KAD3_HUMAN
Evidence for PS localization
Functions
Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. [View more on UniProt]
Protein features
Binary interactions with known binding regions
Interacting region for partners were not defined.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KAD3_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 44.7368 | 4 | no |
| GO:0017076 | purine nucleotide binding | 36.8421 | 4 | yes |
| GO:0032555 | purine ribonucleotide binding | 36.8421 | 4 | yes |
| GO:0030554 | adenyl nucleotide binding | 31.5789 | 5 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 31.5789 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 23.6842 | 4 | yes |
| GO:0005524 | ATP binding | 21.0526 | 5 | yes |
| GO:0003723 | RNA binding | 21.0526 | 4 | no |
| GO:0042578 | phosphoric ester hydrolase activity | 21.0526 | 4 | no |
| GO:0016301 | kinase activity | 15.7895 | 4 | yes |
| GO:0019001 | guanyl nucleotide binding | 15.7895 | 5 | yes |
| GO:0032561 | guanyl ribonucleotide binding | 15.7895 | 5 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 13.1579 | 4 | yes |
| GO:0019205 | nucleobase-containing compound kinase activity | 13.1579 | 5 | yes |
| GO:0005525 | GTP binding | 7.8947 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KAD3_HUMAN |
|---|---|---|---|---|
| GO:0048523 | negative regulation of cellular process | 52.6316 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 50.0000 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 47.3684 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 47.3684 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 47.3684 | 4 | yes |
| GO:0006796 | phosphate-containing compound metabolic process | 47.3684 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 47.3684 | 5 | yes |
| GO:0009893 | positive regulation of metabolic process | 44.7368 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 39.4737 | 5 | yes |
| GO:0072521 | purine-containing compound metabolic process | 39.4737 | 4 | yes |
| GO:0010468 | regulation of gene expression | 39.4737 | 5 | no |
| GO:0031323 | regulation of cellular metabolic process | 39.4737 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 36.8421 | 4 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 36.8421 | 6 | yes |
| GO:0009259 | ribonucleotide metabolic process | 36.8421 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 36.8421 | 4 | yes |
| GO:0009966 | regulation of signal transduction | 36.8421 | 4 | no |
| GO:0010604 | positive regulation of macromolecule metabolic process | 36.8421 | 5 | no |
| GO:0010646 | regulation of cell communication | 36.8421 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 34.2105 | 5 | no |
| GO:0048585 | negative regulation of response to stimulus | 34.2105 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 31.5789 | 4 | yes |
| GO:0009889 | regulation of biosynthetic process | 31.5789 | 4 | no |
| GO:0010556 | regulation of macromolecule biosynthetic process | 31.5789 | 5 | no |
| GO:0010941 | regulation of cell death | 31.5789 | 4 | no |
| GO:0031326 | regulation of cellular biosynthetic process | 31.5789 | 5 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 28.9474 | 5 | no |
| GO:0051173 | positive regulation of nitrogen compound metabolic process | 28.9474 | 5 | no |
| GO:0051252 | regulation of RNA metabolic process | 28.9474 | 5 | no |
| GO:0060548 | negative regulation of cell death | 28.9474 | 5 | no |
| GO:1901565 | organonitrogen compound catabolic process | 28.9474 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 28.9474 | 5 | no |
| GO:0019752 | carboxylic acid metabolic process | 28.9474 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 28.9474 | 4 | no |
| GO:0006996 | organelle organization | 28.9474 | 4 | no |
| GO:0048584 | positive regulation of response to stimulus | 28.9474 | 4 | no |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 28.9474 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 28.9474 | 4 | no |
| GO:0009968 | negative regulation of signal transduction | 28.9474 | 5 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 28.9474 | 5 | no |
| GO:0010648 | negative regulation of cell communication | 28.9474 | 5 | no |
| GO:0019219 | regulation of nucleobase-containing compound metabolic process | 28.9474 | 5 | no |
| GO:0023057 | negative regulation of signaling | 28.9474 | 4 | no |
| GO:0042981 | regulation of apoptotic process | 28.9474 | 6 | no |
| GO:0043067 | regulation of programmed cell death | 28.9474 | 5 | no |
| GO:1903506 | regulation of nucleic acid-templated transcription | 26.3158 | 7 | no |
| GO:2001141 | regulation of RNA biosynthetic process | 26.3158 | 6 | no |
| GO:0071310 | cellular response to organic substance | 26.3158 | 4 | no |
| GO:0018130 | heterocycle biosynthetic process | 26.3158 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 26.3158 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 26.3158 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 26.3158 | 4 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 26.3158 | 4 | yes |
| GO:0006355 | regulation of DNA-templated transcription | 26.3158 | 6 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.3158 | 5 | no |
| GO:0043066 | negative regulation of apoptotic process | 26.3158 | 7 | no |
| GO:0043069 | negative regulation of programmed cell death | 26.3158 | 6 | no |
| GO:0051247 | positive regulation of protein metabolic process | 23.6842 | 6 | no |
| GO:1901361 | organic cyclic compound catabolic process | 23.6842 | 4 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 23.6842 | 4 | no |
| GO:0022607 | cellular component assembly | 23.6842 | 4 | no |
| GO:0031325 | positive regulation of cellular metabolic process | 23.6842 | 5 | no |
| GO:0009165 | nucleotide biosynthetic process | 23.6842 | 6 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 23.6842 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 23.6842 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 23.6842 | 5 | yes |
| GO:0080134 | regulation of response to stress | 21.0526 | 4 | no |
| GO:1902532 | negative regulation of intracellular signal transduction | 21.0526 | 6 | no |
| GO:0019439 | aromatic compound catabolic process | 21.0526 | 4 | no |
| GO:0009894 | regulation of catabolic process | 21.0526 | 4 | no |
| GO:1901701 | cellular response to oxygen-containing compound | 21.0526 | 4 | no |
| GO:0006164 | purine nucleotide biosynthetic process | 21.0526 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 21.0526 | 7 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 21.0526 | 6 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 21.0526 | 5 | yes |
| GO:0051049 | regulation of transport | 21.0526 | 4 | no |
| GO:0009132 | nucleoside diphosphate metabolic process | 18.4211 | 5 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 18.4211 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 18.4211 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 18.4211 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 18.4211 | 7 | yes |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 15.7895 | 6 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 15.7895 | 6 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 13.1579 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 13.1579 | 7 | yes |
| GO:0046031 | ADP metabolic process | 13.1579 | 7 | yes |
| GO:0006220 | pyrimidine nucleotide metabolic process | 10.5263 | 5 | yes |
| GO:0009147 | pyrimidine nucleoside triphosphate metabolic process | 10.5263 | 6 | yes |
| GO:0009208 | pyrimidine ribonucleoside triphosphate metabolic process | 10.5263 | 7 | yes |
| GO:0009218 | pyrimidine ribonucleotide metabolic process | 10.5263 | 6 | yes |
| GO:0046039 | GTP metabolic process | 10.5263 | 7 | yes |
| GO:0046051 | UTP metabolic process | 10.5263 | 7 | yes |
| GO:0072527 | pyrimidine-containing compound metabolic process | 10.5263 | 4 | yes |
| GO:0009123 | nucleoside monophosphate metabolic process | 7.8947 | 5 | yes |
| GO:0009126 | purine nucleoside monophosphate metabolic process | 7.8947 | 6 | yes |
| GO:0009161 | ribonucleoside monophosphate metabolic process | 7.8947 | 6 | yes |
| GO:0009167 | purine ribonucleoside monophosphate metabolic process | 7.8947 | 7 | yes |
| GO:0046033 | AMP metabolic process | 7.8947 | 7 | yes |
| GO:0006172 | ADP biosynthetic process | 5.2632 | 8 | yes |
| GO:0009133 | nucleoside diphosphate biosynthetic process | 5.2632 | 6 | yes |
| GO:0009136 | purine nucleoside diphosphate biosynthetic process | 5.2632 | 7 | yes |
| GO:0009180 | purine ribonucleoside diphosphate biosynthetic process | 5.2632 | 8 | yes |
| GO:0009188 | ribonucleoside diphosphate biosynthetic process | 5.2632 | 7 | yes |
Disease
| Term | Name | % | Distance from top the of the tree | Annotated in KAD3_HUMAN |
|---|---|---|---|---|
| DOID:1289 | neurodegenerative disease | 5.2632 | 4 | no |
| DOID:331 | central nervous system disease | 5.2632 | 3 | no |
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| DISC1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| AATC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DAPK3_HUMAN | [view interactions] | High throughput | no | yes |
| ZDH17_HUMAN | [view interactions] | High throughput | no | yes |
| APBP2_HUMAN | [view interactions] | High throughput | no | yes |
| KR108_HUMAN | [view interactions] | High throughput | no | no |
| APOE_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GRN_HUMAN | [view interactions] | High throughput | no | no |
| WFS1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| JPH3_HUMAN | [view interactions] | High throughput | no | no |
| HD_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TRI54_HUMAN | [view interactions] | High throughput | no | no |
| CLPP_HUMAN | [view interactions] | High throughput | no | yes |
| CH60_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MGST3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDK1_HUMAN | [view interactions] | High throughput | no | yes |
| TR61B_HUMAN | [view interactions] | High throughput | no | yes |
| FHI2B_HUMAN | [view interactions] | High throughput | no | yes |
| FBLN1_HUMAN | [view interactions] | High throughput | no | yes |
| ELAV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CAF17_HUMAN | [view interactions] | High throughput | no | no |
| RECQ4_HUMAN | [view interactions] | High throughput | no | yes |
| CFAD_HUMAN | [view interactions] | High throughput | no | no |
| FNDC5_HUMAN | [view interactions] | High throughput | no | no |
| RS4Y1_HUMAN | [view interactions] | High throughput | no | yes |
| ACON_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HNRL2_HUMAN | [view interactions] | High throughput | no | yes |
| RS14_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIM_HUMAN | [view interactions] | High throughput | no | yes |
| COF1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| PRDX5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TXD12_HUMAN | [view interactions] | High throughput | no | no |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| THIK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RAB7A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| COX17_HUMAN | [view interactions] | High throughput | no | yes |
| PPIA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MDHM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SODM_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MSRB2_HUMAN | [view interactions] | High throughput | no | no |
| ISOC2_HUMAN | [view interactions] | High throughput | no | yes |
| NB5R3_HUMAN | [view interactions] | High throughput | no | yes |
| KPYM_HUMAN | [view interactions] | High throughput | no | yes |
| KAD1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| KAD4_HUMAN | [view interactions] | High throughput | no | yes |
| COA4_HUMAN | [view interactions] | High throughput | no | yes |
| CATB_HUMAN | [view interactions] | High throughput | no | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| GBRL2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GIMA8_HUMAN | [view interactions] | High throughput | no | yes |
| LYPA1_HUMAN | [view interactions] | High throughput | no | yes |
| MSRB3_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
| RBP2_HUMAN | [view interactions] | High throughput | no | yes |
| SUMF2_HUMAN | [view interactions] | High throughput | no | yes |
| TRIA1_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| MRM1_HUMAN | [view interactions] | High throughput | no | no |
| GAL3A_HUMAN | [view interactions] | High throughput | no | yes |
| GAL3B_HUMAN | [view interactions] | High throughput | no | yes |
| CISY_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAKD4_HUMAN | [view interactions] | High throughput | no | yes |
| EFTS_HUMAN | [view interactions] | High throughput | no | no |
| SYAM_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDKA_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 5NTD_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| DCK_HUMAN | [view interactions] | Computational | no | no |
| RIR2B_HUMAN | [view interactions] | Computational | no | yes |
| 5NTC_HUMAN | [view interactions] | Computational | no | yes |
| NT5C_HUMAN | [view interactions] | Computational | no | yes |
| PDE1B_HUMAN | [view interactions] | Computational | no | yes |
| PDE4B_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ENTP3_HUMAN | [view interactions] | Computational | no | no |
| NDKB_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| AMPD3_HUMAN | [view interactions] | Computational | no | no |
| RIR1_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| 5NT1B_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PDE7B_HUMAN | [view interactions] | Computational | no | no |
| PDE1A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDE3B_HUMAN | [view interactions] | Computational | no | no |
| RIR2_HUMAN | [view interactions] | Computational | no | no |
| AMPD1_HUMAN | [view interactions] | Computational | no | yes |
| 5NT1A_HUMAN | [view interactions] | Computational | no | yes |
| NT5M_HUMAN | [view interactions] | Computational | no | yes |
| 5NT3B_HUMAN | [view interactions] | Computational | no | yes |
| NDK3_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ENPP3_HUMAN | [view interactions] | Computational | no | no |
| APT_HUMAN | [view interactions] | Computational | no | yes |
| PDE7A_HUMAN | [view interactions] | Computational | no | yes |
| NDK7_HUMAN | [view interactions] | Computational | no | yes |
| NTPCR_HUMAN | [view interactions] | Computational | no | yes |
| ENTP1_HUMAN | [view interactions] | Computational | no | yes |
| PDE8B_HUMAN | [view interactions] | Computational | no | no |
| PDE11_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| PDE8A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| ENTP2_HUMAN | [view interactions] | Computational | no | yes |
| PDE3A_HUMAN | [view interactions] | Computational | no | no |
| NDKM_HUMAN | [view interactions] | Computational | no | yes |
| ENTP8_HUMAN | [view interactions] | Computational | no | no |
| PUR8_HUMAN | [view interactions] | Computational | no | yes |
| KPYR_HUMAN | [view entry] [view interactions] | Computational | yes | no |
| PDE4A_HUMAN | [view interactions] | Computational | no | no |
| PDE4D_HUMAN | [view entry] [view interactions] | Computational | yes | yes |
| KAD9_HUMAN | [view interactions] | Computational | no | yes |
| PDE2A_HUMAN | [view entry] [view interactions] | Computational | yes | yes |