NOE1_HUMAN
Evidence for PS localization
Functions
Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse . May play an important role in regulating the production of neural crest cells by the neural tube . May be required for normal responses to olfactory stimuli . [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
No data found.
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in NOE1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 90.0000 | 4 | yes |
| GO:0051094 | positive regulation of developmental process | 70.0000 | 4 | yes |
| GO:0051128 | regulation of cellular component organization | 70.0000 | 4 | yes |
| GO:0009893 | positive regulation of metabolic process | 60.0000 | 4 | yes |
| GO:0010604 | positive regulation of macromolecule metabolic process | 60.0000 | 5 | yes |
| GO:0045595 | regulation of cell differentiation | 60.0000 | 4 | yes |
| GO:0045597 | positive regulation of cell differentiation | 60.0000 | 5 | yes |
| GO:0060255 | regulation of macromolecule metabolic process | 60.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 60.0000 | 4 | no |
| GO:0009892 | negative regulation of metabolic process | 50.0000 | 4 | yes |
| GO:0010605 | negative regulation of macromolecule metabolic process | 50.0000 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 50.0000 | 4 | no |
| GO:0009966 | regulation of signal transduction | 50.0000 | 4 | no |
| GO:0010468 | regulation of gene expression | 40.0000 | 5 | yes |
| GO:0010628 | positive regulation of gene expression | 40.0000 | 6 | yes |
| GO:0010629 | negative regulation of gene expression | 40.0000 | 6 | yes |
| GO:0048638 | regulation of developmental growth | 40.0000 | 4 | yes |
| GO:0051240 | positive regulation of multicellular organismal process | 40.0000 | 4 | yes |
| GO:0031323 | regulation of cellular metabolic process | 40.0000 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 40.0000 | 5 | no |
| GO:0031344 | regulation of cell projection organization | 40.0000 | 5 | no |
| GO:0051049 | regulation of transport | 40.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 40.0000 | 4 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 40.0000 | 5 | no |
| GO:0051246 | regulation of protein metabolic process | 40.0000 | 5 | no |
| GO:0051247 | positive regulation of protein metabolic process | 40.0000 | 6 | no |
| GO:0080090 | regulation of primary metabolic process | 40.0000 | 4 | no |
| GO:0120035 | regulation of plasma membrane bounded cell projection organization | 40.0000 | 6 | no |
| GO:0010647 | positive regulation of cell communication | 40.0000 | 5 | no |
| GO:0023056 | positive regulation of signaling | 40.0000 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 40.0000 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 40.0000 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 40.0000 | 5 | no |
| GO:0023057 | negative regulation of signaling | 40.0000 | 4 | no |
| GO:0050804 | modulation of chemical synaptic transmission | 40.0000 | 5 | no |
| GO:0099177 | regulation of trans-synaptic signaling | 40.0000 | 4 | no |
| GO:0030111 | regulation of Wnt signaling pathway | 40.0000 | 5 | no |
| GO:0001558 | regulation of cell growth | 30.0000 | 4 | yes |
| GO:0007399 | nervous system development | 30.0000 | 4 | yes |
| GO:0010941 | regulation of cell death | 30.0000 | 4 | yes |
| GO:0010942 | positive regulation of cell death | 30.0000 | 5 | yes |
| GO:0030516 | regulation of axon extension | 30.0000 | 5 | yes |
| GO:0042981 | regulation of apoptotic process | 30.0000 | 6 | yes |
| GO:0043065 | positive regulation of apoptotic process | 30.0000 | 7 | yes |
| GO:0043067 | regulation of programmed cell death | 30.0000 | 5 | yes |
| GO:0043068 | positive regulation of programmed cell death | 30.0000 | 6 | yes |
| GO:0061387 | regulation of extent of cell growth | 30.0000 | 5 | yes |
| GO:0001932 | regulation of protein phosphorylation | 30.0000 | 7 | no |
| GO:0001934 | positive regulation of protein phosphorylation | 30.0000 | 8 | no |
| GO:0010562 | positive regulation of phosphorus metabolic process | 30.0000 | 6 | no |
| GO:0016192 | vesicle-mediated transport | 30.0000 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 30.0000 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 30.0000 | 5 | no |
| GO:0031399 | regulation of protein modification process | 30.0000 | 6 | no |
| GO:0031401 | positive regulation of protein modification process | 30.0000 | 7 | no |
| GO:0032880 | regulation of protein localization | 30.0000 | 5 | no |
| GO:0042325 | regulation of phosphorylation | 30.0000 | 7 | no |
| GO:0042327 | positive regulation of phosphorylation | 30.0000 | 8 | no |
| GO:0045937 | positive regulation of phosphate metabolic process | 30.0000 | 7 | no |
| GO:0050807 | regulation of synapse organization | 30.0000 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 30.0000 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 30.0000 | 5 | no |
| GO:0060341 | regulation of cellular localization | 30.0000 | 4 | no |
| GO:0009967 | positive regulation of signal transduction | 30.0000 | 5 | no |
| GO:0022607 | cellular component assembly | 30.0000 | 4 | no |
| GO:0030030 | cell projection organization | 30.0000 | 4 | no |
| GO:0120036 | plasma membrane bounded cell projection organization | 30.0000 | 5 | no |
| GO:0009894 | regulation of catabolic process | 30.0000 | 4 | no |
| GO:0009896 | positive regulation of catabolic process | 30.0000 | 5 | no |
| GO:0022898 | regulation of transmembrane transporter activity | 30.0000 | 4 | no |
| GO:0030162 | regulation of proteolysis | 30.0000 | 6 | no |
| GO:0031329 | regulation of cellular catabolic process | 30.0000 | 5 | no |
| GO:0031644 | regulation of nervous system process | 30.0000 | 5 | no |
| GO:0032412 | regulation of ion transmembrane transporter activity | 30.0000 | 5 | no |
| GO:0034762 | regulation of transmembrane transport | 30.0000 | 4 | no |
| GO:0034765 | regulation of ion transmembrane transport | 30.0000 | 5 | no |
| GO:0043269 | regulation of ion transport | 30.0000 | 5 | no |
| GO:0044057 | regulation of system process | 30.0000 | 4 | no |
| GO:0045862 | positive regulation of proteolysis | 30.0000 | 7 | no |
| GO:1904062 | regulation of cation transmembrane transport | 30.0000 | 6 | no |
| GO:2001257 | regulation of cation channel activity | 30.0000 | 6 | no |
| GO:0009968 | negative regulation of signal transduction | 30.0000 | 5 | no |
| GO:0030178 | negative regulation of Wnt signaling pathway | 30.0000 | 6 | no |
| GO:0048585 | negative regulation of response to stimulus | 30.0000 | 4 | no |
| GO:0016055 | Wnt signaling pathway | 30.0000 | 5 | no |
| GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling | 30.0000 | 4 | no |
| GO:0001837 | epithelial to mesenchymal transition | 20.0000 | 5 | yes |
| GO:0003190 | atrioventricular valve formation | 20.0000 | 4 | yes |
| GO:0010717 | regulation of epithelial to mesenchymal transition | 20.0000 | 5 | yes |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition | 20.0000 | 5 | yes |
| GO:0048762 | mesenchymal cell differentiation | 20.0000 | 4 | yes |
| GO:0060317 | cardiac epithelial to mesenchymal transition | 20.0000 | 6 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| NOE1_HUMAN | [view entry] [view interactions] | Low throughput | yes | no |
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CE152_HUMAN | [view interactions] | High throughput | no | yes |
| PCOC2_HUMAN | [view interactions] | High throughput | no | no |
| MANEA_HUMAN | [view interactions] | High throughput | no | yes |
| ASPH_HUMAN | [view interactions] | High throughput | no | yes |
| NOE2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SRCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| EGFR_HUMAN | [view interactions] | High throughput | no | no |
| FMR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MIPT3_HUMAN | [view interactions] | High throughput | no | yes |
| MEOX2_HUMAN | [view interactions] | High throughput | no | no |
| TBA3C_HUMAN | [view interactions] | High throughput | no | no |
| TBA3D_HUMAN | [view interactions] | High throughput | no | no |
| TXD11_HUMAN | [view interactions] | High throughput | no | yes |
| EDEM2_HUMAN | [view interactions] | High throughput | no | yes |
| BMAL2_HUMAN | [view interactions] | High throughput | no | yes |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NOE3_HUMAN | [view interactions] | High throughput | no | no |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| T106B_HUMAN | [view interactions] | High throughput | no | yes |
| TEN4_HUMAN | [view interactions] | Computational | no | no |
| WIF1_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| WASF1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| CAC1B_HUMAN | [view interactions] | Computational | no | yes |
| EHMT1_HUMAN | [view interactions] | Computational | no | yes |