PRRT1_HUMAN
Evidence for PS localization
Functions
Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in PRRT1_HUMAN |
|---|---|---|---|---|
| GO:0035254 | glutamate receptor binding | 60.0000 | 4 | no |
| GO:0035255 | ionotropic glutamate receptor binding | 60.0000 | 5 | no |
| GO:0030165 | PDZ domain binding | 40.0000 | 4 | no |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in PRRT1_HUMAN |
|---|---|---|---|---|
| GO:0009966 | regulation of signal transduction | 100.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 100.0000 | 4 | yes |
| GO:0022898 | regulation of transmembrane transporter activity | 100.0000 | 4 | yes |
| GO:0032412 | regulation of ion transmembrane transporter activity | 100.0000 | 5 | yes |
| GO:0034762 | regulation of transmembrane transport | 100.0000 | 4 | yes |
| GO:0034765 | regulation of ion transmembrane transport | 100.0000 | 5 | yes |
| GO:0043269 | regulation of ion transport | 100.0000 | 5 | yes |
| GO:0050804 | modulation of chemical synaptic transmission | 100.0000 | 5 | yes |
| GO:0051049 | regulation of transport | 100.0000 | 4 | yes |
| GO:0099177 | regulation of trans-synaptic signaling | 100.0000 | 4 | yes |
| GO:0099601 | regulation of neurotransmitter receptor activity | 100.0000 | 4 | yes |
| GO:1904062 | regulation of cation transmembrane transport | 100.0000 | 6 | yes |
| GO:2001257 | regulation of cation channel activity | 100.0000 | 6 | yes |
| GO:0008104 | protein localization | 80.0000 | 4 | yes |
| GO:0010647 | positive regulation of cell communication | 80.0000 | 5 | yes |
| GO:0023056 | positive regulation of signaling | 80.0000 | 4 | yes |
| GO:0048522 | positive regulation of cellular process | 80.0000 | 4 | yes |
| GO:0048523 | negative regulation of cellular process | 80.0000 | 4 | yes |
| GO:0050806 | positive regulation of synaptic transmission | 80.0000 | 5 | yes |
| GO:0050890 | cognition | 80.0000 | 4 | yes |
| GO:2000311 | regulation of AMPA receptor activity | 80.0000 | 5 | yes |
| GO:0010648 | negative regulation of cell communication | 60.0000 | 5 | yes |
| GO:0023057 | negative regulation of signaling | 60.0000 | 4 | yes |
| GO:0031644 | regulation of nervous system process | 60.0000 | 5 | no |
| GO:0032880 | regulation of protein localization | 60.0000 | 5 | no |
| GO:0044057 | regulation of system process | 60.0000 | 4 | no |
| GO:0048168 | regulation of neuronal synaptic plasticity | 60.0000 | 4 | no |
| GO:0060341 | regulation of cellular localization | 60.0000 | 4 | no |
| GO:0106104 | regulation of glutamate receptor clustering | 60.0000 | 8 | no |
| GO:1903909 | regulation of receptor clustering | 60.0000 | 7 | no |
| GO:1904717 | regulation of AMPA glutamate receptor clustering | 60.0000 | 9 | no |
| GO:1905475 | regulation of protein localization to membrane | 60.0000 | 6 | no |
| GO:0006468 | protein phosphorylation | 40.0000 | 5 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | yes |
| GO:0016310 | phosphorylation | 40.0000 | 5 | yes |
| GO:0034330 | cell junction organization | 40.0000 | 4 | yes |
| GO:0034394 | protein localization to cell surface | 40.0000 | 5 | yes |
| GO:0036211 | protein modification process | 40.0000 | 4 | yes |
| GO:0043412 | macromolecule modification | 40.0000 | 4 | yes |
| GO:0050805 | negative regulation of synaptic transmission | 40.0000 | 5 | yes |
| GO:0050808 | synapse organization | 40.0000 | 5 | yes |
| GO:0060291 | long-term synaptic potentiation | 40.0000 | 4 | yes |
| GO:0060292 | long-term synaptic depression | 40.0000 | 4 | yes |
| GO:0043113 | receptor clustering | 40.0000 | 5 | no |
| GO:0048172 | regulation of short-term neuronal synaptic plasticity | 40.0000 | 5 | no |
| GO:0072578 | neurotransmitter-gated ion channel clustering | 40.0000 | 6 | no |
| GO:0072657 | protein localization to membrane | 40.0000 | 4 | no |
| GO:0098962 | regulation of postsynaptic neurotransmitter receptor activity | 40.0000 | 5 | no |
| GO:0007268 | chemical synaptic transmission | 40.0000 | 6 | no |
| GO:0098916 | anterograde trans-synaptic signaling | 40.0000 | 5 | no |
| GO:0098970 | postsynaptic neurotransmitter receptor diffusion trapping | 40.0000 | 4 | no |
| GO:0099537 | trans-synaptic signaling | 40.0000 | 4 | no |
| GO:0099628 | neurotransmitter receptor diffusion trapping | 40.0000 | 4 | no |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DLG4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| MAL_HUMAN | [view interactions] | High throughput | no | no |
| PRRT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI55_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| REEP6_HUMAN | [view interactions] | High throughput | no | no |
| PRAF3_HUMAN | [view interactions] | High throughput | no | yes |
| F241B_HUMAN | [view interactions] | High throughput | no | yes |
| K2C8_HUMAN | [view interactions] | High throughput | no | no |
| SHSA6_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| SHSA7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |