KAD1_HUMAN
Evidence for PS localization
Functions
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in KAD1_HUMAN |
|---|---|---|---|---|
| GO:0019900 | kinase binding | 26.6667 | 4 | no |
| GO:0019901 | protein kinase binding | 26.6667 | 5 | no |
| GO:0019205 | nucleobase-containing compound kinase activity | 20.0000 | 5 | yes |
| GO:0030554 | adenyl nucleotide binding | 20.0000 | 5 | yes |
| GO:0032555 | purine ribonucleotide binding | 20.0000 | 4 | yes |
| GO:0032559 | adenyl ribonucleotide binding | 20.0000 | 5 | yes |
| GO:0035639 | purine ribonucleoside triphosphate binding | 20.0000 | 4 | yes |
| GO:0005524 | ATP binding | 20.0000 | 5 | yes |
| GO:0016301 | kinase activity | 20.0000 | 4 | yes |
| GO:0016776 | phosphotransferase activity, phosphate group as acceptor | 20.0000 | 4 | yes |
| GO:0017076 | purine nucleotide binding | 20.0000 | 4 | yes |
| GO:0050145 | nucleoside monophosphate kinase activity | 13.3333 | 5 | yes |
| GO:0004017 | adenylate kinase activity | 13.3333 | 6 | yes |
| GO:0004550 | nucleoside diphosphate kinase activity | 13.3333 | 5 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in KAD1_HUMAN |
|---|---|---|---|---|
| GO:0048522 | positive regulation of cellular process | 46.6667 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 40.0000 | 4 | yes |
| GO:0010646 | regulation of cell communication | 33.3333 | 4 | no |
| GO:0036211 | protein modification process | 33.3333 | 4 | no |
| GO:0043412 | macromolecule modification | 33.3333 | 4 | no |
| GO:0048523 | negative regulation of cellular process | 33.3333 | 4 | no |
| GO:0010038 | response to metal ion | 33.3333 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 26.6667 | 5 | yes |
| GO:0006753 | nucleoside phosphate metabolic process | 26.6667 | 4 | yes |
| GO:0009117 | nucleotide metabolic process | 26.6667 | 5 | yes |
| GO:0009132 | nucleoside diphosphate metabolic process | 26.6667 | 5 | yes |
| GO:0009135 | purine nucleoside diphosphate metabolic process | 26.6667 | 6 | yes |
| GO:0009141 | nucleoside triphosphate metabolic process | 26.6667 | 5 | yes |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 26.6667 | 6 | yes |
| GO:0009150 | purine ribonucleotide metabolic process | 26.6667 | 6 | yes |
| GO:0009179 | purine ribonucleoside diphosphate metabolic process | 26.6667 | 7 | yes |
| GO:0009185 | ribonucleoside diphosphate metabolic process | 26.6667 | 6 | yes |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 26.6667 | 6 | yes |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 26.6667 | 7 | yes |
| GO:0009259 | ribonucleotide metabolic process | 26.6667 | 5 | yes |
| GO:0016310 | phosphorylation | 26.6667 | 5 | yes |
| GO:0019693 | ribose phosphate metabolic process | 26.6667 | 4 | yes |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 26.6667 | 4 | yes |
| GO:0046031 | ADP metabolic process | 26.6667 | 7 | yes |
| GO:0072521 | purine-containing compound metabolic process | 26.6667 | 4 | yes |
| GO:1901566 | organonitrogen compound biosynthetic process | 26.6667 | 4 | yes |
| GO:0009892 | negative regulation of metabolic process | 26.6667 | 4 | no |
| GO:0009893 | positive regulation of metabolic process | 26.6667 | 4 | no |
| GO:0009966 | regulation of signal transduction | 26.6667 | 4 | no |
| GO:0010605 | negative regulation of macromolecule metabolic process | 26.6667 | 5 | no |
| GO:0010941 | regulation of cell death | 26.6667 | 4 | no |
| GO:0019220 | regulation of phosphate metabolic process | 26.6667 | 6 | no |
| GO:0031323 | regulation of cellular metabolic process | 26.6667 | 4 | no |
| GO:0031324 | negative regulation of cellular metabolic process | 26.6667 | 5 | no |
| GO:0031399 | regulation of protein modification process | 26.6667 | 6 | no |
| GO:0042325 | regulation of phosphorylation | 26.6667 | 7 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 26.6667 | 4 | no |
| GO:0051172 | negative regulation of nitrogen compound metabolic process | 26.6667 | 5 | no |
| GO:0051174 | regulation of phosphorus metabolic process | 26.6667 | 5 | no |
| GO:0051240 | positive regulation of multicellular organismal process | 26.6667 | 4 | no |
| GO:0051246 | regulation of protein metabolic process | 26.6667 | 5 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 26.6667 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 26.6667 | 4 | no |
| GO:1902531 | regulation of intracellular signal transduction | 26.6667 | 5 | no |
| GO:0043269 | regulation of ion transport | 26.6667 | 5 | no |
| GO:0051049 | regulation of transport | 26.6667 | 4 | no |
| GO:0071310 | cellular response to organic substance | 26.6667 | 4 | no |
| GO:0080134 | regulation of response to stress | 26.6667 | 4 | no |
| GO:0051128 | regulation of cellular component organization | 26.6667 | 4 | no |
| GO:0051130 | positive regulation of cellular component organization | 26.6667 | 5 | no |
| GO:0006164 | purine nucleotide biosynthetic process | 20.0000 | 6 | yes |
| GO:0006165 | nucleoside diphosphate phosphorylation | 20.0000 | 6 | yes |
| GO:0006172 | ADP biosynthetic process | 20.0000 | 8 | yes |
| GO:0009123 | nucleoside monophosphate metabolic process | 20.0000 | 5 | yes |
| GO:0009126 | purine nucleoside monophosphate metabolic process | 20.0000 | 6 | yes |
| GO:0009133 | nucleoside diphosphate biosynthetic process | 20.0000 | 6 | yes |
| GO:0009136 | purine nucleoside diphosphate biosynthetic process | 20.0000 | 7 | yes |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 20.0000 | 6 | yes |
| GO:0009152 | purine ribonucleotide biosynthetic process | 20.0000 | 7 | yes |
| GO:0009161 | ribonucleoside monophosphate metabolic process | 20.0000 | 6 | yes |
| GO:0009165 | nucleotide biosynthetic process | 20.0000 | 6 | yes |
| GO:0009167 | purine ribonucleoside monophosphate metabolic process | 20.0000 | 7 | yes |
| GO:0009180 | purine ribonucleoside diphosphate biosynthetic process | 20.0000 | 8 | yes |
| GO:0009188 | ribonucleoside diphosphate biosynthetic process | 20.0000 | 7 | yes |
| GO:0009260 | ribonucleotide biosynthetic process | 20.0000 | 6 | yes |
| GO:0018130 | heterocycle biosynthetic process | 20.0000 | 4 | yes |
| GO:0019438 | aromatic compound biosynthetic process | 20.0000 | 4 | yes |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 20.0000 | 4 | yes |
| GO:0046033 | AMP metabolic process | 20.0000 | 7 | yes |
| GO:0046034 | ATP metabolic process | 20.0000 | 7 | yes |
| GO:0046390 | ribose phosphate biosynthetic process | 20.0000 | 5 | yes |
| GO:0046939 | nucleotide phosphorylation | 20.0000 | 6 | yes |
| GO:0072522 | purine-containing compound biosynthetic process | 20.0000 | 5 | yes |
| GO:0090407 | organophosphate biosynthetic process | 20.0000 | 4 | yes |
| GO:1901137 | carbohydrate derivative biosynthetic process | 20.0000 | 4 | yes |
| GO:1901293 | nucleoside phosphate biosynthetic process | 20.0000 | 5 | yes |
| GO:1901362 | organic cyclic compound biosynthetic process | 20.0000 | 4 | yes |
| GO:0015949 | nucleobase-containing small molecule interconversion | 13.3333 | 4 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| FHL2_HUMAN | [view interactions] | Low throughput | no | yes |
| KAD1_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| NBAS_HUMAN | [view interactions] | High throughput | no | yes |
| B3GLT_HUMAN | [view interactions] | High throughput | no | no |
| PCF11_HUMAN | [view interactions] | High throughput | no | no |
| RFIP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CD2B2_HUMAN | [view interactions] | High throughput | no | yes |
| DECR_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GEMI5_HUMAN | [view interactions] | High throughput | no | yes |
| UTP4_HUMAN | [view interactions] | High throughput | no | yes |
| SUCB2_HUMAN | [view interactions] | High throughput | no | no |
| BUD13_HUMAN | [view interactions] | High throughput | no | yes |
| OGT1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| KDM3B_HUMAN | [view interactions] | High throughput | no | yes |
| HNRPU_HUMAN | [view interactions] | High throughput | no | yes |
| TAU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSF1_HUMAN | [view interactions] | High throughput | no | no |
| LRRK2_HUMAN | [view interactions] | High throughput | no | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| CFTR_HUMAN | [view interactions] | High throughput | no | no |
| DUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TENS3_HUMAN | [view interactions] | High throughput | no | no |
| HTRA4_HUMAN | [view interactions] | High throughput | no | no |
| KMT2C_HUMAN | [view interactions] | High throughput | no | no |
| KCMA1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| CAV3_HUMAN | [view interactions] | High throughput | no | no |
| DMD_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| ITM2B_HUMAN | [view interactions] | High throughput | no | yes |
| ANS1B_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TERF1_HUMAN | [view interactions] | High throughput | no | no |
| TE2IP_HUMAN | [view interactions] | High throughput | no | yes |
| TINF2_HUMAN | [view interactions] | High throughput | no | no |
| PCNA_HUMAN | [view interactions] | High throughput | no | no |
| TRI63_HUMAN | [view interactions] | High throughput | no | no |
| BRD4_HUMAN | [view interactions] | High throughput | no | yes |
| FBX32_HUMAN | [view interactions] | High throughput | no | no |
| NXF1_HUMAN | [view interactions] | High throughput | no | yes |
| MRE11_HUMAN | [view interactions] | High throughput | no | yes |
| S12A2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TIA1_HUMAN | [view interactions] | High throughput | no | no |
| COBL1_HUMAN | [view interactions] | High throughput | no | yes |
| ATX1_HUMAN | [view interactions] | High throughput | no | yes |
| PKHA4_HUMAN | [view interactions] | High throughput | no | yes |
| OR2K2_HUMAN | [view interactions] | High throughput | no | no |
| T4S20_HUMAN | [view interactions] | High throughput | no | yes |
| ABTB2_HUMAN | [view interactions] | High throughput | no | yes |
| T2EB_HUMAN | [view interactions] | High throughput | no | yes |
| SAR1B_HUMAN | [view interactions] | High throughput | no | yes |
| VAMP8_HUMAN | [view interactions] | High throughput | no | no |
| A4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| UBC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IDHC_HUMAN | [view interactions] | High throughput | no | no |
| LYPL1_HUMAN | [view interactions] | High throughput | no | yes |
| SH3L1_HUMAN | [view interactions] | High throughput | no | yes |
| PTRD1_HUMAN | [view interactions] | High throughput | no | yes |
| HINT1_HUMAN | [view interactions] | High throughput | no | yes |
| SUMF2_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| KAD3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| FAHD1_HUMAN | [view interactions] | High throughput | no | yes |
| GIMA8_HUMAN | [view interactions] | High throughput | no | yes |
| THIO_HUMAN | [view interactions] | High throughput | no | yes |
| THIOM_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| PGAM2_HUMAN | [view entry] [view interactions] | High throughput | yes | no |