication | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0023056 | positive regulation of signaling | 30.0000 | 4 | no |
| GO:0030111 | regulation of Wnt signaling pathway | 30.0000 | 5 | no |
| GO:0051130 | positive regulation of cellular component organization | 30.0000 | 5 | no |
| GO:0001837 | epithelial to mesenchymal transition | 20.0000 | 5 | yes |
| GO:0003190 | atrioventricular valve formation | 20.0000 | 4 | yes |
| GO:0010717 | regulation of epithelial to mesenchymal transition | 20.0000 | 5 | yes |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition | 20.0000 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 20.0000 | 5 | yes |
| GO:0043065 | positive regulation of apoptotic process | 20.0000 | 6 | yes |
| GO:0043067 | regulation of programmed cell death | 20.0000 | 4 | yes |
| GO:0043068 | positive regulation of programmed cell death | 20.0000 | 5 | yes |
| GO:0048762 | mesenchymal cell differentiation | 20.0000 | 4 | yes |
| GO:0060317 | cardiac epithelial to mesenchymal transition | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NOE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| MANEA_HUMAN | [view interactions] | High throughput | no | yes |
| PCOC2_HUMAN | [view interactions] | High throughput | no | no |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RUNX1_HUMAN | [view interactions] | High throughput | no | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| BMAL2_HUMAN | [view interactions] | High throughput | no | yes |
| MYCN_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOE3_HUMAN | [view interactions] | High throughput | no | no |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| GRIA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TGON2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |