Features Interactions Isoform Disease Linear motifs Fingerprint Network All partners

KAD1_HUMAN

Evidence for PS localization

GO
G2C
SynGO
SynaptomeDB
HPA (protein expression in neurons)

Functions

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. [View more on UniProt]

Protein features

Binary interactions with known binding regions

To display all evidence describing the interaction with a partner, click on the protein name left to the bars.

Network

Download full PS network for entry.

Isoforms

Disease-causing germline mutations

No data found.

Linear motifs

No annotated instance was found. To search for linear motifs, use the ELM prediction server.

Fingerprint

Molecular function

Term Name % Distance from the top of the tree Annotated in KAD1_HUMAN
GO:0043168 anion binding 33.3333 4 yes
GO:0043169 cation binding 33.3333 4 no
GO:0046872 metal ion binding 33.3333 5 no
GO:0000166 nucleotide binding 28.5714 4 yes
GO:0017076 purine nucleotide binding 28.5714 5 yes
GO:0030554 adenyl nucleotide binding 28.5714 6 yes
GO:0046914 transition metal ion binding 28.5714 6 no
GO:0019900 kinase binding 28.5714 4 no
GO:0019901 protein kinase binding 28.5714 5 no
GO:0003779 actin binding 23.8095 4 no
GO:0032555 purine ribonucleotide binding 19.0476 4 yes
GO:0032559 adenyl ribonucleotide binding 19.0476 5 yes
GO:0005524 ATP binding 14.2857 5 yes
GO:0016301 kinase activity 14.2857 4 yes
GO:0016776 phosphotransferase activity, phosphate group as acceptor 14.2857 4 yes
GO:0019205 nucleobase-containing compound kinase activity 14.2857 5 yes
GO:0035639 purine ribonucleoside triphosphate binding 14.2857 4 yes
GO:0046899 nucleoside triphosphate adenylate kinase activity 14.2857 5 yes
GO:0004017 adenylate kinase activity 9.5238 6 yes
GO:0004550 nucleoside diphosphate kinase activity 9.5238 5 yes
GO:0050145 nucleoside monophosphate kinase activity 9.5238 5 yes

Biological process

Term Name % Distance from top the of the tree Annotated in KAD1_HUMAN
GO:0048522 positive regulation of cellular process 57.1429 4 no
GO:0048523 negative regulation of cellular process 42.8571 4 no
GO:0010646 regulation of cell communication 42.8571 4 no
GO:0006796 phosphate-containing compound metabolic process 38.0952 4 yes
GO:0009892 negative regulation of metabolic process 38.0952 4 no
GO:0010605 negative regulation of macromolecule metabolic process 38.0952 5 no
GO:0019220 regulation of phosphate metabolic process 38.0952 6 no
GO:0031323 regulation of cellular metabolic process 38.0952 4 no
GO:0031324 negative regulation of cellular metabolic process 38.0952 5 no
GO:0031399 regulation of protein modification process 38.0952 6 no
GO:0051128 regulation of cellular component organization 38.0952 4 no
GO:0051174 regulation of phosphorus metabolic process 38.0952 5 no
GO:0051246 regulation of protein metabolic process 38.0952 5 no
GO:0060255 regulation of macromolecule metabolic process 38.0952 4 no
GO:0080090 regulation of primary metabolic process 38.0952 4 no
GO:0009966 regulation of signal transduction 38.0952 4 no
GO:0036211 protein modification process 38.0952 4 no
GO:0043412 macromolecule modification 38.0952 4 no
GO:0022607 cellular component assembly 33.3333 4 no
GO:0031400 negative regulation of protein modification process 33.3333 7 no
GO:0042325 regulation of phosphorylation 33.3333 7 no
GO:0043933 protein-containing complex organization 33.3333 4 no
GO:0051049 regulation of transport 33.3333 4 no
GO:0051248 negative regulation of protein metabolic process 33.3333 6 no
GO:0010038 response to metal ion 33.3333 4 no
GO:0009893 positive regulation of metabolic process 33.3333 4 no
GO:0032880 regulation of protein localization 33.3333 5 no
GO:0050804 modulation of chemical synaptic transmission 33.3333 5 no
GO:0060341 regulation of cellular localization 33.3333 4 no
GO:0099177 regulation of trans-synaptic signaling 33.3333 4 no
GO:0080134 regulation of response to stress 33.3333 4 no
GO:0001932 regulation of protein phosphorylation 28.5714 7 no
GO:0010563 negative regulation of phosphorus metabolic process 28.5714 6 no
GO:0042326 negative regulation of phosphorylation 28.5714 8 no
GO:0045936 negative regulation of phosphate metabolic process 28.5714 7 no
GO:0051130 positive regulation of cellular component organization 28.5714 5 no
GO:0065003 protein-containing complex assembly 28.5714 5 no
GO:0044087 regulation of cellular component biogenesis 28.5714 4 no
GO:0048585 negative regulation of response to stimulus 28.5714 4 no
GO:1902531 regulation of intracellular signal transduction 28.5714 5 no
GO:0009889 regulation of biosynthetic process 28.5714 4 no
GO:0009890 negative regulation of biosynthetic process 28.5714 5 no
GO:0010468 regulation of gene expression 28.5714 6 no
GO:0010556 regulation of macromolecule biosynthetic process 28.5714 5 no
GO:0010558 negative regulation of macromolecule biosynthetic process 28.5714 6 no
GO:0010604 positive regulation of macromolecule metabolic process 28.5714 5 no
GO:0031325 positive regulation of cellular metabolic process 28.5714 5 no
GO:0031326 regulation of cellular biosynthetic process 28.5714 5 no
GO:0031327 negative regulation of cellular biosynthetic process 28.5714 6 no
GO:0043549 regulation of kinase activity 28.5714 5 no
GO:0051247 positive regulation of protein metabolic process 28.5714 6 no
GO:0051338 regulation of transferase activity 28.5714 4 no
GO:0048584 positive regulation of response to stimulus 28.5714 4 no
GO:0016310 phosphorylation 23.8095 5 yes
GO:0001933 negative regulation of protein phosphorylation 23.8095 8 no
GO:0006996 organelle organization 23.8095 4 no
GO:0043067 regulation of programmed cell death 23.8095 4 no
GO:0009968 negative regulation of signal transduction 23.8095 5 no
GO:0010648 negative regulation of cell communication 23.8095 5 no
GO:0023057 negative regulation of signaling 23.8095 4 no
GO:0032101 regulation of response to external stimulus 23.8095 4 no
GO:0006355 regulation of DNA-templated transcription 23.8095 7 no
GO:0019219 regulation of nucleobase-containing compound metabolic process 23.8095 5 no
GO:0030162 regulation of proteolysis 23.8095 6 no
GO:0050890 cognition 23.8095 4 no
GO:0051252 regulation of RNA metabolic process 23.8095 5 no
GO:0071310 cellular response to organic substance 23.8095 4 no
GO:1901701 cellular response to oxygen-containing compound 23.8095 4 no
GO:1903829 positive regulation of protein localization 23.8095 5 no
GO:2001141 regulation of RNA biosynthetic process 23.8095 6 no
GO:0009894 regulation of catabolic process 23.8095 4 no
GO:0010647 positive regulation of cell communication 23.8095 5 no
GO:0023056 positive regulation of signaling 23.8095 4 no
GO:0098657 import into cell 23.8095 4 no
GO:0051093 negative regulation of developmental process 23.8095 4 no
GO:0051240 positive regulation of multicellular organismal process 23.8095 4 no
GO:0006163 purine nucleotide metabolic process 19.0476 5 yes
GO:0006753 nucleoside phosphate metabolic process 19.0476 4 yes
GO:0009117 nucleotide metabolic process 19.0476 5 yes
GO:0009132 nucleoside diphosphate metabolic process 19.0476 5 yes
GO:0009135 purine nucleoside diphosphate metabolic process 19.0476 6 yes
GO:0009141 nucleoside triphosphate metabolic process 19.0476 5 yes
GO:0009144 purine nucleoside triphosphate metabolic process 19.0476 6 yes
GO:0009150 purine ribonucleotide metabolic process 19.0476 6 yes
GO:0009179 purine ribonucleoside diphosphate metabolic process 19.0476 7 yes
GO:0009185 ribonucleoside diphosphate metabolic process 19.0476 6 yes
GO:0009199 ribonucleoside triphosphate metabolic process 19.0476 6 yes
GO:0009205 purine ribonucleoside triphosphate metabolic process 19.0476 7 yes
GO:0009259 ribonucleotide metabolic process 19.0476 5 yes
GO:0019693 ribose phosphate metabolic process 19.0476 4 yes
GO:0046031 ADP metabolic process 19.0476 7 yes
GO:0072521 purine-containing compound metabolic process 19.0476 4 yes
GO:1901362 organic cyclic compound biosynthetic process 19.0476 4 yes
GO:1901566 organonitrogen compound biosynthetic process 19.0476 4 yes
GO:0006164 purine nucleotide biosynthetic process 14.2857 6 yes
GO:0006172 ADP biosynthetic process 14.2857 8 yes
GO:0009123 nucleoside monophosphate metabolic process 14.2857 5 yes
GO:0009126 purine nucleoside monophosphate metabolic process 14.2857 6 yes
GO:0009133 nucleoside diphosphate biosynthetic process 14.2857 6 yes
GO:0009136 purine nucleoside diphosphate biosynthetic process 14.2857 7 yes
GO:0009142 nucleoside triphosphate biosynthetic process 14.2857 6 yes
GO:0009152 purine ribonucleotide biosynthetic process 14.2857 7 yes
GO:0009161 ribonucleoside monophosphate metabolic process 14.2857 6 yes
GO:0009165 nucleotide biosynthetic process 14.2857 6 yes
GO:0009167 purine ribonucleoside monophosphate metabolic process 14.2857 7 yes
GO:0009180 purine ribonucleoside diphosphate biosynthetic process 14.2857 8 yes
GO:0009188 ribonucleoside diphosphate biosynthetic process 14.2857 7 yes
GO:0009260 ribonucleotide biosynthetic process 14.2857 6 yes
GO:0034654 nucleobase-containing compound biosynthetic process 14.2857 4 yes
GO:0046033 AMP metabolic process 14.2857 7 yes
GO:0046034 ATP metabolic process 14.2857 7 yes
GO:0046390 ribose phosphate biosynthetic process 14.2857 5 yes
GO:0072522 purine-containing compound biosynthetic process 14.2857 5 yes
GO:0090407 organophosphate biosynthetic process 14.2857 4 yes
GO:1901137 carbohydrate derivative biosynthetic process 14.2857 4 yes
GO:1901293 nucleoside phosphate biosynthetic process 14.2857 5 yes
GO:0015949 nucleobase-containing small molecule interconversion 9.5238 4 yes

Disease

No data found.

All partners

Uniprot ID Details Highest evidence Localizing into PSD HPA (protein expression in neurons)
FHL2_HUMAN [view interactions] Low throughput no yes
KAD1_HUMAN [view entry] [view interactions] Low throughput yes yes
KDM3B_HUMAN [view interactions] High throughput no yes
OGT1_HUMAN [view entry] [view interactions] High throughput yes yes
BUD13_HUMAN [view interactions] High throughput no yes
SUCB2_HUMAN [view interactions] High throughput no no
UTP4_HUMAN [view interactions] High throughput no yes
GEMI5_HUMAN [view interactions] High throughput no yes
DECR_HUMAN [view entry] [view interactions] High throughput yes yes
NBAS_HUMAN [view interactions] High throughput no yes
CD2B2_HUMAN [view interactions] High throughput no yes
RFIP2_HUMAN [view entry] [view interactions] High throughput yes yes
PCF11_HUMAN [view interactions] High throughput no no
B3GLT_HUMAN [view interactions] High throughput no no
HNRPU_HUMAN [view interactions] High throughput no yes
TAU_HUMAN [view entry] [view interactions] High throughput yes yes
CSF1_HUMAN [view interactions] High throughput no no
LRRK2_HUMAN [view interactions] High throughput no yes
MTR1A_HUMAN [view interactions] High throughput no no
CFTR_HUMAN [view interactions] High throughput no no
DUS3_HUMAN [view entry] [view interactions] High throughput yes no
TENS3_HUMAN [view interactions] High throughput no no
HTRA4_HUMAN [view interactions] High throughput no no
KMT2C_HUMAN [view interactions] High throughput no no
KCMA1_HUMAN [view entry] [view interactions] High throughput yes no
CAV3_HUMAN [view interactions] High throughput no no
DMD_HUMAN [view entry] [view interactions] High throughput yes no
ITM2B_HUMAN [view interactions] High throughput no yes
ANS1B_HUMAN [view entry] [view interactions] High throughput yes yes
TERF1_HUMAN [view interactions] High throughput no no
TE2IP_HUMAN [view interactions] High throughput no yes
TINF2_HUMAN [view interactions] High throughput no no
PCNA_HUMAN [view interactions] High throughput no no
TRI63_HUMAN [view interactions] High throughput no no
BRD4_HUMAN [view interactions] High throughput no yes
FBX32_HUMAN [view interactions] High throughput no no
NXF1_HUMAN [view interactions] High throughput no yes
MRE11_HUMAN [view interactions] High throughput no yes
S12A2_HUMAN [view entry] [view interactions] High throughput yes yes
TIA1_HUMAN [view interactions] High throughput no no
COBL1_HUMAN [view interactions] High throughput no yes
ATX1_HUMAN [view interactions] High throughput no yes
PKHA4_HUMAN [view interactions] High throughput no yes
OR2K2_HUMAN [view interactions] High throughput no no
T4S20_HUMAN [view interactions] High throughput no yes
ABTB2_HUMAN [view interactions] High throughput no yes
T2EB_HUMAN [view interactions] High throughput no yes
SAR1B_HUMAN [view interactions] High throughput no yes
VAMP8_HUMAN [view interactions] High throughput no no
E2F4_HUMAN [view interactions] High throughput no no
PRKN_HUMAN [view entry] [view interactions] High throughput yes yes
ZRAN1_HUMAN [view interactions] High throughput no yes
TRI67_HUMAN [view interactions] High throughput no no
RPN2_HUMAN [view entry] [view interactions] High throughput yes yes
UBP48_HUMAN [view interactions] High throughput no yes
PRIO_HUMAN [view entry] [view interactions] High throughput yes yes
A4_HUMAN [view entry] [view interactions] High throughput yes yes
UBC_HUMAN [view entry] [view interactions] High throughput yes yes
IDHC_HUMAN [view interactions] High throughput no no
LYPL1_HUMAN [view interactions] High throughput no yes
SH3L1_HUMAN [view interactions] High throughput no yes
PTRD1_HUMAN [view interactions] High throughput no yes
HINT1_HUMAN [view interactions] High throughput no yes
SUMF2_HUMAN [view interactions] High throughput no yes
ACOT1_HUMAN [view interactions] High throughput no yes
KAD2_HUMAN [view interactions] High throughput no no
KAD3_HUMAN [view entry] [view interactions] High throughput yes yes
FAHD1_HUMAN [view interactions] High throughput no yes
GIMA8_HUMAN [view interactions] High throughput no yes
THIO_HUMAN [view interactions] High throughput no yes
THIOM_HUMAN [view interactions] High throughput no yes
NUD19_HUMAN [view interactions] High throughput no no
PGAM2_HUMAN [view entry] [view interactions] High throughput yes no
QOR_HUMAN [view entry] [view interactions] High throughput yes yes
KAP1_HUMAN [view entry] [view interactions] High throughput yes yes
SYUA_HUMAN [view entry] [view interactions] High throughput yes no
SSR3_HUMAN [view interactions] High throughput no yes