QOR_HUMAN
Evidence for PS localization
Functions
Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding. [View more on UniProt]
Protein features
Binary interactions with known binding regions
To display all evidence describing the interaction with a partner, click on the protein name left to the bars.
Network
Isoforms
Disease-causing germline mutations
No data found.
Linear motifs
No annotated instance was found. To search for linear motifs, use the ELM prediction server.
Fingerprint
Molecular function
| Term | Name | % | Distance from the top of the tree | Annotated in QOR_HUMAN |
|---|---|---|---|---|
| GO:0046872 | metal ion binding | 38.2979 | 4 | yes |
| GO:0016655 | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | 25.5319 | 4 | yes |
| GO:0003723 | RNA binding | 21.2766 | 4 | yes |
| GO:0003954 | NADH dehydrogenase activity | 21.2766 | 4 | no |
| GO:0003955 | NAD(P)H dehydrogenase (quinone) activity | 21.2766 | 5 | no |
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity | 21.2766 | 4 | no |
| GO:0015399 | primary active transmembrane transporter activity | 21.2766 | 4 | no |
| GO:0015453 | oxidoreduction-driven active transmembrane transporter activity | 21.2766 | 5 | no |
| GO:0050136 | NADH dehydrogenase (quinone) activity | 21.2766 | 5 | no |
| GO:0046914 | transition metal ion binding | 12.7660 | 5 | yes |
| GO:0003729 | mRNA binding | 8.5106 | 5 | yes |
| GO:0008270 | zinc ion binding | 8.5106 | 6 | yes |
| GO:0050661 | NADP binding | 6.3830 | 4 | yes |
| GO:0003730 | mRNA 3-UTR binding | 4.2553 | 6 | yes |
| GO:0003960 | NADPH:quinone reductase activity | 4.2553 | 5 | yes |
| GO:0070402 | NADPH binding | 4.2553 | 4 | yes |
Biological process
| Term | Name | % | Distance from top the of the tree | Annotated in QOR_HUMAN |
|---|---|---|---|---|
| GO:0022607 | cellular component assembly | 38.2979 | 4 | yes |
| GO:0019752 | carboxylic acid metabolic process | 38.2979 | 5 | no |
| GO:0043436 | oxoacid metabolic process | 38.2979 | 4 | no |
| GO:0043933 | protein-containing complex organization | 36.1702 | 4 | yes |
| GO:0065003 | protein-containing complex assembly | 36.1702 | 5 | yes |
| GO:0048523 | negative regulation of cellular process | 27.6596 | 4 | no |
| GO:0006796 | phosphate-containing compound metabolic process | 27.6596 | 4 | no |
| GO:0006753 | nucleoside phosphate metabolic process | 23.4043 | 4 | no |
| GO:0009117 | nucleotide metabolic process | 23.4043 | 5 | no |
| GO:0072521 | purine-containing compound metabolic process | 23.4043 | 4 | no |
| GO:0032787 | monocarboxylic acid metabolic process | 23.4043 | 6 | no |
| GO:0022900 | electron transport chain | 23.4043 | 4 | no |
| GO:0022904 | respiratory electron transport chain | 23.4043 | 5 | no |
| GO:0006996 | organelle organization | 21.2766 | 4 | no |
| GO:0043603 | cellular amide metabolic process | 21.2766 | 4 | no |
| GO:1901566 | organonitrogen compound biosynthetic process | 21.2766 | 4 | no |
| GO:0006163 | purine nucleotide metabolic process | 21.2766 | 5 | no |
| GO:0009150 | purine ribonucleotide metabolic process | 21.2766 | 6 | no |
| GO:0009259 | ribonucleotide metabolic process | 21.2766 | 5 | no |
| GO:0019693 | ribose phosphate metabolic process | 21.2766 | 4 | no |
| GO:0031323 | regulation of cellular metabolic process | 21.2766 | 4 | no |
| GO:0048522 | positive regulation of cellular process | 21.2766 | 4 | no |
| GO:0051171 | regulation of nitrogen compound metabolic process | 21.2766 | 4 | no |
| GO:0060255 | regulation of macromolecule metabolic process | 21.2766 | 4 | no |
| GO:0080090 | regulation of primary metabolic process | 21.2766 | 4 | no |
| GO:0051259 | protein complex oligomerization | 14.8936 | 6 | yes |
| GO:0051260 | protein homooligomerization | 14.8936 | 7 | yes |
| GO:0051262 | protein tetramerization | 12.7660 | 7 | yes |
| GO:0051289 | protein homotetramerization | 12.7660 | 8 | yes |
| GO:0007600 | sensory perception | 4.2553 | 4 | yes |
| GO:0007601 | visual perception | 4.2553 | 6 | yes |
| GO:0042178 | xenobiotic catabolic process | 4.2553 | 4 | yes |
| GO:0050953 | sensory perception of light stimulus | 4.2553 | 5 | yes |
Disease
No data found.
All partners
| Uniprot ID | Details | Highest evidence | Localizing into PSD | HPA (protein expression in neurons) |
|---|---|---|---|---|
| QOR_HUMAN | [view entry] [view interactions] | Low throughput | yes | yes |
| ODO1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCNT_HUMAN | [view interactions] | High throughput | no | yes |
| ODPA_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PDPR_HUMAN | [view interactions] | High throughput | no | yes |
| PPIF_HUMAN | [view interactions] | High throughput | no | no |
| PTCD3_HUMAN | [view interactions] | High throughput | no | yes |
| P5CR1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| P5CR2_HUMAN | [view interactions] | High throughput | no | yes |
| GLYM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SGT1_HUMAN | [view interactions] | High throughput | no | no |
| TACO1_HUMAN | [view interactions] | High throughput | no | yes |
| TIM44_HUMAN | [view interactions] | High throughput | no | yes |
| UBP47_HUMAN | [view interactions] | High throughput | no | yes |
| SYVM_HUMAN | [view interactions] | High throughput | no | yes |
| MET17_HUMAN | [view interactions] | High throughput | no | yes |
| IF3M_HUMAN | [view interactions] | High throughput | no | yes |
| RF1ML_HUMAN | [view interactions] | High throughput | no | yes |
| EFTU_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CSK22_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| MD2BP_HUMAN | [view interactions] | High throughput | no | no |
| ZN526_HUMAN | [view interactions] | High throughput | no | yes |
| ASPM_HUMAN | [view interactions] | High throughput | no | no |
| PP6R1_HUMAN | [view interactions] | High throughput | no | no |
| P4R3A_HUMAN | [view interactions] | High throughput | no | yes |
| CUL3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PCH2_HUMAN | [view interactions] | High throughput | no | no |
| SODC_HUMAN | [view interactions] | High throughput | no | yes |
| RL4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MTR1A_HUMAN | [view interactions] | High throughput | no | no |
| VGFR2_HUMAN | [view interactions] | High throughput | no | no |
| CRCM_HUMAN | [view interactions] | High throughput | no | no |
| IKKE_HUMAN | [view interactions] | High throughput | no | yes |
| CBX5_HUMAN | [view interactions] | High throughput | no | yes |
| KIF14_HUMAN | [view interactions] | High throughput | no | no |
| PPCEL_HUMAN | [view interactions] | High throughput | no | yes |
| MTG2_HUMAN | [view interactions] | High throughput | no | yes |
| MUTA_HUMAN | [view interactions] | High throughput | no | yes |
| CSK_HUMAN | [view interactions] | High throughput | no | yes |
| BASP1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IF2B3_HUMAN | [view interactions] | High throughput | no | no |
| K1C17_HUMAN | [view interactions] | High throughput | no | no |
| PFKAP_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SPTN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| G3P_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBA4A_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| TBB5_HUMAN | [view interactions] | High throughput | no | yes |
| TRXR1_HUMAN | [view interactions] | High throughput | no | yes |
| CAB39_HUMAN | [view interactions] | High throughput | no | yes |
| FKBP2_HUMAN | [view interactions] | High throughput | no | yes |
| FSCN1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| YKT6_HUMAN | [view interactions] | High throughput | no | yes |
| DCXR_HUMAN | [view interactions] | High throughput | no | no |
| LEG3_HUMAN | [view interactions] | High throughput | no | yes |
| NNMT_HUMAN | [view interactions] | High throughput | no | no |
| SMAP2_HUMAN | [view interactions] | High throughput | no | yes |
| MTPN_HUMAN | [view interactions] | High throughput | no | yes |
| AL4A1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GLRX5_HUMAN | [view interactions] | High throughput | no | yes |
| FRDA_HUMAN | [view interactions] | High throughput | no | yes |
| SPRE_HUMAN | [view interactions] | High throughput | no | yes |
| ALDOA_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| THTM_HUMAN | [view interactions] | High throughput | no | yes |
| LACB2_HUMAN | [view interactions] | High throughput | no | yes |
| MPPA_HUMAN | [view interactions] | High throughput | no | yes |
| AMPL_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| TBCA_HUMAN | [view interactions] | High throughput | no | yes |
| ACO13_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| CLIC4_HUMAN | [view interactions] | High throughput | no | no |
| PRDX2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| PRDX6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SAP3_HUMAN | [view interactions] | High throughput | no | yes |
| PARK7_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| GSTP1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| KAD2_HUMAN | [view interactions] | High throughput | no | no |
| ALDOC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ETFA_HUMAN | [view interactions] | High throughput | no | yes |
| ETFB_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| IMA3_HUMAN | [view interactions] | High throughput | no | yes |
| THIL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ACOT1_HUMAN | [view interactions] | High throughput | no | yes |
| ACOT2_HUMAN | [view interactions] | High throughput | no | yes |
| AFG32_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ATIF1_HUMAN | [view interactions] | High throughput | no | yes |
| AT5F1_HUMAN | [view interactions] | High throughput | no | yes |
| ATP5J_HUMAN | [view interactions] | High throughput | no | yes |
| ATPF1_HUMAN | [view interactions] | High throughput | no | yes |
| BCS1_HUMAN | [view interactions] | High throughput | no | yes |
| CQ080_HUMAN | [view interactions] | High throughput | no | yes |
| RT29_HUMAN | [view interactions] | High throughput | no | yes |
| ODP2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ODO2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| DNJA2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| ECHM_HUMAN | [view interactions] | High throughput | no | yes |
| RNZ2_HUMAN | [view interactions] | High throughput | no | yes |
| GLSK_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| HINT2_HUMAN | [view interactions] | High throughput | no | yes |
| SYIM_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| SYLM_HUMAN | [view interactions] | High throughput | no | yes |
| LETM1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| LPPRC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| MMAB_HUMAN | [view interactions] | High throughput | no | yes |
| RM43_HUMAN | [view interactions] | High throughput | no | no |
| RT10_HUMAN | [view interactions] | High throughput | no | yes |
| RT14_HUMAN | [view interactions] | High throughput | no | yes |
| RT16_HUMAN | [view interactions] | High throughput | no | yes |
| RT17_HUMAN | [view interactions] | High throughput | no | yes |
| RT18B_HUMAN | [view interactions] | High throughput | no | yes |
| RT02_HUMAN | [view interactions] | High throughput | no | no |
| RT22_HUMAN | [view interactions] | High throughput | no | yes |
| RT23_HUMAN | [view interactions] | High throughput | no | yes |
| RT24_HUMAN | [view interactions] | High throughput | no | yes |
| RT25_HUMAN | [view interactions] | High throughput | no | yes |
| RT26_HUMAN | [view interactions] | High throughput | no | yes |
| RT27_HUMAN | [view interactions] | High throughput | no | yes |
| RT28_HUMAN | [view interactions] | High throughput | no | yes |
| RT31_HUMAN | [view interactions] | High throughput | no | yes |
| RT33_HUMAN | [view interactions] | High throughput | no | no |
| RT34_HUMAN | [view interactions] | High throughput | no | yes |
| RT35_HUMAN | [view interactions] | High throughput | no | yes |
| KGD4_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| RT05_HUMAN | [view interactions] | High throughput | no | yes |
| RT06_HUMAN | [view interactions] | High throughput | no | yes |
| RT07_HUMAN | [view interactions] | High throughput | no | yes |
| RT09_HUMAN | [view interactions] | High throughput | no | yes |
| IF2M_HUMAN | [view interactions] | High throughput | no | yes |
| NDUAC_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA5_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUA6_HUMAN | [view interactions] | High throughput | no | no |
| NDUA9_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUF4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS1_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS3_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS4_HUMAN | [view interactions] | High throughput | no | yes |
| NDUS6_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUS7_HUMAN | [view entry] [view interactions] | High throughput | yes | no |
| NDUS8_HUMAN | [view interactions] | High throughput | no | yes |
| NDUV1_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV2_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NDUV3_HUMAN | [view interactions] | High throughput | no | yes |
| NFL_HUMAN | [view entry] [view interactions] | High throughput | yes | yes |
| NFS1_HUMAN | [view interactions] | High throughput | no | yes |
| NDKM_HUMAN | [view interactions] | High throughput | no | yes |
| NUD19_HUMAN | [view interactions] | High throughput | no | no |
| CREB1_HUMAN | [view interactions] | Computational | no | yes |
| JUN_HUMAN | [view interactions] | Computational | no | yes |
| ATNG_HUMAN | [view interactions] | Computational | no | no |
| NQO1_HUMAN | [view interactions] | Computational | no | no |
| FOS_HUMAN | [view interactions] | Computational | no | yes |
| NF2L2_HUMAN | [view interactions] | Computational | no | yes |
| MCEE_HUMAN | [view interactions] | Computational | no | no |
| HMOX1_HUMAN | [view interactions] | Computational | no | no |